SUSUMU NAKAE

Last Updated :2025/03/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
snakaehiroshima-u.ac.jp
Self-introduction
Our research focus is the understanding of pathogenesis of acute and chronic inflammatory disorders such as allergy and autoimmunity using gene-modified mice.

Basic Information

Academic Degrees

  • The University of Tokyo
  • The University of Tokyo

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Molecular Agro-Life Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

Research Fields

  • Biological Sciences;Laboratory animal science;Laboratory animal science
  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology

Research Keywords

  • mast cell
  • Th17 cells
  • Interleukin-33
  • Interleukin-17
  • Mouse models of human diseases
  • allergy
  • Cytokine

Affiliated Academic Societies

  • Collegium Internationale Allergologicum
  • JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
  • JAPANESE SOCIETY OF ALLERGOLOGY
  • THE JAPANESE SOCIETY FOR IMMUNOLOGY

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2024, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  3. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  4. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  5. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  6. 2024, Undergraduate Education, 4Term, Systemic Life Science
  7. 2024, Undergraduate Education, Intensive, Problem Based Learning for Molecular Agro-Life ScienceII
  8. 2024, Undergraduate Education, 4Term, Bio-Analytical Science
  9. 2024, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  10. 2024, Undergraduate Education, Intensive, (AIMS)Molecular Agro-life Science
  11. 2024, Undergraduate Education, Intensive, Molecular Agro-life Science
  12. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  13. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  14. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  15. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  16. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  17. 2024, Graduate Education (Master's Program) , 2Term, Applied Molecular Cell Biology I
  18. 2024, Graduate Education (Master's Program) , 4Term, Applied Molecular Cell Biology II
  19. 2024, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models

