河本 正次Seiji Kawamoto

Last Updated :2021/03/02

所属・職名
大学院統合生命科学研究科 教授
ホームページ
メールアドレス
skawahiroshima-u.ac.jp
その他連絡先
〒739-8530 東広島市鏡山1-3-1 先端科学総合研究棟707W
TEL:082-424-7753 FAX:082-424-7867
自己紹介
研究内容 健康と医療のバイオテクノロジー

基本情報

主な職歴

  • 2002年07月01日, 2004年06月30日, ハーバード大学医学部, リサーチフェロー(日本学術振興会海外特別研究員)
  • 1997年04月01日, 広島大学, 工学部, 助手
  • 1996年04月01日, 1997年03月31日, 日本学術振興会, 特別研究員PD
  • 1996年01月01日, 1996年03月31日, 日本学術振興会, 特別研究員DC2
  • 1999年04月01日, 広島大学, 大学院先端物質科学研究科, 助手
  • 2008年06月01日, 広島大学, 大学院先端物質科学研究科, 准教授
  • 2014年09月01日, 広島大学, 大学院先端物質科学研究科, 教授
  • 2019年04月01日, 広島大学, 大学院統合生命科学研究科, 教授
  • 2015年04月01日, 広島大学健康長寿研究拠点 (HiHA), 拠点リーダー

学歴

  • 愛媛県立今治西高等学校, 1987年
  • 九州大学, 農学部, 食糧化学工学科, 日本, 1987年04月, 1991年03月
  • 九州大学, 大学院農学研究科遺伝子資源工学専攻, 日本, 1991年04月, 1996年03月

学位

  • 博士(農学) (九州大学)
  • 修士(農学) (九州大学)

担当主専攻プログラム

  • 生物工学プログラム

研究分野

  • 医歯薬学 / 基礎医学 / 免疫学
  • 農学 / 境界農学 / 応用分子細胞生物学
  • 農学 / 農芸化学 / 応用生物化学
  • 農学 / 農芸化学 / 食品科学
  • 複合領域 / 生活科学 / 食生活学

研究キーワード

  • 免疫制御による加齢病の克服
  • アレルギーの次世代診断・治療技術の開発
  • 食による炎症性難病の予防

所属学会

  • 日本免疫学会
  • 日本農芸化学会
  • 日本生物工学会
  • 日本動物細胞工学会
  • 日本食品免疫学会
  • 癌・炎症と抗酸化研究会

教育活動

授業担当

  1. 2020年, 学部専門, セメスター(後期), 基礎化学実験
  2. 2020年, 学部専門, 2ターム, 基礎工業概論
  3. 2020年, 学部専門, 3ターム, 生物化学II
  4. 2020年, 学部専門, 4ターム, 糖鎖・免疫工学
  5. 2020年, 修士課程・博士課程前期, 1ターム, 生命科学概論
  6. 2020年, 修士課程・博士課程前期, セメスター(前期), 分子生命機能科学セミナー
  7. 2020年, 修士課程・博士課程前期, セメスター(後期), 分子生命機能科学セミナー
  8. 2020年, 修士課程・博士課程前期, 1ターム, 生物工学特別演習A
  9. 2020年, 修士課程・博士課程前期, 2ターム, 生物工学特別演習A
  10. 2020年, 修士課程・博士課程前期, 1ターム, 統合生命科学特別講義
  11. 2020年, 博士課程・博士課程後期, セメスター(後期), 生命科学キャリアデザイン開発
  12. 2020年, 修士課程・博士課程前期, 1ターム, 生命科学概論
  13. 2020年, 修士課程・博士課程前期, 集中, 生物工学特別講義C
  14. 2020年, 修士課程・博士課程前期, 年度, 生物工学演習
  15. 2020年, 修士課程・博士課程前期, 年度, 生物工学演習
  16. 2020年, 修士課程・博士課程前期, 3ターム, 生物工学特別演習B
  17. 2020年, 修士課程・博士課程前期, 4ターム, 生物工学特別演習B
  18. 2020年, 修士課程・博士課程前期, 年度, 生物工学特別研究
  19. 2020年, 博士課程・博士課程後期, 集中, 先端生物工学特別講義C
  20. 2020年, 博士課程・博士課程後期, 年度, 統合生命科学特別研究

教育に関する受賞

  • 2017年01月10日, 広島大学大学院先端物質科学研究科教育顕彰, 広島大学大学院先端物質科学研究科

研究活動

学術論文(★は代表的な論文)

