山田 崇史TAKASHI YAMADA

Last Updated :2025/06/04

所属・職名
大学院医系科学研究科（保）　教授
ホームページ
https://sporehalab.wixsite.com/website-3
メールアドレス
yama1976hiroshima-u.ac.jp
自己紹介
骨格筋の機能低下に対する新しい治療法を開発するために、特に運動による骨格筋の適応機構、および加齢や一次性・二次性筋疾患における骨格筋の不適応機構の解明を目指しています。

基本情報

主な職歴

  • 2007年04月01日, 2010年03月31日, カロリンスカ研究所, 研究員
  • 2016年04月01日, 2025年03月31日, 札幌医科大学, 准教授
  • 2011年05月01日, 2016年03月31日, 札幌医科大学, 講師
  • 2010年04月01日, 2011年04月31日, 札幌医科大学, 助手

学歴

  • 広島大学, 大学院医学研究科 博士課程後期, 2001年04月01日, 2004年03月31日

担当主専攻プログラム

  • 理学療法学プログラム

研究分野

  • 複合領域 / 人間医工学 / リハビリテーション科学・福祉工学

研究キーワード

  • スポーツ傷害予防，スポーツパフォーマンス向上，スポーツリハビリテーションの応用

所属学会

  • 日本運動生理学会
  • 日本筋学会
  • 日本基礎理学療法学会
  • 日本体力医学会

教育活動

授業担当

  1. 2025年, 教養教育, ２ターム, 健康スポーツ科学[1医理,1医作]
  2. 2025年, 学部専門, セメスター（後期）, スポーツ外傷理学療法学実習
  3. 2025年, 学部専門, １ターム, スポーツ外傷理学療法学総論
  4. 2025年, 学部専門, ２ターム, スポーツ外傷理学療法学各論
  5. 2025年, 修士課程・博士課程前期, ２ターム, 多職種連携A
  6. 2025年, 博士課程・博士課程後期, ２ターム, 多職種連携B
  7. 2025年, 博士課程・博士課程後期, セメスター（前期）, 心身機能生活制御科学特別研究
  8. 2025年, 博士課程・博士課程後期, セメスター（後期）, 心身機能生活制御科学特別研究
  9. 2025年, 修士課程・博士課程前期, セメスター（前期）, スポーツリハビリテーション学特論
  10. 2025年, 修士課程・博士課程前期, セメスター（前期）, スポーツリハビリテーション学特論
  11. 2025年, 修士課程・博士課程前期, セメスター（前期）, スポーツリハビリテーション学特別演習
  12. 2025年, 修士課程・博士課程前期, セメスター（後期）, スポーツリハビリテーション学特別演習
  13. 2025年, 修士課程・博士課程前期, セメスター（前期）, スポーツリハビリテーション学特別演習
  14. 2025年, 修士課程・博士課程前期, セメスター（後期）, スポーツリハビリテーション学特別演習
  15. 2025年, 修士課程・博士課程前期, 通年, スポーツリハビリテーション学特別研究
  16. 2025年, 博士課程・博士課程後期, セメスター（前期）, スポーツリハビリテーション学特講
  17. 2025年, 博士課程・博士課程後期, セメスター（前期）, スポーツリハビリテーション学特講
  18. 2025年, 博士課程・博士課程後期, セメスター（前期）, スポーツリハビリテーション学特講演習
  19. 2025年, 博士課程・博士課程後期, セメスター（後期）, スポーツリハビリテーション学特講演習
  20. 2025年, 博士課程・博士課程後期, セメスター（前期）, スポーツリハビリテーション学特講演習
  21. 2025年, 博士課程・博士課程後期, セメスター（後期）, スポーツリハビリテーション学特講演習
  22. 2025年, 修士課程・博士課程前期, セメスター（前期）, スポーツリハビリテーション学特別研究
  23. 2025年, 修士課程・博士課程前期, セメスター（後期）, スポーツリハビリテーション学特別研究

