谷本 圭司Keiji Tanimoto

Last Updated :2021/10/05

所属・職名
原爆放射線医科学研究所 准教授
メールアドレス
ktanimohiroshima-u.ac.jp
自己紹介
分子生物学(低酸素応答機構,遺伝子発現機構など)

基本情報

主な職歴

  • 2007年04月01日, 2020年03月31日, 広島大学, 原爆放射線医科学研究所, 助教
  • 2001年04月01日, 2002年03月31日, 広島大学, 原爆放射能医学研究所
  • 1996年04月01日, 1997年09月30日, 埼玉県立がんセンター研究所, 研究生
  • 2001年04月01日, 2007年03月31日, 広島大学, 原爆放射線医科学研究所, 助手
  • 2000年01月01日, 2001年03月31日, 日本学術振興会, 特別研究員(PD)
  • 1998年07月01日, 1999年12月31日, スウェーデン王立カロリンスカ研究所, 細胞分子生物学部, 訪問研究員

学歴

  • 広島大学, 歯学研究科, 歯学臨床系, 日本, 1994年04月, 1998年03月
  • 広島大学, 歯学部, 歯学, 日本, 1988年04月, 1994年03月

学位

  • 博士(歯学) (広島大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程後期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 放射線医科学専門プログラム

研究分野

  • 医歯薬学 / 基礎医学 / 医化学一般
  • 医歯薬学 / 歯学 / 外科系歯学

研究キーワード

  • 遺伝子
  • 転写因子
  • 転写制御
  • 低酸素
  • 個別化療法
  • ゲノム薬理学

所属学会

  • 米国癌学会
  • がんとハイポキシア研究会
  • がん分子標的治療学会
  • 放射線影響学会
  • 日本分子生物学会
  • 日本口腔外科学会
  • 日本抗加齢医学会
  • 日本歯科基礎医学会
  • 日本癌学会
  • 日本癌治療学会
  • 日本薬理学会

教育活動

授業担当

  1. 2021年, 学部専門, 集中, 医学研究実習
  2. 2021年, 修士課程・博士課程前期, セメスター(前期), 分子生物学と放射線防護
  3. 2021年, 博士課程・博士課程後期, セメスター(後期), 放射線生物学入門

研究活動

学術論文(★は代表的な論文)