  1. Intravenous immunoglobulin (IVIg) acts directly on conventional T cells to suppress T cell receptor signaling, Biochem. Biophys. Res. Commun., 522巻, pp. 792-798, 2020
  2. Influences of maternal factors over offspring
 allergies and the application for food allergy, Front. Immunol., pp. doi: 10.3389/fimmu.2019.01933, 2019
  3. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3, Pharmacol. Rep., 71巻, pp. 289-298, 2019
  4. Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis, World Allergy Organ. J., 11巻, pp. 31, 2018
  5. Rapid multiplex nucleic acid amplification test developed using paper chromatography chip and azobenzene-modified oligonucleotides, J. Biosci. Bioeng., 126巻, pp. 397-403, 2018
  6. Melilotus indicus extract induces apoptosis in hepatocellular carcinoma cells via a mechanism involving mitochondria-mediated pathways, Cytotechnology, 70巻, pp. 831-842, 2018
  7. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, Cytotechnology, 70巻, pp. 921-927, 2018
  8. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, Cytotechnology, 70巻, pp. 913-919, 2018
  9. A novel methoxyflavanone derivative from an Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, Cytotechnology, 70巻, pp. 899-912, 2018
  10. Design, synthesis and cytotoxicity evaluation of new 3,5-disubstituted-2-thioxoimidazolidinones, Anti-Cancer Agents Med. Chem., 18巻, pp. 573-582, 2018
  11. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, J. Biochem., 163巻, pp. 51-60, 2018
  12. A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation, BioFactors, 44巻, pp. 597-608, 2018
  13. Plasma cluster ions reduce the IgE-binding capacity of house dust mite allergens under a simulated indoor environmental condition, Int. Arch. Allergy Immunol., 173巻, pp. 199-203, 2017
  14. Der f 35: an MD-2−like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, Allergy, 72巻, pp. 1728-1736, 2017
  15. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 483巻, 1号, pp. 674-679, 20170129
  16. Der f 34, a novel major house dust mite allergen belonging to a highly conserved Rid/YjgF/YER057c/UK114 family of imine deaminases, JOURNAL OF BIOLOGICAL CHEMISTRY, 20160818
  17. Impact of histone H1 on the progression of allergic rhinitis and its suppression by neutralizing antibody in mice, PLoS ONE, 11巻, pp. e0153630, 20160418
  18. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens, WORLD ALLERGY ORGANIZATION JOURNAL, 9巻, pp. 27, 20160906
  19. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases, JOURNAL OF LIPID RESEARCH, 57巻, 1号, pp. 89-99, 201601
  20. A Novel Anti-Histone H1 Monoclonal Antibody, SSV Monoclonal Antibody, Improves Lung Injury and Survival in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Like Syndrome, Biomed Research International, 2015
  21. Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy, ALLERGOLOGY INTERNATIONAL, 64巻, 4号, pp. 312-320, 201510
  22. Regulation of Polyunsaturated Fatty Acid Biosynthesis by Seaweed Fucoxanthin and Its Metabolite in Cultured Hepatocytes, LIPIDS, 49巻, 2号, pp. 133-141, 201402
  23. Glyceraldehyde-3-phosphate dehydrogenase ( GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice, SCIENTIFIC REPORTS, 4巻, 20140606
  24. Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78巻, 4号, pp. 655-661, 201404
  25. Unexpected T cell regulatory activity of anti-histone H1 autoantibody: Its mode of action in regulatory T cell-dependent and -independent manners, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431巻, 2号, pp. 246-252, 20130208
  26. Competitive advantage and tolerance of selected shochu yeast in barley shochu mash, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 116巻, 1号, pp. 79-84, 201307
  27. Utilization of Waste Syrup for Production of Polyunsaturated Fatty Acids and Xanthophylls by Aurantiochytrium, JOURNAL OF OLEO SCIENCE, 62巻, 9号, pp. 729-736, 201309
  28. Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules, PLOS ONE, 8巻, 11号, 20131108
  29. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109巻, 13号, pp. 4992-4997, 20120327
  30. Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113巻, 4号, pp. 536-541, 201204
  31. Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance, PLOS ONE, 7巻, 5号, 20120515
  32. Sake Less Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, Bioscience, biotechnology, and biochemistry, 75巻, 1号, pp. 140-144, 20110123
  33. Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea., J. Oleo Sci., 60巻, 1号, pp. 11-17, 20110101