Research Activities

Academic Papers

  1. ★, Characterization of long-term interleukin-33 administration as an animal model of pulmonary arterial hypertension, Biochem Biophys Res Commun, 734, 150750-150750, 20240927
    Link to Paper Search Results by DOI
  2. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts, IMMUNITY, 57(8), 20240813
    Link to Paper Search Results by DOI
  3. The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 185(8), 752-760, 202408
    Link to Paper Search Results by DOI
  4. Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation, LIFE SCIENCE ALLIANCE, 7(9), 202409
    Link to Paper Search Results by DOI
  5. A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury, NATURE COMMUNICATIONS, 14(1), 20230905
    Link to Paper Search Results by DOI
  6. ★, Characterization of novel, severely immunodeficient Prkdcex57/ex57 mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 678, 193-199, 20231020
    Link to Paper Search Results by DOI
  7. Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s, ALLERGY, 78(7), 1878-1892, 202307
    Link to Paper Search Results by DOI
  8. Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas, JOURNAL OF IMMUNOLOGY, 210(10), 1552-1563, 20230515
    Link to Paper Search Results by DOI
  9. Measurement of human skin moisture via high-frequency spectroscopy, Anal Sci, 39(6), 851-856, 202306
    Link to Paper Search Results by DOI
  10. The roles of BST-2 in murine B cell development and on virus propagation, MICROBIOLOGY AND IMMUNOLOGY, 67(3), 105-113, 202303
    Link to Paper Search Results by DOI
  11. IL-33 deficiency suppresses alveolar bone loss in a ligature-induced periodontitis model, BIOMEDICAL RESEARCH-TOKYO, 44(1), 9-16, 2023
    Link to Paper Search Results by DOI
  12. ★, IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 628, 57-63, 20221105
    Link to Paper Search Results by DOI
  13. Heterogeneity of Group 2 Innate Lymphoid Cells Defines Their Pleiotropic Roles in Cancer, Obesity, and Cardiovascular Diseases, FRONTIERS IN IMMUNOLOGY, 13, 20220629
    Link to Paper Search Results by DOI
  14. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma., Sci Immunol, 7(72), eabl7209, 20220624
    Link to Paper Search Results by DOI
  15. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions., Allergy, 77(3), 843-855, 2022
    Link to Paper Search Results by DOI
  16. ★, Roles of Mast Cells in Cutaneous Diseases, FRONTIERS IN IMMUNOLOGY, 13, 20220706
    Link to Paper Search Results by DOI
  17. Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(3), 20220118
    Link to Paper Search Results by DOI
  18. Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases, ALLERGY, 76(11), 3332-3348, 202111
    Link to Paper Search Results by DOI
  19. Innate IL-17A Enhances IL-33-Independent Skin Eosinophilia and IgE Response on Subcutaneous Papain Sensitization, J Invest Dermatol, 141(1), 105-113, 2021
    Link to Paper Search Results by DOI
  20. A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain, Allergy, 76(1), 390-394, 2021
  21. Experimental Mouse Models of Ragweed- and Papain-Induced Allergic Conjunctivitis, Methods Mol Biol, 2223, 133-149, 2021
  22. ★, Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin, Sci Rep, 11(1), 5913, 2021
  23. Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases, Allergy, 2021
  24. Regulatory T Cells Exhibit Interleukin-33-Dependent Migratory Behavior during Skin Barrier Disruption., Int J Mol Sci, 22(14), 7443, 2021
  25. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions., Allergy, 2021
  26. New insights of human atopic dermatitis provided by mouse models., J Allergy Clin Immunol., 148(3), 722-724, 2021
  27. ★, Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia, Biochem Biophys Res Commun, 533(3), 493-500, 2020
  28. Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses., J Clin Invest, 130(7), 3919-3935, 2020
  29. TSLP is a negative regulator of RANKL-induced osteoclastogenesis, Biochem Biophys Res Commun, 530(3), 508-512, 2020
  30. Th2 signals are not essential for the anti-arthritic effects of Trichinella spiralis in mice., Parasite Immunol, 42(1), e12677, 2020
  31. ★, IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice., Sci Rep, 9(1), 17067, 2019
  32. Endogenous IL-33 exerts CD8+ T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model., Biochem Biophys Res Commun, 518(2), 331-336, 2019
  33. Innate Lymphoid Cells in the Induction of Obesity, Cell Rep, 28(1), 202-217, 2019
  34. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33., Allergy, 74(11), 2237-2240, 2019
  35. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium., Cell, 176(5), 982-997, 2019
  36. Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid., J Allergy Clin Immunol, 143(6), 2190-2201, 2019
  37. The roles of IL-17C in T cell-dependent and -independent inflammatory diseases., Scientific reports, 8(1), 15750-15750, 20181024
  38. IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity., Biochemical and biophysical research communications, 201810
  39. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities, Neuroscience, 385, 75-89, 20180810
  40. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs., Scientific reports, 8(1), 11721-11721, 20180806
  41. Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice., The Laryngoscope, 201808
  42. Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota., Nature immunology, 19(7), 755-765, 201807
  43. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity., Scientific reports, 8(1), 6639-6639, 20180427
  44. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients, Journal of Allergy and Clinical Immunology, 141(1), 300-310.e11, 20180101
