下村 学MANABU SHIMOMURA

Last Updated :2024/02/02

所属・職名
大学院医系科学研究科(医) 助教
メールアドレス
mshimohiroshima-u.ac.jp
自己紹介
大腸癌の治療成績の向上を目指して、基礎的、臨床的なアプローチで取り組んでいます。

基本情報

学位

  • 博士(医学) (広島大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 医学専門プログラム

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 外科系臨床医学 / 消化器外科学

研究キーワード

  • 大腸癌 大腸肛門病 内視鏡手術 ロボット手術

所属学会

  • 日本外科学会
  • 日本ロボット外科学会
  • 日本臨床腫瘍学会
  • 日本消化器病学会
  • 日本内視鏡外科学会
  • 日本大腸肛門病学会
  • 日本消化器外科学会

教育活動

授業担当

  1. 2023年, 学部専門, セメスター(前期), 外科学I
  2. 2023年, 博士課程・博士課程後期, 1ターム, がん診療各論
  3. 2023年, 博士課程・博士課程後期, セメスター(前期), 消化器・移植外科学特別演習
  4. 2023年, 博士課程・博士課程後期, セメスター(後期), 消化器・移植外科学特別演習
  5. 2023年, 博士課程・博士課程後期, セメスター(前期), 消化器・移植外科学特別研究
  6. 2023年, 博士課程・博士課程後期, セメスター(後期), 消化器・移植外科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Author response to: Comment on: Non-invasive measurement of intestinal tissue oxygen saturation for evaluation of reconstructed blood flow in rectal cancer surgery: HiSCO-09 study., British Journal of Surgery, 111巻, 1号, 20240103
  2. Association between social background and implementation of postoperative adjuvant chemotherapy for older patients undergoing curative resection of colorectal cancers, sub-analysis of the HiSCO-04 study., International Journal of Colorectal Diseseas, 39巻, 1号, 20231228
  3. Non-invasive measurement of intestinal tissue oxygen saturation for evaluation of reconstructed blood flow in rectal cancer surgery: HiSCO-09 study., Birish Journal of Surgery, 9巻, 110号, pp. 1769-1773, 20231109
  4. Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II-III: A retrospective cohort study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 38巻, 1号, 20230121
  5. Laparoscopic repair of Morgagni hernia with extra-abdominal sutures and ileocecal resection for colon cancer: a case report., Journal of Surgical Case Report, 12巻, pp. 572-572, 20221220
  6. Ischemic Necrosis of the Gastric Remnant Treated Successfully Using Total Remnant Gastrectomy, Case Report in Gastroenterology, 16巻, 2号, pp. 507-514, 20220829
  7. Castleman's Disease Arising from the Hepatoduodenal Ligament Mimicking a Duodenal Gastrointestinal Stromal Tumor, Case Report in Gastroenterology, 15巻, 1号, pp. 424-430, 20210419
  8. Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report, Asian Journal of Endoscopic Surgery, 2巻, pp. 271-274, 20210414
  9. Mucinous nonneoplastic cyst of the pancreas penetrates the colon causing infection: a case report, Journal of Medical Case Reports, 13巻, 1号, pp. 264, 20190810
  10. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer., Oncogenesis, 5巻, 8号, pp. e253, 20160815
  11. Initial experiences of robotic versus conventional laparoscopic surgery for colorectal cancer, focusing on short-term outcomes: a matched case-control study., World Journal of Surgical Oncology, 13巻, pp. 103, 20150512
  12. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results., World Journal of Surgical Oncology, 10巻, pp. 61, 20120424
  13. Survival outcomes of patients with stage III colorectal cancer aged ≥ 80 years who underwent curative resection: the HiSCO-04 prospective cohort study, International Journal of Clinical Oncology, 15巻, 202312