  34. Autoimmunity and liver transplantation immunology, Curr. Trends Immunol., 12巻, pp. 41285, 20111101
  35. アレルゲンによる上皮細胞からのTSLP産生誘導, 臨床免疫・アレルギー科, 56巻, 5号, pp. 473-477, 20111101
  36. 微粉砕コンニャクグルコマンナンの抗炎症作用, 生物機能研究, 15巻, pp. 44-47, 20111101
  37. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75巻, 1号, pp. 140-144, 201101
  38. Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea, JOURNAL OF OLEO SCIENCE, 60巻, 1号, pp. 11-17, 201101
  39. Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea, NEW BIOTECHNOLOGY, 28巻, 2号, pp. 158-164, 20110228
  40. Selective Detection of Antigen-Antibody Reaction Using Si Ring Optical Resonators, JAPANESE JOURNAL OF APPLIED PHYSICS, 49巻, 4号, 2010
  41. アレルギーワクチンの創製, 化学と生物, 48巻, 7号, pp. 453-455, 20100701
  42. アレルギーワクチンの創製, 化学と生物, 48巻, 7号, pp. 453-455, 20100701
  43. Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease., World Allergy Organization J., 3巻, 11号, pp. 262-265, 20101101
  44. Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis., Immunology, 129巻, 4号, pp. 547-555, 20100401
  45. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152巻, 3号, pp. 207-218, 20100601
  46. メタボも免疫病?, 生物工学会誌, 88巻, 8号, pp. 412, 20100801
  47. A new lipid transfer protein homologue identified as a cross-reactive allergen from Japanese cedar pollen., Biosci. Biotechnol. Biochem., 74巻, 3号, pp. 504-509, 20100301
  48. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152巻, 3号, pp. 207-218, 20100201
  49. A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74巻, 3号, pp. 504-509, 201003
  50. Molecular Cloning and Immunochemical Characterization of a Novel Major Japanese Cedar Pollen Allergen Belonging to the Aspartic Protease Family, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152巻, 3号, pp. 207-218, 2010
  51. Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis, IMMUNOLOGY, 129巻, 4号, pp. 547-555, 201004
  52. A novel peptide mimotope identified as a potential immunosuppressive vaccine for organ transplantation., J. Immunol., 182巻, pp. 4282-8, 20090401
  53. A Novel Peptide Mimotope Identified As a Potential Immunosuppressive Vaccine for Organ Transplantation, JOURNAL OF IMMUNOLOGY, 182巻, 7号, pp. 4282-4288, 20090401
  54. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding, ARCHIVES OF DERMATOLOGICAL RESEARCH, 300巻, 2号, pp. 95-99, 200802
  55. Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity, BIOMEDICAL CHROMATOGRAPHY, 22巻, 1号, pp. 13-19, 200801
  56. アレルギーワクチンの開発に向けて, バイオインダストリー, 25巻, 9号, pp. 69-77, 20080901
  57. Involvement of autoimmunity against nuclear histone H1 in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 19巻, 2号, pp. 87-92, 200805
  58. 喘息における好酸球の役割, The 14th Symposium of Asthma in Tokyo, 33-36号, 20070401
  59. Nutritional enrichment in larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls., Journal of Bioscience and Bioengineering, 104巻, pp. 200-206, 20070901
  60. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice., Biosci. Biotechnol. Biochem., 71巻, pp. 2551-2556, 20071007
  61. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice., Int. Arch. Allergy Immunol., 144巻, pp. 95-104, 20070524
  62. Experimental and clinical significance of antinuclear antibodies in liver transplantation., Transplantation, 83巻, 1122-1125号, 20070427
  63. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation., Transplant Immunology, 17巻, 147-152号, 20070401
  64. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance., Transplant Immunology, 17巻, 130-136号, 20070201
  65. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 17巻, 2号, pp. 130-136, 200702
  66. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation, TRANSPLANT IMMUNOLOGY, 17巻, 3号, pp. 147-152, 200704
  67. Experimental and clinical significance of antinuclear antibodies in liver transplantation, TRANSPLANTATION, 83巻, 8号, pp. 1122-1125, 20070427
  68. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 144巻, 2号, pp. 95-104, 2007
  69. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71巻, 10号, pp. 2551-2556, 200710
  70. Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 104巻, 3号, pp. 200-206, 200709
  71. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45., International Immunology, 18巻, pp. 101-111, 20060401
  72. 肝移植により誘導される自然免疫寛容の成立機構解明, 上原記念生命科学財団研究報告集, 20巻, pp. 286-288, 20060401
  73. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls by thraustochytrid., Journal of Bioscience and Bioengineering, 102巻, pp. 323-327, 20061001
