Keiji Tanimoto

Last Updated :2021/10/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
ktanimohiroshima-u.ac.jp
Self-introduction
Molecular Biology (Mechanisms of response to hypoxia or various stress stimuli, and transcriptional regulation of genes.)

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2020/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor
  • 2001/04/01, 2002/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine
  • 1996/04/01, 1997/09/30, Saitama Cancer Center, Research Institute
  • 2001/04/01, 2007/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Research Associate
  • 2000/01/01, 2001/03/31, Japan Society for the Promotion of Science, research fellow
  • 1998/07/01, 1999/12/31, Cell and Molecular Biology, Karolinska Institutet, guest researcher

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 1994/04, 1998/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1988/04, 1994/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • transcription
  • HIF-1
  • Transcription
  • hypoxia
  • individualized therapy
  • Pharmacogenetics

Affiliated Academic Societies

  • American Association for Cancer Research
  • The Japanese Pharmacological Society

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Intensive, Practice for medical research
  2. 2021, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  3. 2021, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. IL-1 beta-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway, JOURNAL OF CELLULAR BIOCHEMISTRY, 113(10), 3246-3253, 201210
  2. Regulation of estragen receptar alpha gene mediated by prometer B responsible for its enhanced expression in human breast cancer, Nucleic Acids Research, 27(3), 903-909, 19990401
  3. ★, Mechanism of Regulation of Hypoxia-inducible Factor-1a by von Hippel-Lindan Tumor suppressor protein, EMBO Journal, 19(16), 4298-4309, 20000805
  4. Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose., Oral Oncology, 35, 191-196, 19990401
  5. Abnormal FHIT transcripts found in both lung cancer and normal lung tissue., Genes Chromosomes and Cancer, 24, 105-111, 19990401
  6. Abnormal FHIT Transcripts in Human Breast Carcinomas: A Clinicopathological and Epidemiological Analysis of 61 Japanese Case., Cancer Research, 57, 1981-1985, 19970401
  7. Antitumor Effect of Carboplatin Conbined with Radiation on Tumors in Mice., Anticancer Research, 17, 2535-2538, 19970401
  8. ★, Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-Inducible Factor-1a by the von Hippel-Lindau Tumor Suppresor Gene Product, Journal of Biological Chemistry, 278, 6816-6823, 20030401
  9. Targeted gene delivery to human osteosarcoma cells with magnetic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22, 1065-1071, 20030401
  10. The expression and function of estrogen receptor a and b in human breast cancer and its clinical application., Endocrine- Related Cancer, 10, 193-202, 20030401
  11. ★, Hypoxia-Inducible Factor-1a Polymorphisms Associated with Enhanced Transactivation Capacity, Implying Clinical Significance., Carcinogenesis, 24, 20030401
  12. Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1a, Cancer Science, 95, 149-153, 20040401
  13. Aberrant Methylation of Dihydropyrimidine Dehydrogenase Gene (DPYD) Promoter, DPYD Expression, and Cellular Sensitivity to 5-fluorouracil in Cancer Cells, Clinical Cancer Research, 10, 7100-7107, 20040401
  14. Activator Protein Accelerates Dihydropyrimidine Dehydrogenase Gene Transcription in Cancer Cells, Cancer Research, 65, 1055-1062, 20050401
  15. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, British Journal of Oral and Maxillofacial Surgery, 41, 348-350, 20030401
  16. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24, 1435-1442, 20041201
  17. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, Mol Cancer Ther, 5(3), 767-775, 20060301
  18. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, Int J Oncol, 28, 1153-1162, 20060501
  19. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncology Reports, 17, 1405-1411, 20070601
  20. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts., Exp Lung Res, 34(7), 373-390, 20080901
  21. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma., Cancer Letters, 274(2009), 25-32, 20090201
  22. EMP3 as a candidate tumor suppressor gene for solid tumors., Expert Opin. Ther. Targets., 13(7), 811-822, 20090701
  23. Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1, Journal of Pathology, 224(3), 420-429, 20110701
  24. HIF-1a polymorphisms associate with genetic aberrations in lung cancer, Respirology, 16(5), 796-802, 20110701
  25. Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer, International Journal of Oncology, 36(5), 1217-1227, 20100501
  26. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells, International Journal of Oncology, 87-95, 20050701
  27. Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma, Oncology Reports, 1033-1037, 20041101
  28. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, International Journal of Cancer, 111(4), 617-626, 20040901
  29. Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2, Molecular and Cellular Biology, 24(8), 3473-3484, 20040401
  30. Personalized Medicine, and Our Recent Approaches, Annals of Cancer Research and Therapy, 11, 61-72, 20031001
  31. Bcl-2 in cancer and normal tissue cells as a prediction marker of response to 5-fluorouracil, International Journal of Oncology, 22(1), 181-186, 20030101
