山田 崇史TAKASHI YAMADA
Last Updated :2025/06/04
- 所属・職名
- 大学院医系科学研究科(保) 教授
- ホームページ
- メールアドレス
- yama1976
hiroshima-u.ac.jp
- 自己紹介
- 骨格筋の機能低下に対する新しい治療法を開発するために、特に運動による骨格筋の適応機構、および加齢や一次性・二次性筋疾患における骨格筋の不適応機構の解明を目指しています。
基本情報
主な職歴
- 2007年04月01日, 2010年03月31日, カロリンスカ研究所, 研究員
- 2016年04月01日, 2025年03月31日, 札幌医科大学, 准教授
- 2011年05月01日, 2016年03月31日, 札幌医科大学, 講師
- 2010年04月01日, 2011年04月31日, 札幌医科大学, 助手
学歴
- 広島大学, 大学院医学研究科 博士課程後期, 2001年04月01日, 2004年03月31日
担当主専攻プログラム
研究分野
- 複合領域 / 人間医工学 / リハビリテーション科学・福祉工学
研究キーワード
- スポーツ傷害予防,スポーツパフォーマンス向上,スポーツリハビリテーションの応用
所属学会
- 日本運動生理学会
- 日本筋学会
- 日本基礎理学療法学会
- 日本体力医学会
教育活動
授業担当
- 2025年, 教養教育, 2ターム, 健康スポーツ科学[1医理,1医作]
- 2025年, 学部専門, セメスター(後期), スポーツ外傷理学療法学実習
- 2025年, 学部専門, 1ターム, スポーツ外傷理学療法学総論
- 2025年, 学部専門, 2ターム, スポーツ外傷理学療法学各論
- 2025年, 修士課程・博士課程前期, 2ターム, 多職種連携A
- 2025年, 博士課程・博士課程後期, 2ターム, 多職種連携B
- 2025年, 博士課程・博士課程後期, セメスター(前期), 心身機能生活制御科学特別研究
- 2025年, 博士課程・博士課程後期, セメスター(後期), 心身機能生活制御科学特別研究
- 2025年, 修士課程・博士課程前期, セメスター(前期), スポーツリハビリテーション学特論
- 2025年, 修士課程・博士課程前期, セメスター(前期), スポーツリハビリテーション学特論
- 2025年, 修士課程・博士課程前期, セメスター(前期), スポーツリハビリテーション学特別演習
- 2025年, 修士課程・博士課程前期, セメスター(後期), スポーツリハビリテーション学特別演習
- 2025年, 修士課程・博士課程前期, セメスター(前期), スポーツリハビリテーション学特別演習
- 2025年, 修士課程・博士課程前期, セメスター(後期), スポーツリハビリテーション学特別演習
- 2025年, 修士課程・博士課程前期, 通年, スポーツリハビリテーション学特別研究
- 2025年, 博士課程・博士課程後期, セメスター(前期), スポーツリハビリテーション学特講
- 2025年, 博士課程・博士課程後期, セメスター(前期), スポーツリハビリテーション学特講
- 2025年, 博士課程・博士課程後期, セメスター(前期), スポーツリハビリテーション学特講演習
- 2025年, 博士課程・博士課程後期, セメスター(後期), スポーツリハビリテーション学特講演習
- 2025年, 博士課程・博士課程後期, セメスター(前期), スポーツリハビリテーション学特講演習
- 2025年, 博士課程・博士課程後期, セメスター(後期), スポーツリハビリテーション学特講演習
- 2025年, 修士課程・博士課程前期, セメスター(前期), スポーツリハビリテーション学特別研究
- 2025年, 修士課程・博士課程前期, セメスター(後期), スポーツリハビリテーション学特別研究
研究活動
学術論文(★は代表的な論文)
- 筋収縮における乳酸の役割, 体育学研究, 51巻, pp. 229-239, 20060401
- 骨格筋を知る―分子レベルから覗く骨格筋研究―7,老化に伴う筋弱化のメカニズム, 体育の科学, 51巻, pp. 229-239, 20060401
- 関節リウマチにおける筋力低下のメカニズムとその対策, 日本基礎理学療法学雑誌, 15巻, pp. 9-16, 20120401
- 関節リウマチに伴う筋弱化のメカニズム, 理学療法学, 42巻, pp. 819-820, 20150401
- 「ICUAWの診断と治療 up to date」重症疾患ミオパチーの病態メカニズム, 臨床神経生理学, 48巻, pp. 136-140, 20200401
- 筋力低下に対する神経-筋電気刺激の処方:その安全性と有効性, 物理療法科学, 29巻, pp. 19-25, 20220401
- ストレッチは脱神経後早期における骨格筋の興奮性低下を軽減する, 基礎理学療法学, 24巻, pp. 1-10, 20210401
- 神経筋電気刺激療法とグルタミン投与の併用がcolon 26がんモデルマウスにおける筋萎縮に及ぼす影響, 日本基礎理学療法学雑誌, 22巻, pp. 39-47, 20190401
- 神経筋電気刺激誘引性の筋肥大における負荷強度と力積の役割, 日本基礎理学療法学雑誌, 20巻, pp. 37-43, 20170401
- 熱刺激負荷がアジュバント関節炎ラットの長趾伸筋における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 19巻, pp. 39-47, 20160401
- 熱刺激がモノクロタリン誘発性肺高血圧症ラットの横隔膜における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 19巻, pp. 55-64, 20160401
- 神経-筋電気刺激療法が癌性カへキシアに伴う筋量低下に及ぼす影響, 物理療法科学, 23巻, pp. 35-43, 20160401
- 熱刺激が脱神経後のラット骨格筋における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 17巻, pp. 53-62, 20130401
- N-acetylcysteineが筋疲労時の横隔膜筋小胞体の機能に及ぼす影響, 広島体育学研究, 29巻, pp. 27-34, 20030401
- Endurance training-induced changes in alkali light chain patterns in type IIB fibers of the rat, J. Appl. Physiol., 94巻, pp. 923-929, 20030401
- 骨格筋損傷後の再生単一筋線維におけるミオシン重鎖アイソフォームの発現, 理学療法学, 29巻, pp. 6-13, 20020401
- 骨格筋再生過程におけるミオシン重鎖アイソフォームとmyogenin・MyoD発現について, 広島大学保健学ジャーナル, 2巻, pp. 12-18, 20020401
- 右心不全ラットにおける骨格筋筋小胞体のCa2+取り込み能およびSERCA発現について, 広島大学保健学ジャーナル, 2巻, pp. 19-25, 20020401
- 筋ジストロフィーモデル動物(mdxマウス)の脳梗塞修復機転におけるアストロサイトの役割について, 広島大学保健学ジャーナル, 2巻, pp. 26-33, 20020401
- 脊髄半切ラットにおける半切側下肢の過用が脊髄交叉性セロトニン線維の増加におよぼす影響, 理学療法学, 28巻, pp. 1-8, 20010401
- 脊髄損傷ラットにおける骨格筋Myosin heavy chainアイソフォームの経時的変化, 広島大学保健学ジャーナル, 1巻, pp. 60-64, 20010401