  74. プロテオーム解析によるスギ花粉・ダニアレルゲンの全容解明, アレルギー・免疫, 13巻, pp. 340-344, 20060301
  75. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions., International Archives of Allergy and Immunology, 141巻, 313-321号, 20060801
  76. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice., Clinical and Experimental Allergy, 36巻, 102-110号, 20060401
  77. Role of antinuclear antibodies in experimental and clinical liver transplantation., Transplantation Proceedings, 38巻, 3605-3606号, 20061201
  78. Histone H1 vaccine therapy for overcoming acute rejection in experimental organ transplantation., Transplantation Proceedings, 38巻, 3247-3248号, 20061201
  79. Anti-histone H1 autoantibody: an inducible immunosuppressive factor in liver transplantation., Animal Cell Technology: Basic & Applied Aspects, 15巻, IN PRESS号, 20060925
  80. Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity., Animal Cell Technology: Basic & Applied Aspects, 15巻, IN PRESS号, 20060925
  81. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice, CLINICAL AND EXPERIMENTAL ALLERGY, 36巻, 1号, pp. 102-110, 200601
  82. TRAF1 regulates T(h)2 differentiation, allergic inflammation and nuclear localization of the T(h)2 transcription factor, NIP45, INTERNATIONAL IMMUNOLOGY, 18巻, 1号, pp. 101-111, 200601
  83. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 141巻, 4号, pp. 313-321, 2006
  84. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 102巻, 4号, pp. 323-327, 200610
  85. COX-2 inhibition enhances the Th2 immune response to epicutaneous sensitization., Journal of Allergy and Clinical Immunology, 116巻, pp. 390-396, 20050401
  86. TRAF1 controls the Th2 differentiation of T cells by limiting NIP45 nuclear translocation, FASEB Journal, 19巻, pp. A1448, 20050401
  87. イオン処理によるダニアレルゲンのアレルゲン性の低減化, アレルギーの臨床, 25巻, pp. 818-822, 20051001
  88. ダニアレルゲン-分子種構成、分子多型、ならびに特異的免疫治療-, アレルギー科, 19巻, pp. 549-556, 20050601
  89. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation., Transplantation Proceedings, 37巻, pp. 80-81, 20050401
  90. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction., Molecular Immunology, 42巻, 1155-1164号, 20050601
  91. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum., Clinical and Experimental Allergy, 35巻, 234-243号, 20050201
  92. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice., International Archives of Allergy and Immunology, 136巻, 258-265号, 20050301
  93. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum, CLINICAL AND EXPERIMENTAL ALLERGY, 35巻, 2号, pp. 234-243, 200502
  94. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: Its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 136巻, 3号, pp. 258-265, 2005
  95. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation, TRANSPLANTATION PROCEEDINGS, 37巻, 1号, pp. 80-81, 200501
  96. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction, MOLECULAR IMMUNOLOGY, 42巻, 10号, pp. 1155-1164, 200506
  97. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens., Int. Arch. Allergy Immunol., 133巻, pp. 125-135, 20040201
  98. ★, The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen., Journal of Clinical Investigation, 114巻, pp. 399-407, 20040801
  99. Liver transplantation-induced anti-histone H1 autoantibodies suppress mixed lymphocyte reaction., Transplant, 77巻, pp. 1595-1603, 20040401
  100. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size., BioFactors, 21巻, 163-166号, 20041230
  101. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 133巻, 2号, pp. 125-135, 2004
  102. Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction, TRANSPLANTATION, 77巻, 10号, pp. 1595-1603, 20040327
  103. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen, JOURNAL OF CLINICAL INVESTIGATION, 114巻, 3号, pp. 399-407, 200408
  104. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size, BIOFACTORS, 21巻, 1-4号, pp. 163-166, 2004
  105. Differential response to low temperature of two D6 fatty acid desaturases from Mucor circinelloides., Appl. Microbiol. Biotechnol., 62巻, pp. 362-368, 20030401
  106. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes., Marine Biotechnol., 5巻, pp. 450-457, 20030401
  107. Thraustochytrid as a potential source of carotenoids., J. Am. Oil Chem. Soc., 80巻, 8号, pp. 789-794, 20030401
  108. Extracellular secretion of free fatty acids by disruption of fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae., J. Biosci. Bioeng., 95巻, 5号, pp. 435-440, 20030401