  14. A prospective feasibility study of uracil-tegafur and leucovorin as adjuvant chemotherapy for patients aged >= 80 years after curative resection of colorectal cancer, the HiSCO-03 study, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 91巻, 4号, pp. 317-324, 202304
  15. Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras., Journal of gastroenterology, 51巻, 5号, pp. 447-457, 201605
  16. The modified Glasgow prognostic score for early mortality in patients with synchronous peritoneal carcinomatosis from colorectal cancer., Surgery Today, 45巻, 11号, pp. 1396-1403, 201511
  17. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases., World Journal of Surgical Oncology, 201504
  18. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer., International Journal of Cancer, 201404
  19. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, International Journal of Colorectal Diseases, 29巻, 2号, pp. 217-223, 201402
  20. Effect of left colonic artery preservation on anastomotic leakage in laparoscopic anterior resection for middle and low rectal cancer., World Journal of Surgery, 37巻, 12号, pp. 2935-2943, 201312
  21. Submucosal invasive micropapillary carcinoma of the colon with massive lymph node metastases: a case report., Case Rep Oncol, 201209
  22. Abscess in the inguinal hernial sac after peritonitis surgery: a case report., World Journal of Gastroenterology, 200902
  23. 当院における虫垂炎治療の現状, 広島医学, 75巻, 3号, pp. 123-129, 2022
  24. Success rate of acquiring informed consent and barriers to participation in a randomized controlled trial of laparoscopic versus open surgery for non-curative stage IV colon cancer in Japan (JCOG1107)., Jpn J Clin Oncol, pp. 112, 2022
  25. Ischemic Necrosis of the Gastric Remnant Treated Successfully Using Total Remnant Gastrectomy., Case Rep Gastroenterol., 16巻, 2号, pp. 507-514, 2022
  26. 当院におけるロボット支援直腸がん手術の短期成績と導入の工夫, 広島医学, 74巻, 3号, pp. 122-127, 2021
  27. 腹腔鏡下大腸亜全摘術を施行した慢性特発性大腸偽性腸閉塞症の1例, 日本内視鏡外科学会雑誌, 26巻, 1号, pp. 57-63, 2021
  28. 術前化学放射線療法+全身化学療法により、病理学的完全奏効を得た局所進行直腸癌の1例, 広島医学, 74巻, 8号, pp. 390-395, 2021
  29. Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report., Asian J Endosc Surg, 14巻, 2号, pp. 271-274, 2021
  30. Castleman's Disease Arising from the Hepatoduodenal Ligament Mimicking a Duodenal Gastrointestinal Stromal Tumor., Case Rep Gastroenterol, 15巻, 1号, pp. 424-430, 2021
  31. A safe and reliable technique for fascial closure without special devices after laparoscopic surgery., Asian J Endosc Surg, 14巻, 1号, pp. 149-153, 2021
  32. Long-term outcomes of laparoscopic surgery in elderly patients with colorectal cancer: A single institutional matched case-control study., Asian J Endosc Surg., 14巻, 2号, pp. 200-206, 2021
  33. Establishment of an antiemetic protocol for chemotherapy-imduced nausea and vomiting evaluated using the Multinational Association of Supportive Care in Cancer Antiemesis Tool in colorectal cancer., Hiroshima J. Med.Sci., 70巻, 1号, pp. 1-5, 2021
  34. 外科治療介入した直腸神経内分泌腫瘍21例の臨床病理, 日本臨床外科学会雑誌, 81巻, 10号, pp. 1947-1952, 2020
  35. Successful surgical management of non-perforating acute appendicitis with septic disseminated intravascular coagulation: A case report and review of the literature., International Journal of Surgical Case Reports, 55巻, pp. 103-106, 2019
  36. Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review., World J Surg Oncol, 15巻, 17号, 2019