  32. Identification of Functional Hypoxia Response Elements in Promoter Region of the DEC1 and DEC2 Gene, Journal of Biological Chemistry, 277(49), 47014-47021, 20021201
  33. O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives, Japanese Journal of Cancer Research, 93(1), 93-102, 20020101
  34. Unique action determinants of double acting topoisomerase inhibitor, TAS-103, International Journal of Oncology, 19(5), 921-927, 20011101
  35. Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers, International Journal of Oncology, 20(2), 333-338, 20010201
  36. Interactive effects of cell therapy and rehabilitation realize the full potential of neurogenesis in brain injury model, Neurosci Lett, 555(25), 73-78, 20131001
  37. Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22(5), 1065-1071, 200305
  38. Hypoxia-inducible factor-1 alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance, CARCINOGENESIS, 24(11), 1779-1783, 200311
  39. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 41(5), 348-350, 200310
  40. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, INTERNATIONAL JOURNAL OF CANCER, 111(4), 617-626, 20040910
  41. Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells, CLINICAL CANCER RESEARCH, 10(20), 7100-7107, 20041015
  42. Single nucleotide polymorphism in the hypoxia-inducible factor-1 alpha gene in colorectal carcinoma, ONCOLOGY REPORTS, 12(5), 1033-1037, 200411
  43. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5(3), 767-775, 200603
  44. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, INTERNATIONAL JOURNAL OF ONCOLOGY, 28(5), 1153-1162, 200605
  45. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17(6), 1405-1411, 200706
  46. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 200701
  47. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, 200704
  48. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98(9), 1394-1401, 200709
  49. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response, INTERNATIONAL JOURNAL OF ONCOLOGY, 32(2), 413-423, 200802
  50. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2, ONCOGENE, 27(30), 4200-4209, 200807
  51. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
  52. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443(4), 1286-1290, 20140124
  53. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9(11), 1709-1713, 201411
  54. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6, 201501
  55. ★, The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer, PLOS ONE, 10(8), 20150811
  56. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 2007
  57. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, 2007
  58. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17(6), 1405-1411, 2007
  59. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98(9), 1394-1401, 2007
  60. Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(4), 800-805, 2010
  61. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 2007
  62. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
  63. The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation, ONCOGENE, 35(27), 3598-3606, 20160707
  64. The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms., Biochemical and Biophysical Research Communications, 441(2), 499-506, 2013
  65. An association study between Hypoxia inducible Factor-1alpha (HIF-1) polymorphisms and osteonecrosis, PLOS ONE, 8(11), e79647, 2013
  66. Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro, Neuroscience Letters, 545, 29-34, 2013
  67. ★, Development of lymphoproliferative diseases by hypoxia-inducible factor-1a is associated with prolonged lymphocyte survival, PLOS ONE, 8(4), e57833, 2013
  68. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist, MOLECULAR CANCER THERAPEUTICS, 17(2), 432-442, 201802
  69. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13(2), 20180221
  70. Genetics of the hypoxia-inducible factors in human cancers, EXPERIMENTAL CELL RESEARCH, 356(2), 166-172, 20170715
  71. Simulated microgravity attenuates myogenic differentiation via epigenetic regulations, NPJ MICROGRAVITY, 4, 20180523
  72. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells, PLOS ONE, 14(7), e0219363, 20190719
  73. GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A., Carcinogenesis, 41(9), 1184-1194, 202009
  74. A step forward into respiratory genetics: overview contribution of genetics in respiratory diseases, ASIAN BIOMEDICINE, 6(5), 639-651, 2012
  75. Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8(4), 2013
  76. The Kruppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 499-506, 2013
  77. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9(11), 1709-1713, 2014
  78. Studies on Genetic Polymorphisms of the Xenobiotic Metabolizing Enzymes in Oral Cancer Patients and Susceptibility to Oral Cancer, 30(1), 115-128, 19980601
  79. Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer, PLOS ONE, 16(6), 20210608
  80. ★, Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, Scientific Reports, 11(1), 16629, 20210817
  81. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6, 2015

Invited Lecture, Oral Presentation, Poster Presentation

  1. Significance of low-dose-rate irradiation in anti-cancer therap, 2021/05/22, Without Invitation, Japanese
  2. The effects of low-dose irradiation on the hypoxic cells., Kiichi Shimabukuro, Keiji Tanimoto, Naoya Kakimoto, Nobuyuki Hirohashi, The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2020/02/12, Without Invitation, English, Hiroshima