YASUO TSUTSUMI

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
yasuo223hiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami, Hiroshima 734-8551 JAPAN, Japan
TEL : (+81)82-257-5267 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2019/.6, Hiroshima University, Anesthesiology and Critical Care, Professor
  • 2015/.2, 2019/.5, Tokushima University, Anesthesiology, Associate Professor
  • 2010/.1, 2015/.1, Tokushima University, Anesthesiology, Associate Professor
  • 2009/.4, 2009/.1, Tokushima University, Anesthesiology, Assistant Professor
  • 2008/.7, 2009/.3, Tokushima University Hospital, Anesthesiology, Assistant Professor

Educational Backgrounds

  • The University of Tokushima, Japan
  • The University of Tokushima, Japan

Academic Degrees

  • The University of Tokushima

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Anesthesiology

Research Keywords

  • Perioperative Management、Cardiac Ischemia-Reperfusion Injury

Affiliated Academic Societies

  • Japanese Society of Anesthesiologists、The Japan Society for Clinical Anesthesia、American Society of Anesthesiologists

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Systemic Disease Control
  2. 2025, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2025, Undergraduate Education, Intensive, Practice for medical research
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Anesthesiology and Critical Care
  7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Anesthesiology and Critical Care
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Anesthesiology and Critical Care
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Anesthesiology and Critical Care