  45. The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice, Allergology International, 67(3), 380-387, 2018
  46. IL-25 enhances TH17 cell–mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells, Journal of Allergy and Clinical Immunology, 2018
  47. IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation., Scientific Reports, 8(1), 18052, 2018
  48. Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice, Biochemistry and Biophysics Reports, 12, 62-65, 20171201
  49. A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease, SCIENTIFIC REPORTS, 7(1), 12765, 201710
  50. IL-33 in clinical practice: Size matters?, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 381-383, 201708
  51. Human eosinophils constitutively express a unique serine protease, PRSS33, ALLERGOLOGY INTERNATIONAL, 66(3), 463-471, 201707
  52. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(7), 1578-1582, 201707
  53. Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice, EXPERIMENTAL PARASITOLOGY, 177, 1-12, 201706
  54. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment, SCIENTIFIC REPORTS, 7(1), 4298, 201706
  55. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation, NATURE MEDICINE, 23(5), 611-+, 201705
  56. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy., JCI insight, 2(7), e90721, 20170406
  57. Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice, JOURNAL OF DERMATOLOGICAL SCIENCE, 85(2), 106-114, 201702
  58. Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(5), E741-E750, 201701
  59. Contributions of interleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival inflammation model, Immunity Inflammation and Disease, 5(4), 515-525, 2017
  60. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection., Immunity, inflammation and disease, 4(4), 401-412, 201612
  61. Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(5), 1395-+, 201611
  62. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens, ALLERGOLOGY INTERNATIONAL, 65(4), 459-465, 201610
  63. Regulatory roles of mast cells in immune responses, SEMINARS IN IMMUNOPATHOLOGY, 38(5), 623-629, 201609
  64. TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice., Biochemistry and biophysics reports, 7, 119-123, 201609
  65. Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(1), 135-142, 201609
  66. IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGF beta Release, PLOS ONE, 11(8), e0161507, 201608
  67. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(7), 1408-1417, 201607
  68. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(6), 1290-1292, 201606
  69. Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes, JOURNAL OF IMMUNOLOGY, 196(9), 3559-3569, 201605
  70. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages, NATURE COMMUNICATIONS, 7, 11385, 201605
  71. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria, Biochemistry and Biophysics Reports, 5, 191-195, 20160301
  72. Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis, PLOS PATHOGENS, 12(3), e1005507, 201603
  73. Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(6), E762-E771, 201602
  74. Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer, CELL DEATH & DISEASE, 7, e2057, 201601
  75. Interferon-gamma constrains cytokine production of group 2 innate lymphoid cells, IMMUNOLOGY, 147(1), 21-29, 201601
  76. Interleukin-33 in allergic diseases, Japanese Journal of Allergology, 65(10), 1269-1276, 2016
  77. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function, INFLAMMATORY BOWEL DISEASES, 21(12), 2737-2746, 201512
  78. Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(9), 5194-5202, 201508
  79. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms, JOURNAL OF CLINICAL INVESTIGATION, 125(7), 2579-2591, 201507
  80. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation, NATURE COMMUNICATIONS, 6, 7600, 201507
  81. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers, IMMUNITY, 43(1), 175-186, 201507
  82. IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, PLOS ONE, 10(7), e0134226, 201507
  83. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD, BLOOD, 125(20), 3183-3192, 201505
  84. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes, INTERNATIONAL IMMUNOLOGY, 27(4), 169-181, 201504
  85. The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice, PLOS ONE, 10(4), e0123584, 201504
  86. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells, NATURE IMMUNOLOGY, 16(3), 276-U239, 201503
  87. IL-33 Is Required for Disposal of Unnecessary Cells during Ovarian Atresia through Regulation of Autophagy and Macrophage Migration, JOURNAL OF IMMUNOLOGY, 194(5), 2140-2147, 201503
  88. Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice, PARASITOLOGY INTERNATIONAL, 64(1), 13-17, 201502
  89. The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway, IMMUNITY, 42(2), 294-308, 201502
  90. Emerging roles of IL-33 in inflammation and immune regulation., Inflammation and Regeneration, 35(2), 69-77, 2015
  91. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 453(1), 1-6, 201410
  92. Silica and Double-Stranded RNA Synergistically Induce Bronchial Epithelial Apoptosis and Airway Inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 344-353, 201409
  93. IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134(8), 2122-2130, 201408
  94. Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation, IMMUNITY, 40(5), 758-771, 201405
  95. Galectin-9 Enhances Cytokine Secretion, but Suppresses Survival and Degranulation, in Human Mast Cell Line, PLOS ONE, 9(1), e86106, 201401
  96. IFN-gamma deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(12), G891-G899, 201312