研究活動

学術論文（★は代表的な論文）

  1. 筋収縮における乳酸の役割, 体育学研究, 51巻, pp. 229-239, 20060401
  2. 骨格筋を知る―分子レベルから覗く骨格筋研究―7，老化に伴う筋弱化のメカニズム, 体育の科学, 51巻, pp. 229-239, 20060401
  3. 関節リウマチにおける筋力低下のメカニズムとその対策, 日本基礎理学療法学雑誌, 15巻, pp. 9-16, 20120401
  4. 関節リウマチに伴う筋弱化のメカニズム, 理学療法学, 42巻, pp. 819-820, 20150401
  5. 「ICUAWの診断と治療 up to date」重症疾患ミオパチーの病態メカニズム, 臨床神経生理学, 48巻, pp. 136-140, 20200401
  6. 筋力低下に対する神経-筋電気刺激の処方：その安全性と有効性, 物理療法科学, 29巻, pp. 19-25, 20220401
  7. ストレッチは脱神経後早期における骨格筋の興奮性低下を軽減する, 基礎理学療法学, 24巻, pp. 1-10, 20210401
  8. 神経筋電気刺激療法とグルタミン投与の併用がcolon 26がんモデルマウスにおける筋萎縮に及ぼす影響, 日本基礎理学療法学雑誌, 22巻, pp. 39-47, 20190401
  9. 神経筋電気刺激誘引性の筋肥大における負荷強度と力積の役割, 日本基礎理学療法学雑誌, 20巻, pp. 37-43, 20170401
  10. 熱刺激負荷がアジュバント関節炎ラットの長趾伸筋における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 19巻, pp. 39-47, 20160401
  11. 熱刺激がモノクロタリン誘発性肺高血圧症ラットの横隔膜における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 19巻, pp. 55-64, 20160401
  12. 神経-筋電気刺激療法が癌性カへキシアに伴う筋量低下に及ぼす影響, 物理療法科学, 23巻, pp. 35-43, 20160401
  13. 熱刺激が脱神経後のラット骨格筋における収縮機能に及ぼす影響, 日本基礎理学療法学雑誌, 17巻, pp. 53-62, 20130401
  14. N-acetylcysteineが筋疲労時の横隔膜筋小胞体の機能に及ぼす影響, 広島体育学研究, 29巻, pp. 27-34, 20030401
  15. Endurance training-induced changes in alkali light chain patterns in type IIB fibers of the rat, J. Appl. Physiol., 94巻, pp. 923-929, 20030401
  16. 骨格筋損傷後の再生単一筋線維におけるミオシン重鎖アイソフォームの発現, 理学療法学, 29巻, pp. 6-13, 20020401
  17. 骨格筋再生過程におけるミオシン重鎖アイソフォームとmyogenin・MyoD発現について, 広島大学保健学ジャーナル, 2巻, pp. 12-18, 20020401
  18. 右心不全ラットにおける骨格筋筋小胞体のCa2+取り込み能およびSERCA発現について, 広島大学保健学ジャーナル, 2巻, pp. 19-25, 20020401
  19. 筋ジストロフィーモデル動物（mdxマウス）の脳梗塞修復機転におけるアストロサイトの役割について, 広島大学保健学ジャーナル, 2巻, pp. 26-33, 20020401
  20. 脊髄半切ラットにおける半切側下肢の過用が脊髄交叉性セロトニン線維の増加におよぼす影響, 理学療法学, 28巻, pp. 1-8, 20010401
  21. 脊髄損傷ラットにおける骨格筋Myosin heavy chainアイソフォームの経時的変化, 広島大学保健学ジャーナル, 1巻, pp. 60-64, 20010401
  22. 脊髄半切ラットにおける脊髄交叉性セロトニン線維の経時的変化：歩行動作機能回復との関連について, 理学療法の医学的基礎, 4巻, pp. 14-24, 20000401
  23. Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load, FASEB JOURNAL, 39巻, 10号, pp. e70631, 20250531
    DOIを用いた論文検索結果へのリンク
  24. Erratum: Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4 (iScience (2021) 24(4), (S2589004221002716), (10.1016/j.isci.2021.102303)), iScience, 28巻, 6号, 20250620
  25. Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice, Advanced Science, 12巻, 16号, 20250424
  26. Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle, Journal of Applied Physiology, 138巻, 1号, pp. 107-120, 20250101
  27. Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression, Exercise and Sport Sciences Reviews, 53巻, 1号, pp. 41-47, 20250101
  28. Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain, Journal of Orthopaedic Research, 42巻, 6号, pp. 1190-1199, 20240601
  29. High-intensity interval training using electrical stimulation ameliorates muscle fatigue in chronic kidney disease-related cachexia by restoring mitochondrial respiratory dysfunction, Frontiers in Physiology, 15巻, 20240101
  30. High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle, Journal of Physiology, 601巻, 14号, pp. 2917-2933, 20230715
  31. Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats, Journal of Applied Physiology, 135巻, 4号, pp. 731-746, 20230101
  32. Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca2+ release in compensatory hypertrophied muscle fibers following synergist ablation, American Journal of Physiology - Cell Physiology, 325巻, 3号, pp. C599-C612, 20230101
  33. Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training, Arthritis Research and Therapy, 24巻, 1号, 20221201
  34. Citrullination is linked to reduced Ca2+ sensitivity in hearts of a murine model of rheumatoid arthritis, Acta Physiologica, 236巻, 3号, 20221101
  35. Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles, American Journal of Physiology - Cell Physiology, 323巻, 3号, pp. C885-C895, 20220901
  36. Preconditioning contractions prevent prolonged force depression and Ca2 - dependent proteolysis of STAC3 after damaging eccentric contractions, Journal of Applied Physiology, 131巻, 5号, pp. 1399-1407, 20211101
