TAKASHI YAMADA

Last Updated :2025/07/18

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
Web Site
https://sporehalab.wixsite.com/website-3
E-mail
yama1976hiroshima-u.ac.jp
Self-introduction
To develop novel therapeutic interventions to treat skeletal muscle weakness, we investigate the mechanisms behind muscle adaptations in response to physical therapy and maladaptations in aging and primary and secondary myopathies.

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2010/03/31, karolinska Institutet, Research fellow
  • 2016/04/01, 2025/03/31, Sapporo Medical Univsesity, Associate Professor
  • 2011/05/01, 2016/03/31, Sapporo Medical Univsesity, Lecturer
  • 2010/04/01, 2011/04/31, Sapporo Medical Univsesity, Assistant Professor

Research Fields

  • Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering

Research Keywords

  • Prevention of Sports Injury, Enhancement of Sports Performance, Application of Sports Rehabilitation

Affiliated Academic Societies

  • Japan Society of Exercise and Sports Physiology
  • Japan Muscle Society
  • Japan Society of Physical Therapy Fundamentals
  • Japanese Society of Physical Fitness and Sports Medicine

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, Health and Sports Sciences
  2. 2025, Undergraduate Education, Second Semester, Basic Theory of Athletic Training　(practice)
  3. 2025, Undergraduate Education, 1Term, Sport Physical Therapy Ⅰ
  4. 2025, Undergraduate Education, 2Term, Sport Physical Therapy II
  5. 2025, Graduate Education (Master's Program) , 2Term, Multidisciplinary Cooperation A
  6. 2025, Graduate Education (Doctoral Program) , 2Term, Multidisciplinary Cooperation B
  7. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
  8. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
  9. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Sports Rehabilitation
  10. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Sports Rehabilitation
  11. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Sports Rehabilitation
  12. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Sports Rehabilitation
  13. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Sports Rehabilitation
  14. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Sports Rehabilitation
  15. 2025, Graduate Education (Master's Program) , Year, Research on Sports Rehabilitation
  16. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Sports Rehabilitation
  17. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Sports Rehabilitation
  18. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Sports Rehabilitation
  19. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Sports Rehabilitation
  20. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Sports Rehabilitation
  21. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Sports Rehabilitation
  22. 2025, Graduate Education (Master's Program) , First Semester, Research on Sports Rehabilitation
  23. 2025, Graduate Education (Master's Program) , Second Semester, Research on Sports Rehabilitation

