TAKASHI YAMADA
Last Updated :2025/06/16
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences, Professor
- Web Site
- E-mail
- yama1976
hiroshima-u.ac.jp
- Self-introduction
- To develop novel therapeutic interventions to treat skeletal muscle weakness, we investigate the mechanisms behind muscle adaptations in response to physical therapy and maladaptations in aging and primary and secondary myopathies.
Basic Information
Major Professional Backgrounds
- 2007/04/01, 2010/03/31, karolinska Institutet, Research fellow
- 2016/04/01, 2025/03/31, Sapporo Medical Univsesity, Associate Professor
- 2011/05/01, 2016/03/31, Sapporo Medical Univsesity, Lecturer
- 2010/04/01, 2011/04/31, Sapporo Medical Univsesity, Assistant Professor
Research Fields
- Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering
Research Keywords
- Prevention of Sports Injury, Enhancement of Sports Performance, Application of Sports Rehabilitation
Affiliated Academic Societies
- Japan Society of Exercise and Sports Physiology
- Japan Muscle Society
- Japan Society of Physical Therapy Fundamentals
- Japanese Society of Physical Fitness and Sports Medicine
Educational Activity
Course in Charge
- 2025, Liberal Arts Education Program1, 2Term, Health and Sports Sciences
- 2025, Undergraduate Education, Second Semester, Basic Theory of Athletic Training (practice)
- 2025, Undergraduate Education, 1Term, Sport Physical Therapy Ⅰ
- 2025, Undergraduate Education, 2Term, Sport Physical Therapy II
- 2025, Graduate Education (Master's Program) , 2Term, Multidisciplinary Cooperation A
- 2025, Graduate Education (Doctoral Program) , 2Term, Multidisciplinary Cooperation B
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2025, Graduate Education (Master's Program) , First Semester, Lecture on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , First Semester, Lecture on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , First Semester, Seminar on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , First Semester, Seminar on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , Year, Research on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Sports Rehabilitation
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , First Semester, Research on Sports Rehabilitation
- 2025, Graduate Education (Master's Program) , Second Semester, Research on Sports Rehabilitation
Research Activities
Academic Papers
- Erratum: Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4 (iScience (2021) 24(4), (S2589004221002716), (10.1016/j.isci.2021.102303)), iScience, 28(6), 20250620
- Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load, FASEB JOURNAL, 39(10), e70631, 20250531
- Polyplex Nanomicelle-Mediated Pgc-1a4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice, Advanced Science, 12(16), 20250424
- Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle, Journal of Applied Physiology, 138(1), 107-120, 20250101
- Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression, Exercise and Sport Sciences Reviews, 53(1), 41-47, 20250101
- Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain, Journal of Orthopaedic Research, 42(6), 1190-1199, 20240601
- High-intensity interval training using electrical stimulation ameliorates muscle fatigue in chronic kidney disease-related cachexia by restoring mitochondrial respiratory dysfunction, Frontiers in Physiology, 15, 20240101
- High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle, Journal of Physiology, 601(14), 2917-2933, 20230715
- Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats, Journal of Applied Physiology, 135(4), 731-746, 20230101
- Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca2+ release in compensatory hypertrophied muscle fibers following synergist ablation, American Journal of Physiology - Cell Physiology, 325(3), C599-C612, 20230101
- Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training, Arthritis Research and Therapy, 24(1), 20221201
- Citrullination is linked to reduced Ca2+ sensitivity in hearts of a murine model of rheumatoid arthritis, Acta Physiologica, 236(3), 20221101
- Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles, American Journal of Physiology - Cell Physiology, 323(3), C885-C895, 20220901
- Preconditioning contractions prevent prolonged force depression and Ca2 - dependent proteolysis of STAC3 after damaging eccentric contractions, Journal of Applied Physiology, 131(5), 1399-1407, 20211101
- Larger improvements in fatigue resistance and mitochondrial function with high- than with low-intensity contractions during interval training of mouse skeletal muscle, FASEB Journal, 35(11), 20211101
- Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats, Physiological Reports, 9(18), 20210901
- Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies, Arthritis and Rheumatology, 73(5), 848-857, 20210501
- Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4, iScience, 24(4), 20210423
- Mechanisms of decline in muscle quality in sarcopenia, Sarcopenia: Molecular Mechanism and Treatment Strategies, 295-322, 20210101
- BGP-15: A potential therapeutic agent for critical illness myopathy, Acta Physiologica, 229(1), 20200501
- Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation, Frontiers in Physiology, 11, 20200428
- Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load, PLoS ONE, 14(10), 20191001
- A Mechanism for Statin-Induced Susceptibility to Myopathy, JACC: Basic to Translational Science, 4(4), 509-523, 20190801
- Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle, Nutrition, 58, 23-29, 20190201
- Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans, Experimental Brain Research, 237(1), 47-56, 20190131
- Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis, JCI Insight, 4(9), 20190101
- Eccentric training enhances the B-crystallin binding to the myofibrils and prevents skeletal muscle weakness in adjuvant-induced arthritis rat, Journal of Applied Physiology, 127(1), 71-80, 20190101
- Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions, Journal of Physiology, 596(18), 4427-4442, 20180915
- Electrical stimulation prevents preferential skeletal muscle myosin loss in steroid-denervation rats, Frontiers in Physiology, 9(AUG), 20180810
- High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice, PLoS ONE, 13(6), 20180601
- Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy, Journal of Applied Physiology, 124(2), 341-348, 20180201
- Preconditioning contractions suppress muscle pain markers after damaging eccentric contractions, Pain Research and Management, 2018, 20180101
- l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain, Physiological Reports, 6(2), 20180101
- Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2 + and Free Radical Signaling, EBioMedicine, 23, 12-19, 20170901
- Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat, PLoS ONE, 12(6), 20170601
- Role of calpain in eccentric contraction-induced proteolysis of Ca2+ - Regulatory proteins and force depression in rat fast-twitch skeletal muscle, Journal of Applied Physiology, 122(2), 396-405, 20170201
- Superoxide dismutase/catalase mimetic EUK- 134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension, PLoS ONE, 12(2), 20170201
- The role of reactive oxygen species in B-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome, PLoS ONE, 11(12), 20161201
- Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery, Journal of Physiology, 594(18), 5149-5160, 20160915
- Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness, Annals of the Rheumatic Diseases, 74(10), 1907-1914, 20151001
- Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment, Skeletal Muscle, 5(1), 20150709
- Response of heat shock protein 72 to repeated bouts of hyperthermia in rat skeletal muscle, Physiological Research, 64(6), 935-938, 20150101
- Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice, Journal of Physiology, 590(23), 6187-6197, 20121201
- Characteristics and mechanisms of low-frequency muscle fatigue: Alterations in skeletal muscle, Japanese Journal of Physical Fitness and Sports Medicine, 61(3), 297-306, 20120101
- Mitochondrial production of reactive oxygen species contributes to the B-adrenergic stimulation of mouse cardiomycytes, Journal of Physiology, 589(7), 1791-1801, 20110401
- Mechanisms of skeletal muscle weakness, Advances in Experimental Medicine and Biology, 682, 279-296, 20101201
- Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice, Journal of Physiology, 588(21), 4275-4288, 20101101
- Beta-hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle, American Journal of Physiology - Endocrinology and Metabolism, 299(3), 20100901
- Muscle fatigue: From observations in humans to underlying mechanisms studied in intact single muscle fibres, European Journal of Applied Physiology, 110(1), 1-15, 20100901
- Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies, FASEB Journal, 24(2), 570-578, 20100201
- Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis, Arthritis and Rheumatism, 60(11), 3280-3289, 20091101
- High temperature does not alter fatigability in intact mouse skeletal muscle fibres, Journal of Physiology, 587(19), 4717-4724, 20091001
- No relationship between enzyme activity and structure of nucleotide binding site in sarcoplasmic reticulum Ca2+-ATPase from short-term stimulated rat muscle, Acta Physiologica, 196(4), 401-409, 20090801