  109. cDNA cloning and functional expression of α-glucosidase from Mortierella alliacea., Appl. Microbiol. Biotechnol., 62巻, pp. 202-209, 20030401
  110. Evidence of isozymes for Δ6 fatty acid desaturase in rat hepatocytes., Biosci. Biotechnol. Biochem., 67巻, pp. 451-454, 20030401
  111. Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from macrophages stimulated with high-molecular size mite antigen HM1., Allergol. Int., 52巻, pp. 97-103, 20030401
  112. Epicutaneous sensitization with superantigen induces allergic skin inflammation., Journal of Allergy and Clinical Immunology, 112巻, pp. 981-987, 20031101
  113. Extracellular secretion of free fatty acids by disruption of a fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 95巻, 5号, pp. 435-440, 200305
  114. Evidence of isozymes for Delta 6 fatty acid desaturase in rat hepatocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67巻, 2号, pp. 451-454, 200302
  115. Thraustochytrid as a potential source of carotenoids, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 80巻, 8号, pp. 789-794, 200308
  116. cDNA cloning and functional expression of alpha-glucosidase from Mortierella alliacea, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62巻, 2-3号, pp. 202-209, 200308
  117. Differential response to low temperature of two Delta 6 fatty acid desaturases from Mucor circinelloides, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62巻, 4号, pp. 362-368, 200309
  118. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes, MARINE BIOTECHNOLOGY, 5巻, 5号, pp. 450-457, 200309
  119. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids., Biosci. Biotech. Biochem., 66巻, 3号, pp. 613-621, 20020301
  120. Analysis of immunosuppressive factors expressed in serum of liver transplanted rats., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 257-261, 20020401
  121. Identification of differentially expressed genes in atopic dermatitis-prone NC/Nga mouse., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 379-383, 20020401
  122. Gamma-linolenic acid suppresses IgE production in vitro as well as in vivo., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 461-465, 20020401
  123. Purification and characterization of a novel fungal α-glucosidase from Mortierella alliacea with high starch-hydrolytic activity., Biosci. Biotechnol. Biochem., 66巻, 11号, pp. 2415-2423, 20021101
  124. A high-molecular-size mite antigen (HM1) fraction aggravated airway hyperresponsiveness of allergic mice in house dusts and whole mite cultures., Int. Arch. Allergy Immunol., 129巻, pp. 204-211, 20020401
  125. Toward elucidating the full spectrum of mite allergen ---state of the art., J. Biosci. Bioeng., 94巻, pp. 285-298, 20020401
  126. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family., Clin. Exp. Allergy, 32巻, pp. 1064-1070, 20020401
  127. Enzyme preparation of glycerides rich in docosahexaenoic acid from Thraustochytrid single cell oils by Candida rugosa Lipase., J. Oleo Sci., 51巻, pp. 447-455, 20020401
  128. Der f 16: a novel gelsolin related molecule identified as an allergen from the house dust mite, Dermatophgoides farinae., FEBS Lett, 516巻, pp. 234-238, 20020401
  129. Induction of a proliferativere sponse of T cells by a high molecular antigen in Dermatophgoides farinae feces., Int. Arch. Allergy Immunol., 127巻, pp. 276-284, 20020401
  130. 1. High molecular-size mite antigen (HM1) fraction aggravated airway hyperresponsiveness of allergic mice in house dusts and whole mite cultures., Int. Archives Allergy Immunol, 129巻, 20020601
  131. Inducing proliferative response of T cell on high-molecular-size antigen in Dermatophagoides farinae feces., Int. Archives Allergy Immunol, 127巻, pp. 127、276-284, 20020501
  132. Enzymatic preparation of glycerides rich in dochosahexaenoic acid from Thraustochytrid singlr cell oills by Candida rugosa lipase., J. Oleo Sci., pp. 51,447-455, 20020401
  133. 4. Der f 16: a novel gelsplin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae., FEBS Let. (2002) ., pp. 516, 234-238, 20020401
  134. 多価不飽和脂肪酸を用いたアトピー予防効果を有する機能性食品の創製, ネスレ科学振興会年報, 9巻, 20020401
  135. スギ花粉,ダニ抗原の分子種構成と分子多型, アレルギー科, 14巻, pp. 275-284, 20020401
  136. Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae, FEBS LETTERS, 516巻, 1-3号, pp. 234-238, 20020410
  137. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66巻, 3号, pp. 613-621, 200203
  138. Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 127巻, 4号, pp. 276-284, 200204
