YASUO TSUTSUMI

Last Updated :2026/06/24

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
E-mail
yasuo223hiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami, Hiroshima 734-8551 JAPAN, Japan
TEL : (+81)82-257-5267 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2019/.6, Hiroshima University, Anesthesiology and Critical Care, Professor
  • 2015/.2, 2019/.5, Tokushima University, Anesthesiology, Associate Professor
  • 2010/.1, 2015/.1, Tokushima University, Anesthesiology, Associate Professor
  • 2009/.4, 2009/.1, Tokushima University, Anesthesiology, Assistant Professor
  • 2008/.7, 2009/.3, Tokushima University Hospital, Anesthesiology, Assistant Professor

Educational Backgrounds

  • The University of Tokushima, Japan
  • The University of Tokushima, Japan

Academic Degrees

  • The University of Tokushima

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Anesthesiology

Research Keywords

  • Perioperative Management、Cardiac Ischemia-Reperfusion Injury

Affiliated Academic Societies

  • Japanese Society of Anesthesiologists、The Japan Society for Clinical Anesthesia、American Society of Anesthesiologists

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Systemic Disease Control
  2. 2026, Undergraduate Education, Intensive, Practice for medical research
  3. 2026, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2026, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Anesthesiology and Critical Care
  6. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Anesthesiology and Critical Care
  7. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Anesthesiology and Critical Care
  8. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Anesthesiology and Critical Care