- Interpolated twitches in fatiguing single mouse muscle fibres: Implications for the assessment of central fatigue, Journal of Physiology, 586(11), 2799-2805, 20080601
- Time course of changes in in vitro sarcoplasmic reticulum Ca 2+-handling and Na+-K+-ATPase activity during repetitive contractions, Pflugers Archiv European Journal of Physiology, 456(3), 601-609, 20080601
- Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling, International Journal of Sport Nutrition and Exercise Metabolism, 18(4), 399-411, 20080101
- Effect of high-intensity training and acute exercise on Ca 2+-sequestering function of sarcoplasmic reticulum : Role of oxidative modification, Japanese Journal of Physical Fitness and Sports Medicine, 57(3), 327-338, 20080101
- Alterations in in vitro function and protein oxidation of rat sarcoplasmic reticulum Ca2+-ATPase during recovery from high-intensity exercise, Experimental Physiology, 93(3), 426-433, 20080101
- Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice, Journal of Physiology, 586(1), 175-184, 20080101
- Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat diaphragm, Journal of Applied Physiology, 102(5), 1850-1855, 20070501
- Effects of high-intensity training and acute exercise on in vitro function of rat sarcoplasmic reticulum, European Journal of Applied Physiology, 99(6), 641-649, 20070401
- Relationship between oxidation of myofibrillar proteins and contractile properties in soleus muscles from hyperthyroid rat, Japanese Journal of Physical Fitness and Sports Medicine, 56(5), 473-480, 20070101
- Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus, Journal of Applied Physiology, 100(5), 1520-1526, 20060501
- Effects of reduced glycogen on structure and in vitro function of rat sarcoplasmic reticulum Ca2+-ATPase, Pflugers Archiv European Journal of Physiology, 452(1), 117-123, 20060401
- Changes in sarcoplasmic reticulum Ca2+-sequestering capacity during recovery following high-intensity exercise: Comparisons between fast- and slow-twitch muscles, Japanese Journal of Physical Fitness and Sports Medicine, 55(5), 503-512, 20060101
- N-acetylcysteine fails to modulate the in vitro function of sarcoplasmic reticulum of diaphragm in the final phase of fatigue, Acta Physiologica Scandinavica, 184(3), 195-202, 20050701
- Effects of thyroid hormone on sarcoplasmic reticulum Ca2+ uptake and contractile properties in rat soleus muscle, Japanese Journal of Physical Fitness and Sports Medicine, 53(5), 509-518, 20040101
- Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism, Acta Physiologica Scandinavica, 180(1), 79-87, 20040101
- Oxidation of sarcoplasmic reticulum Ca2+-ATPase induced by high-intensity exercise, Pflugers Archiv European Journal of Physiology, 446(3), 394-399, 20030601
- Endurance training-induced changes in alkali light chain patterns in type IIB fibers of the rat, J. Appl. Physiol., 94, 923-929, 20030401
- Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise, Acta Physiologica Scandinavica, 176(3), 227-232, 20021126
External Funds
Acceptance Results of Competitive Funds
- 2025, 2028
- 2023, 2026
- 2022, 2024
- 2021, 2023
- 2021, 2024
- 2018, 2021
- 2017, 2020
- 2015, 2016
- 2014, 2016
- 2012, 2013
- 2010, 2011
Social Activities
History as Peer Reviews of Academic Papers
- 2025, Front Physiol, Editor
- 2025, Physiol Rep, Others
- 2024, Front Physiol, Editor
- 2024, J Appl Physiol, Others
- 2024, Histol Histopathol, Others
- 2023, Am J Physiol, Others
- 2023, Front Physiol, Editor
- 2023, J Physiol, Others
- 2023, Front Physiol, Editor
- 2022, JPFSM, Others
- 2022, Sci Rep, Others
- 2022, Am J Pathol, Others
- 2022, Exp Physiol, Others
- 2022, Exp Physiol, Editor
- 2021, Exp Physiol, Others
- 2021, Cells, Others
- 2021, Antioxidants, Editor
- 2020, Mol Ther, Others
- 2020, Exp Physiol, Others
- 2020, Exp Physiol, Editor
- 2019, J Physiol Sci, Others
- 2019, Acta Physiol, Others
- 2019, Exp Physiol, Editor
- 2019, J Muscle Res Cell Motil, Others
- 2018, Eur J Appl Physiol, Others
- 2018, Exp Physiol, Others
- 2018, Exp Physiol, Others
- 2018, Exp Physiol, Others
- 2018, Exp Physiol, Others
- 2018, Oxid Med Cell Longev, Others
- 2018, J Appl Physiol, Others
- 2017, Exp Physiol, Others
- 2017, Exp Physiol, Others
- 2017, Exp Physiol, Others
- 2016, Exp Physiol, Others
- 2015, Exp Physiol, Others
- 2015, Exp Physiol, Others
- 2014, Exp Physiol, Others
- 2014, Exp Physiol, Others
- 2013, Exp Physiol, Others
- 2013, Exp Physiol, Others
- 2013, Acta Physiol, Others
- 2012, Exp Physiol, Others
- 2012, Exp Physiol, Others
- 2012, Exp Physiol, Others
- 2012, Exp Physiol, Others
- 2012, Exp Physiol, Others
- 2011, Adv in Exp Med and Biol, Others
- 2010, Exp Physiol, Others
- 2009, Acta Physiol, Others