堤 保夫YASUO TSUTSUMI

Last Updated :2023/02/02

所属・職名
大学院医系科学研究科(医) 教授
メールアドレス
yasuo223hiroshima-u.ac.jp
その他連絡先
734-8551 広島市南区霞1-2-3 広島大学 麻酔蘇生学 
TEL:082-257-5267

基本情報

主な職歴

  • 2019年.6月, 広島大学, 麻酔蘇生学, 教授
  • 2015年.2月, 2019年.5月, 徳島大学, 麻酔・疼痛治療医学分野, 准教授
  • 2010年.1月, 2015年.1月, 徳島大学, 麻酔・疼痛治療医学分野, 講師
  • 2009年.4月, 2009年.1月, 徳島大学, 麻酔・疼痛治療医学分野, 助教
  • 2008年.7月, 2009年.3月, 徳島大学病院, 麻酔科, 助教

学歴

  • 徳島大学, 医学部, 医学科, 日本
  • 徳島大学, 大学院医学研究科博士課程, 日本

学位

  • 博士(医学) (徳島大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 麻酔科学

研究キーワード

  • 周術期管理、心筋虚血再灌流障害

所属学会

  • 日本麻酔科学会、日本臨床麻酔学会、American Society of Anesthesiologists

教育活動

授業担当

  1. 2022年, 学部専門, 通年, 全身性疾患制御学
  2. 2022年, 学部専門, 集中, 臨床実習入門プログラム
  3. 2022年, 学部専門, 集中, 医学研究実習
  4. 2022年, 学部専門, 集中, 臨床実習I
  5. 2022年, 学部専門, 集中, 臨床実習II
  6. 2022年, 博士課程・博士課程後期, セメスター(前期), 麻酔蘇生学特別演習
  7. 2022年, 博士課程・博士課程後期, セメスター(後期), 麻酔蘇生学特別演習
  8. 2022年, 博士課程・博士課程後期, セメスター(前期), 麻酔蘇生学特別研究
  9. 2022年, 博士課程・博士課程後期, セメスター(後期), 麻酔蘇生学特別研究

研究活動

学術論文(★は代表的な論文)

