福士 雅也MASAYA FUKUSHI

Last Updated :2024/12/02

所属・職名
大学院医系科学研究科（医）　助教
メールアドレス
mfukushihiroshima-u.ac.jp
自己紹介
患者さんに還元できるような研究をしたいと考えています。

基本情報

学位

  • 博士（医学）　(東京医科歯科大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程後期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 医学専門プログラム

研究分野

  • 医歯薬学 / 基礎医学 / ウイルス学

研究キーワード

  • ウイルス感染
  • 筋萎縮性側索硬化症

所属学会

  • 日本ウイルス学会
  • 日本分子生物学会

教育活動

授業担当

  1. 2024年, 学部専門, 通年, 生体反応学

研究活動

学術論文（★は代表的な論文）

  1. ★, Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18巻, 6号, 2023
    DOIを用いた論文検索結果へのリンク
  2. ★, Laninamivir Octanoate and Artificial Surfactant Combination Therapy Significantly Increases Survival of Mice Infected with Lethal Influenza H1N1 Virus, PLOS ONE, 7巻, 8号, 20120801
    DOIを用いた論文検索結果へのリンク
  3. ★, Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86巻, 21号, pp. 11745-11753, 201211
    DOIを用いた論文検索結果へのリンク
  4. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS., Journal of Neuroscience, 20120801
  5. ★, Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain., PLoS ONE, 20110601
  6. Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model., Journal of Infectious Diseases, 20110601
  7. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89巻, 22号, pp. 11487-11499, 201511
    DOIを用いた論文検索結果へのリンク
  8. Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus., Virology, 380巻, 1号, pp. 99-108, 2008
  9. A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences., Virus Genes, 34巻, 2007
  10. Visualization of a functional KSHV episome-maintenance protein LANA in living cells., Virus Genes, 29巻, 2004
  11. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3., Virology, 320巻, 2004
  12. PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line., Virology, 318巻, 2004
  13. ★, Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha., Virus Genes, 21巻, 2003
  14. ★, Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1., Journal of Virology, 76巻, 2002
  15. Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 tax protein in T cell lines., Virology, 2002
  16. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling., Biochemical Biophysical Research Communications, 2002
  17. Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases., Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 2002
  18. Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax., Journal of Virology, 2002
  19. Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo., Virus Genes, 2001
  20. Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1., AIDS Research and Human Retroviruses,, 2000
  21. Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: comparison with ELISA using synthetic peptides., Viral Immunology, 1999
  22. ★, Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression., FEBS Letter, 1999
  23. Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo., Journal of Virology, 1997
  24. Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: Requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo, Journal of Virology, 71巻, 11号, pp. 8456-8466, 19971101
  25. Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression, FEBS Letters, 442巻, 1号, pp. 83-88, 19990108
  26. Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1, AIDS Research and Human Retroviruses, 16巻, 16号, pp. 1603-1606, 20001101
  27. Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo, Virus Genes, 23巻, 3号, pp. 263-271, 20011222
  28. Human T-cell leukemia virus type 2 (HTLV-2) tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax, Journal of Virology, 76巻, 6号, pp. 2648-2653, 20020311
  29. Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 Tax protein in T cell lines, Virology, 302巻, 1号, pp. 132-143, 20020101
  30. Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 93巻, 3号, pp. 305-310, 20020101
  31. Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1, Journal of Virology, 76巻, 24号, pp. 12917-12924, 20021201
  32. Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus, Uirusu. Journal of virology, 52巻, 2号, pp. 281-285, 20021201
  33. Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Human Myeloid Cell Nuclear Differentiation Antigen Induced by Interferon α, Virus Genes, 27巻, 3号, pp. 237-247, 20031216
  34. PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line, Virology, 318巻, 1号, pp. 327-336, 20040105
  35. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3, Virology, 320巻, 1号, pp. 52-62, 20040301
  36. Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: Comparison with ELISA using synthetic peptides, Viral Immunology, 12巻, 1号, pp. 57-66, 19990527
  37. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling, Biochemical and Biophysical Research Communications, 297巻, 1号, pp. 17-23, 20021014
  38. A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences, Virus Genes, 34巻, 2号, pp. 127-136, 20070401
  39. Visualization of a functional KSHV episome-maintenance protein LANA in living cells, Virus Genes, 29巻, 2号, pp. 175-182, 20041001
  40. Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus, Virology, 380巻, 1号, pp. 99-108, 20081010
  41. Fully human monoclonal antibody directed to proteolytic cleavage site in Severe Acute Respiratory Syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model, Journal of Infectious Diseases, 203巻, 11号, pp. 1574-1581, 20110601
  42. Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain, PLoS ONE, 6巻, 6号, 20110623
  43. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS, Journal of Neuroscience, 32巻, 34号, pp. 11586-11599, 20120822
  44. Eligibility of feline calicivirus for a surrogate of human norovirus in comparison with murine norovirus, poliovirus and coxsackievirus., Biocontrol Science, 23巻, pp. 145-149, 2018
  45. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66巻, pp. 97-101, 2017
  46. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019巻, 20191203
    DOIを用いた論文検索結果へのリンク
  47. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses, COMMUNICATIONS BIOLOGY, 3巻, 1号, 20200403
    DOIを用いた論文検索結果へのリンク
  48. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant, Cell Reports, 32巻, 20200922
  49. Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86巻, 21号, pp. 11745-11753, 2012
  50. Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86巻, 21号, pp. 11745-11753, 2012
  51. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7巻, 8号, 20120801
  52. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7巻, 8号, 20120801
  53. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7巻, 8号, 20120801
  54. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89巻, 22号, pp. 11487-11499, 20150101
  55. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89巻, 22号, pp. 11487-11499, 20150101
  56. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89巻, 22号, pp. 11487-11499, 20150101

