Seiji Kawamoto

Last Updated :2023/06/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
http://hiha.hiroshima-u.ac.jp/en/
E-mail
skawahiroshima-u.ac.jp
Other Contact Details
1-3-1 KAGAMIYAMA, HIGASHI-HIROSHIMA 739-8530, JAPAN, Japan
TEL : (+81)82-424-7753 FAX : (+81)82-424-7867
Self-introduction
Research Topics Healthcare Biotechnology

Basic Information

Major Professional Backgrounds

  • 2002/07/01, 2004/06/30, Boston Children's Hospital/Harvard Medical School, Research Fellow
  • 1997/04/01, Hiroshima University, Faculty of Engineering, Assistant Professor
  • 1996/04/01, 1997/03/31, Japan Society for the Promotion of Science, Special Postdoctoral Researcher
  • 1996/01/01, 1996/03/31, Japan Society for the Promotion of Science, Special Postdoctoral Researcher
  • 1999/04/01, Hiroshima University, Graduate School of Advanced Sciences of Matter, Assistant Professor
  • 2008/06/01, Hiroshima University, Graduate School of Advanced Sciences of Matter, Associate Professor
  • 2014/09/01, Hiroshima University, Graduate School of Advanced Sciences of Matter, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor
  • 2015/04/01, Hiroshima Research Center for Healthy Aging (HiHA), Director

Educational Backgrounds

  • Kyushu University, Faculty of Agriculture, Department of Food Science and Technology, Japan, 1987/04, 1991/03
  • Kyushu University, Graduate School of Genetic Resources Technology, Japan, 1991/04, 1996/03

Academic Degrees

  • Ph.D., Kyushu University
  • Master of Agriculture, Kyushu University

In Charge of Primary Major Programs

  • Biotechnology

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology
  • Agricultural sciences;Boundary agriculture;Applied molecular and cellular biology
  • Agricultural sciences;Agricultural chemistry;Applied biochemistry
  • Agricultural sciences;Agricultural chemistry;Food science
  • Complex systems;Human life science;Eating habits

Research Keywords

  • Immune regulation of age-related disorders
  • Development of molecular diagnostics and immunotherapeutic strategies for allergic disorders
  • Prevention of proinflammatory disorders by food factors

Affiliated Academic Societies

  • Japanese Society for Immunology
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Society for Biotechnology, Japan
  • Japanese Association for Animal Cell Technology
  • Japanese Association for Food Immunology
  • Society for Cancer, Inflammation, and Antioxidant

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2023, Undergraduate Education, 2Term, Introduction to Fundamental Industry
  3. 2023, Undergraduate Education, 3Term, Biochemistry II
  4. 2023, Undergraduate Education, 4Term, Glycotechnology & Immunotechnology
  5. 2023, Graduate Education (Doctoral Program) , Second Semester, Career Development for Life Science
  6. 2023, Graduate Education (Master's Program) , 4Term, Cell Function Science B
  7. 2023, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  8. 2023, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  9. 2023, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  10. 2023, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  11. 2023, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  12. 2023, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  13. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  14. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Award of Education

  1. 2017/01/10, AdSM Education Award, Hiroshima Univ., Grad. Sch. AdSM, Hiroshima Univ.