  1. IL-1 beta-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway, JOURNAL OF CELLULAR BIOCHEMISTRY, 113巻, 10号, pp. 3246-3253, 201210
  2. Regulation of estragen receptar alpha gene mediated by prometer B responsible for its enhanced expression in human breast cancer, Nucleic Acids Research, 27巻, 3号, pp. 903-909, 19990401
  3. ★, Mechanism of Regulation of Hypoxia-inducible Factor-1a by von Hippel-Lindan Tumor suppressor protein, EMBO Journal, 19巻, 16号, pp. 4298-4309, 20000805
  4. Distinct mechanisms of loss of estrogen receptor α gene expression in human breast cancer : methylation of the gene and alteration of trans-acting factor, Carcinogenesis, 21巻, pp. 2193-2201, 20000401
  5. Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose., Oral Oncology, 35巻, pp. 191-196, 19990401
  6. Abnormal FHIT transcripts found in both lung cancer and normal lung tissue., Genes Chromosomes and Cancer, 24巻, pp. 105-111, 19990401
  7. Abnormal FHIT Transcripts in Human Breast Carcinomas: A Clinicopathological and Epidemiological Analysis of 61 Japanese Case., Cancer Research, 57巻, pp. 1981-1985, 19970401
  8. Antitumor Effect of Carboplatin Conbined with Radiation on Tumors in Mice., Anticancer Research, 17巻, pp. 2535-2538, 19970401
  9. ★, Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-Inducible Factor-1a by the von Hippel-Lindau Tumor Suppresor Gene Product, Journal of Biological Chemistry, 278巻, pp. 6816-6823, 20030401
  10. Targeted gene delivery to human osteosarcoma cells with magnetic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22巻, pp. 1065-1071, 20030401
  11. The expression and function of estrogen receptor a and b in human breast cancer and its clinical application., Endocrine- Related Cancer, 10巻, pp. 193-202, 20030401
  12. ★, Hypoxia-Inducible Factor-1a Polymorphisms Associated with Enhanced Transactivation Capacity, Implying Clinical Significance., Carcinogenesis, 24巻, 20030401
  13. Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1a, Cancer Science, 95巻, pp. 149-153, 20040401
  14. Aberrant Methylation of Dihydropyrimidine Dehydrogenase Gene (DPYD) Promoter, DPYD Expression, and Cellular Sensitivity to 5-fluorouracil in Cancer Cells, Clinical Cancer Research, 10巻, pp. 7100-7107, 20040401
  15. Activator Protein Accelerates Dihydropyrimidine Dehydrogenase Gene Transcription in Cancer Cells, Cancer Research, 65巻, pp. 1055-1062, 20050401
  16. 特集:呼吸器のpharmacogenomics 肺癌のpharmacogenomics, THE LUNG perspectives, 12巻, 3号, pp. 20-26, 20040701
  17. cDNAマイクロアレイにより選択した関連遺伝子群の発現解析による抗癌剤効果予測システム, 癌の臨床, 50巻, 1号, pp. 15-20, 20040201
  18. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, British Journal of Oral and Maxillofacial Surgery, 41巻, pp. 348-350, 20030401
  19. 口腔癌患者における薬物代謝酵素遺伝子多型と発癌感受性に関する研究, 広島大学歯学雑誌, 30巻, 1号, 19980401
  20. 低酸素と遺伝子不安定性, 癌治療と宿主, 15巻, pp. 233-238, 20030401
  21. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24巻, pp. 1435-1442, 20041201
  22. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, Mol Cancer Ther, 5巻, 3号, pp. 767-775, 20060301
  23. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, Int J Oncol, 28巻, pp. 1153-1162, 20060501
  24. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncology Reports, 17巻, pp. 1405-1411, 20070601
  25. 分子情報に基づく癌化学療法の治療効果予測, 放射線生物研究, 40巻, 2号, pp. 202-213, 20050601
  26. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts., Exp Lung Res, 34巻, 7号, pp. 373-390, 20080901
  27. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma., Cancer Letters, 274巻, 2009号, pp. 25-32, 20090201
  28. 肺癌とテロメア・テロメラーゼ,肺癌-基礎・臨床研究のアップデート-,疫学・基礎研究Ⅱ., 分子生物学, 66巻, 6号, pp. 59-64, 20080801
  29. 肺癌の分子生物学①-carcinogenesisとはなにか-.特集「肺癌のUp-To-Date」., THE LUNG perspectives, 16巻, 4号, pp. 503-507, 20081001
  30. 日本における遺伝子診療・研究の現状., 腫瘍内科, 2巻, 5号, pp. 433-439, 20081001
  31. 分子標的治療法開発にむけた低酸素研究., 日本癌病態治療研究会誌, 20080601
  32. 癌と低酸素., 医学のあゆみ, 20080601
  33. EMP3 as a candidate tumor suppressor gene for solid tumors., Expert Opin. Ther. Targets., 13巻, 7号, pp. 811-822, 20090701
  34. Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1, Journal of Pathology, 224巻, 3号, pp. 420-429, 20110701
  35. HIF-1a polymorphisms associate with genetic aberrations in lung cancer, Respirology, 16巻, 5号, pp. 796-802, 20110701
  36. Genetic variations in detoxification enzymes and HIF-1α in Japanese patients with COPD, Clinical Respiratory Journal, 20110601
  37. Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer, International Journal of Oncology, 36巻, 5号, pp. 1217-1227, 20100501
  38. 固形癌の治療抵抗性に関わる低酸素応答分子機構, 癌の臨床, 54巻, 2号, pp. 91-96, 20080201
  39. 固形癌の治療抵抗性に関わる低酸素応答分子機構, 放射線生物研究, 43巻, 1号, pp. 54-67, 20080101
  40. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells, International Journal of Oncology, 27号, pp. 87-95, 20050701
  41. Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma, Oncology Reports, 12号, pp. 1033-1037, 20041101
  42. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, International Journal of Cancer, 111巻, 4号, pp. 617-626, 20040901
  43. Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2, Molecular and Cellular Biology, 24巻, 8号, pp. 3473-3484, 20040401
  44. Personalized Medicine, and Our Recent Approaches, Annals of Cancer Research and Therapy, 11巻, pp. 61-72, 20031001
  45. Bcl-2 in cancer and normal tissue cells as a prediction marker of response to 5-fluorouracil, International Journal of Oncology, 22巻, 1号, pp. 181-186, 20030101
  46. Identification of Functional Hypoxia Response Elements in Promoter Region of the DEC1 and DEC2 Gene, Journal of Biological Chemistry, 277巻, 49号, pp. 47014-47021, 20021201
  47. O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives, Japanese Journal of Cancer Research, 93巻, 1号, pp. 93-102, 20020101
