大野 晴也HARUYA OHNO

Last Updated :2021/11/01

所属・職名
大学院医系科学研究科(医) 助教

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 代謝学

教育活動

授業担当

  1. 2021年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2021年, 学部専門, 集中, 臨床実習入門プログラム
  3. 2021年, 学部専門, 集中, 臨床実習I
  4. 2021年, 学部専門, 集中, 臨床実習II

研究活動

学術論文(★は代表的な論文)

  1. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308巻, 2号, pp. G151-G158, 20150115
  2. ★, Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10巻, 3号, 20150326
  3. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet., PloS one, 10巻, 8号, 2015
  4. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma, INTERNAL MEDICINE, 54巻, 18号, pp. 2355-2360, 2015
  5. ★, EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex, Nature, 504巻, 7478号, pp. 163-167, 20131205
  6. ★, PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein, Cell Metabolism, 15巻, 3号, pp. 395-405, 201204
  7. Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells., Plos One, 7巻, 11号, pp. e49452, 2012
  8. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice, JOURNAL OF DIABETES INVESTIGATION, 7巻, 1号, pp. 94-99, 201601
  9. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95巻, 20号, 201605
  10. Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy, AMERICAN JOURNAL OF NEURORADIOLOGY, 37巻, 11号, pp. 2123-2128, 201611
  11. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68巻, 6号, pp. 1432-1437, 201612
  12. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16巻, 20170706
  13. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 2017
  14. Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles., Journal of atherosclerosis and thrombosis, 2017
  15. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model., Journal of gastroenterology, 2017
  16. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test., Pancreas, 46巻, 4号, 2017
  17. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma., Hypertension (Dallas, Tex. : 1979), 68巻, 6号, 2016
  18. The Relationship Between Tumor Genotype and Clinical or Pathological Characteristics in Patients with Aldosterone Producing Adenoma, ENDOCRINE REVIEWS, 35巻, 3号, 2014
  19. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285巻, 43号, pp. 33018-33027, 2010
  20. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300巻, 5号, pp. C1047-C1054, 2011
  21. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286巻, 23号, pp. 20812-20822, 2011
  22. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302巻, 3号, pp. E286-E296, 2012
  23. NFIA co-localizes with PPAR gamma and transcriptionally controls the brown fat gene program, NATURE CELL BIOLOGY, 19巻, 9号, pp. 1081-+, 201709
  24. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model, JOURNAL OF GASTROENTEROLOGY, 52巻, 11号, pp. 1180-1191, 201711
  25. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71巻, 1号, pp. 125-133, 201801
  26. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24巻, 12号, pp. 1206-1214, 2017
  27. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461巻, C号, pp. 100-104, 2018
  28. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103巻, 3号, pp. 965-971, 201803
  29. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25巻, 9号, pp. 984-1001, 2018
  30. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice, JOURNAL OF DIABETES INVESTIGATION, 7巻, 1号, pp. 94-99, 2016
  31. Functionally distinct roles of each member of the resistin family in insulin resistance and atherosclerosis, DIABETES, 57巻, pp. A405-A405, 2008
  32. Hepatic LKB1-AMPK Pathway Is Activated by Both Insulin and Energy Deficiency, and Is Regulated Differently between High-Fat Diet Fed and Ob/ob Mice, DIABETES, 58巻, pp. A345-A346, 2009
  33. 4F2hc Associates with and Stabilizes GLUT1 Protein and Increases Glucose Transport Activity, DIABETES, 59巻, pp. A366-A366, 2010
  34. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287巻, 53号, pp. 44526-44535, 2012
  35. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6巻, 4号, pp. E288-E297, 2012
  36. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434巻, 2号, pp. 197-202, 2013
  37. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308巻, 2号, pp. G151-G158, 2015
  38. Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10巻, 3号, 2015
  39. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10巻, 8号, 2015
  40. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma, INTERNAL MEDICINE, 54巻, 18号, pp. 2355-2360, 2015
  41. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95巻, 20号, 2016
  42. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68巻, 6号, pp. 1432-1437, 2016
  43. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test, PANCREAS, 46巻, 4号, pp. E34-E35, 2017
  44. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16巻, 2017
  45. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma, Internal Medicine, 54巻, 18号, pp. 2355-2360, 2015
  46. 膵切除術式別による術後インスリン分泌能および耐糖能異常の比較, 糖尿病, 59巻, 3号, pp. 149-155, 2016
  47. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma., Internal medicine (Tokyo, Japan), 54巻, 18号, 2015
  48. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice., Journal of diabetes investigation, 7巻, 1号, 2016
  49. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma., Medicine, 95巻, 20号, 2016
  50. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin., Cardiovascular diabetology, 16巻, 1号, 2017
  51. 糖代謝概論 糖輸送担体 (新時代の糖尿病学(1)病因・診断・治療研究の進歩) -- (糖尿病基礎研究の進歩 糖代謝とその調節機序), 日本臨床, 66巻, 0号, pp. 98-102, 200805
  52. エネルギー代謝における運動の分子機構にせまる (特集 運動と生活習慣病のかかわりにせまる), Life style medicine, 4巻, 3号, pp. 192-196, 201007
  53. ナトリウム/グルコース共役輸送担体2(SGLT2)阻害薬 (特集 糖尿病とその合併症の新薬の現状と未来), 内分泌・糖尿病・代謝内科, 31巻, 1号, pp. 22-26, 201007
  54. メタボリックシンドローム発症基盤としてのインスリン抵抗性 臓器別インスリン抵抗性とその病態生理学的意義 骨格筋におけるインスリン抵抗性 (メタボリックシンドローム(第2版)--基礎・臨床の最新知見) -- (成因と病態生理), 日本臨床, 69巻, 0号, pp. 176-179, 201101
  55. SGLT2阻害薬の現状と展望 (特集 糖尿病治療最前線2011) -- (新しい糖尿病治療薬), 糖尿病, 3巻, 1号, pp. 108-113, 201101
  56. 褐色脂肪細胞およびベージュ脂肪細胞の由来 (第5土曜特集 肥満の医学 : 臨床と研究の最先端) -- (前駆脂肪細胞,褐色脂肪細胞と白色脂肪細胞), 医学のあゆみ, 250巻, 9号, pp. 811-815, 20140830
  57. 若手研究者ドキュメンタリー ライジングスター 輝ける研究者たち(第25回)インタビュー 大野晴也先生 広島大学大学院医歯薬保健学研究院分子内科学, Diabetes strategy : journal of diabetes strategy, 7巻, 2号, pp. 89-93, 2017
  58. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19巻, 10号, 201810
  59. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140巻, pp. 179-184, 201812
  60. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185巻, pp. 137-141, 201901
  61. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10巻, 2号, pp. 352-357, 201903
  62. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26巻, 12号, pp. 3221-+, 20190319
  63. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10巻, 5号, pp. 1229-1236, 201909
  64. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10巻, 6号, pp. 1463-1470, 201911
  65. Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE, EUROPEAN JOURNAL OF RADIOLOGY OPEN, 6巻, pp. 182-186, 2019
  66. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75巻, 2号, pp. 492-499, 202002
  67. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98巻, 49号, 201912