中江 進SUSUMU NAKAE

Last Updated :2021/04/07

所属・職名
大学院統合生命科学研究科 教授
メールアドレス
snakaehiroshima-u.ac.jp
自己紹介
アレルギー疾患などの慢性炎症疾患に関わる遺伝子の探索、その遺伝子改編マウスの作成、および利用により、その遺伝子が疾患の発症にどのように関わるのか、個体・細胞・分子レベルでの解明に取り組んでいます。

基本情報

学位

  • 修士(農学) (東京大学)
  • 博士(農学) (東京大学)

教育担当

  • 【学士課程】 生物生産学部 : 生物生産学科
  • 【博士課程前期】 統合生命科学研究科 : 統合生命科学専攻 : 食品生命科学プログラム
  • 【博士課程後期】 統合生命科学研究科 : 統合生命科学専攻 : 食品生命科学プログラム

研究分野

  • 総合生物 / 実験動物学 / 実験動物学
  • 医歯薬学 / 基礎医学 / 免疫学
  • 医歯薬学 / 内科系臨床医学 / 膠原病・アレルギー内科学

研究キーワード

  • 肥満細胞
  • Th17細胞
  • インターロイキン33
  • インターロイキン17
  • マウス疾患モデル
  • アレルギー
  • サイトカイン

所属学会

  • Collegium Internationale Allergologicum

教育活動

授業担当

  1. 2021年, 学部専門, 3ターム, 生物生産リサーチフロント
  2. 2021年, 学部専門, 4ターム, 分子生化学入門
  3. 2021年, 学部専門, 集中, PBL型実験実習II
  4. 2021年, 学部専門, 3ターム, 分子農学生命科学外書講読
  5. 2021年, 学部専門, 集中, (AIMS)Molecular Agro-life Science
  6. 2021年, 学部専門, 3ターム, Molecular Agro-life Science

研究活動

学術論文(★は代表的な論文)