- 脊髄半切ラットにおける脊髄交叉性セロトニン線維の経時的変化:歩行動作機能回復との関連について, 理学療法の医学的基礎, 4巻, pp. 14-24, 20000401
- Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load, FASEB JOURNAL, 39巻, 10号, pp. e70631, 20250531
- Erratum: Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4 (iScience (2021) 24(4), (S2589004221002716), (10.1016/j.isci.2021.102303)), iScience, 28巻, 6号, 20250620
- Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice, Advanced Science, 12巻, 16号, 20250424
- Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle, Journal of Applied Physiology, 138巻, 1号, pp. 107-120, 20250101
- Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression, Exercise and Sport Sciences Reviews, 53巻, 1号, pp. 41-47, 20250101
- Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain, Journal of Orthopaedic Research, 42巻, 6号, pp. 1190-1199, 20240601
- High-intensity interval training using electrical stimulation ameliorates muscle fatigue in chronic kidney disease-related cachexia by restoring mitochondrial respiratory dysfunction, Frontiers in Physiology, 15巻, 20240101
- High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle, Journal of Physiology, 601巻, 14号, pp. 2917-2933, 20230715
- Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats, Journal of Applied Physiology, 135巻, 4号, pp. 731-746, 20230101
- Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca2+ release in compensatory hypertrophied muscle fibers following synergist ablation, American Journal of Physiology - Cell Physiology, 325巻, 3号, pp. C599-C612, 20230101
- Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training, Arthritis Research and Therapy, 24巻, 1号, 20221201
- Citrullination is linked to reduced Ca2+ sensitivity in hearts of a murine model of rheumatoid arthritis, Acta Physiologica, 236巻, 3号, 20221101
- Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles, American Journal of Physiology - Cell Physiology, 323巻, 3号, pp. C885-C895, 20220901
- Preconditioning contractions prevent prolonged force depression and Ca2 - dependent proteolysis of STAC3 after damaging eccentric contractions, Journal of Applied Physiology, 131巻, 5号, pp. 1399-1407, 20211101
- Larger improvements in fatigue resistance and mitochondrial function with high- than with low-intensity contractions during interval training of mouse skeletal muscle, FASEB Journal, 35巻, 11号, 20211101
- Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats, Physiological Reports, 9巻, 18号, 20210901
- Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies, Arthritis and Rheumatology, 73巻, 5号, pp. 848-857, 20210501
- Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4, iScience, 24巻, 4号, 20210423
- Mechanisms of decline in muscle quality in sarcopenia, Sarcopenia: Molecular Mechanism and Treatment Strategies, pp. 295-322, 20210101
- BGP-15: A potential therapeutic agent for critical illness myopathy, Acta Physiologica, 229巻, 1号, 20200501
- Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation, Frontiers in Physiology, 11巻, 20200428
- Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load, PLoS ONE, 14巻, 10号, 20191001
- A Mechanism for Statin-Induced Susceptibility to Myopathy, JACC: Basic to Translational Science, 4巻, 4号, pp. 509-523, 20190801
- Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle, Nutrition, 58巻, pp. 23-29, 20190201
- Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans, Experimental Brain Research, 237巻, 1号, pp. 47-56, 20190131
- Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis, JCI Insight, 4巻, 9号, 20190101
- Eccentric training enhances the B-crystallin binding to the myofibrils and prevents skeletal muscle weakness in adjuvant-induced arthritis rat, Journal of Applied Physiology, 127巻, 1号, pp. 71-80, 20190101
- Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions, Journal of Physiology, 596巻, 18号, pp. 4427-4442, 20180915
- Electrical stimulation prevents preferential skeletal muscle myosin loss in steroid-denervation rats, Frontiers in Physiology, 9巻, AUG号, 20180810
- High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice, PLoS ONE, 13巻, 6号, 20180601
- Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy, Journal of Applied Physiology, 124巻, 2号, pp. 341-348, 20180201
- Preconditioning contractions suppress muscle pain markers after damaging eccentric contractions, Pain Research and Management, 2018巻, 20180101
- l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain, Physiological Reports, 6巻, 2号, 20180101
- Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2 + and Free Radical Signaling, EBioMedicine, 23巻, pp. 12-19, 20170901
- Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat, PLoS ONE, 12巻, 6号, 20170601
- Role of calpain in eccentric contraction-induced proteolysis of Ca2+ - Regulatory proteins and force depression in rat fast-twitch skeletal muscle, Journal of Applied Physiology, 122巻, 2号, pp. 396-405, 20170201
- Superoxide dismutase/catalase mimetic EUK- 134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension, PLoS ONE, 12巻, 2号, 20170201
- The role of reactive oxygen species in β-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome, PLoS ONE, 11巻, 12号, 20161201
- Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery, Journal of Physiology, 594巻, 18号, pp. 5149-5160, 20160915
- Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness, Annals of the Rheumatic Diseases, 74巻, 10号, pp. 1907-1914, 20151001
- Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment, Skeletal Muscle, 5巻, 1号, 20150709
- Response of heat shock protein 72 to repeated bouts of hyperthermia in rat skeletal muscle, Physiological Research, 64巻, 6号, pp. 935-938, 20150101
- Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice, Journal of Physiology, 590巻, 23号, pp. 6187-6197, 20121201
- Characteristics and mechanisms of low-frequency muscle fatigue: Alterations in skeletal muscle, Japanese Journal of Physical Fitness and Sports Medicine, 61巻, 3号, pp. 297-306, 20120101
- Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes, Journal of Physiology, 589巻, 7号, pp. 1791-1801, 20110401
- Mechanisms of skeletal muscle weakness, Advances in Experimental Medicine and Biology, 682巻, pp. 279-296, 20101201
- Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice, Journal of Physiology, 588巻, 21号, pp. 4275-4288, 20101101
- β-hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle, American Journal of Physiology - Endocrinology and Metabolism, 299巻, 3号, 20100901
- Muscle fatigue: From observations in humans to underlying mechanisms studied in intact single muscle fibres, European Journal of Applied Physiology, 110巻, 1号, pp. 1-15, 20100901
- Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies, FASEB Journal, 24巻, 2号, pp. 570-578, 20100201
- Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis, Arthritis and Rheumatism, 60巻, 11号, pp. 3280-3289, 20091101