  37. Is laparoscopic colorectal surgery with continuation of antiplatelet therapy safe without increasing bleeding complications?, Surg Today, 49巻, 11号, pp. 948-957, 2019
  38. Surgical Venous Cutdown for the Insertion of Totally Implantable Venous Access Devices., Int Surg, 103巻, pp. 415-421, 2018
  39. Prognostic Nutritional Index Predicts Treatment Outcomes following Palliative Surgery for Colorectal Adenocarcinoma., J Anus Rectum Colon., 25巻, 1号, pp. 118-114, 2018
  40. Successful resection of liver metastasis detected by exacerbation of skin symptom in a patient with dermatomyositis accompanied by rectal cancer: a case report and literature review., Surg Case Rep, 3巻, 1号, pp. 3, 2017
  41. possible role of soluble fibrin monomer complex after gastroenterological surgery., World J Gastroenterol., 23巻, 12号, pp. 2209-2216, 2017
  42. Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor beta Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation, PLos One, 2016
  43. Chemotherapeutic outcomes for metastatic colorectal cancer in elderly patients aged ≥75 years: A single-institutional retrospective analysis., Asia Pac J Clin Oncol, 12巻, 2号, pp. 151-158, 2016
  44. Clinical Significance of Pharmacological Prophylaxis based on the Original Risk Classification of Venous Thromboembolism after Lower Abdominal Surgery., Hiroshima Journal of medical sciences, 65巻, 3-4号, pp. 53-59, 2016
  45. A multi-institutional feasibility study of S-1/oxaliplatin plus bevacizumab in patients with advanced/metastatic colorectal cancer: the HiSCO-02 prospective phase II study., Springerplus, 18巻, 5号, pp. 1800, 2016
  46. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery., Surgery Today, 2015
  47. Total colectomy for multiple metachronous colon cancers in a patient with Lynch syndrome. Kochi M, Shimomura M, Hinoi T, Niitsu H, Yano T, Mukai S, Sawada H, Miguchi M, Saito Y, Adachi T, Ishizaki Y, Egi H, Ohdan H., Surg Case Rep, 26巻, 13号, pp. 123, 2015
  48. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery., Langenbecks Arch Surg, 2013
  49. A case of advanced colorectal carcinoma with aggressively growing liver metastases successfully managed with the induction of cetuximab single-agent therapy., Gan To Kagaku Ryoho, 2013
  50. Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases., Ann Surg Oncol, 20巻, Suppl 3号, pp. 527-536, 2013
  51. ★, Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery., Surgery, 153巻, 3号, pp. 344-356, 2013
  52. Single-incision laparoscopic colectomy using the Gelport system for early colon cancer., Scandinavian Journal of Surgery, 101巻, 1号, pp. 16-20, 2012
  53. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer., Int J Colorectal Dis., 27巻, 10号, pp. 1339-1346, 2012
  54. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer., Surg Today, 41巻, 10号, pp. 1370-1379, 2011
  55. Alterations in portal vein blood pH, hepatic functions, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model., Surgical Endoscopy, 2010
  56. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review., Pediatr Surg Int., 26巻, 6号, pp. 649-654, 2010
  57. Surgical techniques for prevention of recurrence after total enterolysis in encapsulating peritoneal sclerosis., Adv Perit Dial., 2008