  1. Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses., J Clin Invest, 130巻, 7号, pp. 3919-3935, 2020
  2. TSLP is a negative regulator of RANKL-induced osteoclastogenesis, Biochem Biophys Res Commun, 530巻, 3号, pp. 508-512, 2020
  3. Th2 signals are not essential for the anti-arthritic effects of Trichinella spiralis in mice., Parasite Immunol, 42巻, 1号, pp. e12677, 2020
  4. ★, IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice., Sci Rep, 9巻, 1号, pp. 17067, 2019
  5. Endogenous IL-33 exerts CD8+ T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model., Biochem Biophys Res Commun, 518巻, 2号, pp. 331-336, 2019
  6. Innate Lymphoid Cells in the Induction of Obesity, Cell Rep, 28巻, 1号, pp. 202-217, 2019
  7. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33., Allergy, 74巻, 11号, pp. 2237-2240, 2019
  8. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium., Cell, 176巻, 5号, pp. 982-997, 2019
  9. Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid., J Allergy Clin Immunol, 143巻, 6号, pp. 2190-2201, 2019
  10. IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation., Scientific Reports, 8巻, 1号, pp. 18052, 2018
  11. The roles of IL-17C in T cell-dependent and -independent inflammatory diseases., Scientific reports, 8巻, 1号, pp. 15750-15750, 20181024
  12. IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity., Biochemical and biophysical research communications, 201810
  13. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities, Neuroscience, 385巻, pp. 75-89, 20180810
  14. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs., Scientific reports, 8巻, 1号, pp. 11721-11721, 20180806
  15. Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice., The Laryngoscope, 201808
  16. Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota., Nature immunology, 19巻, 7号, pp. 755-765, 201807
  17. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity., Scientific reports, 8巻, 1号, pp. 6639-6639, 20180427
  18. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients, Journal of Allergy and Clinical Immunology, 141巻, 1号, pp. 300-310.e11, 20180101
  19. The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice, Allergology International, 67巻, 3号, pp. 380-387, 2018
  20. IL-25 enhances TH17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells., The Journal of allergy and clinical immunology, 2018
  21. Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice, Biochemistry and Biophysics Reports, 12巻, pp. 62-65, 20171201
  22. A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease, SCIENTIFIC REPORTS, 7巻, 1号, pp. 12765, 201710
  23. IL-33 in clinical practice: Size matters?, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140巻, 2号, pp. 381-383, 201708
  24. Human eosinophils constitutively express a unique serine protease, PRSS33, ALLERGOLOGY INTERNATIONAL, 66巻, 3号, pp. 463-471, 201707
  25. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137巻, 7号, pp. 1578-1582, 201707
  26. Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice, EXPERIMENTAL PARASITOLOGY, 177巻, pp. 1-12, 201706
  27. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment, SCIENTIFIC REPORTS, 7巻, 1号, pp. 4298, 201706
  28. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation, NATURE MEDICINE, 23巻, 5号, pp. 611-+, 201705
  29. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy., JCI insight, 2巻, 7号, pp. e90721, 20170406
  30. Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice, JOURNAL OF DERMATOLOGICAL SCIENCE, 85巻, 2号, pp. 106-114, 201702
  31. Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114巻, 5号, pp. E741-E750, 201701
  32. Contributions of interleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival inflammation model, Immunity Inflammation and Disease, 5巻, 4号, pp. 515-525, 2017
  33. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection., Immunity, inflammation and disease, 4巻, 4号, pp. 401-412, 201612
  34. Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138巻, 5号, pp. 1395-+, 201611
  35. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens, ALLERGOLOGY INTERNATIONAL, 65巻, 4号, pp. 459-465, 201610
  36. Regulatory roles of mast cells in immune responses, SEMINARS IN IMMUNOPATHOLOGY, 38巻, 5号, pp. 623-629, 201609
  37. TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice., Biochemistry and biophysics reports, 7巻, pp. 119-123, 201609
  38. Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478巻, 1号, pp. 135-142, 201609
  39. IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release., PloS one, 11巻, 8号, pp. e0161507, 201608
  40. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136巻, 7号, pp. 1408-1417, 201607
  41. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity., The Journal of investigative dermatology, 136巻, 6号, pp. 1290-1292, 201606
  42. Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes, JOURNAL OF IMMUNOLOGY, 196巻, 9号, pp. 3559-3569, 201605
  43. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages, NATURE COMMUNICATIONS, 7巻, pp. 11385, 201605
  44. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria, Biochemistry and Biophysics Reports, 5巻, pp. 191-195, 20160301
