Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Our research focus is the understanding of pathogenesis of acute and chronic inflammatory disorders such as allergy and autoimmunity using gene-modified mice.

Basic Information

Academic Degrees

  • The University of Tokyo
  • The University of Tokyo

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Molecular Agro-Life Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

Research Fields

  • Biological Sciences;Laboratory animal science;Laboratory animal science
  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology

Research Keywords

  • mast cell
  • Th17 cells
  • Interleukin-33
  • Interleukin-17
  • Mouse models of human diseases
  • allergy
  • Cytokine

Affiliated Academic Societies

  • Collegium Internationale Allergologicum

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  2. 2022, Undergraduate Education, Second Semester, Graduation Thesis I
  3. 2022, Undergraduate Education, First Semester, Graduation Thesis II
  4. 2022, Undergraduate Education, 4Term, Systemic Life Science
  5. 2022, Undergraduate Education, Intensive, Problem Based Learning for Molecular Agro-Life ScienceII
  6. 2022, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  7. 2022, Undergraduate Education, First Semester, Graduate Thesis I
  8. 2022, Undergraduate Education, Second Semester, Graduate Thesis II
  9. 2022, Undergraduate Education, Intensive, (AIMS)Molecular Agro-life Science
  10. 2022, Undergraduate Education, 3Term, Molecular Agro-life Science
  11. 2022, Graduate Education (Master's Program) , 2Term, Applied Molecular Cell Biology I
  12. 2022, Graduate Education (Master's Program) , 4Term, Applied Molecular Cell Biology II
  13. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  14. 2022, Liberal Arts Education Program1, 1Term, Introduction to Applied Biological Sciences toward SDGs
  15. 2022, Undergraduate Education, 1Term, Introduction to Applied Biological Sciences
  16. 2022, Undergraduate Education, 3Term, Research Front of Applied Biological Science