Research Activities

Academic Papers

  1. Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report, JA CLINICAL REPORTS, 10(1), 20240422
    Link to Paper Search Results by DOI
  2. The Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Paclitaxel-Induced Neuropathic Pain, MEDICINA-LITHUANIA, 60(3), 202403
    Link to Paper Search Results by DOI
  3. Impact of Olfactory Change on Postoperative Body Weight Loss in Patients with Gastric Cancer after Gastrectomy, NUTRIENTS, 16(6), 202403
    Link to Paper Search Results by DOI
  4. Elastic Banding Compression as a Novel Treatment to Maintain Hemodynamics in a Patient With Klippel-Trenaunay Syndrome, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(2), 20240213
    Link to Paper Search Results by DOI
  5. Reply to Su et al. Comment on "Matsumoto et al. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial. J. Clin. Med. 2023, 12, 5402", JOURNAL OF CLINICAL MEDICINE, 13(4), 202402
    Link to Paper Search Results by DOI
  6. Rapid Dantrolene Administration with Body Temperature Monitoring Is Associated with Decreased Mortality in Japanese Malignant Hyperthermia Events, BIOMED RESEARCH INTERNATIONAL, 2023, 20230222
    Link to Paper Search Results by DOI
  7. New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care, SCIENTIFIC REPORTS, 13(1), 20231118
    Link to Paper Search Results by DOI
  8. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care, JOURNAL OF MEDICAL INVESTIGATION, 70(3-4), 430-435, 202308
  9. A Case of a Father and Son With Complex Regional Pain Syndrome Type 1 Exhibiting Different Resting-State Functional Connectivity on Functional MRI, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(1), 20240119
    Link to Paper Search Results by DOI
  10. Prediction of blood pressure changes during surgical incision using the minimum evoked current of vascular stiffness value under sevoflurane anesthesia, SCIENTIFIC REPORTS, 13(1), 20231122
    Link to Paper Search Results by DOI
  11. Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: A randomized controlled trial, MEDICINE, 102(46), 20231117
    Link to Paper Search Results by DOI
  12. Delayed Nonimmune Anaphylaxis Caused by Ropivacaine for Preoperative Nerve Blocks: A Case Report, A & A PRACTICE, 17(11), 202311
    Link to Paper Search Results by DOI
  13. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells, FRONTIERS IN PHARMACOLOGY, 14, 20231107
    Link to Paper Search Results by DOI
  14. Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants, GENES, 14(11), 202311
    Link to Paper Search Results by DOI
  15. Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice, NUTRIENTS, 15(19), 202310
    Link to Paper Search Results by DOI
  16. Identification of protein kinase C domains involved in its translocation induced by propofol, EUROPEAN JOURNAL OF PHARMACOLOGY, 955, 20230915
    Link to Paper Search Results by DOI
  17. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial, JOURNAL OF CLINICAL MEDICINE, 12(16), 202308
    Link to Paper Search Results by DOI
  18. Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis., 5, 86-101, 20220401
  19. Genetic screening for malignant hyperthermia and comparison of clinical symptoms in Japan., Hiroshima J Med Sci, 71, 128-135, 20220401
  20. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report, AMERICAN JOURNAL OF CASE REPORTS, 24, 20230321
    Link to Paper Search Results by DOI
  21. Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center, BIOMED RESEARCH INTERNATIONAL, 2022, 20221022
    Link to Paper Search Results by DOI
  22. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report, JA CLINICAL REPORTS, 8(1), 20221005
    Link to Paper Search Results by DOI
  23. Subacute postoperative myofascial pain diagnosed and treated successfully by ultrasound: a case after laparoscopic hepatectomy, JA CLINICAL REPORTS, 8(1), 20220719
    Link to Paper Search Results by DOI
  24. Postoperative Tracheal Compression Requiring Transposition of the Brachiocephalic Artery After Bentall Surgery Combined With Total Arch Replacement in a Patient With Loeys-Dietz Syndrome, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 36(8), 2532-2535, 202208
    Link to Paper Search Results by DOI
  25. Awake craniotomy with intraoperative open magnetic resonance imaging under anesthesia management using an anesthesia information management system via a wireless local area network: Case report, INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 29, 202209
    Link to Paper Search Results by DOI
  26. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 202207
    Link to Paper Search Results by DOI
  27. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 202207
    Link to Paper Search Results by DOI
  28. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8(1), 20220609
    Link to Paper Search Results by DOI
  29. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8(1), 20220412
    Link to Paper Search Results by DOI
  30. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery, JOURNAL OF ANESTHESIA, 36(2), 265-269, 202204
    Link to Paper Search Results by DOI
  31. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8(1), 225-230, 202202
    Link to Paper Search Results by DOI
  32. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17(2), 2022
    Link to Paper Search Results by DOI
  33. ★, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology, 92, 1154-1159, 2000
  34. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, 95, 766-770, 2001
  35. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice., Anesthesiology, 104, 495-502, 2006
  36. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice., Am J Physiol Heart Circ Physiol, 291, H979-H983, 2006
  37. ★, Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1., FASEB J, 21, 1565-1574, 2007
  38. ★, Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization., Life Sciences, 81, 1223-1227, 2007
  39. ★, Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning., Circulation, 118, 1979-1988, 2008
  40. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection., Anesthesiology, 112, 1136-1145, 2010
  41. Opioid-induced preconditioning is dependent on caveolin-3 expression., Anesthesia and Analgesia, 111, 1117-1121, 2010
  42. Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway., Life Sciences, 88, 725-729, 2011
  43. Neurokinin-1 receptor antagonism, aprepitant, effectively post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures., Journal of Medical Investigation, 58, 246-251, 2011
