HARUYA OHNO

Last Updated :2025/04/03

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2025, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2025, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  6. 2025, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B

Research Activities

Academic Papers

  1. NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(31), 20230801
    Link to Paper Search Results by DOI
  2. ★, Selective activation of PPAR alpha maintains thermogenic capacity of beige adipocytes, ISCIENCE, 26(7), 20230721
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  3. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes, ISCIENCE, 25(8), 20220819
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  4. Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLOS ONE, 17(6), 20220630
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  5. ★, Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
    Link to Paper Search Results by DOI
  6. ★, EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex, Nature, 504(7478), 163-167, 20131205
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  7. ★, PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein, Cell Metabolism, 15(3), 395-405, 201204
    Link to Paper Search Results by DOI
  8. Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells., Plos One, 7(11), e49452, 2012
  9. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 202208
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  10. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
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  11. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

    , MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 20220515
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  12. Dietary Vitamins A, C, and Potassium Intake Is Associated With Narrower Retinal Venular Caliber, FRONTIERS IN MEDICINE, 9, 20220210
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  13. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308(2), G151-G158, 20150115
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  14. Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy, AMERICAN JOURNAL OF NEURORADIOLOGY, 37(11), 2123-2128, 201611
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  15. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
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  16. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 2017
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  17. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model., Journal of gastroenterology, 2017
  18. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 2010
  19. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300(5), C1047-C1054, 2011
  20. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20812-20822, 2011
  21. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E286-E296, 2012
  22. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
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  23. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
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  24. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 2018
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  25. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
    Link to Paper Search Results by DOI
  26. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25(9), 984-1001, 2018
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  27. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(53), 44526-44535, 2012
  28. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6(4), E288-E297, 2012
  29. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 197-202, 2013
  30. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 2015
  31. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 2016
  32. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test, PANCREAS, 46(4), E34-E35, 2017
  33. Comparison of Operative Procedures of Partial Pancreatectomy by Postoperative Insulin Secretory Capacity and Glucose Intolerance, Journal of the Japan Diabetes Society, 59(3), 149-155, 2016
  34. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma., Internal medicine (Tokyo, Japan), 54(18), 2015
  35. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice., Journal of diabetes investigation, 7(1), 2016
  36. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin., Cardiovascular diabetology, 16(1), 2017
  37. Glucose transporter, Japanese journal of clinical medicine, 66(0), 98-102, 200805
  38. SGLT2 inhibitors, Endocrinology, diabetology & metabolism, 31(1), 22-26, 201007
  39. Skeletal muscle insulin resistance, Japanese journal of clinical medicine, 69(0), 176-179, 201101
  40. Developmental lineages of brown and beige adipocytes, 250(9), 811-815, 20140830
  41. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
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  42. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
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  43. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
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  44. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10(2), 352-357, 201903
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  45. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26(12), 3221-+, 20190319
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  46. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
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  47. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
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  48. Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE, EUROPEAN JOURNAL OF RADIOLOGY OPEN, 6, 182-186, 2019
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  49. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
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  50. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98(49), 201912
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  51. Effect of the use of passive body trunk exercise equipment on oxygen consumption and self-efficacy for carrying out exercise in patients with type 2 diabetes, JOURNAL OF DIABETES INVESTIGATION, 11(5), 1265-1271, 202009
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  52. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
  53. Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104
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  54. Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538, 20211201
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  55. Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans, METABOLITES, 11(10), 202110
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  56. ATP1A1

    Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

    , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110
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External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
  3. KAKENHI, 2016, 2018
  4. 2017, 2019
  5. 2014
  6. 2014
  7. 2012, 2013