Research Activities

Academic Papers

  1. ★, IL-25 contribute to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice., Biochem Biophys Res Commun, 628, 57-63, 20220828
  2. ★, Heterogeneity of Group 2 Innate Lymphoid Cells Defines Their Pleiotropic Roles in Cancer, Obesity, and Cardiovascular Diseases., Front Immunol., 13, 923495, 20220606
  3. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma., Sci Immunol, 7(72), eabl7209, 20220624
  4. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions., Allergy, 77(3), 843-855, 2022
  5. ★, Roles of Mast Cells in Cutaneous Diseases, FRONTIERS IN IMMUNOLOGY, 13, 20220706
  6. Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(3), 20220118
  7. Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases, ALLERGY, 76(11), 3332-3348, 202111
  8. Innate IL-17A Enhances IL-33-Independent Skin Eosinophilia and IgE Response on Subcutaneous Papain Sensitization, J Invest Dermatol, 141(1), 105-113, 2021
  9. A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain, Allergy, 76(1), 390-394, 2021
  10. Experimental Mouse Models of Ragweed- and Papain-Induced Allergic Conjunctivitis, Methods Mol Biol, 2223, 133-149, 2021
  11. ★, Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin, Sci Rep, 11(1), 5913, 2021
  12. Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases, Allergy, 2021
  13. Regulatory T Cells Exhibit Interleukin-33-Dependent Migratory Behavior during Skin Barrier Disruption., Int J Mol Sci, 22(14), 7443, 2021
  14. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions., Allergy, 2021
  15. New insights of human atopic dermatitis provided by mouse models., J Allergy Clin Immunol., 148(3), 722-724, 2021
  16. ★, Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia, Biochem Biophys Res Commun, 533(3), 493-500, 2020
  17. Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses., J Clin Invest, 130(7), 3919-3935, 2020
  18. TSLP is a negative regulator of RANKL-induced osteoclastogenesis, Biochem Biophys Res Commun, 530(3), 508-512, 2020
  19. Th2 signals are not essential for the anti-arthritic effects of Trichinella spiralis in mice., Parasite Immunol, 42(1), e12677, 2020
  20. ★, IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice., Sci Rep, 9(1), 17067, 2019
  21. Endogenous IL-33 exerts CD8+ T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model., Biochem Biophys Res Commun, 518(2), 331-336, 2019
  22. Innate Lymphoid Cells in the Induction of Obesity, Cell Rep, 28(1), 202-217, 2019
  23. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33., Allergy, 74(11), 2237-2240, 2019
  24. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium., Cell, 176(5), 982-997, 2019
  25. Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid., J Allergy Clin Immunol, 143(6), 2190-2201, 2019
  26. The roles of IL-17C in T cell-dependent and -independent inflammatory diseases., Scientific reports, 8(1), 15750-15750, 20181024
  27. IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity., Biochemical and biophysical research communications, 201810
  28. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities, Neuroscience, 385, 75-89, 20180810
  29. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs., Scientific reports, 8(1), 11721-11721, 20180806
  30. Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice., The Laryngoscope, 201808
  31. Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota., Nature immunology, 19(7), 755-765, 201807
  32. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity., Scientific reports, 8(1), 6639-6639, 20180427
  33. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients, Journal of Allergy and Clinical Immunology, 141(1), 300-310.e11, 20180101
  34. The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice, Allergology International, 67(3), 380-387, 2018
  35. IL-25 enhances TH17 cell–mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells, Journal of Allergy and Clinical Immunology, 2018
  36. IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation., Scientific Reports, 8(1), 18052, 2018
  37. Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice, Biochemistry and Biophysics Reports, 12, 62-65, 20171201
  38. A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease, SCIENTIFIC REPORTS, 7(1), 12765, 201710
  39. IL-33 in clinical practice: Size matters?, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 381-383, 201708
  40. Human eosinophils constitutively express a unique serine protease, PRSS33, ALLERGOLOGY INTERNATIONAL, 66(3), 463-471, 201707
  41. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(7), 1578-1582, 201707
  42. Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice, EXPERIMENTAL PARASITOLOGY, 177, 1-12, 201706
  43. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment, SCIENTIFIC REPORTS, 7(1), 4298, 201706
  44. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation, NATURE MEDICINE, 23(5), 611-+, 201705
  45. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy., JCI insight, 2(7), e90721, 20170406
  46. Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice, JOURNAL OF DERMATOLOGICAL SCIENCE, 85(2), 106-114, 201702
  47. Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(5), E741-E750, 201701