  97. Screening of novel malaria DNA vaccine candidates using full-length cDNA library, Experimental Parasitology, 135(3), 546-550, 201311
  98. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes, EMBO MOLECULAR MEDICINE, 5(11), 1720-1739, 201311
  99. GATA-1 regulates the generation and function of basophils, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(46), 18620-18625, 201311
  100. IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis, PLoS ONE, 8(10), e78099, 20131025
  101. Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6-and IL-10-independent mechanisms, EXPERIMENTAL PARASITOLOGY, 135(2), 388-396, 201310
  102. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(9), 2170-2179, 201309
  103. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation, Journal of Immunology, 190(9), 4489-4499, 20130501
  104. Role of Interleukin-33 in Innate-Type Immune Cells in Allergy, ALLERGOLOGY INTERNATIONAL, 62(1), 13-20, 201303
  105. Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., Genes to cells : devoted to molecular & cellular mechanisms, 18(1), 56-65, 201301
  106. Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin., International archives of allergy and immunology, 162(2), 104-114, 2013
  107. Role of IL-25 and IL-33 in allergic diseases, Japanese Journal of Allergology, 62(8), 924-935, 2013
  108. Interleukin-33 in allergy, ALLERGY, 67(10), 1203-1214, 201210
  109. Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma, JOURNAL OF IMMUNOLOGY, 189(7), 3641-3652, 201210
  110. Potential Role of gamma delta T Cell-Derived IL-17 in Acute Cardiac Allograft Rejection, ANNALS OF THORACIC SURGERY, 94(2), 542-548, 201208
  111. Th17 cell-derived IL-17 is dispensable for B cell antibody production, CYTOKINE, 59(1), 108-114, 201207
  112. ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, ALLERGOLOGY INTERNATIONAL, 61(2), 265-273, 201206
  113. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness, JOURNAL OF IMMUNOLOGY, 188(4), 1809-1818, 201202
  114. The Alarmin Interleukin-33 Drives Protective Antiviral CD8(+) T Cell Responses, SCIENCE, 335(6071), 984-989, 201202
  115. Interleukin-17A is involved in enhancement of tumor progression in murine intestine, IMMUNOBIOLOGY, 217(1), 54-60, 201201
  116. Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells, BONE MARROW TRANSPLANTATION, 46(12), 1557-1565, 201112
  117. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 30(12), 1409-1417, 201112
  118. N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria, EXPERIMENTAL PARASITOLOGY, 129(3), 318-321, 201111
  119. Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion, CIRCULATION, 124(11), S187-S196, 201109
  120. Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity, PLOS ONE, 6(9), e25538, 201109
  121. Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils, JOURNAL OF IMMUNOLOGY, 186(9), 5254-5260, 201105
  122. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology, JOURNAL OF EXPERIMENTAL MEDICINE, 208(5), 1027-1040, 201105
  123. IL-33 and Airway Inflammation, ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 3(2), 81-88, 201104
  124. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation., PloS one, 6(4), e18404, 201104
  125. Functional Specialization of Interleukin-17 Family Members, IMMUNITY, 34(2), 149-162, 201102
  126. Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation, Allergology International, 60(3), 345-354, 2011
  127. Cimetidine enhances antigen-specific IgE and Th2 cytokine production, Allergology International, 60(3), 339-344, 2011
  128. Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(6), 1252-U283, 201012
  129. IL-33 is a crucial amplifier of innate rather than acquired immunity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(43), 18581-18586, 201010
  130. Altered Effector CD4(+) T Cell Function in IL-21R(-/-) CD4(+) T Cell-Mediated Graft-Versus-Host Disease, JOURNAL OF IMMUNOLOGY, 185(3), 1920-1926, 201008
  131. TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn(-/-) Mice, JOURNAL OF IMMUNOLOGY, 185(3), 1887-1893, 201008
  132. IL-33-induced activation of human basophils and eosinophils via ST2, Inflammation and Regeneration, 30, 181-185, 201005
  133. The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(4), 401-409, 201004
  134. Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung, JOURNAL OF IMMUNOLOGY, 184(8), 4414-4422, 201004
  135. IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model, JOURNAL OF CLINICAL IMMUNOLOGY, 30(2), 235-240, 201003
  136. IL-1 and allergy, Allergology International, 59(2), 125-135, 2010
  137. IL-33 and IL-33 receptors in host defense and diseases, Allergology International, 59(2), 143-160, 2010
  138. Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice, Allergology International, 59(2), 207-211, 2010
  139. Amphiregulin is not essential for induction of contact hypersensitivity, Allergology International, 59(3), 277-284, 2010
  140. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression, Allergology International, 59(4), 399-408, 2010
  141. Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses, JOURNAL OF IMMUNOLOGY, 183(11), 7523-7530, 200912
  142. Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages, JOURNAL OF IMMUNOLOGY, 183(12), 7890-7897, 200912
  143. T(H)2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124(3), 612-U328, 200909
  144. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse, GENE THERAPY, 16(8), 982-989, 200908
  145. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB x NZB) F-1 male mice: a new mouse model, MODERN RHEUMATOLOGY, 19(3), 316-322, 200906
  146. A protective function for interleukin 17A in T cell-mediated intestinal inflammation, NATURE IMMUNOLOGY, 10(6), 603-U65, 200906