Research Activities

Academic Papers

  1. Evaluation of clinically relevant sevoflurane concentrations in the development of malignant hyperthermia in an Ryr1 mutant mouse model, BMC ANESTHESIOLOGY, 26(1), 20260324
  2. Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 46, 202606
  3. JSA guideline for management of malignant hyperthermia in 2025, JOURNAL OF ANESTHESIA, 40(1), 4-12, 202602
  4. Anesthetic and airway management for inguinal hernia repair in a pediatric patient with fibrodysplasia ossificans progressiva: a case report, JOURNAL OF MEDICAL CASE REPORTS, 20(1), 20260128
  5. Association of energy expenditure with body composition and nutritional intake in male patients with esophageal and head and neck cancer, JOURNAL OF MEDICAL INVESTIGATION, 72(3-4), 252-259, 202508
  6. The impact of snack and vegetable intake on body composition in young healthy subjects, JOURNAL OF MEDICAL INVESTIGATION, 72(3-4), 281-285, 202508
  7. Ventilatory Management Using Electrical Impedance Tomography in an Obese Patient Undergoing Robot-Assisted Laparoscopic Rectal Resection : A Case Report, JOURNAL OF MEDICAL INVESTIGATION, 72(3-4), 447-450, 202508
  8. Genetic Panel Testing for Malignant Hyperthermia in Japan: Discovery of Novel Variants and Clinical Implications, GENES, 16(8), 20250811
  9. Multifaceted analysis of presenteeism: contributions of pain, psychological factors and daily functioning - a cross-sectional study in Japan, BMJ OPEN, 15(8), 20250812
  10. DNA methyltransferase inhibition by 5-azacytidine promotes thermogenic programming in beige adipocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 774, 20250808
  11. Comparison between single bolus dose administration and continuous infusion of remimazolam for general anesthesia induction in non-cardiac surgery: a single-center prospective randomized controlled trial, BMC ANESTHESIOLOGY, 25(1), 20250402
  12. Gut-pancreas axis in the control of insulin secretion in streptozotocin-resistant rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 752, 20250308
  13. Impact of Operating Table Height on the Difficulty of Mask Ventilation and Laryngoscopic View, JOURNAL OF CLINICAL MEDICINE, 13(19), 202410
  14. Protein kinase C (PKC) inhibitor Calphostin C activates PKC in a light-dependent manner at high concentrations via the production of singlet oxygen, EUROPEAN JOURNAL OF PHARMACOLOGY, 984, 20241205
  15. Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Diabetes-Induced Neuropathic Pain, JOURNAL OF CLINICAL MEDICINE, 13(14), 202407
  16. Anesthetic management with remimazolam for a patient with hereditary angioedema : a case report, JOURNAL OF MEDICAL INVESTIGATION, 71(1-2), 184-186, 202402
  17. Impact of proficiency in the transcatheter aortic valve implantation procedure on clinical outcomes: a single center retrospective study, BMC ANESTHESIOLOGY, 24(1), 20240621
  18. Prevention of Oxygen Desaturation in a Patient With Previous Experience of Severe Hypoxia in Modified Electroconvulsive Therapy by Transnasal Humidified Rapid-Insufflation Ventilator Exchange: A Case Report, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(5), 20240518
  19. Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report, JA CLINICAL REPORTS, 10(1), 20240422
  20. The Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Paclitaxel-Induced Neuropathic Pain, MEDICINA-LITHUANIA, 60(3), 202403
  21. Impact of Olfactory Change on Postoperative Body Weight Loss in Patients with Gastric Cancer after Gastrectomy, NUTRIENTS, 16(6), 202403
  22. Elastic Banding Compression as a Novel Treatment to Maintain Hemodynamics in a Patient With Klippel-Trenaunay Syndrome, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(2), 20240213
  23. Reply to Su et al. Comment on "Matsumoto et al. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial. J. Clin. Med. 2023, 12, 5402", JOURNAL OF CLINICAL MEDICINE, 13(4), 202402
  24. Rapid Dantrolene Administration with Body Temperature Monitoring Is Associated with Decreased Mortality in Japanese Malignant Hyperthermia Events, BIOMED RESEARCH INTERNATIONAL, 2023, 20230222
  25. New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care, SCIENTIFIC REPORTS, 13(1), 20231118
  26. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care, JOURNAL OF MEDICAL INVESTIGATION, 70(3-4), 430-435, 202308
  27. A Case of a Father and Son With Complex Regional Pain Syndrome Type 1 Exhibiting Different Resting-State Functional Connectivity on Functional MRI, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(1), 20240119
  28. Prediction of blood pressure changes during surgical incision using the minimum evoked current of vascular stiffness value under sevoflurane anesthesia, SCIENTIFIC REPORTS, 13(1), 20231122
  29. Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: A randomized controlled trial, MEDICINE, 102(46), 20231117
  30. Delayed Nonimmune Anaphylaxis Caused by Ropivacaine for Preoperative Nerve Blocks: A Case Report, A & A PRACTICE, 17(11), 202311
  31. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells, FRONTIERS IN PHARMACOLOGY, 14, 20231107
  32. Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants, GENES, 14(11), 202311
  33. Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice, NUTRIENTS, 15(19), 202310
  34. Identification of protein kinase C domains involved in its translocation induced by propofol, EUROPEAN JOURNAL OF PHARMACOLOGY, 955, 20230915
  35. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial, JOURNAL OF CLINICAL MEDICINE, 12(16), 202308
  36. Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis., 5, 86-101, 20220401
  37. Genetic screening for malignant hyperthermia and comparison of clinical symptoms in Japan., Hiroshima J Med Sci, 71, 128-135, 20220401
  38. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report, AMERICAN JOURNAL OF CASE REPORTS, 24, 20230321
  39. Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center, BIOMED RESEARCH INTERNATIONAL, 2022, 20221022
  40. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report, JA CLINICAL REPORTS, 8(1), 20221005
  41. Subacute postoperative myofascial pain diagnosed and treated successfully by ultrasound: a case after laparoscopic hepatectomy, JA CLINICAL REPORTS, 8(1), 20220719
  42. Postoperative Tracheal Compression Requiring Transposition of the Brachiocephalic Artery After Bentall Surgery Combined With Total Arch Replacement in a Patient With Loeys-Dietz Syndrome, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 36(8), 2532-2535, 202208
  43. Awake craniotomy with intraoperative open magnetic resonance imaging under anesthesia management using an anesthesia information management system via a wireless local area network: Case report, INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 29, 202209
  44. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 202207
  45. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 202207
  46. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8(1), 20220609
  47. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8(1), 20220412