  45. Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis, PLOS PATHOGENS, 12巻, 3号, pp. e1005507, 201603
  46. Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113巻, 6号, pp. E762-E771, 201602
  47. Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer, CELL DEATH & DISEASE, 7巻, pp. e2057, 201601
  48. Interferon-γ constrains cytokine production of group 2 innate lymphoid cells., Immunology, 147巻, 1号, pp. 21-29, 201601
  49. Interleukin-33 in allergic diseases, Japanese Journal of Allergology, 65巻, 10号, pp. 1269-1276, 2016
  50. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function, INFLAMMATORY BOWEL DISEASES, 21巻, 12号, pp. 2737-2746, 201512
  51. Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56巻, 9号, pp. 5194-5202, 201508
  52. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms, JOURNAL OF CLINICAL INVESTIGATION, 125巻, 7号, pp. 2579-2591, 201507
  53. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation, NATURE COMMUNICATIONS, 6巻, pp. 7600, 201507
  54. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers, IMMUNITY, 43巻, 1号, pp. 175-186, 201507
  55. IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, PLOS ONE, 10巻, 7号, pp. e0134226, 201507
  56. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD, BLOOD, 125巻, 20号, pp. 3183-3192, 201505
  57. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes, INTERNATIONAL IMMUNOLOGY, 27巻, 4号, pp. 169-181, 201504
  58. The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice, PLOS ONE, 10巻, 4号, pp. e0123584, 201504
  59. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells, NATURE IMMUNOLOGY, 16巻, 3号, pp. 276-U239, 201503
  60. IL-33 Is Required for Disposal of Unnecessary Cells during Ovarian Atresia through Regulation of Autophagy and Macrophage Migration, JOURNAL OF IMMUNOLOGY, 194巻, 5号, pp. 2140-2147, 201503
  61. Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice, PARASITOLOGY INTERNATIONAL, 64巻, 1号, pp. 13-17, 201502
  62. The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway, IMMUNITY, 42巻, 2号, pp. 294-308, 201502
  63. Emerging roles of IL-33 in inflammation and immune regulation., Inflammation and Regeneration, 35巻, 2号, pp. 69-77, 2015
  64. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 453巻, 1号, pp. 1-6, 201410
  65. Silica and Double-Stranded RNA Synergistically Induce Bronchial Epithelial Apoptosis and Airway Inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51巻, 3号, pp. 344-353, 201409
  66. IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134巻, 8号, pp. 2122-2130, 201408
  67. Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation, IMMUNITY, 40巻, 5号, pp. 758-771, 201405
  68. Galectin-9 Enhances Cytokine Secretion, but Suppresses Survival and Degranulation, in Human Mast Cell Line, PLOS ONE, 9巻, 1号, pp. e86106, 201401
  69. IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet., American journal of physiology. Gastrointestinal and liver physiology, 305巻, 12号, pp. G891-G899, 201312
  70. Screening of novel malaria DNA vaccine candidates using full-length cDNA library, Experimental Parasitology, 135巻, 3号, pp. 546-550, 201311
  71. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes, EMBO MOLECULAR MEDICINE, 5巻, 11号, pp. 1720-1739, 201311
  72. GATA-1 regulates the generation and function of basophils, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110巻, 46号, pp. 18620-18625, 201311
  73. IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis, PLoS ONE, 8巻, 10号, pp. e78099, 20131025
  74. Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6-and IL-10-independent mechanisms, EXPERIMENTAL PARASITOLOGY, 135巻, 2号, pp. 388-396, 201310
  75. Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production., The Journal of investigative dermatology, 133巻, 9号, pp. 2170-2179, 201309
  76. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation, Journal of Immunology, 190巻, 9号, pp. 4489-4499, 20130501
  77. Role of Interleukin-33 in Innate-Type Immune Cells in Allergy, ALLERGOLOGY INTERNATIONAL, 62巻, 1号, pp. 13-20, 201303
  78. Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., Genes to cells : devoted to molecular & cellular mechanisms, 18巻, 1号, pp. 56-65, 201301
  79. Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin., International archives of allergy and immunology, 162巻, 2号, pp. 104-114, 2013
  80. Role of IL-25 and IL-33 in allergic diseases, Japanese Journal of Allergology, 62巻, 8号, pp. 924-935, 2013
  81. Interleukin-33 in allergy, ALLERGY, 67巻, 10号, pp. 1203-1214, 201210
  82. Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma, JOURNAL OF IMMUNOLOGY, 189巻, 7号, pp. 3641-3652, 201210
  83. Potential role of γδ T cell-derived IL-17 in acute cardiac allograft rejection., The Annals of thoracic surgery, 94巻, 2号, pp. 542-548, 201208
  84. Th17 cell-derived IL-17 is dispensable for B cell antibody production, CYTOKINE, 59巻, 1号, pp. 108-114, 201207
  85. ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, ALLERGOLOGY INTERNATIONAL, 61巻, 2号, pp. 265-273, 201206