Research Activities

Academic Papers

  1. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding, ARCHIVES OF DERMATOLOGICAL RESEARCH, 300(2), 95-99, 200802
    Link to Paper Search Results by DOI
  2. Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity, BIOMEDICAL CHROMATOGRAPHY, 22(1), 13-19, 200801
    Link to Paper Search Results by DOI
  3. Selective Detection of Antigen-Antibody Reaction Using Si Ring Optical Resonators, JAPANESE JOURNAL OF APPLIED PHYSICS, 49(4), 2010
    Link to Paper Search Results by DOI
  4. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(13), 4992-4997, 20120327
    Link to Paper Search Results by DOI
  5. Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113(4), 536-541, 201204
    Link to Paper Search Results by DOI
  6. Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance, PLOS ONE, 7(5), 20120515
    Link to Paper Search Results by DOI
  7. Unexpected T cell regulatory activity of anti-histone H1 autoantibody: Its mode of action in regulatory T cell-dependent and -independent manners, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431(2), 246-252, 20130208
    Link to Paper Search Results by DOI
  8. Altered antigenicity of M-177, a 177-KDa allergen from the house dust mite, Dermatophagoides farinae, in stored extract., Clin. Exp. Allergy, 28, 1549-58, 19980401
  9. Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae., Biochim= Biophys. Acta, 1454, 201-7, 19990401
  10. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids., Biosci. Biotech. Biochem., 66(3), 613-621, 20020301
  11. Analysis of immunosuppressive factors expressed in serum of liver transplanted rats., 12, 257-261, 20020401
  12. Identification of differentially expressed genes in atopic dermatitis-prone NC/Nga mouse., 12, 379-383, 20020401
  13. Gamma-linolenic acid suppresses IgE production in vitro as well as in vivo., 12, 461-465, 20020401
  14. Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15., J. Am. Oil Chem. Soc., 78(6), 599-604, 20010601
  15. Profile of polyunsaturated fatty acids produced by Thraustochytrium sp. KK17-3., J. Am. Oil Chem. Soc., 78(6), 605-610, 20010601
  16. Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, Biosci. Biotech. Biochem., 65(2), 431-434, 20010201
  17. Proteome analysis in liver transplantation., Transplant Proc, 33(1-2), 156, 20010201
  18. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae., Immunol. Lett., 72(1), 53-60, 20000401
  19. Newly described house dust mite allergens., Allergy Clin. Immunol. Int., (Suppl.) 1, 74-76, 20001001
  20. Altered expression of the Cip/Kip family CDK inhibitors in tumor phenotype-suppressed human lung cancer cells., 10, 347-351, 19981201
  21. Molecular cloning and functional characterization of rat Delta-6 fatty acid desaturase., Biochem. Biophys. Res. Commun., 255(3), 575-579, 19990201
  22. Purification and characterization of M-177, a 177 kD allergen, from the house dust mite, Dermatophagoides farinae., Allergol. Int., 48, 43-51, 19990101
  23. Lipid composition of a newly isolated polyunsaturated fatty acid-producing fungus, Achlya sp. ma-2801., J. Ferment. Bioeng., 86(5), 504-507, 19981101
  24. Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma., Cytotechnology, 33, 253-257, 20000401
  25. Properties of ras-amplified recombinant BHK-21 cells in protein-free culture., Cytotechnology, 33, 21-26, 20000401
  26. Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies., Cytotechnology, 31, 77-883, 19990401
  27. Protein-free culture of ras-amplified recombinant BHK-21 cells., Animal Cell Technology: Challenges for the 21 st Century, 133-137, 19990401
  28. Vitamin A acetate for efficient production of monoclonal antibody by human-human hybridomas., 10, 317-321, 19980401
  29. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma., Biochemical and Biophysical Research Communications, 237, 313-317, 19970801
  30. Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4., Human Antibodies, 8, 195-202, 19970401
  31. Suppression of tumor phenotypes and increased cell death susceptibility in class II major histocompatibility complex antigen-inducible human lung carcinoma cells., 8, 615-619, 19970401
  32. Identification and characterization of antigens recognized by the cancer-associated human monoclonal antibody AE6F4., 8, 465-470, 19970401
  33. Mass production of recombinant human monoclonal antibody using hyper producing BHK-21 cells in protein-free medium., 8, 179-183, 19970401
  34. Lung cancer-reacting human recombinant antibody AE6F4: potential usefulness in the sputum cytodiagnosis., Human Antibodies and Hybridomas, 7, 27-36, 19960401
  35. Production of recombinant human monoclonal antibody using ras-amplified BHK-21 cells in a protein-free medium., Bioscience= Biotechnology and Biochemistry, 60, 811-817, 19960501
  36. Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system., Journal of Fermentation and Bioengineering, 81, 466-469, 19960401
  37. Epitope in cytochrome c from Candida krusei cross-reacts lung cancer-specific human monoclonal antibody HB4C5., In Vitro Cellular and Developmental Biology, 31, 424-426, 19950601
  38. Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an antigen recognized by the lung cancer-specific human monoclonal antibody, AE6F4., Cytotechnology, 17, 103-108, 19950401