  139. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family, CLINICAL AND EXPERIMENTAL ALLERGY, 32巻, 7号, pp. 1064-1070, 200207
  140. Purification and characterization of a novel fungal alpha-glucosidase from Mortierella alliacea with high starch-hydrolytic activity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66巻, 11号, pp. 2415-2423, 200211
  141. A high-molecular-weight mite antigen (HM1) fraction aggravates airway hyperresponsiveness of allergic mice to house dusts and whole mite cultures, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 129巻, 3号, pp. 204-211, 200211
  142. Toward elucidating the full spectrum of mite allergens - State of the art, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 94巻, 4号, pp. 285-298, 200210
  143. Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15., J. Am. Oil Chem. Soc., 78巻, 6号, pp. 599-604, 20010601
  144. Profile of polyunsaturated fatty acids produced by Thraustochytrium sp. KK17-3., J. Am. Oil Chem. Soc., 78巻, 6号, pp. 605-610, 20010601
  145. Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, Biosci. Biotech. Biochem., 65巻, 2号, pp. 431-434, 20010201
  146. Proteome analysis in liver transplantation., Transplant Proc, 33巻, 1-2号, pp. 156, 20010201
  147. Immunosuppressive autoreactive antibodies induced by liver transplantation., Scandinavian Journal of Immunology, 54巻, S1号, pp. 109, 20010401
  148. Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 65巻, 2号, pp. 431-434, 200102
  149. Proteome analysis in liver transplantation, TRANSPLANTATION PROCEEDINGS, 33巻, 1-2号, pp. 156-156, 200102
  150. Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78巻, 6号, pp. 599-604, 200106
  151. Profile of polyunsaturated fatty acids produced by Thraustochytrium sp KK17-3, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78巻, 6号, pp. 605-610, 200106
  152. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae., Immunol. Lett., 72巻, 1号, pp. 53-60, 20000401
  153. Newly described house dust mite allergens., Allergy Clin. Immunol. Int., (Suppl.) 1巻, pp. 74-76, 20001001
  154. Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma., Cytotechnology, 33巻, pp. 253-257, 20000401
  155. Properties of ras-amplified recombinant BHK-21 cells in protein-free culture., Cytotechnology, 33巻, pp. 21-26, 20000401
  156. Purification and characterization of sea squirt alpha-N-acetylgalactosaminidase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89巻, 1号, pp. 84-86, 200001
  157. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae, IMMUNOLOGY LETTERS, 72巻, 1号, pp. 53-60, 20000403
  158. Properties of ras-amplified recombinant BHK-21 cells in protein-free culture, CYTOTECHNOLOGY, 33巻, 1-3号, pp. 21-26, 200007
  159. Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 33巻, 1-3号, pp. 253-257, 200007
  160. Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae., Biochim= Biophys. Acta, 1454巻, pp. 201-7, 19990401
  161. Molecular cloning and functional characterization of rat Delta-6 fatty acid desaturase., Biochem. Biophys. Res. Commun., 255巻, 3号, pp. 575-579, 19990201
  162. Purification and characterization of M-177, a 177 kD allergen, from the house dust mite, Dermatophagoides farinae., Allergol. Int., 48巻, pp. 43-51, 19990101
  163. Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies., Cytotechnology, 31巻, pp. 77-883, 19990401
  164. Protein-free culture of ras-amplified recombinant BHK-21 cells., Animal Cell Technology: Challenges for the 21 st Century, pp. 133-137, 19990401
  165. A newly identified allergen p29, the C-terminal fragment of Cry j 1, induces potently conjunctival congestion of patients with cedar pollenosis., The 9th Tohwa University International Symposium, pp. 271-274, 19990401
  166. Altered antigenicity of M-177, a 177-KDa allergen from the house dust mite, Dermatophagoides farinae, in stored extract., Clin. Exp. Allergy, 28巻, pp. 1549-58, 19980401
  167. Altered expression of the Cip/Kip family CDK inhibitors in tumor phenotype-suppressed human lung cancer cells., Animal Cell Technology: Basic & Applied Aspects, 10巻, pp. 347-351, 19981201
  168. Lipid composition of a newly isolated polyunsaturated fatty acid-producing fungus, Achlya sp. ma-2801., J. Ferment. Bioeng., 86巻, 5号, pp. 504-507, 19981101
  169. Vitamin A acetate for efficient production of monoclonal antibody by human-human hybridomas., Animal Cell Technology: Basic & Applied Aspects, 10巻, pp. 317-321, 19980401