- High temperature does not alter fatigability in intact mouse skeletal muscle fibres, Journal of Physiology, 587巻, 19号, pp. 4717-4724, 20091001
- No relationship between enzyme activity and structure of nucleotide binding site in sarcoplasmic reticulum Ca2+-ATPase from short-term stimulated rat muscle, Acta Physiologica, 196巻, 4号, pp. 401-409, 20090801
- Interpolated twitches in fatiguing single mouse muscle fibres: Implications for the assessment of central fatigue, Journal of Physiology, 586巻, 11号, pp. 2799-2805, 20080601
- Time course of changes in in vitro sarcoplasmic reticulum Ca 2+-handling and Na+-K+-ATPase activity during repetitive contractions, Pflugers Archiv European Journal of Physiology, 456巻, 3号, pp. 601-609, 20080601
- Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling, International Journal of Sport Nutrition and Exercise Metabolism, 18巻, 4号, pp. 399-411, 20080101
- Effect of high-intensity training and acute exercise on Ca 2+-sequestering function of sarcoplasmic reticulum : Role of oxidative modification, Japanese Journal of Physical Fitness and Sports Medicine, 57巻, 3号, pp. 327-338, 20080101
- Alterations in in vitro function and protein oxidation of rat sarcoplasmic reticulum Ca2+-ATPase during recovery from high-intensity exercise, Experimental Physiology, 93巻, 3号, pp. 426-433, 20080101
- Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice, Journal of Physiology, 586巻, 1号, pp. 175-184, 20080101
- Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat diaphragm, Journal of Applied Physiology, 102巻, 5号, pp. 1850-1855, 20070501
- Effects of high-intensity training and acute exercise on in vitro function of rat sarcoplasmic reticulum, European Journal of Applied Physiology, 99巻, 6号, pp. 641-649, 20070401
- Relationship between oxidation of myofibrillar proteins and contractile properties in soleus muscles from hyperthyroid rat, Japanese Journal of Physical Fitness and Sports Medicine, 56巻, 5号, pp. 473-480, 20070101
- Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus, Journal of Applied Physiology, 100巻, 5号, pp. 1520-1526, 20060501
- Effects of reduced glycogen on structure and in vitro function of rat sarcoplasmic reticulum Ca2+-ATPase, Pflugers Archiv European Journal of Physiology, 452巻, 1号, pp. 117-123, 20060401
- Changes in sarcoplasmic reticulum Ca2+-sequestering capacity during recovery following high-intensity exercise: Comparisons between fast- and slow-twitch muscles, Japanese Journal of Physical Fitness and Sports Medicine, 55巻, 5号, pp. 503-512, 20060101
- N-acetylcysteine fails to modulate the in vitro function of sarcoplasmic reticulum of diaphragm in the final phase of fatigue, Acta Physiologica Scandinavica, 184巻, 3号, pp. 195-202, 20050701
- Effects of thyroid hormone on sarcoplasmic reticulum Ca2+ uptake and contractile properties in rat soleus muscle, Japanese Journal of Physical Fitness and Sports Medicine, 53巻, 5号, pp. 509-518, 20040101
- Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism, Acta Physiologica Scandinavica, 180巻, 1号, pp. 79-87, 20040101
- Oxidation of sarcoplasmic reticulum Ca2+-ATPase induced by high-intensity exercise, Pflugers Archiv European Journal of Physiology, 446巻, 3号, pp. 394-399, 20030601
- Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise, Acta Physiologica Scandinavica, 176巻, 3号, pp. 227-232, 20021126