  48. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery, JOURNAL OF ANESTHESIA, 36(2), 265-269, 202204
  49. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8(1), 225-230, 202202
  50. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17(2), 2022
  51. ★, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology, 92, 1154-1159, 2000
  52. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, 95, 766-770, 2001
  53. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice., Anesthesiology, 104, 495-502, 2006
  54. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice., Am J Physiol Heart Circ Physiol, 291, H979-H983, 2006
  55. ★, Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1., FASEB J, 21, 1565-1574, 2007
  56. ★, Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization., Life Sciences, 81, 1223-1227, 2007
  57. ★, Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning., Circulation, 118, 1979-1988, 2008
  58. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection., Anesthesiology, 112, 1136-1145, 2010
  59. Opioid-induced preconditioning is dependent on caveolin-3 expression., Anesthesia and Analgesia, 111, 1117-1121, 2010
  60. Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway., Life Sciences, 88, 725-729, 2011
  61. Neurokinin-1 receptor antagonism, aprepitant, effectively post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures., Journal of Medical Investigation, 58, 246-251, 2011
  62. Geranylgeranylacetone protects the heart via caveolae and caveolin-3., Life Sciences, 101, 43-48, 2014
  63. Geranylgeranylacetone and volatile anesthetic induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, 28, 733-739, 2014
  64. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study., BioMed Research International, 2014, 307025, 2014
  65. Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3, Cardiovascular Diabetology, 13, 132, 2014
  66. Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression., European Review for Medical and Pharmacological Sciences, 19, 1285-1290, 2015
  67. Whey-protein based formulas with omega-3 fatty acids are protective in LPS mediated sepsis., Journal of Parenteral and Enteral Nutrition, 39, 552-561, 2015
  68. Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study., Journal of Anesthesia, 29, 696-701, 2015
  69. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo lower limb surgery. –A prospective, randomized, double-blind study–, Journal of Anesthesia, 29, 836-841, 2015
  70. Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting., JA Clinical Reports, 2, 9, 2016
  71. Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial., Journal of Anesthesia, 30, 842-849, 2016
  72. Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers., Journal of Anesthesia, 31, 472-475, 2017
  73. ★, A comparison of fosaprepitant and ondansetron for preventing postoperative nausea and vomiting in moderate to high risk patients: a retrospective database analysis., BioMed Research International, 2017, 5703528, 2017
  74. Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy., Journal of Medical Investigation, 65, 69-73, 2018
  75. Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions., Clinical Nutrition Experimental, 19, 1-11, 2018
  76. The efficacy of programmed intermittent epidural bolus for postoperative analgesia after open gynecological surgery: a randomized double-blind study., BioMed Research International, 2018, 6297247, 2018
  77. Caveolins: targeting pro-survival signaling in the heart and brain., Frontiers in Physiology, 3, 393, 2012
  78. ★, Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection., Current Pharmaceutical Design, 20, 5681-5689, 2014
  79. Postoperative nausea and vomiting following lower limb surgery: a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia, JOURNAL OF MEDICAL INVESTIGATION, 66(3-4), 303-307, 201908
  80. Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices, JOURNAL OF INTENSIVE CARE, 7(1), 20191216
  81. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 20200315
  82. Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 139-144, 202002
  83. Early Diagnosis of the Cardiopulmonary Collapse Type of Amniotic Fluid Embolism with Obstetrical Disseminated Intravascular Coagulation during Elective Cesarean Section : A Case Report, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 207-210, 202002
  84. The effect of 1% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial, BMC ANESTHESIOLOGY, 20(1), 20200606
  85. Anesthetic management of patient with Dravet Syndrome: a case report., Anesth Prog, 66, 156-158, 2019
  86. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
  87. Evaluation of a new face mask concept for oxygen administration: a crossover study in healthy volunteers, JOURNAL OF ANESTHESIA, 34(6), 950-952, 202012
  88. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
  89. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases, JA CLINICAL REPORTS, 6(1), 20201209
  90. An outcome study of adult in-hospital cardiac arrests in non-monitored areas with resuscitation attempted using AED, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 38(12), 2524-2530, 20201209
  91. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation, BIOMED RESEARCH INTERNATIONAL, 2021, 20210104
  92. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, 16(1), 169-174, 202103
  93. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 202104
  94. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report, JOURNAL OF ANESTHESIA, 35(2), 311-314, 202104
  95. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy, SCIENTIFIC REPORTS, 11(1), 20210304
  96. Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia, JA CLINICAL REPORTS, 7(1), 20210420
  97. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 20210505
  98. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report, JA CLINICAL REPORTS, 7(1), 20210602
  99. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 202105
  100. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(10), 2979-2986, 20210922
  101. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133(5), 1107-1115, 202111
  102. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation : A case report, JOURNAL OF MEDICAL INVESTIGATION, 68(3-4), 383-385, 202108
  103. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(10), 10160-10169, 202110
  104. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, DIABETOLOGY & METABOLIC SYNDROME, 13(1), 20211120
  105. Rocuronium-induced respiratory paralysis refractory to sugammadex in Charcot-Marie-Tooth disease, CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 69(3), 364-368, 202203
  106. Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora, TRANSLATIONAL RESEARCH, 237, 16-30, 202111

External Funds

Acceptance Results of Competitive Funds

  1. 2009, 2012
  2. 2009, 2010
  3. 2010, 2011
  4. 2013, 2015
  5. 2016, 2018
  6. 2016
  7. 2017, 2018
  8. 2019, 2021
  9. 2019, 2020
  10. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024