  170. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma., 生化的生物物理学的研究報告集, 237巻, pp. 313-317, 19970801
  171. Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4., Human Antibodies, 8巻, pp. 195-202, 19970401
  172. Suppression of tumor phenotypes and increased cell death susceptibility in class II major histocompatibility complex antigen-inducible human lung carcinoma cells., Animal Cell Technology: Basic & Applied Aspects, 8巻, pp. 615-619, 19970401
  173. Identification and characterization of antigens recognized by the cancer-associated human monoclonal antibody AE6F4., Animal Cell Technology: Basic & Applied Aspects, 8巻, pp. 465-470, 19970401
  174. Mass production of recombinant human monoclonal antibody using hyper producing BHK-21 cells in protein-free medium., Animal Cell Technology: Basic & Applied Aspects, 8巻, pp. 179-183, 19970401
  175. Lung cancer-reacting human recombinant antibody AE6F4: potential usefulness in the sputum cytodiagnosis., Human Antibodies and Hybridomas, 7巻, pp. 27-36, 19960401
  176. Production of recombinant human monoclonal antibody using ras-amplified BHK-21 cells in a protein-free medium., Bioscience= Biotechnology and Biochemistry, 60巻, pp. 811-817, 19960501
  177. Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system., Journal of Fermentation and Bioengineering, 81巻, pp. 466-469, 19960401
  178. Epitope in cytochrome c from Candida krusei cross-reacts lung cancer-specific human monoclonal antibody HB4C5., In Vitro Cellular and Developmental Biology, 31巻, pp. 424-426, 19950601
  179. Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an antigen recognized by the lung cancer-specific human monoclonal antibody, AE6F4., Cytotechnology, 17巻, pp. 103-108, 19950401
  180. ★, Molecular cloning of yeast cytochrome c-like polypeptide expressed in human lung carcinoma: an antigen recognizable by lung cancer-specific human monoclonal antibody., In Vitro Cellular and Developmental Biology, 31巻, pp. 724-729, 19951001
  181. ★, Impaired tumor phenotypes in class II major histocompatibility complex antigen-inducible cells originated from human lung adenocarcinoma., 生化的生物物理学的研究報告集, 215巻, pp. 280-285, 19951001
  182. The 31 kDa cytosolic phospholipase A2 is a target molecule for the lung cancer-specific human monoclonal antibody AE6F4., Animal Cell Technology: Developments Towards the 21 st Century, pp. 1011-1015, 19950401
  183. Specific reactivity of human monoclonal antibody AE6F4 against cancer cells in tissues and sputa from lung cancer patients., Human Antibodies and Hybridomas, 5巻, pp. 116-122, 19940401
  184. The 14-3-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4., Human Antibodies and Hybridomas, 5巻, pp. 123-130, 19940401
  185. A retrovirus-associated antigen expressed in human lung carcinoma., Animal Cell Technology: Basic & Applied Aspects, 6巻, pp. 601-605, 19940401
  186. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, Biochemical and Biophisical Research Communications, 483巻, 1号, pp. 674-679, 2017
  187. The significance of a nuclear protein as a moonlight protein: diagnostic and therapeutic potentials in liver transplantation, International Journal of Surgery & Surgical Procedures, 2巻, pp. 117, 2017
  188. Plasma cluster ions reduce the IgE-binding capacity of house dust mite allergens under a simulated indoor environmental condition, International Archives of Allergy and Immunology, 173巻, pp. 199-203
  189. A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation, BioFactors, 44巻, pp. 597-608, 2018
  190. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, Journal of Biochemistry, 163巻, pp. 51-60, 2018
  191. A novel methoxyflavanone derivative from an Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, Cytotechnology, 70巻, pp. 899-912, 2018
  192. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, Cytotechnology, 70巻, pp. 913-919, 2018
  193. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, Cytotechnology, 70巻, pp. 921-927, 2018
  194. Rapid multiplex nucleic acid amplification test developed using paper chromatography chip and azobenzene-modified oligonucleotides, Journal of Bioscience and Bioengineering, 126巻, pp. 397-403, 2018
  195. Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis, World Allergy Organization Journal, 11巻, pp. 31, 2018
  196. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3, Pharmacological Reports, 71巻, pp. 289-298, 2019