Research Activities

Academic Papers

  1. Erratum: Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4 (iScience (2021) 24(4), (S2589004221002716), (10.1016/j.isci.2021.102303)), iScience, 28(6), 20250620
  2. Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load, FASEB JOURNAL, 39(10), e70631, 20250531
    Link to Paper Search Results by DOI
  3. Polyplex Nanomicelle-Mediated Pgc-1a4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice, Advanced Science, 12(16), 20250424
  4. Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle, Journal of Applied Physiology, 138(1), 107-120, 20250101
  5. Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression, Exercise and Sport Sciences Reviews, 53(1), 41-47, 20250101
  6. Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain, Journal of Orthopaedic Research, 42(6), 1190-1199, 20240601
  7. High-intensity interval training using electrical stimulation ameliorates muscle fatigue in chronic kidney disease-related cachexia by restoring mitochondrial respiratory dysfunction, Frontiers in Physiology, 15, 20240101
  8. High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle, Journal of Physiology, 601(14), 2917-2933, 20230715
  9. Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats, Journal of Applied Physiology, 135(4), 731-746, 20230101
  10. Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca2+ release in compensatory hypertrophied muscle fibers following synergist ablation, American Journal of Physiology - Cell Physiology, 325(3), C599-C612, 20230101
  11. Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training, Arthritis Research and Therapy, 24(1), 20221201
  12. Citrullination is linked to reduced Ca2+ sensitivity in hearts of a murine model of rheumatoid arthritis, Acta Physiologica, 236(3), 20221101
  13. Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles, American Journal of Physiology - Cell Physiology, 323(3), C885-C895, 20220901
  14. Preconditioning contractions prevent prolonged force depression and Ca2 - dependent proteolysis of STAC3 after damaging eccentric contractions, Journal of Applied Physiology, 131(5), 1399-1407, 20211101
  15. Larger improvements in fatigue resistance and mitochondrial function with high- than with low-intensity contractions during interval training of mouse skeletal muscle, FASEB Journal, 35(11), 20211101
  16. Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats, Physiological Reports, 9(18), 20210901
  17. Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies, Arthritis and Rheumatology, 73(5), 848-857, 20210501
  18. Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4, iScience, 24(4), 20210423
  19. Mechanisms of decline in muscle quality in sarcopenia, Sarcopenia: Molecular Mechanism and Treatment Strategies, 295-322, 20210101
  20. BGP-15: A potential therapeutic agent for critical illness myopathy, Acta Physiologica, 229(1), 20200501
  21. Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation, Frontiers in Physiology, 11, 20200428
  22. Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load, PLoS ONE, 14(10), 20191001
  23. A Mechanism for Statin-Induced Susceptibility to Myopathy, JACC: Basic to Translational Science, 4(4), 509-523, 20190801
  24. Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle, Nutrition, 58, 23-29, 20190201
  25. Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans, Experimental Brain Research, 237(1), 47-56, 20190131
  26. Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis, JCI Insight, 4(9), 20190101
  27. Eccentric training enhances the B-crystallin binding to the myofibrils and prevents skeletal muscle weakness in adjuvant-induced arthritis rat, Journal of Applied Physiology, 127(1), 71-80, 20190101
  28. Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions, Journal of Physiology, 596(18), 4427-4442, 20180915
  29. Electrical stimulation prevents preferential skeletal muscle myosin loss in steroid-denervation rats, Frontiers in Physiology, 9(AUG), 20180810
  30. High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice, PLoS ONE, 13(6), 20180601
  31. Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy, Journal of Applied Physiology, 124(2), 341-348, 20180201
  32. Preconditioning contractions suppress muscle pain markers after damaging eccentric contractions, Pain Research and Management, 2018, 20180101
  33. l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain, Physiological Reports, 6(2), 20180101
  34. Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2 + and Free Radical Signaling, EBioMedicine, 23, 12-19, 20170901
  35. Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat, PLoS ONE, 12(6), 20170601
  36. Role of calpain in eccentric contraction-induced proteolysis of Ca2+ - Regulatory proteins and force depression in rat fast-twitch skeletal muscle, Journal of Applied Physiology, 122(2), 396-405, 20170201
  37. Superoxide dismutase/catalase mimetic EUK- 134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension, PLoS ONE, 12(2), 20170201
  38. The role of reactive oxygen species in B-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome, PLoS ONE, 11(12), 20161201
  39. Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery, Journal of Physiology, 594(18), 5149-5160, 20160915
  40. Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness, Annals of the Rheumatic Diseases, 74(10), 1907-1914, 20151001
  41. Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment, Skeletal Muscle, 5(1), 20150709
  42. Response of heat shock protein 72 to repeated bouts of hyperthermia in rat skeletal muscle, Physiological Research, 64(6), 935-938, 20150101
  43. Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice, Journal of Physiology, 590(23), 6187-6197, 20121201
  44. Characteristics and mechanisms of low-frequency muscle fatigue: Alterations in skeletal muscle, Japanese Journal of Physical Fitness and Sports Medicine, 61(3), 297-306, 20120101
  45. Mitochondrial production of reactive oxygen species contributes to the B-adrenergic stimulation of mouse cardiomycytes, Journal of Physiology, 589(7), 1791-1801, 20110401
  46. Mechanisms of skeletal muscle weakness, Advances in Experimental Medicine and Biology, 682, 279-296, 20101201
  47. Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice, Journal of Physiology, 588(21), 4275-4288, 20101101
  48. Beta-hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle, American Journal of Physiology - Endocrinology and Metabolism, 299(3), 20100901
  49. Muscle fatigue: From observations in humans to underlying mechanisms studied in intact single muscle fibres, European Journal of Applied Physiology, 110(1), 1-15, 20100901
  50. Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies, FASEB Journal, 24(2), 570-578, 20100201
  51. Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis, Arthritis and Rheumatism, 60(11), 3280-3289, 20091101
  52. High temperature does not alter fatigability in intact mouse skeletal muscle fibres, Journal of Physiology, 587(19), 4717-4724, 20091001
  53. No relationship between enzyme activity and structure of nucleotide binding site in sarcoplasmic reticulum Ca2+-ATPase from short-term stimulated rat muscle, Acta Physiologica, 196(4), 401-409, 20090801
  54. Interpolated twitches in fatiguing single mouse muscle fibres: Implications for the assessment of central fatigue, Journal of Physiology, 586(11), 2799-2805, 20080601
  55. Time course of changes in in vitro sarcoplasmic reticulum Ca 2+-handling and Na+-K+-ATPase activity during repetitive contractions, Pflugers Archiv European Journal of Physiology, 456(3), 601-609, 20080601
  56. Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling, International Journal of Sport Nutrition and Exercise Metabolism, 18(4), 399-411, 20080101
  57. Effect of high-intensity training and acute exercise on Ca 2+-sequestering function of sarcoplasmic reticulum : Role of oxidative modification, Japanese Journal of Physical Fitness and Sports Medicine, 57(3), 327-338, 20080101
  58. Alterations in in vitro function and protein oxidation of rat sarcoplasmic reticulum Ca2+-ATPase during recovery from high-intensity exercise, Experimental Physiology, 93(3), 426-433, 20080101
  59. Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice, Journal of Physiology, 586(1), 175-184, 20080101
  60. Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat diaphragm, Journal of Applied Physiology, 102(5), 1850-1855, 20070501
  61. Effects of high-intensity training and acute exercise on in vitro function of rat sarcoplasmic reticulum, European Journal of Applied Physiology, 99(6), 641-649, 20070401
  62. Relationship between oxidation of myofibrillar proteins and contractile properties in soleus muscles from hyperthyroid rat, Japanese Journal of Physical Fitness and Sports Medicine, 56(5), 473-480, 20070101
  63. Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus, Journal of Applied Physiology, 100(5), 1520-1526, 20060501
  64. Effects of reduced glycogen on structure and in vitro function of rat sarcoplasmic reticulum Ca2+-ATPase, Pflugers Archiv European Journal of Physiology, 452(1), 117-123, 20060401
  65. Changes in sarcoplasmic reticulum Ca2+-sequestering capacity during recovery following high-intensity exercise: Comparisons between fast- and slow-twitch muscles, Japanese Journal of Physical Fitness and Sports Medicine, 55(5), 503-512, 20060101
  66. N-acetylcysteine fails to modulate the in vitro function of sarcoplasmic reticulum of diaphragm in the final phase of fatigue, Acta Physiologica Scandinavica, 184(3), 195-202, 20050701
  67. Effects of thyroid hormone on sarcoplasmic reticulum Ca2+ uptake and contractile properties in rat soleus muscle, Japanese Journal of Physical Fitness and Sports Medicine, 53(5), 509-518, 20040101
  68. Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism, Acta Physiologica Scandinavica, 180(1), 79-87, 20040101
  69. Oxidation of sarcoplasmic reticulum Ca2+-ATPase induced by high-intensity exercise, Pflugers Archiv European Journal of Physiology, 446(3), 394-399, 20030601
  70. Endurance training-induced changes in alkali light chain patterns in type IIB fibers of the rat, J. Appl. Physiol., 94, 923-929, 20030401
  71. Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise, Acta Physiologica Scandinavica, 176(3), 227-232, 20021126