  39. ★, Molecular cloning of yeast cytochrome c-like polypeptide expressed in human lung carcinoma: an antigen recognizable by lung cancer-specific human monoclonal antibody., In Vitro Cellular and Developmental Biology, 31, 724-729, 19951001
  40. ★, Impaired tumor phenotypes in class II major histocompatibility complex antigen-inducible cells originated from human lung adenocarcinoma., Biochemical and Biophysical Research Communications, 215, 280-285, 19951001
  41. The 31 kDa cytosolic phospholipase A2 is a target molecule for the lung cancer-specific human monoclonal antibody AE6F4., Animal Cell Technology: Developments Towards the 21 st Century, 1011-1015, 19950401
  42. Specific reactivity of human monoclonal antibody AE6F4 against cancer cells in tissues and sputa from lung cancer patients., Human Antibodies and Hybridomas, 5, 116-122, 19940401
  43. The 14-3-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4., Human Antibodies and Hybridomas, 5, 123-130, 19940401
  44. A retrovirus-associated antigen expressed in human lung carcinoma., 6, 601-605, 19940401
  45. Differential response to low temperature of two D6 fatty acid desaturases from Mucor circinelloides., Appl. Microbiol. Biotechnol., 62, 362-368, 20030401
  46. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes., Marine Biotechnol., 5, 450-457, 20030401
  47. Thraustochytrid as a potential source of carotenoids., J. Am. Oil Chem. Soc., 80(8), 789-794, 20030401
  48. Extracellular secretion of free fatty acids by disruption of fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae., J. Biosci. Bioeng., 95(5), 435-440, 20030401
  49. A high-molecular-size mite antigen (HM1) fraction aggravated airway hyperresponsiveness of allergic mice in house dusts and whole mite cultures., Int. Arch. Allergy Immunol., 129, 204-211, 20020401
  50. Toward elucidating the full spectrum of mite allergen ---state of the art., J. Biosci. Bioeng., 94, 285-298, 20020401
  51. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family., Clin. Exp. Allergy, 32, 1064-1070, 20020401
  52. Enzyme preparation of glycerides rich in docosahexaenoic acid from Thraustochytrid single cell oils by Candida rugosa Lipase., J. Oleo Sci., 51, 447-455, 20020401
  53. Der f 16: a novel gelsolin related molecule identified as an allergen from the house dust mite, Dermatophgoides farinae., FEBS Lett, 516, 234-238, 20020401
  54. Induction of a proliferativere sponse of T cells by a high molecular antigen in Dermatophgoides farinae feces., Int. Arch. Allergy Immunol., 127, 276-284, 20020401
  55. 1. High molecular-size mite antigen (HM1) fraction aggravated airway hyperresponsiveness of allergic mice in house dusts and whole mite cultures., Int. Archives Allergy Immunol, 129, 20020601
  56. Inducing proliferative response of T cell on high-molecular-size antigen in Dermatophagoides farinae feces., Int. Archives Allergy Immunol, 127, 127、276-284, 20020501
  57. Enzymatic preparation of glycerides rich in dochosahexaenoic acid from Thraustochytrid singlr cell oills by Candida rugosa lipase., J. Oleo Sci., 51,447-455, 20020401
  58. 4. Der f 16: a novel gelsplin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae., FEBS Let. (2002) ., 516, 234-238, 20020401
  59. Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from macrophages stimulated with high-molecular size mite antigen HM1., Allergol. Int., 52, 97-103, 20030401
  60. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens., Int. Arch. Allergy Immunol., 133, 125-135, 20040201
  61. ★, The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen., Journal of Clinical Investigation, 114, 399-407, 20040801
  62. Epicutaneous sensitization with superantigen induces allergic skin inflammation., Journal of Allergy and Clinical Immunology, 112, 981-987, 20031101
  63. COX-2 inhibition enhances the Th2 immune response to epicutaneous sensitization., Journal of Allergy and Clinical Immunology, 116, 390-396, 20050401
  64. TRAF1 controls the Th2 differentiation of T cells by limiting NIP45 nuclear translocation, FASEB Journal, 19, A1448, 20050401
  65. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45., International Immunology, 18, 101-111, 20060401
  66. Nutritional enrichment in larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls., Journal of Bioscience and Bioengineering, 104, 200-206, 20070901
  67. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls by thraustochytrid., Journal of Bioscience and Bioengineering, 102, 323-327, 20061001
  68. A newly identified allergen p29, the C-terminal fragment of Cry j 1, induces potently conjunctival congestion of patients with cedar pollenosis., The 9th Tohwa University International Symposium, 271-274, 19990401
  69. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation., Transplantation Proceedings, 37, 80-81, 20050401
  70. Immunosuppressive autoreactive antibodies induced by liver transplantation., Scandinavian Journal of Immunology, 54(S1), 109, 20010401
  71. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice., Biosci. Biotechnol. Biochem., 71, 2551-2556, 20071007
  72. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice., Int. Arch. Allergy Immunol., 144, 95-104, 20070524
  73. Experimental and clinical significance of antinuclear antibodies in liver transplantation., Transplantation, 83(1122-1125), 20070427