  147. Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction, JOURNAL OF EXPERIMENTAL MEDICINE, 206(6), 1351-1364, 200906
  148. Differential Roles of Interleukin-17A and-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses, IMMUNITY, 30(1), 108-119, 200901
  149. The roles of IL-17A in inflammatory immune responses and host defense against pathogens, IMMUNOLOGICAL REVIEWS, 226, 57-79, 200812
  150. Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils, LABORATORY INVESTIGATION, 88(11), 1245-1253, 200811
  151. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor., Journal of immunology (Baltimore, Md. : 1950), 181(9), 5981-5989, 200811
  152. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver., Journal of immunology (Baltimore, Md. : 1950), 181(5), 3456-63, 20080901
  153. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis, JOURNAL OF EXPERIMENTAL MEDICINE, 205(10), 2207-2220, 200809
  154. Role of regulatory and proinflammatory T-cell populations in allergic diseases., The World Allergy Organization journal, 1(1), 9-14, 200801
  155. Mast cells and T-cell expansion., Blood, 111, 2947, 2008
  156. Th17 and allergy, Allergology International, 57(2), 121-134, 2008
  157. IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc epsilon RI signals, JOURNAL OF LEUKOCYTE BIOLOGY, 82(6), 1481-1490, 200712
  158. TIM-1 and TIM-3 enhancement of Th2 cytokine poduction by mast cells, BLOOD, 110(7), 2565-2568, 200710
  159. IL-33 can promote survival, adhesion and cytokine production in human mast cells, LABORATORY INVESTIGATION, 87(10), 971-978, 200710
  160. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B, NATURE IMMUNOLOGY, 8(10), 1095-1104, 200710
  161. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and T(H)2 cytokine production in an asthma model in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 120(1), 48-55, 200707
  162. Mast cells in the promotion and limitation of chronic inflammation, IMMUNOLOGICAL REVIEWS, 217, 304-328, 200706
  163. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice, BLOOD, 109(9), 3640-3648, 200705
  164. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17, JOURNAL OF LEUKOCYTE BIOLOGY, 81(5), 1258-1268, 200705
  165. TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(3), 680-686, 200703
  166. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection., Journal of immunology (Baltimore, Md. : 1950), 178(6), 3786-3796, 200703
  167. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice, AMERICAN JOURNAL OF PATHOLOGY, 169(5), 1713-1721, 200611
  168. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis., Journal of immunology (Baltimore, Md. : 1950), 177(1), 566-573, 200607
  169. IL-1 beta, but not IL-1 alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses, INTERNATIONAL IMMUNOLOGY, 18(5), 701-712, 200605
  170. Mast cell-associated TNF promotes dendritic cell migration., Journal of immunology (Baltimore, Md. : 1950), 176(7), 4102-4112, 200604
  171. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis, INTERNATIONAL IMMUNOLOGY, 18(2), 399-407, 200602
  172. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF., Journal of immunology (Baltimore, Md. : 1950), 176(4), 2238-2248, 200602
  173. RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(8), 2659-2664, 200602
  174. TNF and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice., Ernst Schering Res Found Workshop, 56, 129-153, 2006
  175. Monomeric IgE enhances human mast cell chemokine production: ILA-4 augments and dexamethasone suppresses the response, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 116(6), 1357-1363, 200512
  176. Mast cells enhance T cell activation: Importance of mast cell-derived TNF, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(18), 6467-6472, 200505
  177. Mast cells in the development of adaptive immune responses, NATURE IMMUNOLOGY, 6(2), 135-142, 200502
  178. RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation., Novartis Foundation symposium, 271, 115-24; discussion 124, 2005
  179. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease, BLOOD, 104(12), 3789-3796, 200412
  180. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice, JOURNAL OF CLINICAL INVESTIGATION, 114(11), 1603-1611, 200412
  181. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation., Journal of immunology (Baltimore, Md. : 1950), 173(12), 7531-7538, 200412
  182. RabGEF1 is a negative regulator of mast cell activation and skin inflammation, NATURE IMMUNOLOGY, 5(8), 844-852, 200408
  183. Mast cells to the defense, NATURE IMMUNOLOGY, 4(12), 1160-1162, 200312
  184. Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice, BLOOD, 102(5), 1678-1685, 200309
  185. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(10), 5986-5990, 200305
  186. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice., Journal of immunology (Baltimore, Md. : 1950), 171(11), 6173-6177, 200312
  187. IL-1 is required for allergen-specific T(h)2 cell activation and the development of airway hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15(4), 483-490, 200304
  188. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15(2), 251-260, 200302
  189. Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses, IMMUNITY, 17(3), 375-387, 200209
  190. Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production, IMMUNOLOGY, 104(4), 402-409, 200112
  191. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity, INTERNATIONAL IMMUNOLOGY, 13(12), 1471-1478, 200112
  192. IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells, JOURNAL OF IMMUNOLOGY, 167(1), 90-97, 200107
  193. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice., J Exp Med, 191(2), 313-320, 200001