  44. Geranylgeranylacetone protects the heart via caveolae and caveolin-3., Life Sciences, 101, 43-48, 2014
  45. Geranylgeranylacetone and volatile anesthetic induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, 28, 733-739, 2014
  46. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study., BioMed Research International, 2014, 307025, 2014
  47. Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3, Cardiovascular Diabetology, 13, 132, 2014
  48. Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression., European Review for Medical and Pharmacological Sciences, 19, 1285-1290, 2015
  49. Whey-protein based formulas with omega-3 fatty acids are protective in LPS mediated sepsis., Journal of Parenteral and Enteral Nutrition, 39, 552-561, 2015
  50. Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study., Journal of Anesthesia, 29, 696-701, 2015
  51. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo lower limb surgery. –A prospective, randomized, double-blind study–, Journal of Anesthesia, 29, 836-841, 2015
  52. Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting., JA Clinical Reports, 2, 9, 2016
  53. Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial., Journal of Anesthesia, 30, 842-849, 2016
  54. Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers., Journal of Anesthesia, 31, 472-475, 2017
  55. ★, A comparison of fosaprepitant and ondansetron for preventing postoperative nausea and vomiting in moderate to high risk patients: a retrospective database analysis., BioMed Research International, 2017, 5703528, 2017
  56. Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy., Journal of Medical Investigation, 65, 69-73, 2018
  57. Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions., Clinical Nutrition Experimental, 19, 1-11, 2018
  58. The efficacy of programmed intermittent epidural bolus for postoperative analgesia after open gynecological surgery: a randomized double-blind study., BioMed Research International, 2018, 6297247, 2018
  59. Caveolins: targeting pro-survival signaling in the heart and brain., Frontiers in Physiology, 3, 393, 2012
  60. ★, Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection., Current Pharmaceutical Design, 20, 5681-5689, 2014
  61. Postoperative nausea and vomiting following lower limb surgery: a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia, JOURNAL OF MEDICAL INVESTIGATION, 66(3-4), 303-307, 201908
    Link to Paper Search Results by DOI
  62. Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices, JOURNAL OF INTENSIVE CARE, 7(1), 20191216
    Link to Paper Search Results by DOI
  63. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 20200315
    Link to Paper Search Results by DOI
  64. Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 139-144, 202002
  65. Early Diagnosis of the Cardiopulmonary Collapse Type of Amniotic Fluid Embolism with Obstetrical Disseminated Intravascular Coagulation during Elective Cesarean Section : A Case Report, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 207-210, 202002
  66. The effect of 1% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial, BMC ANESTHESIOLOGY, 20(1), 20200606
    Link to Paper Search Results by DOI
  67. Anesthetic management of patient with Dravet Syndrome: a case report., Anesth Prog, 66, 156-158, 2019
  68. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
    Link to Paper Search Results by DOI
  69. Evaluation of a new face mask concept for oxygen administration: a crossover study in healthy volunteers, JOURNAL OF ANESTHESIA, 34(6), 950-952, 202012
    Link to Paper Search Results by DOI
  70. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
    Link to Paper Search Results by DOI
  71. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases, JA CLINICAL REPORTS, 6(1), 20201209
    Link to Paper Search Results by DOI
  72. An outcome study of adult in-hospital cardiac arrests in non-monitored areas with resuscitation attempted using AED, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 38(12), 2524-2530, 20201209
    Link to Paper Search Results by DOI
  73. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation, BIOMED RESEARCH INTERNATIONAL, 2021, 20210104
    Link to Paper Search Results by DOI
  74. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, 16(1), 169-174, 202103
    Link to Paper Search Results by DOI
  75. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 202104
    Link to Paper Search Results by DOI
  76. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report, JOURNAL OF ANESTHESIA, 35(2), 311-314, 202104
    Link to Paper Search Results by DOI
  77. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy, SCIENTIFIC REPORTS, 11(1), 20210304
    Link to Paper Search Results by DOI
  78. Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia, JA CLINICAL REPORTS, 7(1), 20210420
    Link to Paper Search Results by DOI
  79. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 20210505
    Link to Paper Search Results by DOI
  80. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report, JA CLINICAL REPORTS, 7(1), 20210602
    Link to Paper Search Results by DOI
  81. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 202105
    Link to Paper Search Results by DOI
  82. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(10), 2979-2986, 20210922
    Link to Paper Search Results by DOI
  83. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133(5), 1107-1115, 202111
    Link to Paper Search Results by DOI
  84. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation : A case report, JOURNAL OF MEDICAL INVESTIGATION, 68(3-4), 383-385, 202108
  85. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(10), 10160-10169, 202110
    Link to Paper Search Results by DOI
  86. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, DIABETOLOGY & METABOLIC SYNDROME, 13(1), 20211120
    Link to Paper Search Results by DOI
  87. Rocuronium-induced respiratory paralysis refractory to sugammadex in Charcot-Marie-Tooth disease, CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 69(3), 364-368, 202203
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  88. Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora, TRANSLATIONAL RESEARCH, 237, 16-30, 202111
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External Funds

Acceptance Results of Competitive Funds

  1. 2009, 2012
  2. 2009, 2010
  3. 2010, 2011
  4. 2013, 2015
  5. 2016, 2018
  6. 2016
  7. 2017, 2018
  8. 2019, 2021
  9. 2019, 2020
  10. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024