  74. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation., Transplant Immunology, 17(147-152), 20070401
  75. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance., Transplant Immunology, 17(130-136), 20070201
  76. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions., International Archives of Allergy and Immunology, 141(313-321), 20060801
  77. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice., Clinical and Experimental Allergy, 36(102-110), 20060401
  78. Role of antinuclear antibodies in experimental and clinical liver transplantation., Transplantation Proceedings, 38(3605-3606), 20061201
  79. Histone H1 vaccine therapy for overcoming acute rejection in experimental organ transplantation., Transplantation Proceedings, 38(3247-3248), 20061201
  80. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction., Molecular Immunology, 42(1155-1164), 20050601
  81. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum., Clinical and Experimental Allergy, 35(234-243), 20050201
  82. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice., International Archives of Allergy and Immunology, 136(258-265), 20050301
  83. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size., BioFactors, 21(163-166), 20041230
  84. Anti-histone H1 autoantibody: an inducible immunosuppressive factor in liver transplantation., Animal Cell Technology: Basic & Applied Aspects, 15(IN PRESS), 20060925
  85. Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity., Animal Cell Technology: Basic & Applied Aspects, 15(IN PRESS), 20060925
  86. Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea., J. Oleo Sci., 60(1), 11-17, 20110101
  87. Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease., World Allergy Organization J., 3(11), 262-265, 20101101
  88. Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis., Immunology, 129(4), 547-555, 20100401
  89. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152(3), 207-218, 20100601
  90. A new lipid transfer protein homologue identified as a cross-reactive allergen from Japanese cedar pollen., Biosci. Biotechnol. Biochem., 74(3), 504-509, 20100301
  91. A novel peptide mimotope identified as a potential immunosuppressive vaccine for organ transplantation., J. Immunol., 182, 4282-8, 20090401
  92. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152(3), 207-218, 20100201
  93. Autoimmunity and liver transplantation immunology, Curr. Trends Immunol., 12, 41285, 20111101
  94. Purification and characterization of sea squirt alpha-N-acetylgalactosaminidase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89(1), 84-86, 200001
    Link to Paper Search Results by DOI
  95. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae, IMMUNOLOGY LETTERS, 72(1), 53-60, 20000403
    Link to Paper Search Results by DOI
  96. Properties of ras-amplified recombinant BHK-21 cells in protein-free culture, CYTOTECHNOLOGY, 33(1-3), 21-26, 200007
    Link to Paper Search Results by DOI
  97. Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 33(1-3), 253-257, 200007
    Link to Paper Search Results by DOI
  98. Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 65(2), 431-434, 200102
    Link to Paper Search Results by DOI
  99. Proteome analysis in liver transplantation, TRANSPLANTATION PROCEEDINGS, 33(1-2), 156-156, 200102
    Link to Paper Search Results by DOI
  100. Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78(6), 599-604, 200106
    Link to Paper Search Results by DOI
  101. Profile of polyunsaturated fatty acids produced by Thraustochytrium sp KK17-3, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78(6), 605-610, 200106
    Link to Paper Search Results by DOI
  102. Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae, FEBS LETTERS, 516(1-3), 234-238, 20020410
    Link to Paper Search Results by DOI
  103. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(3), 613-621, 200203
    Link to Paper Search Results by DOI
  104. Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 127(4), 276-284, 200204
    Link to Paper Search Results by DOI
  105. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family, CLINICAL AND EXPERIMENTAL ALLERGY, 32(7), 1064-1070, 200207
    Link to Paper Search Results by DOI
  106. Purification and characterization of a novel fungal alpha-glucosidase from Mortierella alliacea with high starch-hydrolytic activity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(11), 2415-2423, 200211
    Link to Paper Search Results by DOI
  107. Extracellular secretion of free fatty acids by disruption of a fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 95(5), 435-440, 200305
    Link to Paper Search Results by DOI
  108. A high-molecular-weight mite antigen (HM1) fraction aggravates airway hyperresponsiveness of allergic mice to house dusts and whole mite cultures, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 129(3), 204-211, 200211
    Link to Paper Search Results by DOI
  109. Toward elucidating the full spectrum of mite allergens - State of the art, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 94(4), 285-298, 200210
    Link to Paper Search Results by DOI
  110. Evidence of isozymes for Delta 6 fatty acid desaturase in rat hepatocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67(2), 451-454, 200302
