MASAYA FUKUSHI

Last Updated :2025/06/27

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Assistant Professor
E-mail
mfukushihiroshima-u.ac.jp
Self-introduction
I want to perform a research for patients.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Tokyo Medical and Dental University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • viral infection
  • ALS

Affiliated Academic Societies

  • The Japanese Society for Virology
  • The Molecular Biology society of Japan

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Biological Responses

Research Activities

Academic Papers

  1. Viral coexistence and insertional mutations in the ORF8 region of SARS-CoV-2: A possible mechanism of nucleotide insertion, VIRUS RESEARCH, 350, 202412
    Link to Paper Search Results by DOI
  2. ★, Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18(6), 2023
    Link to Paper Search Results by DOI
  3. ★, Laninamivir Octanoate and Artificial Surfactant Combination Therapy Significantly Increases Survival of Mice Infected with Lethal Influenza H1N1 Virus, PLOS ONE, 7(8), 20120801
    Link to Paper Search Results by DOI
  4. ★, Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 201211
    Link to Paper Search Results by DOI
  5. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS., Journal of Neuroscience, 20120801
  6. ★, Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain., PLoS ONE, 20110601
  7. Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model., Journal of Infectious Diseases, 20110601
  8. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 201511
    Link to Paper Search Results by DOI
  9. Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus., Virology, 380(1), 99-108, 2008
  10. A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences., Virus Genes, 34, 2007
  11. Visualization of a functional KSHV episome-maintenance protein LANA in living cells., Virus Genes, 29, 2004
  12. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3., Virology, 320, 2004
  13. PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line., Virology, 318, 2004
  14. ★, Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha., Virus Genes, 21, 2003
  15. ★, Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1., Journal of Virology, 76, 2002
  16. Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 tax protein in T cell lines., Virology, 2002
  17. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling., Biochemical Biophysical Research Communications, 2002
  18. Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases., Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 2002
  19. Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax., Journal of Virology, 2002
  20. Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo., Virus Genes, 2001
  21. Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1., AIDS Research and Human Retroviruses,, 2000
  22. Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: comparison with ELISA using synthetic peptides., Viral Immunology, 1999
  23. ★, Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression., FEBS Letter, 1999
  24. Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo., Journal of Virology, 1997
  25. Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: Requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo, Journal of Virology, 71(11), 8456-8466, 19971101
  26. Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression, FEBS Letters, 442(1), 83-88, 19990108
  27. Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1, AIDS Research and Human Retroviruses, 16(16), 1603-1606, 20001101
  28. Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo, Virus Genes, 23(3), 263-271, 20011222
  29. Human T-cell leukemia virus type 2 (HTLV-2) tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax, Journal of Virology, 76(6), 2648-2653, 20020311
  30. Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 Tax protein in T cell lines, Virology, 302(1), 132-143, 20020101
  31. Castleman's disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 93(3), 305-310, 20020101
  32. Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1, Journal of Virology, 76(24), 12917-12924, 20021201
  33. Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus, Uirusu. Journal of virology, 52(2), 281-285, 20021201
  34. Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Human Myeloid Cell Nuclear Differentiation Antigen Induced by Interferon α, Virus Genes, 27(3), 237-247, 20031216
  35. PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line, Virology, 318(1), 327-336, 20040105
  36. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3, Virology, 320(1), 52-62, 20040301
  37. Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: Comparison with ELISA using synthetic peptides, Viral Immunology, 12(1), 57-66, 19990527
  38. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling, Biochemical and Biophysical Research Communications, 297(1), 17-23, 20021014
  39. A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences, Virus Genes, 34(2), 127-136, 20070401
  40. Visualization of a functional KSHV episome-maintenance protein LANA in living cells, Virus Genes, 29(2), 175-182, 20041001
  41. Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus, Virology, 380(1), 99-108, 20081010
  42. Fully human monoclonal antibody directed to proteolytic cleavage site in Severe Acute Respiratory Syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model, Journal of Infectious Diseases, 203(11), 1574-1581, 20110601
  43. Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain, PLoS ONE, 6(6), 20110623
  44. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS, Journal of Neuroscience, 32(34), 11586-11599, 20120822
  45. Eligibility of feline calicivirus for a surrogate of human norovirus in comparison with murine norovirus, poliovirus and coxsackievirus., Biocontrol Science, 23, 145-149, 2018
  46. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66, 97-101, 2017
  47. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 20191203
    Link to Paper Search Results by DOI
  48. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses, COMMUNICATIONS BIOLOGY, 3(1), 20200403
    Link to Paper Search Results by DOI
  49. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant, Cell Reports, 32, 20200922
  50. Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 2012
  51. Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 86(21), 11745-11753, 2012
  52. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
  53. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
  54. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with Lethal influenza H1N1 virus, PLoS ONE, 7(8), 20120801
  55. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101
  56. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101
  57. Structural basis of the inhibition of STAT1 activity by Sendai virus C protein, Journal of Virology, 89(22), 11487-11499, 20150101

Invited Lecture, Oral Presentation, Poster Presentation

  1. Study of pathogen resistance in optineurin knock-out mice, 2024/11/26, Without Invitation, English
  2. Optineurin, a causative gene of amyotrophic lateral sclerosis, is involved in interferon beta expression., Masaya Fukushi, 日本免疫学会総会, 2016/12/05, Without Invitation, English
  3. Optineurin is involved in interferon beta expression., Masaya Fukushi, 2015/12/01, Without Invitation, Japanese
  4. Optineurin decreases the expression of interferon beta in pathogen infections., Masaya Fukushi, 2017/12/06, Without Invitation, Japanese
  5. Functional analysis of Optineurin in infection., Masaya Fukushi, Ryosuke Ohsawa, Hideshi Kawakami, Takemasa Sakaguchi, 2018/11/29, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2024/04/01
  2. KAKENHI, 2019, 2021
  3. KAKENHI, 2016, 2018
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  4. 2015, 2017
  5. 2013, 2016
  6. KAKENHI, 2013, 2015
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  7. KAKENHI, 2001, 2002
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  8. KAKENHI, 2017, 2018
  9. 2018, 2018
  10. 2018, 2018
  11. 2019, 2019
  12. 2017, 2019