  48. Unique action determinants of double acting topoisomerase inhibitor, TAS-103, International Journal of Oncology, 19巻, 5号, pp. 921-927, 20011101
  49. Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers, International Journal of Oncology, 20巻, 2号, pp. 333-338, 20010201
  50. Interactive effects of cell therapy and rehabilitation realize the full potential of neurogenesis in brain injury model, Neurosci Lett, 555巻, 25号, pp. 73-78, 20131001
  51. 食道癌における新規癌抑制遺伝子EMP3の同定と放射線感受性因子としての検討, 広島医学, 63巻, 4号, pp. 307-310, 20100401
  52. Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22巻, 5号, pp. 1065-1071, 200305
  53. Hypoxia-inducible factor-1 alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance, CARCINOGENESIS, 24巻, 11号, pp. 1779-1783, 200311
  54. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 41巻, 5号, pp. 348-350, 200310
  55. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, INTERNATIONAL JOURNAL OF CANCER, 111巻, 4号, pp. 617-626, 20040910
  56. Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells, CLINICAL CANCER RESEARCH, 10巻, 20号, pp. 7100-7107, 20041015
  57. Single nucleotide polymorphism in the hypoxia-inducible factor-1 alpha gene in colorectal carcinoma, ONCOLOGY REPORTS, 12巻, 5号, pp. 1033-1037, 200411
  58. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5巻, 3号, pp. 767-775, 200603
  59. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, INTERNATIONAL JOURNAL OF ONCOLOGY, 28巻, 5号, pp. 1153-1162, 200605
  60. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17巻, 6号, pp. 1405-1411, 200706
  61. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 200701
  62. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17巻, 4号, pp. 871-878, 200704
  63. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98巻, 9号, pp. 1394-1401, 200709
  64. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response, INTERNATIONAL JOURNAL OF ONCOLOGY, 32巻, 2号, pp. 413-423, 200802
  65. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2, ONCOGENE, 27巻, 30号, pp. 4200-4209, 200807
  66. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34巻, 7号, pp. 373-390, 2008
  67. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443巻, 4号, pp. 1286-1290, 20140124
  68. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9巻, 11号, pp. 1709-1713, 201411
  69. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6巻, 201501
  70. ★, The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer, PLOS ONE, 10巻, 8号, 20150811
  71. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 2007
  72. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17巻, 4号, pp. 871-878, 2007
  73. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17巻, 6号, pp. 1405-1411, 2007
  74. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98巻, 9号, pp. 1394-1401, 2007
  75. Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393巻, 4号, pp. 800-805, 2010
  76. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 2007
  77. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5巻, 20151112
  78. The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation, ONCOGENE, 35巻, 27号, pp. 3598-3606, 20160707
  79. The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms., Biochemical and Biophysical Research Communications, 441巻, 2号, pp. 499-506, 2013
  80. An association study between Hypoxia inducible Factor-1alpha (HIF-1) polymorphisms and osteonecrosis, PLOS ONE, 8巻, 11号, pp. e79647, 2013
  81. Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro, Neuroscience Letters, 545巻, pp. 29-34, 2013
  82. ★, Development of lymphoproliferative diseases by hypoxia-inducible factor-1α is associated with prolonged lymphocyte survival, PLOS ONE, 8巻, 4号, pp. e57833, 2013
  83. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist, MOLECULAR CANCER THERAPEUTICS, 17巻, 2号, pp. 432-442, 201802
  84. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13巻, 2号, 20180221
  85. Genetics of the hypoxia-inducible factors in human cancers, EXPERIMENTAL CELL RESEARCH, 356巻, 2号, pp. 166-172, 20170715
  86. Simulated microgravity attenuates myogenic differentiation via epigenetic regulations, NPJ MICROGRAVITY, 4巻, 20180523
  87. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells, PLOS ONE, 14巻, 7号, pp. e0219363, 20190719
  88. GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A., Carcinogenesis, 41巻, 9号, pp. 1184-1194, 202009
  89. A step forward into respiratory genetics: overview contribution of genetics in respiratory diseases, ASIAN BIOMEDICINE, 6巻, 5号, pp. 639-651, 2012
  90. Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8巻, 4号, 2013
  91. The Kruppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441巻, 2号, pp. 499-506, 2013
  92. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9巻, 11号, pp. 1709-1713, 2014
  93. ヒト乳癌細胞におけるエストロゲンレセプター遺伝子の転写調節機構, 日本分子生物学会年会プログラム・講演要旨集, 19巻, 19960801
  94. 口腔癌患者における薬物代謝酵素遺伝子多型と発癌感受性に関する研究, 広島大学歯学雑誌, 30巻, 1号, pp. 115-128, 19980601
  95. Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer, PLOS ONE, 16巻, 6号, 20210608
  96. ★, Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, Scientific Reports, 11巻, 1号, pp. 16629, 20210817
  97. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6巻, 2015
  98. 0073 CDDP新規効果規定因子としてのIFITM1遺伝子の有用性(食道化学療法,一般演題,第61回日本消化器外科学会定期学術総会), 日本消化器外科学会雑誌, 39巻, 7号, 20060701
  99. 分子情報に基づく癌化学療法の治療効果予測, 放射線生物研究, 40巻, 2号, pp. 202-213, 200506

招待講演、口頭・ポスター発表等

  1. 低線量率放射線のがん化学放射線療法における意義, 島袋紀一,谷本圭司,廣橋伸之,柿本直也, 第61回日本歯科放射線学会, 2021年05月22日, 通常, 日本語, 那覇
  2. 低線量率放射線および低酸素刺激により変動する遺伝子群, 島袋紀一,谷本圭司,柿本直也,廣橋伸之, 第45回中国放射線影響研究会, 2020年08月07日, 通常, 日本語, 広島
  3. The effects of low-dose irradiation on the hypoxic cells., Kiichi Shimabukuro, Keiji Tanimoto, Naoya Kakimoto, Nobuyuki Hirohashi, The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2020年02月12日, 通常, 英語, Hiroshima