    Link to Paper Search Results by DOI
  111. Thraustochytrid as a potential source of carotenoids, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 80(8), 789-794, 200308
    Link to Paper Search Results by DOI
  112. cDNA cloning and functional expression of alpha-glucosidase from Mortierella alliacea, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62(2-3), 202-209, 200308
    Link to Paper Search Results by DOI
  113. Differential response to low temperature of two Delta 6 fatty acid desaturases from Mucor circinelloides, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62(4), 362-368, 200309
    Link to Paper Search Results by DOI
  114. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes, MARINE BIOTECHNOLOGY, 5(5), 450-457, 200309
    Link to Paper Search Results by DOI
  115. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 133(2), 125-135, 2004
    Link to Paper Search Results by DOI
  116. Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction, TRANSPLANTATION, 77(10), 1595-1603, 20040327
    Link to Paper Search Results by DOI
  117. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen, JOURNAL OF CLINICAL INVESTIGATION, 114(3), 399-407, 200408
    Link to Paper Search Results by DOI
  118. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum, CLINICAL AND EXPERIMENTAL ALLERGY, 35(2), 234-243, 200502
    Link to Paper Search Results by DOI
  119. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size, BIOFACTORS, 21(1-4), 163-166, 2004
    Link to Paper Search Results by DOI
  120. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: Its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 136(3), 258-265, 2005
    Link to Paper Search Results by DOI
  121. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation, TRANSPLANTATION PROCEEDINGS, 37(1), 80-81, 200501
    Link to Paper Search Results by DOI
  122. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction, MOLECULAR IMMUNOLOGY, 42(10), 1155-1164, 200506
    Link to Paper Search Results by DOI
  123. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice, CLINICAL AND EXPERIMENTAL ALLERGY, 36(1), 102-110, 200601
    Link to Paper Search Results by DOI
  124. TRAF1 regulates T(h)2 differentiation, allergic inflammation and nuclear localization of the T(h)2 transcription factor, NIP45, INTERNATIONAL IMMUNOLOGY, 18(1), 101-111, 200601
    Link to Paper Search Results by DOI
  125. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 141(4), 313-321, 2006
    Link to Paper Search Results by DOI
  126. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 102(4), 323-327, 200610
    Link to Paper Search Results by DOI
  127. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 17(2), 130-136, 200702
    Link to Paper Search Results by DOI
  128. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation, TRANSPLANT IMMUNOLOGY, 17(3), 147-152, 200704
    Link to Paper Search Results by DOI
  129. Experimental and clinical significance of antinuclear antibodies in liver transplantation, TRANSPLANTATION, 83(8), 1122-1125, 20070427
    Link to Paper Search Results by DOI
  130. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 144(2), 95-104, 2007
    Link to Paper Search Results by DOI
  131. Involvement of autoimmunity against nuclear histone H1 in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 19(2), 87-92, 200805
    Link to Paper Search Results by DOI
  132. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(10), 2551-2556, 200710
    Link to Paper Search Results by DOI
  133. Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 104(3), 200-206, 200709
    Link to Paper Search Results by DOI
  134. A Novel Peptide Mimotope Identified As a Potential Immunosuppressive Vaccine for Organ Transplantation, JOURNAL OF IMMUNOLOGY, 182(7), 4282-4288, 20090401
    Link to Paper Search Results by DOI
  135. A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(3), 504-509, 201003
    Link to Paper Search Results by DOI
  136. Molecular Cloning and Immunochemical Characterization of a Novel Major Japanese Cedar Pollen Allergen Belonging to the Aspartic Protease Family, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152(3), 207-218, 2010
    Link to Paper Search Results by DOI
  137. Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis, IMMUNOLOGY, 129(4), 547-555, 201004
    Link to Paper Search Results by DOI
  138. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75(1), 140-144, 201101
    Link to Paper Search Results by DOI
  139. Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea, JOURNAL OF OLEO SCIENCE, 60(1), 11-17, 201101
    Link to Paper Search Results by DOI
  140. Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea, NEW BIOTECHNOLOGY, 28(2), 158-164, 20110228
    Link to Paper Search Results by DOI
  141. Competitive advantage and tolerance of selected shochu yeast in barley shochu mash, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 116(1), 79-84, 201307
    Link to Paper Search Results by DOI
  142. Utilization of Waste Syrup for Production of Polyunsaturated Fatty Acids and Xanthophylls by Aurantiochytrium, JOURNAL OF OLEO SCIENCE, 62(9), 729-736, 201309
    Link to Paper Search Results by DOI
  143. Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules, PLOS ONE, 8(11), 20131108