  48. Contributions of interleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival inflammation model, Immunity Inflammation and Disease, 5(4), 515-525, 2017
  49. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection., Immunity, inflammation and disease, 4(4), 401-412, 201612
  50. Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(5), 1395-+, 201611
  51. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens, ALLERGOLOGY INTERNATIONAL, 65(4), 459-465, 201610
  52. Regulatory roles of mast cells in immune responses, SEMINARS IN IMMUNOPATHOLOGY, 38(5), 623-629, 201609
  53. TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice., Biochemistry and biophysics reports, 7, 119-123, 201609
  54. Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(1), 135-142, 201609
  55. IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGF beta Release, PLOS ONE, 11(8), e0161507, 201608
  56. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(7), 1408-1417, 201607
  57. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(6), 1290-1292, 201606
  58. Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes, JOURNAL OF IMMUNOLOGY, 196(9), 3559-3569, 201605
  59. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages, NATURE COMMUNICATIONS, 7, 11385, 201605
  60. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria, Biochemistry and Biophysics Reports, 5, 191-195, 20160301
  61. Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis, PLOS PATHOGENS, 12(3), e1005507, 201603
  62. Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(6), E762-E771, 201602
  63. Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer, CELL DEATH & DISEASE, 7, e2057, 201601
  64. Interferon-gamma constrains cytokine production of group 2 innate lymphoid cells, IMMUNOLOGY, 147(1), 21-29, 201601
  65. Interleukin-33 in allergic diseases, Japanese Journal of Allergology, 65(10), 1269-1276, 2016
  66. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function, INFLAMMATORY BOWEL DISEASES, 21(12), 2737-2746, 201512
  67. Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(9), 5194-5202, 201508
  68. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms, JOURNAL OF CLINICAL INVESTIGATION, 125(7), 2579-2591, 201507
  69. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation, NATURE COMMUNICATIONS, 6, 7600, 201507
  70. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers, IMMUNITY, 43(1), 175-186, 201507
  71. IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, PLOS ONE, 10(7), e0134226, 201507
  72. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD, BLOOD, 125(20), 3183-3192, 201505
  73. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes, INTERNATIONAL IMMUNOLOGY, 27(4), 169-181, 201504
  74. The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice, PLOS ONE, 10(4), e0123584, 201504
  75. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells, NATURE IMMUNOLOGY, 16(3), 276-U239, 201503
  76. IL-33 Is Required for Disposal of Unnecessary Cells during Ovarian Atresia through Regulation of Autophagy and Macrophage Migration, JOURNAL OF IMMUNOLOGY, 194(5), 2140-2147, 201503
  77. Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice, PARASITOLOGY INTERNATIONAL, 64(1), 13-17, 201502
  78. The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway, IMMUNITY, 42(2), 294-308, 201502
  79. Emerging roles of IL-33 in inflammation and immune regulation., Inflammation and Regeneration, 35(2), 69-77, 2015
  80. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 453(1), 1-6, 201410
  81. Silica and Double-Stranded RNA Synergistically Induce Bronchial Epithelial Apoptosis and Airway Inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 344-353, 201409
  82. IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134(8), 2122-2130, 201408
  83. Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation, IMMUNITY, 40(5), 758-771, 201405
  84. Galectin-9 Enhances Cytokine Secretion, but Suppresses Survival and Degranulation, in Human Mast Cell Line, PLOS ONE, 9(1), e86106, 201401
  85. IFN-gamma deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(12), G891-G899, 201312
  86. Screening of novel malaria DNA vaccine candidates using full-length cDNA library, Experimental Parasitology, 135(3), 546-550, 201311
  87. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes, EMBO MOLECULAR MEDICINE, 5(11), 1720-1739, 201311
  88. GATA-1 regulates the generation and function of basophils, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(46), 18620-18625, 201311
  89. IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis, PLoS ONE, 8(10), e78099, 20131025
  90. Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6-and IL-10-independent mechanisms, EXPERIMENTAL PARASITOLOGY, 135(2), 388-396, 201310
  91. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(9), 2170-2179, 201309
  92. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation, Journal of Immunology, 190(9), 4489-4499, 20130501
  93. Role of Interleukin-33 in Innate-Type Immune Cells in Allergy, ALLERGOLOGY INTERNATIONAL, 62(1), 13-20, 201303
  94. Dok adaptors play anti-inflammatory roles in pulmonary homeostasis., Genes to cells : devoted to molecular & cellular mechanisms, 18(1), 56-65, 201301