招待講演、口頭・ポスター発表等

  1. 直腸切除術における縫合不全を予防するための再建腸管血流の客観的、定量的評価法の確立-近赤外線光を用いた非侵襲的腸管組織酸素飽和度測定-, 三口真司 下村学 好中久昌 恵木浩之 清水亘 安達智洋 池田聡 中原雅浩 斎藤保文 吉満政義 豊田和広 大段秀樹, 第123回日本外科学会定期学術集会, 2023年04月29日, 通常, 日本語
  2. 高齢がん患者に対して術後補助化学療法を行うべきか? -80歳以上のリンパ節転移陽性大腸癌根治切除症例の前向き臨床研究から-, 向井正一郎 下村学 池田聡 中原雅浩 安達智洋 斎藤保文 清水洋祐 豊田和広 石崎康代 吉満政義 高倉有二 清水亘 住谷大輔 児玉真也 藤森正彦 大枝守 小林弘典 大段秀樹, 第123回日本外科学会定期学術集会, 2023年04月27日, 通常, 日本語
  3. Phase  two multi-institutional prospective feasibility study of uracil-tegafur and leucovorin (UFT/LV) as adjuvant chemotherapy for patients aged 80 years or more after curative resection of colorectal cancer The HiSCO-03 study, Manabu Shimomura, Satoshi Ikeda, Masahiro Nakahara, Tomohiro Adachi, Yasuyo Ishizaki, Yasuhumi Saitoh, Kazuhiro Toyota, Daisuke Sumitani, Yosuke Shimizu, Yuji Takakura, Wataru Shimizu, Masanori Yoshimitsu, Shinya Kodama Masahiko Fujimori, Mamoru Oheda, Hironori Kobayashi, and Hideki Ohdan, 第20回日本臨床腫瘍学会, 2023年03月16日, 通常, 英語
  4. Prospective cohort study of patients with stage III colorectal cancer aged ≥80 years who underwent curative resection: the HiSCO-04 study, Manabu Shimomura, Satoshi Ikeda, Masahiro Nakahara, Tomohiro Adachi, Yasufumi Saitoh, Yosuke Shimizu, Kazuhiro Toyota, Yasuyo Ishizaki, Masanori Yoshimitsu, Yuji Takakura, Wataru Shimizu, Daisuke Sumitani, Shinya Kodama, Masahiko Fujimori, Mamoru Oeda, Hironori Kobayashi, Hideki Ohdan, ASCO Gastrointestinal Cancers Symposium, 2023年01月19日, 通常, 英語
  5. Phase two multi-institutuional prospective feasibility study of uracil-tegafur and leucovotrin as adjuvant chemotherapy for patiensts aged 80 yeas or more after curatrive resectrion of colorectal cancer: The HiSCO-03 study, Masashi Miguchi, Satoshi Ikeda, Manabu Shimomura, Masahiro Nakahara, Tomohiro Adachi, Yasuyo Ishizaki, Yasuhumi Saitoh, Kazuhiro Toyota, Daisuke Sumitani, Yosuke Shimizu, Yuji Takakura, Wataru Shimizu, Masanori Yoshimitsu, Shinya Kodama Masahiko Fujimori, Mamoru Oheda, Hironori Kobayashi, and Hideki Ohdan, ASCO Gastrointestinal Cacners Symposium, 2023年01月19日, 通常, 英語
  6. ロボット支援下直腸がん手術の短期成績の検討と普及、手技の安定化の工夫, 下村学, 第35回日本内視鏡外科学会, 2022年12月08日, 通常, 日本語
  7. 術後癒着性腸閉塞の予防に低侵襲手術がもたらした意義-基礎的研究と大規模データベースを用いた解析から-, 下村 学、清水 亘、安達智洋、三口真司、吉満政義、香山茂平、中原雅裕、池田聡、小林弘典、豊田和広、清水洋祐、住谷大輔、斎藤保文、高倉有二、石崎康代、児玉真也、藤森正彦、大段秀樹, 第77回日本大腸肛門病学会, 2022年10月14日, 通常, 日本語
  8. 当院におけるロボット支援下直腸がん手術の導入、普及、手術手技の工夫, 下村学, 第77回日本消化器外科学会総会, 通常, 日本語
  9. Initial experiences of robotic assisted rectal cancer surgery in our institution, Manabu Shimomura, 第33回日本内視鏡外科学会総会, 2021年, 通常, 日本語
  10. 超高齢者の大腸癌術後補助化学療法の実施に社会背景が及ぼす影響 -80歳以上のStage III大腸癌214症例の前向き観察研究より-, 河内雅年、下村学、中原雅浩、池田聡、斎藤保文、清水洋祐、豊田和広 石崎康代、吉満政義、徳永真和、清水亘、住谷大輔、児玉真也、藤森正彦 大枝守、宮本勝也、大段秀樹, 第95回大腸癌研究会, 2021年, 通常, 日本語
  11. 当院におけるロボット支援下直腸がん手術の導入と普及の工夫, 下村学, 安達智洋、原鐵洋、新原健介、青木義朗、加納幹浩、徳本憲昭、小橋俊彦、檜原淳、向田秀典, 第77回日本消化器外科学会総会, 2022年, 通常, 日本語
  12. 術前栄養指標からみた腹腔鏡下直腸切除術における 術後縫合不全のリスク評価と対策, 下村学, 安達智洋、三口真司、 吉満政義、 香山茂平、中原雅浩、池田聡、小林弘典、豊田和広、清水亘、清水洋祐、大城望史、大段秀樹, 第34回日本内視鏡外科学会総会, 2021年, 通常, 日本語