  86. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness, JOURNAL OF IMMUNOLOGY, 188巻, 4号, pp. 1809-1818, 201202
  87. The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses., Science (New York, N.Y.), 335巻, 6071号, pp. 984-989, 201202
  88. Interleukin-17A is involved in enhancement of tumor progression in murine intestine, IMMUNOBIOLOGY, 217巻, 1号, pp. 54-60, 201201
  89. Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells, BONE MARROW TRANSPLANTATION, 46巻, 12号, pp. 1557-1565, 201112
  90. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 30巻, 12号, pp. 1409-1417, 201112
  91. N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria, EXPERIMENTAL PARASITOLOGY, 129巻, 3号, pp. 318-321, 201111
  92. Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion, CIRCULATION, 124巻, 11号, pp. S187-S196, 201109
  93. Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity, PLOS ONE, 6巻, 9号, pp. e25538, 201109
  94. Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils, JOURNAL OF IMMUNOLOGY, 186巻, 9号, pp. 5254-5260, 201105
  95. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology, JOURNAL OF EXPERIMENTAL MEDICINE, 208巻, 5号, pp. 1027-1040, 201105
  96. IL-33 and Airway Inflammation, ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 3巻, 2号, pp. 81-88, 201104
  97. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation., PloS one, 6巻, 4号, pp. e18404, 201104
  98. Functional Specialization of Interleukin-17 Family Members, IMMUNITY, 34巻, 2号, pp. 149-162, 201102
  99. Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation, Allergology International, 60巻, 3号, pp. 345-354, 2011
  100. Cimetidine enhances antigen-specific IgE and Th2 cytokine production, Allergology International, 60巻, 3号, pp. 339-344, 2011
  101. Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126巻, 6号, pp. 1252-U283, 201012
  102. IL-33 is a crucial amplifier of innate rather than acquired immunity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107巻, 43号, pp. 18581-18586, 201010
  103. Altered Effector CD4(+) T Cell Function in IL-21R(-/-) CD4(+) T Cell-Mediated Graft-Versus-Host Disease, JOURNAL OF IMMUNOLOGY, 185巻, 3号, pp. 1920-1926, 201008
  104. TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn(-/-) Mice, JOURNAL OF IMMUNOLOGY, 185巻, 3号, pp. 1887-1893, 201008
  105. IL-33-induced activation of human basophils and eosinophils via ST2, Inflammation and Regeneration, 30巻, pp. 181-185, 201005
  106. The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29巻, 4号, pp. 401-409, 201004
  107. Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung, JOURNAL OF IMMUNOLOGY, 184巻, 8号, pp. 4414-4422, 201004
  108. IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model, JOURNAL OF CLINICAL IMMUNOLOGY, 30巻, 2号, pp. 235-240, 201003
  109. IL-1 and allergy, Allergology International, 59巻, 2号, pp. 125-135, 2010
  110. IL-33 and IL-33 receptors in host defense and diseases, Allergology International, 59巻, 2号, pp. 143-160, 2010
  111. Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice, Allergology International, 59巻, 2号, pp. 207-211, 2010
  112. Amphiregulin is not essential for induction of contact hypersensitivity, Allergology International, 59巻, 3号, pp. 277-284, 2010
  113. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression, Allergology International, 59巻, 4号, pp. 399-408, 2010
  114. Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses, JOURNAL OF IMMUNOLOGY, 183巻, 11号, pp. 7523-7530, 200912
  115. Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages, JOURNAL OF IMMUNOLOGY, 183巻, 12号, pp. 7890-7897, 200912
  116. T(H)2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124巻, 3号, pp. 612-U328, 200909
  117. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse, GENE THERAPY, 16巻, 8号, pp. 982-989, 200908
  118. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB x NZB) F-1 male mice: a new mouse model, MODERN RHEUMATOLOGY, 19巻, 3号, pp. 316-322, 200906
  119. A protective function for interleukin 17A in T cell-mediated intestinal inflammation, NATURE IMMUNOLOGY, 10巻, 6号, pp. 603-U65, 200906
  120. Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction, JOURNAL OF EXPERIMENTAL MEDICINE, 206巻, 6号, pp. 1351-1364, 200906
  121. Differential Roles of Interleukin-17A and-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses, IMMUNITY, 30巻, 1号, pp. 108-119, 200901
  122. The roles of IL-17A in inflammatory immune responses and host defense against pathogens, IMMUNOLOGICAL REVIEWS, 226巻, pp. 57-79, 200812
  123. Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils, LABORATORY INVESTIGATION, 88巻, 11号, pp. 1245-1253, 200811
  124. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor., Journal of immunology (Baltimore, Md. : 1950), 181巻, 9号, pp. 5981-5989, 200811
  125. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver., Journal of immunology (Baltimore, Md. : 1950), 181巻, 5号, pp. 3456-63, 20080901
  126. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis, JOURNAL OF EXPERIMENTAL MEDICINE, 205巻, 10号, pp. 2207-2220, 200809
  127. Mast cells and T-cell expansion., Blood, 111巻, pp. 2947, 2008