Publications such as books

  1. 2024/01/06, Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI), Physiology and pathology of innate lymphoid cells, ILC2s in pathogenesis of cardiovascular disease, 2024, 1, Scholarly Book, Joint work, J, Masashi Ikutani, Susumu Nakae, 0039-2359, 101, 5
  2. 2023/01/20, The Allergy in Practice, Regulation mechanism of ILC2, 2023, 1, J, Tatsukuni Ohno, Susumu Nakae, ISSN 0285-6379
  3. 2022/11/20, The Allergy in Practice, Mechanism of induction of chitin-mediated innate-type airway inflammation, 2022, 11, Joint work, J, Ken Arae, Susumu Nakae, ISSN 0285-6379
  4. 2020/08/25, Clinical Immunology & Allergology, IL-33 in allergy, 2020, 08, Takafumi Numata, Tatsukuni Ohno, Susumu Nakae, ISSN:1881-1930
  5. 2019/10/10, N/A, Th17 cells in immune responses in the skin., 2019, 10, Takafumi Numata, Susumu Nakae, ISBN 978-4-7792-2297-9
  6. 2019/06/10, Experimental Medicine, Role of IL-33, TSLP and IL-25 in allergy., 2019, 06, Tatsukuni Ohno, Takafumi Numata, Susumu Nakae, ISBN 978-4-7581-0379-4
  7. 2018/03/24, Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI), IL-33 as DAMPs., 2018, 03, Tatsukuni Ohno, Susumu Nakae, ISSN: 0039-2359
  8. 2017/12/01, THE LUNG perspectives, IL-33 in airway inflammation., 2017, 12, Ken Arae, Susumu Nakae, ISSN: 0909-5742
  9. 2017/03/20, The Allergy in Practice "Innate immunity in allergic diseases", Interleukin-33 in airway inflammation., 2017, 03, Ken Arae, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Susumu Nakae, ISSN: 0285-6379
  10. 2016/07/24, Japanese Journal of Allergology, Interleukin-33 in allergy., 2016, 7, Ken Arae, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Susumu Nakae, ISSN: 0021-4884
  11. 2016/07, N/A, IL-33 in mast cells., 2016, 07, Hideaki Morita, Sumika Toyama, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae, ISSN: 1348-7280
  12. 2016/09, N/A, Regulatory role of mast cells in airway inflammation., 2016, 09, Hideaki Morita, Susumu Nakae, Kenji Matsumoto, ISSN: 0386-9806
  13. 2016/07/10, Infection, Inflammation & Immunity, Regulatory role of IL-33-stimulated mast cells in airway inflammation., 2016, 07, Hideaki Morita, Kenji Matsumoto, Susumu Nakae, 0387-1010
  14. 2016/03/25, Clinical immunology & Allergology, Regulatory role of mast cells in airway inflammation., 2016, 03, Hideaki Morita, Susumu Nakae, Kenji Matsumoto, ISSN:1881-1930
  15. 2015/03/21, N/A, IL-33 in allergy., 2015, 03, Hirotoshi Unno, Kenji Matsumoto, Susumu Nakae
  16. 2015/03/21, N/A, IL-33, 2015, 03, Susumu Nakae, ISSN: 0039-2359
  17. 2014, The roles of IL-17A and IL-17F in infection and inflammatory disorders. In Cytokine Frontiers (ed. Y. Yoshimoto & Y. Yoshimoto)., Springer Science + Buisiness Media, LLC, New York, NY, 2014, Scholarly Book, Joint work, Ishigame H, Nakae S
  18. 2014/12/12, The Allergy in Practice "Allergic diseases and biological products", Basic medical pursuit of target molecules., 2014, 12, Maho Suzukawa, Susumu Nakae
  19. 2014/07/01, Respiratory Medical Resaerch, IL-17, 2014, 07, Maho Suzukawa, Susumu Nakae, ISSN: 2187-8560
  20. 2014/04, BIO Clinica "Innate immunity and diseases", DAMPs in allergic diseases., New Science Co., LTD., 2014, 04, Ken Arae, Hirotoshi Unno, Hideaki Morita, Kenji Matsumoto, Susumu Nakae
  21. 2013/10/18, Experimental Medicine, Role of DAMPs in allergic diseases., 2013, 10, Hirotoshi Unno, Hideaki Morita, Ken Arae, Tatsukuni Ohno, Hirohisa Saito, Kenji, Matsumoto, Susumu Nakae, ISBN 978-4-7581-0334-3
  22. 2013/10/18, Experimental Medicine, Eosinophils in chronic allergic diseases., 2013, 10, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto, Susumu Nakae, ISBN 978-4-7581-0334-3
  23. 2013/12/01, Japanese Journal of Allergology, Novel cytokines in allergy, 2013, 12, Hideaki Morita, Hirotoshi Unno, Ken Arae, Tatsukuni Ohno, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae, ISSN: 0021-4884
  24. 2013/03, The Medical Frontline, IL-33 in allergy, 2013, 03, Ken Arae, Hideaki Morita, Tatsukuni Ohno, Kenji Matsumoto, Susumu Nakae, ISSN: 0370-8241
  25. 2013/03/25, Clinical Immunology & Allergology, Mechanism of induction of IL-33 production from macrophages, 2013, 3, Tatsukuni Ohno, Hideaki Morita, Ken Arae, Miyuki Azuma, Susumu Nakae
  26. 2012/09/20, The Allergy in Practice, IL-33 in chronic allergic diseases., 2012, 09, Tatsukuni Ohno, Hideaki Morita, Ken Arae, Kenji Matsumoto, Susumu Nakae, ISSN 0285-6379
  27. 2012/11/20, Experimental Medicine, Role of IL-25 and IL-33 in innate lymphoid cells in infectious and allergic diseases., 2012, 11, Tatsukuni Ohno, Miyuki Azuma, Susumu Nakae, ISBN 978-4-7581-0090-8