    Link to Paper Search Results by DOI
  144. Regulation of Polyunsaturated Fatty Acid Biosynthesis by Seaweed Fucoxanthin and Its Metabolite in Cultured Hepatocytes, LIPIDS, 49(2), 133-141, 201402
    Link to Paper Search Results by DOI
  145. Glyceraldehyde-3-phosphate dehydrogenase ( GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice, SCIENTIFIC REPORTS, 4, 20140606
    Link to Paper Search Results by DOI
  146. Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(4), 655-661, 201404
    Link to Paper Search Results by DOI
  147. A Novel Anti-Histone H1 Monoclonal Antibody, SSV Monoclonal Antibody, Improves Lung Injury and Survival in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Like Syndrome, Biomed Research International, 2015
    Link to Paper Search Results by DOI
  148. Sake Less Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, Agricultural and Biological Chemistry, 75(1), 140-144, 20110123
  149. Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy, ALLERGOLOGY INTERNATIONAL, 64(4), 312-320, 201510
    Link to Paper Search Results by DOI
  150. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases, JOURNAL OF LIPID RESEARCH, 57(1), 89-99, 201601
    Link to Paper Search Results by DOI
  151. Impact of histone H1 on the progression of allergic rhinitis and its suppression by neutralizing antibody in mice, PLoS ONE, 11, e0153630, 20160418
    Link to Paper Search Results by DOI
  152. Der f 34, a novel major house dust mite allergen belonging to a highly conserved Rid/YjgF/YER057c/UK114 family of imine deaminases, JOURNAL OF BIOLOGICAL CHEMISTRY, 20160818
    Link to Paper Search Results by DOI
  153. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens, WORLD ALLERGY ORGANIZATION JOURNAL, 9, 27, 20160906
    Link to Paper Search Results by DOI
  154. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 483(1), 674-679, 20170129
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  155. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, Biochemical and Biophisical Research Communications, 483(1), 674-679, 2017
  156. Der f 35: an MD-2−like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, Allergy, 72, 1728-1736, 2017
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  157. The significance of a nuclear protein as a moonlight protein: diagnostic and therapeutic potentials in liver transplantation, International Journal of Surgery & Surgical Procedures, 2, 117, 2017
  158. Plasma cluster ions reduce the IgE-binding capacity of house dust mite allergens under a simulated indoor environmental condition, International Archives of Allergy and Immunology, 173, 199-203
  159. A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation, 44, 597-608, 2018
  160. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, Journal of Biochemistry, 163, 51-60, 2018
  161. A novel methoxyflavanone derivative from an Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, Cytotechnology, 70, 899-912, 2018
  162. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, Cytotechnology, 70, 913-919, 2018
  163. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, Cytotechnology, 70, 921-927, 2018
  164. Rapid multiplex nucleic acid amplification test developed using paper chromatography chip and azobenzene-modified oligonucleotides, Journal of Bioscience and Bioengineering, 126, 397-403, 2018
  165. Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis, World Allergy Organization Journal, 11, 31, 2018
  166. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3, Pharmacological Reports, 71, 289-298, 2019
  167. Plasma cluster ions reduce the IgE-binding capacity of house dust mite allergens under a simulated indoor environmental condition, Int. Arch. Allergy Immunol., 173, 199-203, 2017
  168. A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation, BioFactors, 44, 597-608, 2018
  169. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, J. Biochem., 163, 51-60, 2018
  170. Design, synthesis and cytotoxicity evaluation of new 3,5-disubstituted-2-thioxoimidazolidinones, Anti-Cancer Agents Med. Chem., 18, 573-582, 2018
  171. A novel methoxyflavanone derivative from an Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, Cytotechnology, 70, 899-912, 2018
  172. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, Cytotechnology, 70, 913-919, 2018
  173. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, Cytotechnology, 70, 921-927, 2018
  174. Melilotus indicus extract induces apoptosis in hepatocellular carcinoma cells via a mechanism involving mitochondria-mediated pathways, Cytotechnology, 70, 831-842, 2018
  175. Rapid multiplex nucleic acid amplification test developed using paper chromatography chip and azobenzene-modified oligonucleotides, J. Biosci. Bioeng., 126, 397-403, 2018
  176. Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis, World Allergy Organ. J., 11, 31, 2018
  177. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3, Pharmacol. Rep., 71, 289-298, 2019
  178. Influences of maternal factors over offspring
allergies and the application for food allergy, Front. Immunol., doi: 10.3389/fimmu.2019.01933, 2019
  179. Intravenous immunoglobulin (IVIg) acts directly on conventional T cells to suppress T cell receptor signaling, Biochem. Biophys. Res. Commun., 522, 792-798, 2020