招待講演、口頭・ポスター発表等

  1. Optineurin, a causative gene of amyotrophic lateral sclerosis, is involved in interferon beta expression., 福士雅也, 日本免疫学会総会, 2016年12月05日, 通常, 英語
  2. 筋萎縮性側索硬化症(ALS)原因遺伝子オプチニューリンとインターフェロン・ベータ発現, 福士雅也, 大澤亮介、森脇昌哉、川上秀史、坂口剛正, 第３８回分子生物学会年会(BMB2015), 2015年12月01日, 通常, 日本語
  3. 筋萎縮性側索硬化症(ALS)原因遺伝子オプチニューリンは、病原体感染時のインターフェロン・ベータ産生を抑制する, 福士雅也, 大澤亮介、川上秀史、坂口剛正, 第４０回分子生物学会年会, 2017年12月06日, 通常, 日本語
  4. 筋萎縮性側索硬化症(ALS)原因遺伝子オプチニューリンの欠損は、病原体感染によるインターフェロン・ベータ産生を増加させる, 福士雅也, 大澤亮介、川上秀史、坂口剛正, 第４１回日本分子生物学会年会, 2018年11月29日, 通常, 英語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(基盤研究(C)), ウイルス感染は筋萎縮性側索硬化症（ＡＬＳ）の発症に関与するか？, 2016年, 2018年
    関連URL
  2. 科学研究費助成事業(基盤研究(C)), インフルエンザ肺炎の重症化メカニズムの解明～その治療を目指して～, 2013年, 2015年
    関連URL
  3. 科学研究費助成事業(奨励研究(A)), いかにしてヒトヘルペス8型は潜伏感染するのか, 2001年, 2002年
    関連URL
  4. 科学研究費助成事業(基盤研究(C)), ウイルス感染は筋萎縮性側索硬化症(ALS)の発症に関与するか？, 2017年, 2018年
  5. 科学研究費, ウイルス感染は筋萎縮性側索硬化症(ALS)の発症に関与するか？, 2018年, 2018年
  6. 土谷助成金, 筋萎縮性側索硬化症(ALS)の発症に病原体感染は関与するか？, 2018年, 2018年
  7. 土谷助成金, 筋萎縮性側索硬化症(ALS)の発症に病原体感染は関与するか？, 2019年, 2019年
  8. 土谷助成金, 筋萎縮性側索硬化症(ALS)の発症に病原体感染は関与するか？, 2017年, 2019年
  9. 科学研究費助成事業(挑戦的研究（萌芽）), ウイルス干渉作用を利用した簡便で効率的な新規ウイルスベクター除去技術の開発, 2019年, 2021年