  37. Larger improvements in fatigue resistance and mitochondrial function with high- than with low-intensity contractions during interval training of mouse skeletal muscle, FASEB Journal, 35巻, 11号, 20211101
  38. Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats, Physiological Reports, 9巻, 18号, 20210901
  39. Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies, Arthritis and Rheumatology, 73巻, 5号, pp. 848-857, 20210501
  40. Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4, iScience, 24巻, 4号, 20210423
  41. Mechanisms of decline in muscle quality in sarcopenia, Sarcopenia: Molecular Mechanism and Treatment Strategies, pp. 295-322, 20210101
  42. BGP-15: A potential therapeutic agent for critical illness myopathy, Acta Physiologica, 229巻, 1号, 20200501
  43. Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation, Frontiers in Physiology, 11巻, 20200428
  44. Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load, PLoS ONE, 14巻, 10号, 20191001
  45. A Mechanism for Statin-Induced Susceptibility to Myopathy, JACC: Basic to Translational Science, 4巻, 4号, pp. 509-523, 20190801
  46. Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle, Nutrition, 58巻, pp. 23-29, 20190201
  47. Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans, Experimental Brain Research, 237巻, 1号, pp. 47-56, 20190131
  48. Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis, JCI Insight, 4巻, 9号, 20190101
  49. Eccentric training enhances the B-crystallin binding to the myofibrils and prevents skeletal muscle weakness in adjuvant-induced arthritis rat, Journal of Applied Physiology, 127巻, 1号, pp. 71-80, 20190101
  50. Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions, Journal of Physiology, 596巻, 18号, pp. 4427-4442, 20180915
  51. Electrical stimulation prevents preferential skeletal muscle myosin loss in steroid-denervation rats, Frontiers in Physiology, 9巻, AUG号, 20180810
  52. High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice, PLoS ONE, 13巻, 6号, 20180601
  53. Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy, Journal of Applied Physiology, 124巻, 2号, pp. 341-348, 20180201
  54. Preconditioning contractions suppress muscle pain markers after damaging eccentric contractions, Pain Research and Management, 2018巻, 20180101
  55. l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain, Physiological Reports, 6巻, 2号, 20180101
  56. Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2 + and Free Radical Signaling, EBioMedicine, 23巻, pp. 12-19, 20170901
  57. Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat, PLoS ONE, 12巻, 6号, 20170601
  58. Role of calpain in eccentric contraction-induced proteolysis of Ca2+ - Regulatory proteins and force depression in rat fast-twitch skeletal muscle, Journal of Applied Physiology, 122巻, 2号, pp. 396-405, 20170201
  59. Superoxide dismutase/catalase mimetic EUK- 134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension, PLoS ONE, 12巻, 2号, 20170201
  60. The role of reactive oxygen species in β-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome, PLoS ONE, 11巻, 12号, 20161201
  61. Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery, Journal of Physiology, 594巻, 18号, pp. 5149-5160, 20160915
  62. Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness, Annals of the Rheumatic Diseases, 74巻, 10号, pp. 1907-1914, 20151001
  63. Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment, Skeletal Muscle, 5巻, 1号, 20150709
  64. Response of heat shock protein 72 to repeated bouts of hyperthermia in rat skeletal muscle, Physiological Research, 64巻, 6号, pp. 935-938, 20150101
  65. Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice, Journal of Physiology, 590巻, 23号, pp. 6187-6197, 20121201
  66. Characteristics and mechanisms of low-frequency muscle fatigue: Alterations in skeletal muscle, Japanese Journal of Physical Fitness and Sports Medicine, 61巻, 3号, pp. 297-306, 20120101
  67. Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes, Journal of Physiology, 589巻, 7号, pp. 1791-1801, 20110401
  68. Mechanisms of skeletal muscle weakness, Advances in Experimental Medicine and Biology, 682巻, pp. 279-296, 20101201