Publications such as books

  1. 2020, Arerugi, Latest Advances on the Analysis of Allergens, 2020

Invited Lecture, Oral Presentation, Poster Presentation

  1. Impact of a pollen-derived serine protease on the epithelial TSLP induction and pathogenesis of Japanese cedar pollinosis., Kawamoto S., The Cell Symposia: The Multifaceted Roles of Type 2 Immunity., 2014/12, Without Invitation, Bruges, Belgium

External Funds

Acceptance Results of Competitive Funds

  1. 2012, 2014
  2. KAKENHI, 2013, 2015
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  3. KAKENHI, 2013, 2015
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  4. KAKENHI, 2013, 2014
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  5. KAKENHI, 2012, 2014
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  6. KAKENHI, Development of IgE mimotope-antibody fusion derivatives specific for sensitized allergens, 2012, 2013
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  7. KAKENHI, Challenges towards the generation of the dream immunosuppressant for the 21stcentury without permanent medication, 2011, 2012
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  8. KAKENHI, Molecular characterization of sensitized house dust mite allergens for the generation of tailor-made vaccine, 2010, 2012
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  9. KAKENHI, Elucidation of a novel anti-allergic mechanism of pulverized dietary fiber and its application, 2008, 2010
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  10. KAKENHI, 2006, 2007
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  11. KAKENHI, Exhaustive Allergenome Analysis of Japanese Cedar Pollen Allergen Molecules, 2005, 2006
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  12. KAKENHI, Generation of oral vaccine for mite allergy, 2002, 2004
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  13. KAKENHI, 2000, 2001
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  14. KAKENHI, 1998, 1999
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  15. KAKENHI, Microbial production of n-3 docosapentaenoic acid and development of its utilization, 1998, 2000
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  16. 2007
  17. 2006
  18. 2005
  19. 2004
  20. 2001
  21. 2000
  22. 2000

Social Activities

Organizing Academic Conferences, etc.

  1. HiHA 6th International Symposium, 2019/03
  2. HiHA 5th International Symposium, 2018/03
  3. HiHA 4th International Symposium, 2017/03, 2017/03
  4. HiHA 3rd International Symposium, 2016/03, 2016/03
  5. HiHA 2nd International Symposium, 2015/03, 2015/03

History as Peer Reviews of Academic Papers

  1. 2020, Cytotechnology, Others, review, 2