  95. Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin., International archives of allergy and immunology, 162(2), 104-114, 2013
  96. Role of IL-25 and IL-33 in allergic diseases, Japanese Journal of Allergology, 62(8), 924-935, 2013
  97. Interleukin-33 in allergy, ALLERGY, 67(10), 1203-1214, 201210
  98. Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma, JOURNAL OF IMMUNOLOGY, 189(7), 3641-3652, 201210
  99. Potential Role of gamma delta T Cell-Derived IL-17 in Acute Cardiac Allograft Rejection, ANNALS OF THORACIC SURGERY, 94(2), 542-548, 201208
  100. Th17 cell-derived IL-17 is dispensable for B cell antibody production, CYTOKINE, 59(1), 108-114, 201207
  101. ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice, ALLERGOLOGY INTERNATIONAL, 61(2), 265-273, 201206
  102. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness, JOURNAL OF IMMUNOLOGY, 188(4), 1809-1818, 201202
  103. The Alarmin Interleukin-33 Drives Protective Antiviral CD8(+) T Cell Responses, SCIENCE, 335(6071), 984-989, 201202
  104. Interleukin-17A is involved in enhancement of tumor progression in murine intestine, IMMUNOBIOLOGY, 217(1), 54-60, 201201
  105. Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells, BONE MARROW TRANSPLANTATION, 46(12), 1557-1565, 201112
  106. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 30(12), 1409-1417, 201112
  107. N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria, EXPERIMENTAL PARASITOLOGY, 129(3), 318-321, 201111
  108. Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion, CIRCULATION, 124(11), S187-S196, 201109
  109. Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity, PLOS ONE, 6(9), e25538, 201109
  110. Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils, JOURNAL OF IMMUNOLOGY, 186(9), 5254-5260, 201105
  111. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology, JOURNAL OF EXPERIMENTAL MEDICINE, 208(5), 1027-1040, 201105
  112. IL-33 and Airway Inflammation, ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 3(2), 81-88, 201104
  113. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation., PloS one, 6(4), e18404, 201104
  114. Functional Specialization of Interleukin-17 Family Members, IMMUNITY, 34(2), 149-162, 201102
  115. Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation, Allergology International, 60(3), 345-354, 2011
  116. Cimetidine enhances antigen-specific IgE and Th2 cytokine production, Allergology International, 60(3), 339-344, 2011
  117. Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(6), 1252-U283, 201012
  118. IL-33 is a crucial amplifier of innate rather than acquired immunity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(43), 18581-18586, 201010
  119. Altered Effector CD4(+) T Cell Function in IL-21R(-/-) CD4(+) T Cell-Mediated Graft-Versus-Host Disease, JOURNAL OF IMMUNOLOGY, 185(3), 1920-1926, 201008
  120. TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn(-/-) Mice, JOURNAL OF IMMUNOLOGY, 185(3), 1887-1893, 201008
  121. IL-33-induced activation of human basophils and eosinophils via ST2, Inflammation and Regeneration, 30, 181-185, 201005
  122. The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(4), 401-409, 201004
  123. Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung, JOURNAL OF IMMUNOLOGY, 184(8), 4414-4422, 201004
  124. IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model, JOURNAL OF CLINICAL IMMUNOLOGY, 30(2), 235-240, 201003
  125. IL-1 and allergy, Allergology International, 59(2), 125-135, 2010
  126. IL-33 and IL-33 receptors in host defense and diseases, Allergology International, 59(2), 143-160, 2010
  127. Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice, Allergology International, 59(2), 207-211, 2010
  128. Amphiregulin is not essential for induction of contact hypersensitivity, Allergology International, 59(3), 277-284, 2010
  129. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression, Allergology International, 59(4), 399-408, 2010
  130. Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses, JOURNAL OF IMMUNOLOGY, 183(11), 7523-7530, 200912
  131. Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages, JOURNAL OF IMMUNOLOGY, 183(12), 7890-7897, 200912
  132. T(H)2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124(3), 612-U328, 200909
  133. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse, GENE THERAPY, 16(8), 982-989, 200908
  134. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB x NZB) F-1 male mice: a new mouse model, MODERN RHEUMATOLOGY, 19(3), 316-322, 200906
  135. A protective function for interleukin 17A in T cell-mediated intestinal inflammation, NATURE IMMUNOLOGY, 10(6), 603-U65, 200906
  136. Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction, JOURNAL OF EXPERIMENTAL MEDICINE, 206(6), 1351-1364, 200906
  137. Differential Roles of Interleukin-17A and-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses, IMMUNITY, 30(1), 108-119, 200901
  138. The roles of IL-17A in inflammatory immune responses and host defense against pathogens, IMMUNOLOGICAL REVIEWS, 226, 57-79, 200812
  139. Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils, LABORATORY INVESTIGATION, 88(11), 1245-1253, 200811