  69. Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice, Journal of Physiology, 588巻, 21号, pp. 4275-4288, 20101101
  70. β-hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle, American Journal of Physiology - Endocrinology and Metabolism, 299巻, 3号, 20100901
  71. Muscle fatigue: From observations in humans to underlying mechanisms studied in intact single muscle fibres, European Journal of Applied Physiology, 110巻, 1号, pp. 1-15, 20100901
  72. Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies, FASEB Journal, 24巻, 2号, pp. 570-578, 20100201
  73. Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis, Arthritis and Rheumatism, 60巻, 11号, pp. 3280-3289, 20091101
  74. High temperature does not alter fatigability in intact mouse skeletal muscle fibres, Journal of Physiology, 587巻, 19号, pp. 4717-4724, 20091001
  75. No relationship between enzyme activity and structure of nucleotide binding site in sarcoplasmic reticulum Ca2+-ATPase from short-term stimulated rat muscle, Acta Physiologica, 196巻, 4号, pp. 401-409, 20090801
  76. Interpolated twitches in fatiguing single mouse muscle fibres: Implications for the assessment of central fatigue, Journal of Physiology, 586巻, 11号, pp. 2799-2805, 20080601
  77. Time course of changes in in vitro sarcoplasmic reticulum Ca 2+-handling and Na+-K+-ATPase activity during repetitive contractions, Pflugers Archiv European Journal of Physiology, 456巻, 3号, pp. 601-609, 20080601
  78. Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling, International Journal of Sport Nutrition and Exercise Metabolism, 18巻, 4号, pp. 399-411, 20080101
  79. Effect of high-intensity training and acute exercise on Ca 2+-sequestering function of sarcoplasmic reticulum : Role of oxidative modification, Japanese Journal of Physical Fitness and Sports Medicine, 57巻, 3号, pp. 327-338, 20080101
  80. Alterations in in vitro function and protein oxidation of rat sarcoplasmic reticulum Ca2+-ATPase during recovery from high-intensity exercise, Experimental Physiology, 93巻, 3号, pp. 426-433, 20080101
  81. Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice, Journal of Physiology, 586巻, 1号, pp. 175-184, 20080101
  82. Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat diaphragm, Journal of Applied Physiology, 102巻, 5号, pp. 1850-1855, 20070501
  83. Effects of high-intensity training and acute exercise on in vitro function of rat sarcoplasmic reticulum, European Journal of Applied Physiology, 99巻, 6号, pp. 641-649, 20070401
  84. Relationship between oxidation of myofibrillar proteins and contractile properties in soleus muscles from hyperthyroid rat, Japanese Journal of Physical Fitness and Sports Medicine, 56巻, 5号, pp. 473-480, 20070101
  85. Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus, Journal of Applied Physiology, 100巻, 5号, pp. 1520-1526, 20060501
  86. Effects of reduced glycogen on structure and in vitro function of rat sarcoplasmic reticulum Ca2+-ATPase, Pflugers Archiv European Journal of Physiology, 452巻, 1号, pp. 117-123, 20060401
  87. Changes in sarcoplasmic reticulum Ca2+-sequestering capacity during recovery following high-intensity exercise: Comparisons between fast- and slow-twitch muscles, Japanese Journal of Physical Fitness and Sports Medicine, 55巻, 5号, pp. 503-512, 20060101
  88. N-acetylcysteine fails to modulate the in vitro function of sarcoplasmic reticulum of diaphragm in the final phase of fatigue, Acta Physiologica Scandinavica, 184巻, 3号, pp. 195-202, 20050701
  89. Effects of thyroid hormone on sarcoplasmic reticulum Ca2+ uptake and contractile properties in rat soleus muscle, Japanese Journal of Physical Fitness and Sports Medicine, 53巻, 5号, pp. 509-518, 20040101
  90. Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism, Acta Physiologica Scandinavica, 180巻, 1号, pp. 79-87, 20040101
  91. Oxidation of sarcoplasmic reticulum Ca2+-ATPase induced by high-intensity exercise, Pflugers Archiv European Journal of Physiology, 446巻, 3号, pp. 394-399, 20030601
  92. Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise, Acta Physiologica Scandinavica, 176巻, 3号, pp. 227-232, 20021126