的場 優介YUSUKE MATOBA

Last Updated :2025/02/03

所属・職名
病院(医) 助教
メールアドレス
ymtbhiroshima-u.ac.jp
自己紹介
産婦人科医/研究者 【研究テーマ】 - 婦人科疾患の病態解明 - 難治性婦人科悪性腫瘍に対する新規治療法の開発 - 子宮再生 - 子宮移植

基本情報

主な職歴

  • 2024年07月01日, 広島大学, 病院, 助教
  • 2021年07月01日, 2024年06月30日, Massachusetts General Hospital, Vincent Center for Reproductive Biology, Research Fellow
  • 2016年04月01日, 2021年03月31日, 慶應義塾大学医学部産婦人科学教室, 助教
  • 2015年04月01日, 2016年03月31日, 川崎市立川崎病院, 産婦人科, 医員
  • 2014年04月01日, 2015年03月31日, 国家公務員共済組合連合会立川病院, 産婦人科, 医員
  • 2013年04月01日, 2014年03月31日, 慶應義塾大学医学部産婦人科学教室, 助教
  • 2011年04月01日, 2013年03月31日, 亀田総合病院, 初期研修医

学歴

  • 慶應義塾大学大学院, 医学研究科, 博士課程医療科学系専攻, 日本, 2017年04月01日, 2020年09月30日
  • 慶應義塾大学医学部, 医学科, 日本, 2005年04月01日, 2011年03月31日

学位

  • 博士(医学) (慶應義塾大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 産婦人科学

研究キーワード

  • 子宮、卵巣、子宮体がん、卵巣がん、婦人科良性疾患、婦人科悪性疾患、子宮内膜症、子宮腺筋症、ガレクチン3、化学療法、免疫療法、分子細胞生物学、トランスレーショナルリサーチ、臨床研究、再生医療

所属学会

  • 日本産科婦人科内視鏡学会
  • 日本臨床細胞学会
  • 日本婦人科腫瘍学会
  • 日本産科婦人科学会

研究活動

学術論文(★は代表的な論文)

  1. High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options, Reprod Sci, 20240424
  2. ★, Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma, British Journal of Cancer, 20240304
  3. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells., Nature Metabolism, 20231113
  4. The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer., Cancer Drug Resist, 20230614
  5. Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway., Cell, 20230525
  6. Graft Failure after Uterus Transplantation in 16 Recipients: A Review., J Clin Med, 20230303
  7. Massive Hemorrhage Due to Cervical Endometriotic Cyst Rupture: Two Case Reports and a Literature Review, Am J Case Rep, 20221124
  8. Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application, Keio J Med, 20220625
  9. Meningitis caused by Listeria monocytogenes in a locally advanced cervical cancer patient with pyometra: A case report., Gynecol Oncol Rep, 20210529
  10. Evaluation of safety and diagnostic performance for flexible hysteroscopy in 1591 outpatient cases, Jpn J Clin Oncol, 20200928
  11. ★, Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases., Journal of Minimally Invasive Gynecology, 20190812
  12. Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: a retrospective study, J Obstet Gynaecol, 202208
  13. Hysteroscopic treatment assisted by photodynamic diagnosis for atypical polypoid adenomyoma: A report of two cases., Photodiagnosis Photodyn Ther, 202112
  14. Initiatives and achievements of the Japanese Society of Obstetrics and Gynecology, Obstetrics and Gynecology MIRAI Committee 2020, J Obstet Gynaecol Res, 202106
  15. A survey of Japanese interns to prepare for mandatory clinical training in obstetrics and gynecology., J Obstet Gynaecol Res, 2021
  16. Operative and Clinical Outcomes of Minimally Invasive Living-Donor Surgery on Uterus Transplantation: A Literature Review., J Clin Med., 2021
  17. Concerns Associated with Uterus Transplantation in Japan., Keio J Med, 2021
  18. Complete resection of an endometrial cancer lesion by hysteroscopic tumor resection combined with photodynamic diagnosis: a case report., Eur J Gynaecol Oncol, 2020
  19. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques., J Clin Med, 2020
  20. Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques, J Obstet Gynaecol Res, 2020
  21. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques, Sci Rep, 2020
  22. Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report, Photodiagnosis Photodyn Ther, 2019
  23. Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid, Photodiagnosis Photodyn Ther, 2019
  24. Current status of uterine regenerative medicine for absolute uterine factor infertility, Biomed Rep, 2019
  25. Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques, J Clin Med, 2019
  26. Uterus transplantation: advantages and disadvantages of a deceased donor, Arch Gynecol Obstet, 2019
  27. Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?, Eur J Cancer Prev, 2019
  28. Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review, Photodiagnosis Photodyn Ther, 2018
  29. Current Status of Uterus Transplantation and Approaches for Future Clinical Application in Japan., Transplant Proc, 2018
  30. Basic research on uterus transplantation in nonhuman primates in Japan, J Obstet Gynaecol Res, 2018
  31. Emerging problems in uterus transplantation, BJOG, 2018
  32. Re: Starting a uterus transplantation service: notes from a small island., BJOG, 2018
  33. Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer., Oncotarget, 2017
  34. New use of microsatellite instability analysis in endometrial cancer, Oncol Lett, 2017
  35. Recent advances in the molecular mechanisms of Mayer-Rokitansky-Küster-Hauser syndrome, Biomed Rep, 2017
  36. Clear cell carcinoma of the lower uterine segment: A case report., Mol Clin Oncol, 2016
  37. Surgical technique for allogeneic uterus transplantation in macaques, Sci Rep, 2016
  38. Low-Grade Endometrial Stromal Sarcoma Which Relapsed a Month after Transcervical Resection as Fertility-sparing Surgery and Diagnosed with Laparoscopic Hysterectomy, J Gynecol Fertil, 2016

著書等出版物

  1. 2020年, Uterus Transplantation. Chapter name: Nonhuman Primate Research in Uterus Transplantation., Medical Sciences International, Ltd, 教科書, 共著, English

招待講演、口頭・ポスター発表等

  1. Targeting Bcl-XL is a potential novel therapy for uterine serous cancer, DF/HCC Breast & Gynecologic Cancer Symposium, 2024年03月29日, 通常, 英語
  2. Mechanisms of resistance to bispecific T-cell engager therapy for ovarian cancer, ASCO annual meeting 2023, 2023年06月, 通常, 英語
  3. Loss of galectin 3 reveals its potential roles in the aggressive pathology of uterine serous carcinoma, AACR annual meeting 2023, 2023年04月, 通常, 英語
  4. The implementation of self-made collection sack for isolation technique in the removal of large ovarian tumors., 18th Annual Congress of the Asia-Pacific Association for Gynecologic Endoscopy and Minimally Invasive Therapy, 2017年09月, 通常, 英語

外部資金

競争的資金等の採択状況

  1. 上原記念生命科学財団海外留学助成金, 海外留学助成リサーチフェローシップ, 2021年, 2022年
  2. 公益社団法人 内視鏡医学研究振興財団 研究助成B, 子宮内腔病変患者におけるアミノレブリン酸塩酸塩を用いた子宮鏡下光線力学的診断法の有用性の検討, 2019年, 2020年

社会活動

委員会等委員歴

  1. 未来委員会, 2019年, 2020年, 日本産科婦人科学会
  2. 若手委員, 2018年, 2019年, 日本産科婦人科学会未来委員会
  3. 若手委員, 2017年, 2018年, 日本産科婦人科学会未来委員会