  1. 侵害刺激と血管 血管弾性研究で分かったこと, 麻酔・集中治療とテクノロジー, 2021巻, pp. 59-64, 20210101
  2. ICD-11時代のペインクリニック―国際疼痛学会 (IASP) 慢性疼痛分類に学ぶ, 日本ペインクリニック学会誌, 28巻, pp. 91-99, 20210101
  3. Subacute postoperative myofascial pain diagnosed and treated successfully by ultrasound: a case after laparoscopic hepatectomy, JA CLINICAL REPORTS, 8巻, 1号, 20220719
  4. Postoperative Tracheal Compression Requiring Transposition of the Brachiocephalic Artery After Bentall Surgery Combined With Total Arch Replacement in a Patient With Loeys-Dietz Syndrome, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 36巻, 8号, pp. 2532-2535, 202208
  5. Awake craniotomy with intraoperative open magnetic resonance imaging under anesthesia management using an anesthesia information management system via a wireless local area network: Case report, INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 29巻, 202209
  6. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135巻, 1号, pp. 128-135, 202207
  7. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50巻, 4号, pp. 312-319, 202207
  8. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8巻, 1号, 20220609
  9. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8巻, 1号, 20220412
  10. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery, JOURNAL OF ANESTHESIA, 36巻, 2号, pp. 265-269, 202204
  11. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8巻, 1号, pp. 225-230, 202202
  12. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17巻, 2号, 2022
  13. ★, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology, 92巻, pp. 1154-1159, 2000
  14. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, 95巻, pp. 766-770, 2001
  15. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice., Anesthesiology, 104巻, pp. 495-502, 2006
  16. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice., Am J Physiol Heart Circ Physiol, 291巻, pp. H979-H983, 2006
  17. ★, Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1., FASEB J, 21巻, pp. 1565-1574, 2007
  18. ★, Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization., Life Sciences, 81巻, pp. 1223-1227, 2007
  19. ★, Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning., Circulation, 118巻, pp. 1979-1988, 2008
  20. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection., Anesthesiology, 112巻, pp. 1136-1145, 2010
  21. Opioid-induced preconditioning is dependent on caveolin-3 expression., Anesthesia and Analgesia, 111巻, pp. 1117-1121, 2010
  22. Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway., Life Sciences, 88巻, pp. 725-729, 2011
  23. Neurokinin-1 receptor antagonism, aprepitant, effectively post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures., Journal of Medical Investigation, 58巻, pp. 246-251, 2011
  24. Geranylgeranylacetone protects the heart via caveolae and caveolin-3., Life Sciences, 101巻, pp. 43-48, 2014
  25. Geranylgeranylacetone and volatile anesthetic induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, 28巻, pp. 733-739, 2014
  26. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study., BioMed Research International, 2014巻, pp. 307025, 2014
  27. Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3, Cardiovascular Diabetology, 13巻, pp. 132, 2014
  28. Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression., European Review for Medical and Pharmacological Sciences, 19巻, pp. 1285-1290, 2015
  29. Whey-protein based formulas with omega-3 fatty acids are protective in LPS mediated sepsis., Journal of Parenteral and Enteral Nutrition, 39巻, pp. 552-561, 2015
  30. Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study., Journal of Anesthesia, 29巻, pp. 696-701, 2015
  31. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo lower limb surgery. –A prospective, randomized, double-blind study–, Journal of Anesthesia, 29巻, pp. 836-841, 2015
  32. Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting., JA Clinical Reports, 2巻, pp. 9, 2016
  33. Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial., Journal of Anesthesia, 30巻, pp. 842-849, 2016
  34. Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers., Journal of Anesthesia, 31巻, pp. 472-475, 2017
  35. ★, A comparison of fosaprepitant and ondansetron for preventing postoperative nausea and vomiting in moderate to high risk patients: a retrospective database analysis., BioMed Research International, 2017巻, pp. 5703528, 2017
  36. Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy., Journal of Medical Investigation, 65巻, pp. 69-73, 2018
  37. Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions., Clinical Nutrition Experimental, 19巻, pp. 1-11, 2018
  38. The efficacy of programmed intermittent epidural bolus for postoperative analgesia after open gynecological surgery: a randomized double-blind study., BioMed Research International, 2018巻, pp. 6297247, 2018
  39. Caveolins: targeting pro-survival signaling in the heart and brain., Frontiers in Physiology, 3巻, pp. 393, 2012
  40. ★, Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection., Current Pharmaceutical Design, 20巻, pp. 5681-5689, 2014
  41. Postoperative nausea and vomiting following lower limb surgery: a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia, JOURNAL OF MEDICAL INVESTIGATION, 66巻, 3-4号, pp. 303-307, 201908
  42. Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices, JOURNAL OF INTENSIVE CARE, 7巻, 1号, 20191216
  43. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245巻, 20200315
  44. Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients, JOURNAL OF MEDICAL INVESTIGATION, 67巻, 1-2号, pp. 139-144, 202002
  45. Early Diagnosis of the Cardiopulmonary Collapse Type of Amniotic Fluid Embolism with Obstetrical Disseminated Intravascular Coagulation during Elective Cesarean Section : A Case Report, JOURNAL OF MEDICAL INVESTIGATION, 67巻, 1-2号, pp. 207-210, 202002
  46. The effect of 1% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial, BMC ANESTHESIOLOGY, 20巻, 1号, 20200606
  47. Anesthetic management of patient with Dravet Syndrome: a case report., Anesth Prog, 66巻, pp. 156-158, 2019
  48. 帝王切開後に産褥性心筋症を発症し心不全に陥った筋緊張性ジストロフィー妊婦の麻酔経験, 麻酔, 68巻, pp. 148-152, 2019
  49. 慢性炎症性脱髄性多発根ニューロパチー患者に対する肝切除術の麻酔経験, 麻酔, 68巻, pp. 409-412, 2019
  50. 血管内ステントと痛み, 臨床麻酔, 43巻, pp. 1484-1488, 2019
  51. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884巻, 20201005
  52. Evaluation of a new face mask concept for oxygen administration: a crossover study in healthy volunteers, JOURNAL OF ANESTHESIA, 34巻, 6号, pp. 950-952, 202012
  53. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70巻, 5号, pp. 508-519, 2020
  54. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases, JA CLINICAL REPORTS, 6巻, 1号, 20201209
  55. An outcome study of adult in-hospital cardiac arrests in non-monitored areas with resuscitation attempted using AED, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 38巻, 12号, pp. 2524-2530, 20201209
  56. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation, BIOMED RESEARCH INTERNATIONAL, 2021巻, 20210104
  57. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, 16巻, 1号, pp. 169-174, 202103
  58. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35巻, 2号, pp. 168-174, 202104
  59. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report, JOURNAL OF ANESTHESIA, 35巻, 2号, pp. 311-314, 202104
  60. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy, SCIENTIFIC REPORTS, 11巻, 1号, 20210304
  61. Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia, JA CLINICAL REPORTS, 7巻, 1号, 20210420
  62. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11巻, 1号, 20210505
  63. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report, JA CLINICAL REPORTS, 7巻, 1号, 20210602
  64. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10巻, 5号, pp. 5119-5127, 202105
  65. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31巻, 10号, pp. 2979-2986, 20210922
  66. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133巻, 5号, pp. 1107-1115, 202111
  67. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation : A case report, JOURNAL OF MEDICAL INVESTIGATION, 68巻, 3-4号, pp. 383-385, 202108
  68. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10巻, 10号, pp. 10160-10169, 202110
  69. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, DIABETOLOGY & METABOLIC SYNDROME, 13巻, 1号, 20211120
  70. Rocuronium-induced respiratory paralysis refractory to sugammadex in Charcot-Marie-Tooth disease, CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 69巻, 3号, pp. 364-368, 202203
  71. Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora, TRANSLATIONAL RESEARCH, 237巻, pp. 16-30, 202111