  28. 2012/09/03, IgE practice in asthma, IL-33 in allerrgy, 2012, 09, Tatsukuni Ohno, Hideaki Morita, Ken Arae, Kenji Matsumoto, Susumu Nakae
  29. 2012/06/20, Inflammation & Immunity, Role of IL-33 in activation of mast cells and basophils in allergic diseases., 2012, 06, Hideaki Morita, Ken Arae, Tatsukuni Ohno, Kenji Matsumoto, Susumu Nakae, ISSN 0918-8371
  30. 2012/06/25, Clinical Immunology & Allergology, Mast cell activation by IL-33, 2012, 06, Ken Arae, Tatsukuni Ohno, Hideaki Morita, Kenji Matsumoto, Susumu Nakae, ISSN 1881-1930
  31. 2012, JEDCA, IL-17 in contact dermatitis, 2012, Eri Shimura, Susumu Nakae
  32. 2012/06/22, N/A, IL-31 in diseases., Aya Nambu, Susumu Nakae, ISBN_10:4-7809-0132-4
  33. 2012/03/19, Experimental Medicine, IL-33 in chronic allergic inflammation., 2012, 03, Tatsukuni Ohno, Miyuki Azuma, Susumu Nakae, ISBN 978-4-7581-0082-3
  34. 2011/11/10, N/A, Mechanism of Th17 cell-mediated allergic diseases., 2011, 11, Susumu Nakae, ISSN 0287-0185
  35. 2011/09/20, Experimental Medicine, N/A, 2011, 09, Aya Nambu, Susumu Nakae, ISBN 978-4-7581-0076-2
  36. 2011/03/01, Surface Science & Technology avant-grade, Role of IL-17 in the lung and skin., 2011, 03, Susumu Nakae, ISSN 0367-648X
  37. 2011/07/01, KASEAA, IL-17 in diseases., 2011, 07, Aya Nambu, Susumu Nakae, ISSN 0453-073X
  38. 2011/03/20, The Allergy in Practice, IL-17 in contact dermatitis, 2011, 03, Eri Shimura, Susumu Nakae, ISSN 0285-6379
  39. 2010/07/20, Experimental Medicine, Role of IL-33 and IL-33 receptor in development of diseases., 2010, 7, Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Hirohisa Saito, Susumu Nakae, ISBN 978-4-7581-0308-4
  40. The roles of IL-17A and IL-17F in mucosal infection and allergy. In Th17 cells in health and disease, (ed. S. Jiang), Springer Science + Buisiness Media, LLC, New York, NY, 2011, Scholarly Book, Joint work, Ishigame H, Nakae S, Iwakura Y
  41. 2010, Allergy From the Nose to the Lung, IL-33 in allergy., 2010, Keisuke Oboki, Susumu Nakae, ISBN 978-4-86034-283-8
  42. 2010/03/17, IgE practice in asthma, N/A, 2010, 03, Keisuke Oboki, Hirohisa Saito, Susumu Nakae
  43. 2010/01/25, Clinical Immunology & Allergology, Regulation of immune responses by mast cells., 2010, 01, Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Hirohisa Saito, Susumu Nakae
  44. 2010/01/05, Infection, Inflammation & Immunity, Th17 cells in inflammation, 2010, 01, Naoki Kajiwara, Keisuke Oboki, Susumu Nakae, ISSN 03871010
  45. 2009/12/04, N/A, IL-33 in allergy, 2009, 12, Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Hirohisa Saito, Susumu Nakae, ISBN 978-4-7581-0303-9
  46. 2009/12/04, N/A, Th17 cells in allergy, 2009, 12, Naoki Kajiwara, Keisuke Oboki, Tatsukuni Ohno, Hirohisa Saito, Susumu Nakae, ISBN 978-4-7581-0303-9
  47. 2009/07/25, Clinical Immunology & Allergology, Mast cells and Th17 cells in allergy, 2009, 7, Joint work, Naoki Kajiwara, Keisuke Oboki, Tatsukuni Ohno, Hirohisa Saito, Susumu Nakae
  48. 2008/12, Minophagen Medical Review, IL-17 and Th17 cells in immune responses, Minophagen Pharmaceutical Co., LTD., 2008, 12, Tatsukuni Ohno, Keisuke Oboki, Naoki Kajiwara, Hiroshisa Saito, Susumu Nakae
  49. 2008/08/15, SEITAI NO KAGAKU, Role of mast cells in development of Th17 cell-mediated airway inflammation., 2008, 08, Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Hirohisa Saito, Susumu Nakae, ISSN 0370-9531
  50. 2008/07/26, N/A, IL-17 and Th17 cells in allergic disorders, 2008, 7, Joint work, Keisuke Oboki, Tatsukuni Ohno, Hirohisa Saito, Susumu Nakae
  51. 2007/06/30, Medical Science Digest, Mechanism for allergic airway inflammation by IL-17 and mast cells., 2007, 6, Susumu Nakae, ISSN 1347-4340
  52. 2007/04/25, Clinical Immunology & Allergology, Mechanism for activation of T cells by mast cells, 2007, 4, Susumu Nakae, ISSN 1881-1930
  53. 2004/08/25, Clinical Immunology, Role of IL-17 in development of arthritis, 2004, 8, Single work, Susumu Nakae, ISSN 0386-9695
  54. 2003, The role of IL-1 in the immune system. In Cytokine Knockouts 2nd edition. (ed. G. Fantuzzi), Humana Press (Totowa, NJ), Scholarly Book, Joint work, Nakae S, Horai R, Komiyama Y, Nambu A, Asano M, Nakane A, Iwakura Y
  55. 2003/06, N/A, N/A, 2003, 6, Susumu Nakae
  56. 2002/08/25, Clinical Immunology, N/A, 2002, 8, Joint work, Susumu Nakae, Hiroshi Komiyama, Yoichiro Iwakura, ISSN 0386-9695
  57. 2000/04/25, Clinical Immunology, N/A, 2000, 4, Joint work, Susumu Nakae, Masahide Asano, Reiko Horai, Yoichiro Iwakura, ISSN 0386-9695

