MASAYA FUKUSHI
Last Updated :2025/02/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
- E-mail
- mfukushi
hiroshima-u.ac.jp
- Self-introduction
- I want to perform a research for patients.
Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, Tokyo Medical and Dental University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Medicine,dentistry, and pharmacy;Basic medicine;Virology
Research Keywords
Affiliated Academic Societies
- The Japanese Society for Virology
- The Molecular Biology society of Japan
Research Activities
Academic Papers
- ★, Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18(6), 2023
- ★, Laninamivir Octanoate and Artificial Surfactant Combination Therapy Significantly Increases Survival of Mice Infected with Lethal Influenza H1N1 Virus, PLOS ONE, 7(8), 20120801
- ★, Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 201211
- Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS., Journal of Neuroscience, 20120801
- ★, Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain., PLoS ONE, 20110601
- Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model., Journal of Infectious Diseases, 20110601
- Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 201511
- Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus., Virology, 380(1), 99-108, 2008
- A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences., Virus Genes, 34, 2007
- Visualization of a functional KSHV episome-maintenance protein LANA in living cells., Virus Genes, 29, 2004
- Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3., Virology, 320, 2004
- PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line., Virology, 318, 2004
- ★, Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha., Virus Genes, 21, 2003
- ★, Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1., Journal of Virology, 76, 2002
- Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 tax protein in T cell lines., Virology, 2002
- A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling., Biochemical Biophysical Research Communications, 2002
- Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases., Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 2002
- Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax., Journal of Virology, 2002
- Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo., Virus Genes, 2001
- Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1., AIDS Research and Human Retroviruses,, 2000
- Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: comparison with ELISA using synthetic peptides., Viral Immunology, 1999
- ★, Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression., FEBS Letter, 1999
- Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo., Journal of Virology, 1997
- Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: Requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo, Journal of Virology, 71(11), 8456-8466, 19971101
- Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression, FEBS Letters, 442(1), 83-88, 19990108
- Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1, AIDS Research and Human Retroviruses, 16(16), 1603-1606, 20001101
- Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo, Virus Genes, 23(3), 263-271, 20011222
- Human T-cell leukemia virus type 2 (HTLV-2) tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax, Journal of Virology, 76(6), 2648-2653, 20020311
- Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 Tax protein in T cell lines, Virology, 302(1), 132-143, 20020101
- Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 93(3), 305-310, 20020101
- Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1, Journal of Virology, 76(24), 12917-12924, 20021201
- Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus, Uirusu. Journal of virology, 52(2), 281-285, 20021201
- Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Human Myeloid Cell Nuclear Differentiation Antigen Induced by Interferon α, Virus Genes, 27(3), 237-247, 20031216
- PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line, Virology, 318(1), 327-336, 20040105
- Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3, Virology, 320(1), 52-62, 20040301
- Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: Comparison with ELISA using synthetic peptides, Viral Immunology, 12(1), 57-66, 19990527
- A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling, Biochemical and Biophysical Research Communications, 297(1), 17-23, 20021014
- A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences, Virus Genes, 34(2), 127-136, 20070401
- Visualization of a functional KSHV episome-maintenance protein LANA in living cells, Virus Genes, 29(2), 175-182, 20041001
- Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus, Virology, 380(1), 99-108, 20081010
- Fully human monoclonal antibody directed to proteolytic cleavage site in Severe Acute Respiratory Syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model, Journal of Infectious Diseases, 203(11), 1574-1581, 20110601
- Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain, PLoS ONE, 6(6), 20110623
- Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS, Journal of Neuroscience, 32(34), 11586-11599, 20120822
- Eligibility of feline calicivirus for a surrogate of human norovirus in comparison with murine norovirus, poliovirus and coxsackievirus., Biocontrol Science, 23, 145-149, 2018
- Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66, 97-101, 2017
- Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 20191203
- Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses, COMMUNICATIONS BIOLOGY, 3(1), 20200403
- SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant, Cell Reports, 32, 20200922
- Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 2012
- Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 2012
- Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
- Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
- Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
- Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101
- Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101
- Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101
Invited Lecture, Oral Presentation, Poster Presentation
- Optineurin, a causative gene of amyotrophic lateral sclerosis, is involved in interferon beta expression., Masaya Fukushi, 日本免疫学会総会, 2016/12/05, Without Invitation, English
- Optineurin is involved in interferon beta expression., Masaya Fukushi, 2015/12/01, Without Invitation, Japanese
- Optineurin decreases the expression of interferon beta in pathogen infections., Masaya Fukushi, 2017/12/06, Without Invitation, Japanese
- Functional analysis of Optineurin in infection., Masaya Fukushi, Ryosuke Ohsawa, Hideshi Kawakami, Takemasa Sakaguchi, 2018/11/29, Without Invitation, English
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, 2016, 2018
- KAKENHI, 2013, 2015
- KAKENHI, 2001, 2002
- KAKENHI, 2017, 2018
- 2018, 2018
- 2018, 2018
- 2019, 2019
- 2017, 2019
- KAKENHI, 2019, 2021