大野 晴也HARUYA OHNO

Last Updated :2024/02/01

所属・職名
病院(医) 講師

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 代謝学

教育活動

授業担当

  1. 2023年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2023年, 学部専門, 集中, 臨床実習入門プログラム
  3. 2023年, 学部専門, 集中, 臨床実習I
  4. 2023年, 学部専門, 集中, 臨床実習II
  5. 2023年, 修士課程・博士課程前期, 1ターム, 予防医学・健康指導特論A
  6. 2023年, 修士課程・博士課程前期, 3ターム, 予防医学・健康指導特論B

研究活動

学術論文(★は代表的な論文)

  1. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes, ISCIENCE, 25巻, 8号, 20220819
  2. Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLOS ONE, 17巻, 6号, 20220630
  3. ★, Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10巻, 3号, 20150326
  4. ★, EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex, Nature, 504巻, 7478号, pp. 163-167, 20131205
  5. ★, PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein, Cell Metabolism, 15巻, 3号, pp. 395-405, 201204
  6. Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells., Plos One, 7巻, 11号, pp. e49452, 2012
  7. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29巻, 8号, pp. 495-502, 202208
  8. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17巻, 6号, 2022
  9. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

    , MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548巻, 20220515
  10. Dietary Vitamins A, C, and Potassium Intake Is Associated With Narrower Retinal Venular Caliber, FRONTIERS IN MEDICINE, 9巻, 20220210
  11. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308巻, 2号, pp. G151-G158, 20150115
  12. Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy, AMERICAN JOURNAL OF NEURORADIOLOGY, 37巻, 11号, pp. 2123-2128, 201611
  13. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68巻, 6号, pp. 1432-1437, 201612
  14. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 2017
  15. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model., Journal of gastroenterology, 2017
  16. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285巻, 43号, pp. 33018-33027, 2010
  17. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300巻, 5号, pp. C1047-C1054, 2011
  18. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286巻, 23号, pp. 20812-20822, 2011
  19. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302巻, 3号, pp. E286-E296, 2012
  20. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71巻, 1号, pp. 125-133, 201801
  21. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24巻, 12号, pp. 1206-1214, 2017
  22. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461巻, C号, pp. 100-104, 2018
  23. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103巻, 3号, pp. 965-971, 201803
  24. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25巻, 9号, pp. 984-1001, 2018
  25. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287巻, 53号, pp. 44526-44535, 2012
  26. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6巻, 4号, pp. E288-E297, 2012
  27. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434巻, 2号, pp. 197-202, 2013
  28. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10巻, 8号, 2015
  29. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95巻, 20号, 2016
  30. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test, PANCREAS, 46巻, 4号, pp. E34-E35, 2017
  31. 膵切除術式別による術後インスリン分泌能および耐糖能異常の比較, 糖尿病, 59巻, 3号, pp. 149-155, 2016
  32. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma., Internal medicine (Tokyo, Japan), 54巻, 18号, 2015
  33. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice., Journal of diabetes investigation, 7巻, 1号, 2016
  34. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin., Cardiovascular diabetology, 16巻, 1号, 2017
  35. 糖代謝概論 糖輸送担体 (新時代の糖尿病学(1)病因・診断・治療研究の進歩) -- (糖尿病基礎研究の進歩 糖代謝とその調節機序), 日本臨床, 66巻, 0号, pp. 98-102, 200805
  36. エネルギー代謝における運動の分子機構にせまる (特集 運動と生活習慣病のかかわりにせまる), Life style medicine, 4巻, 3号, pp. 192-196, 201007
  37. ナトリウム/グルコース共役輸送担体2(SGLT2)阻害薬 (特集 糖尿病とその合併症の新薬の現状と未来), 内分泌・糖尿病・代謝内科, 31巻, 1号, pp. 22-26, 201007
  38. メタボリックシンドローム発症基盤としてのインスリン抵抗性 臓器別インスリン抵抗性とその病態生理学的意義 骨格筋におけるインスリン抵抗性 (メタボリックシンドローム(第2版)--基礎・臨床の最新知見) -- (成因と病態生理), 日本臨床, 69巻, 0号, pp. 176-179, 201101
  39. SGLT2阻害薬の現状と展望 (特集 糖尿病治療最前線2011) -- (新しい糖尿病治療薬), 糖尿病, 3巻, 1号, pp. 108-113, 201101
  40. 褐色脂肪細胞およびベージュ脂肪細胞の由来 (第5土曜特集 肥満の医学 : 臨床と研究の最先端) -- (前駆脂肪細胞,褐色脂肪細胞と白色脂肪細胞), 医学のあゆみ, 250巻, 9号, pp. 811-815, 20140830
  41. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19巻, 10号, 201810
  42. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140巻, pp. 179-184, 201812
  43. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185巻, pp. 137-141, 201901
  44. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10巻, 2号, pp. 352-357, 201903
  45. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26巻, 12号, pp. 3221-+, 20190319
  46. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10巻, 5号, pp. 1229-1236, 201909
  47. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10巻, 6号, pp. 1463-1470, 201911
  48. Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE, EUROPEAN JOURNAL OF RADIOLOGY OPEN, 6巻, pp. 182-186, 2019
  49. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75巻, 2号, pp. 492-499, 202002
  50. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98巻, 49号, 201912
  51. Effect of the use of passive body trunk exercise equipment on oxygen consumption and self-efficacy for carrying out exercise in patients with type 2 diabetes, JOURNAL OF DIABETES INVESTIGATION, 11巻, 5号, pp. 1265-1271, 202009
  52. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68巻, 1号, pp. 95-102, 2021
  53. Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9巻, 4号, 202104
  54. Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538巻, 20211201
  55. Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans, METABOLITES, 11巻, 10号, 202110
  56. ATP1A1

    Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

    , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22巻, 20号, 202110

外部資金

競争的資金等の採択状況

  1. 化学研究費助成事業(基盤研究(C)), エピゲノム修飾によるベージュ脂肪細胞の機能維持機構の解明, 2022年, 2024年
  2. 科学研究費助成事業(基盤研究(C)), ベージュ脂肪細胞の機能維持に必要な因子の探索と機能解析, 2019年, 2021年
  3. 科学研究費助成事業(若手研究(A)), クロマチン修飾による褐色脂肪細胞分化制御機構の解明, 2016年, 2018年
  4. 科学研究費助成事業(若手研究(B)), エイコサペンタエン酸によるGPR120を介したベージュ細胞誘導効果の研究, 2014年, 2015年
  5. 第3回日本糖尿病学会 若手研究助成金, PRDM16/EHMT1/MATⅡα複合体によるベージュ脂肪細胞誘導機構の解明, 2017年, 2019年
  6. 公益財団法人MSD生命科学財団 研究助成2016-生活習慣病領域-, 褐色脂肪細胞の分化に関わる新規転写因子の機能解析と糖代謝に与える影響の解明
  7. 平成29年度 日本糖尿病協会若手研究者助成, ベージュ脂肪細胞維持に関わる分子機構の解明
  8. 平成26年度日本糖尿病財団研究助成金, EHMT1変異に伴う褐色脂肪組織の機能変化と肥満・糖尿病発症への影響の解明, 2014年
  9. 一般財団法人土谷記念医学振興基金, ヒト成人における腎周囲褐色脂肪組織の特性に関する検討と、褐色脂肪細胞へ分化誘導を促す新規因子の探索, 2014年
  10. 鈴木万平糖尿病財団 海外留学助成, 2012年, 2013年