著書等出版物

  1. 2020年, アレルギー, 最新のアレルゲン解析, 2020年
  2. 1995年07月, 生物生産と生体防御 , コロナ社, 1995年, 07, 教科書, 共編著

招待講演、口頭・ポスター発表等

  1. 喘息における好酸球の役割, 河本 正次, The 14th Symposium of Asthma in Tokyo, 2006年12月, 招待, 日本語
  2. アトピーの発症機構を探る-動物病態モデルからのレッスン, 河本 正次, 日本農芸化学会創立80周年記念中四国支部若手研究者交流会, 2004年11月, 招待, 日本語
  3. 2014年12月, 通常
  4. 自己成分認識を基軸とした抗炎症作用機構と疾患制御, 河本正次, HiHA第3回Workshop, 2014年12月, 招待, 東広島市
  5. 食による病気の予防を目指してー「おいしい広島」からの発信ー, 河本正次、小埜和久, フードテクノひろしま平成26年度第4回研究会, 2015年02月, 招待, 広島市

受賞

  1. 2016年09月30日, 平成28年度「科研費」審査委員表彰, 独立行政法人日本学術振興会理事長

外部資金

競争的資金等の採択状況

  1. 日本学術振興会 頭脳循環を加速する若手研究者戦略的海外派遣プログラム, 健康長寿科学を推進する若手研究者国際共同研究, 2012年, 2014年
  2. 科学研究費助成事業(基盤研究(B)), テーラーメイドワクチン創製のための次世代型感作アレルゲン分子診断法の開発, 2013年, 2015年
  3. 科学研究費助成事業(基盤研究(B)), 腸管における炎症に深く関わる免疫細胞の機能解析と腸管保護食品創製への展開, 2013年, 2015年
  4. 科学研究費助成事業(挑戦的萌芽研究), ごはんは免疫を強くするか?-αグルカンによる生体防御システム活性化の分子基盤, 2013年, 2014年
  5. 科学研究費助成事業(基盤研究(B)), 新たに発見した「制御性抗体」による過剰免疫応答調節の分子機構と難病制御, 2012年, 2014年
  6. 科学研究費助成事業(挑戦的萌芽研究), 感作ダニアレルゲン特異的IgEミモトープ抗体誘導体の開発, 2012年, 2013年
  7. 科学研究費助成事業(挑戦的萌芽研究), 永続投与のいらない「夢の 21 世紀型免疫抑制剤」創製への挑戦, 2011年, 2012年
  8. 科学研究費助成事業(基盤研究(B)), テーラーメイド型ワクチン創製のための感作ダニアレルゲンの分子特性解析, 2010年, 2012年
  9. 科学研究費助成事業(基盤研究(C)), 微粉砕食物繊維による新規な抗アレルギー作用機構の解明と応用, 2008年, 2010年
  10. 科学研究費助成事業(若手研究(B)), 局所樹状細胞によるアトピー性皮膚炎病熊制御の分子機構, 2006年, 2007年
  11. 科学研究費助成事業(基盤研究(C)), スギ花粉アレルゲン分子種の網羅的アレルゲノーム解析, 2005年, 2006年
  12. 科学研究費助成事業(基盤研究(B)), ダニアレルギー経口ワクチンの創製, 2002年, 2004年
  13. 科学研究費助成事業(奨励研究(A)), アトピーマウスにおけるアレルギー病態制御の分子機構, 2000年, 2001年
  14. 科学研究費助成事業(奨励研究(A)), アトピー性皮膚炎モデルマウスを用いたアレルギー発症の分子機構に関する解析, 1998年, 1999年
  15. 科学研究費助成事業(基盤研究(B)), n-3系ドコサペンタエン酸の微生物生産とその利用技術の開発, 1998年, 2000年
  16. シーズ発掘試験, 2007年
  17. シーズ発掘試験, 2006年
  18. 長期自主研究, 2005年
  19. 研究奨励金, 2004年
  20. 研究助成, 2001年
  21. 科学技術研究助成, 2000年
  22. 研究助成, 2000年

社会活動

委員会等委員歴

  1. 非常勤講師, 2014年04月, 2014年09月, 愛媛大学農学部
  2. 日本生物学オリンピック本選作題委員会委員, 2019年11月, 2020年08月, 国際生物学オリンピック日本委員会

学術会議等の主催

  1. HiHA 6th International Symposium, 2019年03月
  2. HiHA 5th International Symposium, 2018年03月
  3. HiHA 4th International Symposium, 2017年03月, 2017年03月
  4. HiHA 3rd International Symposium, 2016年03月, 2016年03月
  5. HiHA 2nd International Symposium, 2015年03月, 2015年03月

その他社会貢献活動(広大・部局主催含)

  1. 広島大学公開講座 バイオテクノロジーってなぁに, 2014年/08月, 呉市

学術雑誌論文査読歴

  1. 2020年, Cytotechnology, その他, 査読委員, 2