  140. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor., Journal of immunology (Baltimore, Md. : 1950), 181(9), 5981-5989, 200811
  141. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver., Journal of immunology (Baltimore, Md. : 1950), 181(5), 3456-63, 20080901
  142. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis, JOURNAL OF EXPERIMENTAL MEDICINE, 205(10), 2207-2220, 200809
  143. Role of regulatory and proinflammatory T-cell populations in allergic diseases., The World Allergy Organization journal, 1(1), 9-14, 200801
  144. Mast cells and T-cell expansion., Blood, 111, 2947, 2008
  145. Th17 and allergy, Allergology International, 57(2), 121-134, 2008
  146. IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc epsilon RI signals, JOURNAL OF LEUKOCYTE BIOLOGY, 82(6), 1481-1490, 200712
  147. TIM-1 and TIM-3 enhancement of Th2 cytokine poduction by mast cells, BLOOD, 110(7), 2565-2568, 200710
  148. IL-33 can promote survival, adhesion and cytokine production in human mast cells, LABORATORY INVESTIGATION, 87(10), 971-978, 200710
  149. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B, NATURE IMMUNOLOGY, 8(10), 1095-1104, 200710
  150. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and T(H)2 cytokine production in an asthma model in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 120(1), 48-55, 200707
  151. Mast cells in the promotion and limitation of chronic inflammation, IMMUNOLOGICAL REVIEWS, 217, 304-328, 200706
  152. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice, BLOOD, 109(9), 3640-3648, 200705
  153. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17, JOURNAL OF LEUKOCYTE BIOLOGY, 81(5), 1258-1268, 200705
  154. TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(3), 680-686, 200703
  155. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection., Journal of immunology (Baltimore, Md. : 1950), 178(6), 3786-3796, 200703
  156. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice, AMERICAN JOURNAL OF PATHOLOGY, 169(5), 1713-1721, 200611
  157. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis., Journal of immunology (Baltimore, Md. : 1950), 177(1), 566-573, 200607
  158. IL-1 beta, but not IL-1 alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses, INTERNATIONAL IMMUNOLOGY, 18(5), 701-712, 200605
  159. Mast cell-associated TNF promotes dendritic cell migration., Journal of immunology (Baltimore, Md. : 1950), 176(7), 4102-4112, 200604
  160. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis, INTERNATIONAL IMMUNOLOGY, 18(2), 399-407, 200602
  161. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF., Journal of immunology (Baltimore, Md. : 1950), 176(4), 2238-2248, 200602
  162. RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(8), 2659-2664, 200602
  163. TNF and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice., Ernst Schering Res Found Workshop, 56, 129-153, 2006
  164. Monomeric IgE enhances human mast cell chemokine production: ILA-4 augments and dexamethasone suppresses the response, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 116(6), 1357-1363, 200512
  165. Mast cells enhance T cell activation: Importance of mast cell-derived TNF, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(18), 6467-6472, 200505
  166. Mast cells in the development of adaptive immune responses, NATURE IMMUNOLOGY, 6(2), 135-142, 200502
  167. RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation., Novartis Foundation symposium, 271, 115-24; discussion 124, 2005
  168. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease, BLOOD, 104(12), 3789-3796, 200412
  169. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice, JOURNAL OF CLINICAL INVESTIGATION, 114(11), 1603-1611, 200412
  170. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation., Journal of immunology (Baltimore, Md. : 1950), 173(12), 7531-7538, 200412
  171. RabGEF1 is a negative regulator of mast cell activation and skin inflammation, NATURE IMMUNOLOGY, 5(8), 844-852, 200408
  172. Mast cells to the defense, NATURE IMMUNOLOGY, 4(12), 1160-1162, 200312
  173. Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice, BLOOD, 102(5), 1678-1685, 200309
  174. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(10), 5986-5990, 200305
  175. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice., Journal of immunology (Baltimore, Md. : 1950), 171(11), 6173-6177, 200312
  176. IL-1 is required for allergen-specific T(h)2 cell activation and the development of airway hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15(4), 483-490, 200304
  177. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response, INTERNATIONAL IMMUNOLOGY, 15(2), 251-260, 200302
  178. Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses, IMMUNITY, 17(3), 375-387, 200209
  179. Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production, IMMUNOLOGY, 104(4), 402-409, 200112
  180. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity, INTERNATIONAL IMMUNOLOGY, 13(12), 1471-1478, 200112
  181. IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells, JOURNAL OF IMMUNOLOGY, 167(1), 90-97, 200107
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Publications such as books