External Funds

Acceptance Results of Competitive Funds

  1. 2025, 2028
  2. 2023, 2026
  3. 2022, 2024
  4. 2021, 2023
  5. 2021, 2024
  6. 2018, 2021
  7. 2017, 2020
  8. 2015, 2016
  9. 2014, 2016
  10. 2012, 2013
  11. 2010, 2011

Social Activities

History as Peer Reviews of Academic Papers

  1. 2025, Front Physiol, Editor
  2. 2025, Physiol Rep, Others
  3. 2024, Front Physiol, Editor
  4. 2024, J Appl Physiol, Others
  5. 2024, Histol Histopathol, Others
  6. 2023, Am J Physiol, Others
  7. 2023, Front Physiol, Editor
  8. 2023, J Physiol, Others
  9. 2023, Front Physiol, Editor
  10. 2022, JPFSM, Others
  11. 2022, Sci Rep, Others
  12. 2022, Am J Pathol, Others
  13. 2022, Exp Physiol, Others
  14. 2022, Exp Physiol, Editor
  15. 2021, Exp Physiol, Others
  16. 2021, Cells, Others
  17. 2021, Antioxidants, Editor
  18. 2020, Mol Ther, Others
  19. 2020, Exp Physiol, Others
  20. 2020, Exp Physiol, Editor
  21. 2019, J Physiol Sci, Others
  22. 2019, Acta Physiol, Others
  23. 2019, Exp Physiol, Editor
  24. 2019, J Muscle Res Cell Motil, Others
  25. 2018, Eur J Appl Physiol, Others
  26. 2018, Exp Physiol, Others
  27. 2018, Exp Physiol, Others
  28. 2018, Exp Physiol, Others
  29. 2018, Exp Physiol, Others
  30. 2018, Oxid Med Cell Longev, Others
  31. 2018, J Appl Physiol, Others
  32. 2017, Exp Physiol, Others
  33. 2017, Exp Physiol, Others
  34. 2017, Exp Physiol, Others
  35. 2016, Exp Physiol, Others
  36. 2015, Exp Physiol, Others
  37. 2015, Exp Physiol, Others
  38. 2014, Exp Physiol, Others
  39. 2014, Exp Physiol, Others
  40. 2013, Exp Physiol, Others
  41. 2013, Exp Physiol, Others
  42. 2013, Acta Physiol, Others
  43. 2012, Exp Physiol, Others
  44. 2012, Exp Physiol, Others
  45. 2012, Exp Physiol, Others
  46. 2012, Exp Physiol, Others
  47. 2012, Exp Physiol, Others
  48. 2011, Adv in Exp Med and Biol, Others
  49. 2010, Exp Physiol, Others
  50. 2009, Acta Physiol, Others