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of the IL-17 family of cytokines in dermatitis, Susumu Nakae, The 39th Annual Meeting of the Japanese Society for Psoriasis Research, 2024/08, With Invitation, Japanese, the Japanese Society for Psoriasis Research, Osaka
  2. Epithelial cells and cytokines, Susumu Nakae, 2023/10/20, With Invitation, Japanese, Tokyo
  3. Role of the IL-17 family of cytokines in dermatitis, Susumu Nakae, 2023/09/16, With Invitation, Japanese
  4. DAMP in allergic diseases, Susumu Nakae, 2023/07/22, With Invitation, Japanese
  5. Role of cytokines derived from epithelial cells in development of allergic diseases, Susumu Nakae, 2023/07/08, With Invitation, Japanese
  6. Role of the IL-17 family of cytokines in dermatitis Insights from mouse models, Susumu Nakae, The 5th International Conference on Cutaneous Lupus Erythematosus, 2023/05/10, With Invitation, English, The 5th International Conference on Cutaneous Lupus Erythematosus, Tokyo
  7. Analysis of the pathogenic mechanism of asthma-like airway inflammation induced by chitin, an environmental microparticle, Susumu Nakae, Ken Arae, 2020/12/02, Without Invitation, English
  8. Function of Bronchial Epithelial Cells in Asthma, Susumu Nakae, 2018 American Academy of Allergy Asthma & Immunology/World Allergy Organization Joint Congress, 2018/03/05, Without Invitation, English, American Academy of Allergy Asthma & Immunology World Allergy Organization, Orlando, Florida, USA
  9. IL-33 in Innate-Type Airway Inflammation, Susumu Nakae, 18th International Congress of Mucosal Immunology, 2017/07/21, Without Invitation, English, The Society for Mucosal Immunology, Washington DC, USA
  10. IL-33-mediated allergic inflammation, Susumu Nakae, The 23rd East Asia Joint Symposium, the 15th Cross-Strait Symposium on Biomedical Research and the 13th Symposium of the Frontiers of Biomedical Sciences, 2016/10/19, Without Invitation, Japanese
  11. Role of Interleukin-33 in Innate-Type Immune Cells in Allergy, Susumu Nakae, World Allergy Organization Symposium on Immunotherapy & Biologics, 2013/12/14, With Invitation, Japanese, World Allergy Organization, Chicago, USA
  12. IL-33 in inflammation, Susumu Nakae, International Endotoxin and Innate Immunity Society 2012, 2012/10/24, Without Invitation, Japanese, International Endotoxin and Innate Immunity Society, Tokyo
  13. Role of IL-33 in allergy, Susumu Nakae, 29th Symposium of the Collegium Internationale Allergologicum, 2012/10/17, With Invitation, English, Collegium Internationale Allergologicum, Korea
  14. IL-33, Susumu Nakae, XXII World Allergy Congress, 2011/12/04, With Invitation, English, World Allergy Organization, Mexico
  15. IL-33 in allergy, Susumu Nakae, 2011/10/21, Without Invitation, English, Uppsala University, Sweden
  16. IL-17 family cytokines in allergy, Susumu Nakae, 2011/10/20, Without Invitation, English, Karolinska Institute, Sweden
  17. Role of IL-17 in allergic airway inflammation, Susumu Nakae, The 17th East Asia Joint Symposium on Biomedical Research, 2010/06/01, Without Invitation, English, Taiwan

Awards

  1. 2017, Highly Cited Researchers
  2. 2016, Highly Cited Researchers
  3. 2015, Highly Cited Researchers
  4. 2014, Highly Cited Researchers
  5. 2011/06, Phadia Allergy Research Forum Award 2011

External Funds

Acceptance Results of Competitive Funds

  1. 2024/04, 2027/03
  2. 2021/04, 2024/03
  3. Strategic Basic Research Programs(PRESTO), 2020/04/01, 2022/03/31
  4. 2018/04, 2021/03
  5. 2012/03, 2013/04
  6. 2012/04, 2015/03
  7. 2011/10, 2016/03
  8. 2011/04, 2012/03
  9. 2009/04, 2012/03
  10. 2009/04, 2011/03

Social Activities

History as Committee Members

  1. Editorial Board Member, 2019/06, Scientific Reports

History as Peer Reviews of Academic Papers

  1. 2024, Allergol Int, Others, a reviewer, 2
  2. 2023, Biochem Biophys Res Commun, Others, a reviewer, 1