  1. 2014, The roles of IL-17A and IL-17F in infection and inflammatory disorders. In Cytokine Frontiers (ed. Y. Yoshimoto & Y. Yoshimoto)., Springer Science + Buisiness Media, LLC, New York, NY, 2014, Scholarly Book, Joint work, Ishigame H, Nakae S
  2. The roles of IL-17A and IL-17F in mucosal infection and allergy. In Th17 cells in health and disease, (ed. S. Jiang), Springer Science + Buisiness Media, LLC, New York, NY, 2011, Scholarly Book, Joint work, Ishigame H, Nakae S, Iwakura Y
  3. 2003, The role of IL-1 in the immune system. In Cytokine Knockouts 2nd edition. (ed. G. Fantuzzi), Humana Press (Totowa, NJ), Scholarly Book, Joint work, Nakae S, Horai R, Komiyama Y, Nambu A, Asano M, Nakane A, Iwakura Y

Invited Lecture, Oral Presentation, Poster Presentation

  1. Analysis of the pathogenic mechanism of asthma-like airway inflammation induced by chitin, an environmental microparticle, Susumu Nakae, Ken Arae, 2020/12/02, Without Invitation, English
  2. Function of Bronchial Epithelial Cells in Asthma, Susumu Nakae, 2018 American Academy of Allergy Asthma & Immunology/World Allergy Organization Joint Congress, 2018/03/05, Without Invitation, English, American Academy of Allergy Asthma & Immunology World Allergy Organization, Orlando, Florida, USA
  3. IL-33 in Innate-Type Airway Inflammation, Susumu Nakae, 18th International Congress of Mucosal Immunology, 2017/07/21, Without Invitation, English, The Society for Mucosal Immunology, Washington DC, USA
  4. IL-33-mediated allergic inflammation, Susumu Nakae, The 23rd East Asia Joint Symposium, the 15th Cross-Strait Symposium on Biomedical Research and the 13th Symposium of the Frontiers of Biomedical Sciences, 2016/10/19, Without Invitation, Japanese
  5. Role of Interleukin-33 in Innate-Type Immune Cells in Allergy, Susumu Nakae, World Allergy Organization Symposium on Immunotherapy & Biologics, 2013/12/14, With Invitation, Japanese, World Allergy Organization, Chicago, USA
  6. IL-33 in inflammation, Susumu Nakae, International Endotoxin and Innate Immunity Society 2012, 2012/10/24, Without Invitation, Japanese, International Endotoxin and Innate Immunity Society, Tokyo
  7. Role of IL-33 in allergy, Susumu Nakae, 29th Symposium of the Collegium Internationale Allergologicum, 2012/10/17, With Invitation, English, Collegium Internationale Allergologicum, Korea
  8. IL-33, Susumu Nakae, XXII World Allergy Congress, 2011/12/04, With Invitation, English, World Allergy Organization, Mexico
  9. IL-33 in allergy, Susumu Nakae, 2011/10/21, Without Invitation, English, Uppsala University, Sweden
  10. IL-17 family cytokines in allergy, Susumu Nakae, 2011/10/20, Without Invitation, English, Karolinska Institute, Sweden
  11. Role of IL-17 in allergic airway inflammation, Susumu Nakae, The 17th East Asia Joint Symposium on Biomedical Research, 2010/06/01, Without Invitation, English, Taiwan


  1. 2017, Highly Cited Researchers
  2. 2016, Highly Cited Researchers
  3. 2015, Highly Cited Researchers
  4. 2014, Highly Cited Researchers
  5. 2011/06, Phadia Allergy Research Forum Award 2011

External Funds

Acceptance Results of Competitive Funds

  1. 2021/04, 2024/03
  2. Strategic Basic Research Programs(PRESTO), 2020/04/01, 2022/03/31
  3. 2018/04, 2021/03
  4. 2012/03, 2013/04
  5. 2012/04, 2015/03
  6. 2011/10, 2016/03
  7. 2011/04, 2012/03
  8. 2009/04, 2012/03
  9. 2009/04, 2011/03

Social Activities

History as Committee Members

  1. Editorial Board Member, 2019/06, Scientific Reports