Last Updated :2024/04/03

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2024, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  6. 2024, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B

Research Activities

Academic Papers

  1. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes, ISCIENCE, 25(8), 20220819
  2. Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLOS ONE, 17(6), 20220630
  3. ★, Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
  4. ★, EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex, Nature, 504(7478), 163-167, 20131205
  5. ★, PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein, Cell Metabolism, 15(3), 395-405, 201204
  6. Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells., Plos One, 7(11), e49452, 2012
  7. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 202208
  8. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
  9. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

  10. Dietary Vitamins A, C, and Potassium Intake Is Associated With Narrower Retinal Venular Caliber, FRONTIERS IN MEDICINE, 9, 20220210
  11. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308(2), G151-G158, 20150115
  12. Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy, AMERICAN JOURNAL OF NEURORADIOLOGY, 37(11), 2123-2128, 201611
  13. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
  14. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 2017
  15. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model., Journal of gastroenterology, 2017
  16. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 2010
  17. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300(5), C1047-C1054, 2011
  18. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20812-20822, 2011
  19. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E286-E296, 2012
  20. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
  21. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
  22. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 2018
  23. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
  24. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25(9), 984-1001, 2018
  25. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(53), 44526-44535, 2012
  26. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6(4), E288-E297, 2012
  27. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 197-202, 2013
  28. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 2015
  29. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 2016
  30. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test, PANCREAS, 46(4), E34-E35, 2017
  31. Comparison of Operative Procedures of Partial Pancreatectomy by Postoperative Insulin Secretory Capacity and Glucose Intolerance, Journal of the Japan Diabetes Society, 59(3), 149-155, 2016
  32. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma., Internal medicine (Tokyo, Japan), 54(18), 2015
  33. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice., Journal of diabetes investigation, 7(1), 2016
  34. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin., Cardiovascular diabetology, 16(1), 2017
  35. Glucose transporter, Japanese journal of clinical medicine, 66(0), 98-102, 200805
  36. SGLT2 inhibitors, Endocrinology, diabetology & metabolism, 31(1), 22-26, 201007
  37. Skeletal muscle insulin resistance, Japanese journal of clinical medicine, 69(0), 176-179, 201101
  38. Developmental lineages of brown and beige adipocytes, 250(9), 811-815, 20140830
  39. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
  40. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
  41. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
  42. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10(2), 352-357, 201903
  43. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26(12), 3221-+, 20190319
  44. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
  45. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
  46. Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE, EUROPEAN JOURNAL OF RADIOLOGY OPEN, 6, 182-186, 2019
  47. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
  48. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98(49), 201912
  49. Effect of the use of passive body trunk exercise equipment on oxygen consumption and self-efficacy for carrying out exercise in patients with type 2 diabetes, JOURNAL OF DIABETES INVESTIGATION, 11(5), 1265-1271, 202009
  50. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
  51. Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104
  52. Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538, 20211201
  53. Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans, METABOLITES, 11(10), 202110
  54. ATP1A1

    Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation


External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
  3. KAKENHI, 2016, 2018
  4. 2017, 2019
  5. 2014
  6. 2014
  7. 2012, 2013