HARUYA OHNO

Last Updated :2026/07/06

Affiliations, Positions
Hiroshima University Hospital, Associate Professor/Lecturer

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2026, Undergraduate Education, Intensive, Practice for medical research
  3. 2026, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2026, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2026, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  6. 2026, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B

Research Activities

Academic Papers

  1. Association between diabetes mellitus and impaired single-leg stance in patients with chronic liver disease: A cross-sectional study, PLOS ONE, 21(3), 20260324
    Link to Paper Search Results by DOI
  2. Blood glucose variability in early-onset adrenocorticotropic hormone deficiency induced by immune checkpoint inhibitor therapy with continuous blood glucose monitoring: a case report, DIABETOLOGY INTERNATIONAL, 17(1), 202601
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  3. Clinical characteristics of Japanese Americans with normal glucose tolerance with 1-h hyperglycemia: A cross-sectional study, JOURNAL OF DIABETES INVESTIGATION, 16(11), 2018-2026, 202511
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  4. Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses, FRONTIERS IN ENDOCRINOLOGY, 16, 20251020
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  5. Effectiveness and safety of denosumab monotherapy in patients with primary hyperparathyroidism: A retrospective study, MEDICINE, 104(40), 20251003
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  6. Dynamic changes of blood glucose level during capivasertib treatment in metastatic breast cancer: a case report, DIABETOLOGY INTERNATIONAL, 16(4), 851-854, 202510
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  7. Relationship Between Radiation Dose and Markers of Insulin Resistance and Inflammation in Atomic Bomb Survivors, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 110(6), e1943-e1950, 202506
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  8. Circulatory characteristics of early mobilization after surgery for bilateral pheochromocytoma: a case report, JOURNAL OF MEDICAL CASE REPORTS, 18(1), 20241031
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  9. Clinical Features of Tachycardia-induced Cardiomyopathy in Patients with Atrial Fibrillation, INTERNAL MEDICINE, 63(18), 2509-2517, 2024
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  10. Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(15), 20240806
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  11. Immunoprecipitation with an Anti-Epitope Tag Affinity Gelto Study Protein-Protein Interactions, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 202401
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  12. Detraining after short-term exercise induces hyperphagia and obesity with fatty liver and brown adipose tissue whitening in young male OLETF rats, PHYSIOLOGICAL REPORTS, 12(11), 202406
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  13. NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(31), 20230801
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  14. ★, Selective activation of PPAR alpha maintains thermogenic capacity of beige adipocytes, ISCIENCE, 26(7), 20230721
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  15. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes, ISCIENCE, 25(8), 20220819
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  16. Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLOS ONE, 17(6), 20220630
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  17. ★, Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
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  18. ★, EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex, Nature, 504(7478), 163-167, 20131205
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  19. ★, PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein, Cell Metabolism, 15(3), 395-405, 201204
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  20. Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells., Plos One, 7(11), e49452, 2012
  21. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 202208
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  22. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
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  23. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

    , MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 20220515
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  24. Dietary Vitamins A, C, and Potassium Intake Is Associated With Narrower Retinal Venular Caliber, FRONTIERS IN MEDICINE, 9, 20220210
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  25. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308(2), G151-G158, 20150115
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  26. Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy, AMERICAN JOURNAL OF NEURORADIOLOGY, 37(11), 2123-2128, 201611
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  27. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
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  28. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 2017
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  29. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model., Journal of gastroenterology, 2017
  30. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 2010
  31. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300(5), C1047-C1054, 2011
  32. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20812-20822, 2011
  33. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E286-E296, 2012
  34. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
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  35. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
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  36. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 2018
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  37. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
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  38. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25(9), 984-1001, 2018
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  39. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(53), 44526-44535, 2012
  40. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6(4), E288-E297, 2012
  41. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 197-202, 2013
  42. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 2015
  43. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 2016
  44. Increased Calcium Ion Levels Following Systemic Circulation After the Selective Arterial Calcium Injection Test, PANCREAS, 46(4), E34-E35, 2017
  45. Comparison of Operative Procedures of Partial Pancreatectomy by Postoperative Insulin Secretory Capacity and Glucose Intolerance, Journal of the Japan Diabetes Society, 59(3), 149-155, 2016
  46. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma., Internal medicine (Tokyo, Japan), 54(18), 2015
  47. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice., Journal of diabetes investigation, 7(1), 2016
  48. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin., Cardiovascular diabetology, 16(1), 2017
  49. Glucose transporter, Japanese journal of clinical medicine, 66(0), 98-102, 200805
  50. SGLT2 inhibitors, Endocrinology, diabetology & metabolism, 31(1), 22-26, 201007
  51. Skeletal muscle insulin resistance, Japanese journal of clinical medicine, 69(0), 176-179, 201101
  52. Developmental lineages of brown and beige adipocytes, 250(9), 811-815, 20140830
  53. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
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  54. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
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  55. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
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  56. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10(2), 352-357, 201903
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  57. Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26(12), 3221-+, 20190319
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  58. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
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  59. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
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  60. Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE, EUROPEAN JOURNAL OF RADIOLOGY OPEN, 6, 182-186, 2019
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  61. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
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  62. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98(49), 201912
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  63. Effect of the use of passive body trunk exercise equipment on oxygen consumption and self-efficacy for carrying out exercise in patients with type 2 diabetes, JOURNAL OF DIABETES INVESTIGATION, 11(5), 1265-1271, 202009
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  64. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
  65. Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104
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  66. Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538, 20211201
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  67. Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans, METABOLITES, 11(10), 202110
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  68. ATP1A1

    Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

    , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110
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External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research(C)), 2025, 2027
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  3. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  4. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
  5. KAKENHI, 2016, 2018
  6. 2017, 2019
  7. 2014
  8. 2014
  9. 2012, 2013