  128. Role of regulatory and proinflammatory T-cell populations in allergic diseases., The World Allergy Organization journal, 1巻, 1号, pp. 9-14, 200801
  129. Th17 and allergy, Allergology International, 57巻, 2号, pp. 121-134, 2008
  130. IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc epsilon RI signals, JOURNAL OF LEUKOCYTE BIOLOGY, 82巻, 6号, pp. 1481-1490, 200712
  131. TIM-1 and TIM-3 enhancement of Th2 cytokine poduction by mast cells, BLOOD, 110巻, 7号, pp. 2565-2568, 200710
  132. IL-33 can promote survival, adhesion and cytokine production in human mast cells, LABORATORY INVESTIGATION, 87巻, 10号, pp. 971-978, 200710
  133. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B, NATURE IMMUNOLOGY, 8巻, 10号, pp. 1095-1104, 200710
  134. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and T(H)2 cytokine production in an asthma model in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 120巻, 1号, pp. 48-55, 200707
  135. Mast cells in the promotion and limitation of chronic inflammation, IMMUNOLOGICAL REVIEWS, 217巻, pp. 304-328, 200706
  136. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice, BLOOD, 109巻, 9号, pp. 3640-3648, 200705
  137. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17, JOURNAL OF LEUKOCYTE BIOLOGY, 81巻, 5号, pp. 1258-1268, 200705
  138. TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119巻, 3号, pp. 680-686, 200703
  139. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection., Journal of immunology (Baltimore, Md. : 1950), 178巻, 6号, pp. 3786-3796, 200703
  140. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice, AMERICAN JOURNAL OF PATHOLOGY, 169巻, 5号, pp. 1713-1721, 200611
  141. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis., Journal of immunology (Baltimore, Md. : 1950), 177巻, 1号, pp. 566-573, 200607
  142. IL-1 beta, but not IL-1 alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses, INTERNATIONAL IMMUNOLOGY, 18巻, 5号, pp. 701-712, 200605
  143. Mast cell-associated TNF promotes dendritic cell migration., Journal of immunology (Baltimore, Md. : 1950), 176巻, 7号, pp. 4102-4112, 200604
  144. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis, INTERNATIONAL IMMUNOLOGY, 18巻, 2号, pp. 399-407, 200602
  145. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF., Journal of immunology (Baltimore, Md. : 1950), 176巻, 4号, pp. 2238-2248, 200602
  146. RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103巻, 8号, pp. 2659-2664, 200602
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  148. Monomeric IgE enhances human mast cell chemokine production: ILA-4 augments and dexamethasone suppresses the response, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 116巻, 6号, pp. 1357-1363, 200512
  149. Mast cells enhance T cell activation: Importance of mast cell-derived TNF, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102巻, 18号, pp. 6467-6472, 200505
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  151. RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation., Novartis Foundation symposium, 271巻, pp. 115-24; discussion 124, 2005
  152. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease, BLOOD, 104巻, 12号, pp. 3789-3796, 200412
  153. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice, JOURNAL OF CLINICAL INVESTIGATION, 114巻, 11号, pp. 1603-1611, 200412
  154. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation., Journal of immunology (Baltimore, Md. : 1950), 173巻, 12号, pp. 7531-7538, 200412
  155. RabGEF1 is a negative regulator of mast cell activation and skin inflammation, NATURE IMMUNOLOGY, 5巻, 8号, pp. 844-852, 200408
  156. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice., Journal of immunology (Baltimore, Md. : 1950), 171巻, 11号, pp. 6173-6177, 200312
  157. Mast cells to the defense, NATURE IMMUNOLOGY, 4巻, 12号, pp. 1160-1162, 200312
  158. Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice, BLOOD, 102巻, 5号, pp. 1678-1685, 200309
  159. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100巻, 10号, pp. 5986-5990, 200305
  160. IL-1 is required for allergen-specific T(h)2 cell activation and the development of airway hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15巻, 4号, pp. 483-490, 200304
  161. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15巻, 2号, pp. 251-260, 200302
  162. Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses, IMMUNITY, 17巻, 3号, pp. 375-387, 200209
  163. Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production, IMMUNOLOGY, 104巻, 4号, pp. 402-409, 200112
  164. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity, INTERNATIONAL IMMUNOLOGY, 13巻, 12号, pp. 1471-1478, 200112
  165. IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells, JOURNAL OF IMMUNOLOGY, 167巻, 1号, pp. 90-97, 200107
  166. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice., J Exp Med, 191巻, 2号, pp. 313-320, 200001

受賞

  1. 2017年, Highly Cited Researchers
  2. 2016年, Highly Cited Researchers
  3. 2015年, Highly Cited Researchers
  4. 2014年, Highly Cited Researchers
  5. 2011年11月, 第21回 アボットジャパン・アレルギー学術奨励賞
  6. 2011年06月, Phadia Allergy Research Forum Award 2011
  7. 2010年06月, 第12回 花王研究奨励賞