広島大学

Basic Information

Major Professional Backgrounds

• 2024/07/01, Hiroshima University, Hospital, Assistant Professor
• 2021/07/01, 2024/06/30, Massachusetts General Hospital, Vincent Center for Reproductive Biology, Research Fellow
• 2016/04/01, 2021/03/31, Department of Obstetrics and Gynecology, Keio University School of Medicine, Assistant Professor
• 2015/04/01, 2016/03/31, Kawasaki Hospital, Department of Obstetrics and Gynecology, Medical Doctor
• 2014/04/01, 2015/03/31, Tachikawa Hospital, Department of Obstetrics and Gynecology, Medical Doctor
• 2013/04/01, 2014/03/31, Department of Obstetrics and Gynecology, Keio University School of Medicine, Assistant Professor
• 2011/04/01, 2013/03/31, Kameda Medical Center, Resident

Educational Backgrounds

• Keio University Graduate School, Japan, 2017/04/01, 2020/09/30
• Keio University School of Medicine, Japan, 2005/04/01, 2011/03/31

Academic Degrees

• Keio University

Research Fields

• Medicine,dentistry, and pharmacy;Clinical surgery;Obstetrics and gynecology

Research Keywords

• Uterine cancer, Ovarian cancer, Benign gynecological disease, Gynecological malignant disease, Endometriosis, Adenomyosis, Galectin 3, Chemotherapy, Immunotherapy, Molecular cell biology, Translational research, Clinical research, Regenerative medicine

Affiliated Academic Societies

• Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy
• Japanese Society for Clinical Cytology
• Japan Society of Gynecologic Oncology
• Japan Society of Obstetrics and Gynecology

Research Activities

Academic Papers

1. High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options, Reprod Sci, 20240424
2. ★, Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma, British Journal of Cancer, 20240304
   Link to Paper Search Results by DOI
3. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells., Nature Metabolism, 20231113
4. The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer., Cancer Drug Resist, 20230614
5. Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway., Cell, 20230525
6. Graft Failure after Uterus Transplantation in 16 Recipients: A Review., J Clin Med, 20230303
7. Massive Hemorrhage Due to Cervical Endometriotic Cyst Rupture: Two Case Reports and a Literature Review., Am J Case Rep, 20221124
8. Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application, Keio J Med, 20220625
9. Meningitis caused by Listeria monocytogenes in a locally advanced cervical cancer patient with pyometra: A case report., Gynecol Oncol Rep, 20210529
10. Evaluation of safety and diagnostic performance for flexible hysteroscopy in 1591 outpatient cases, Jpn J Clin Oncol, 20200928
11. ★, Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases., Journal of Minimally Invasive Gynecology, 20190812
    Link to Paper Search Results by DOI
12. Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: a retrospective study, J Obstet Gynaecol, 202208
13. Hysteroscopic treatment assisted by photodynamic diagnosis for atypical polypoid adenomyoma: A report of two cases., Photodiagnosis Photodyn Ther, 202112
14. Initiatives and achievements of the Japanese Society of Obstetrics and Gynecology, Obstetrics and Gynecology MIRAI Committee 2020, J Obstet Gynaecol Res, 202106
15. A survey of Japanese interns to prepare for mandatory clinical training in obstetrics and gynecology., J Obstet Gynaecol Res, 2021
16. Operative and Clinical Outcomes of Minimally Invasive Living-Donor Surgery on Uterus Transplantation: A Literature Review., J Clin Med., 2021
17. Concerns Associated with Uterus Transplantation in Japan., Keio J Med, 2021
18. Complete resection of an endometrial cancer lesion by hysteroscopic tumor resection combined with photodynamic diagnosis: a case report., Eur J Gynaecol Oncol, 2020
19. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques., J Clin Med, 2020
20. Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques, J Obstet Gynaecol Res, 2020
21. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques, Sci Rep, 2020
22. Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report, Photodiagnosis Photodyn Ther, 2019
23. Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid, Photodiagnosis Photodyn Ther, 2019
24. Current status of uterine regenerative medicine for absolute uterine factor infertility, Biomed Rep, 2019
25. Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques, J Clin Med, 2019
26. Uterus transplantation: advantages and disadvantages of a deceased donor, Arch Gynecol Obstet, 2019
27. Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?, Eur J Cancer Prev, 2019
28. Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review, Photodiagnosis Photodyn Ther, 2018
29. Current Status of Uterus Transplantation and Approaches for Future Clinical Application in Japan., Transplant Proc, 2018
30. Basic research on uterus transplantation in nonhuman primates in Japan, J Obstet Gynaecol Res, 2018
31. Emerging problems in uterus transplantation, BJOG, 2018
32. Re: Starting a uterus transplantation service: notes from a small island., BJOG, 2018
33. Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer., Oncotarget, 2017
34. New use of microsatellite instability analysis in endometrial cancer, Oncol Lett, 2017
35. Recent advances in the molecular mechanisms of Mayer-Rokitansky-Küster-Hauser syndrome, Biomed Rep, 2017
36. Clear cell carcinoma of the lower uterine segment: A case report., Mol Clin Oncol, 2016
37. Surgical technique for allogeneic uterus transplantation in macaques, Sci Rep, 2016
38. Low-Grade Endometrial Stromal Sarcoma Which Relapsed a Month after Transcervical Resection as Fertility-sparing Surgery and Diagnosed with Laparoscopic Hysterectomy, J Gynecol Fertil, 2016

Publications such as books

1. 2020, Uterus Transplantation. Chapter name: Nonhuman Primate Research in Uterus Transplantation., Medical Sciences International, Ltd, Textbook, Joint work, English

Invited Lecture, Oral Presentation, Poster Presentation

1. Targeting Bcl-XL is a potential novel therapy for uterine serous cancer, DF/HCC Breast & Gynecologic Cancer Symposium, 2024/03/29, Without Invitation, English
2. Mechanisms of resistance to bispecific T-cell engager therapy for ovarian cancer, ASCO annual meeting 2023, 2023/06, Without Invitation, English
3. Loss of galectin 3 reveals its potential roles in the aggressive pathology of uterine serous carcinoma, AACR annual meeting 2023, 2023/04, Without Invitation, English
4. The implementation of self-made collection sack for isolation technique in the removal of large ovarian tumors., 18th Annual Congress of the Asia-Pacific Association for Gynecologic Endoscopy and Minimally Invasive Therapy, 2017/09, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

1. Uehara Memorial Foundation Overseas Research Fellowship Award, Uehara Memorial Foundation Overseas Research Fellowship Award, 2021, 2022
2. The Japanese Foundation for Research and Promotion of EndoscopyResearch Grant B, Evaluation of the efficacy of hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid for diseases in the uterine cavity., 2019, 2020