著書等出版物

  1. 2020年, 周術期管理 LiSA別冊秋号, 悪性高熱症素因疑い, 2020年, 単行本(学術書), 共著
  2. 2009年, 徹底ガイド 心臓麻酔Q&A, 第5章 心臓麻酔における臓器保護:心臓手術中の心筋保護, 総合医学社, 単行本(学術書), 共著, 田中克哉、堤保夫、大下修造, 901-909
  3. 2013年, 徹底ガイド 心臓麻酔Q&A【新装版】, 第5章 心臓麻酔における臓器保護:心臓手術中の心筋保護, 総合医学社, 単行本(学術書), 共著, 田中克哉、堤保夫、大下修造, 107-115
  4. 2015年, 麻酔科医のための周術期の薬物使用法, アミオダロン, 文光堂, 単行本(学術書), 共著, 田中克哉、堤保夫, 260-263
  5. 2015年, まれな疾患の麻酔 A to Z, フォン ヒッペル・リンダウ病 & 筋萎縮性側索硬化症, 文光堂, 単行本(学術書), 共著, 堤保夫, 40 & 460-461
  6. 重症病態の栄養治療―最新の知識とその実践―, 第5章 栄養組成:ペプチド栄養剤, 総合医学社, 単行本(学術書), 共著, 堤理恵、坂上浩、堤保夫, 585-590
  7. 2016年, 臨床麻酔実践シリーズ8:デスフルランの上手な使い方, 第6章 各科手術での使用:胸部(呼吸器)外科手術―HPV・重症筋無力症 & 第7章 特殊病態や状態下での使用:喘息患者・COPD患者, ライフメディコム, 単行本(学術書), 川西良典、堤保夫、田中克哉 & 堤保夫、川西良典、田中克哉, 106-110 & 152-154
  8. 2017年, 麻酔偶発症AtoZ, マスク換気不全 & 歯牙・口唇損傷, 文光堂, 単行本(学術書), 共著, 田中克哉、堤保夫 & 堤保夫、田中克哉, 482-483 & 496
  9. 2018年, 心臓麻酔 臨床実践ガイド, 第3章 麻酔薬・薬剤 Q13吸入麻酔薬 & 第5章 心臓麻酔における臓器保護 Q18 心臓手術中の心筋保護, 総合医学社, 単行本(学術書), 堤保夫、角田奈美、田中克哉 & 田中克哉、堤保夫、大下修造, 120-128 & 174-188
  10. 2018年, 術式対応“わがまま”術後鎮痛マニュアル, 第2章 体表手術 セクション5 皮膚および形成外科手術, 克誠堂出版, 単行本(学術書), 共著, 櫻井静佳、堤保夫, 24-26

招待講演、口頭・ポスター発表等

  1. 麻酔科からみるERASプロトコル, 堤保夫, 2022年09月02日, 招待, 日本語
  2. Postoperative nausea and vomiting (PONV), 堤保夫, 第40回日本臨床麻酔学会, 2020年11月15日, 招待, 日本語
  3. 悪性高熱症 -up to date-, 堤保夫, 第48回日本歯科麻酔科学会, 2019年10月09日, 招待, 日本語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業 若手研究(A), 細胞膜特殊構造の新しい役割-心筋保護作用に与える影響とそのメカニズムの解明-, 2009年, 2012年
  2. 財団法人武田科学振興財団 研究奨励金, 虚血再潅流障害に対する細胞膜特殊構造の心保護作用に及ぼす影響とそのメカニズムの解明, 2009年, 2010年
  3. 上原記念生命科学財団 研究奨励金(研究助成), 細胞膜マイクロドメインであるカベオラ、及びその構成タンパクであるカベオリンの心筋保護作用に与える影響とそのメカニズムの解明, 2010年, 2011年
  4. 科学研究費助成事業 基盤研究(C), 吸入麻酔薬の心筋保護作用における細胞膜マイクロドメインとオートファジーの役割, 2013年, 2015年
  5. 科学研究費助成事業 基盤研究(C), 細胞膜マイクロドメインを介する心筋保護作用に高血糖が及ぼす影響, 2016年, 2018年
  6. 中冨健康科学振興財団 研究助成金, 術後硬膜外鎮痛の間欠的ボーラス投与法を用いた薬剤減量に関する研究, 2016年
  7. 科学研究費助成事業 国際共同研究加速基金(国際共同研究強化), 吸入麻酔薬の心筋保護作用における細胞膜マイクロドメインとオートファジーの役割(国際共同研究強化), 2017年, 2018年
  8. 科学研究費助成事業 基盤研究(C), 吸入麻酔薬の心筋保護作用とマイクロドメイン・ミトコンドリアダイナミクスの役割, 2019年, 2021年
  9. 公益財団法人上原記念生命科学財団 研究推進特別奨励金(研究助成), 上気道音の集積データによる換気困難患者評価法の確立, 2019年, 2020年
  10. 科学研究費助成事業(基盤研究(C)), 吸入麻酔薬による細胞膜マイクロドメイン・MAMを介した心筋保護作用機序の解明, 2022年, 2024年