MANABU SHIMOMURA

Last Updated :2024/07/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Assistant Professor
E-mail
mshimohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery

Research Keywords

  • Colorectal cancer, Coloproctology, Laparoscopic surgery, Robotic surgery

Affiliated Academic Societies

  • Japan surgical society
  • Japan robotic surgery society
  • Japanese society of medical oncology
  • Japanese society of gastroenterology
  • Japan society of endoscopic surgery
  • Japan society of coloproctology
  • Japanese society of gastroenterological surgery

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Surgery I
  2. 2024, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  3. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  4. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  5. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterological and Transplant Surgery
  6. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterological and Transplant Surgery

Research Activities

Academic Papers

  1. Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study, ACTA MEDICA OKAYAMA, 78(1), 47-52, 202402
  2. Weekday Surgery Associated With Short-term Outcomes in Patients With Colorectal Cancers, JOURNAL OF SURGICAL RESEARCH, 296, 316-324, 202404
    Link to Paper Search Results by DOI
  3. Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases, ANTICANCER RESEARCH, 44(2), 649-658, 202402
    Link to Paper Search Results by DOI
  4. Colonic invasive adenocarcinoma with squamoid morules: A case report, DEN OPEN, 4(1), 202404
    Link to Paper Search Results by DOI
  5. Author response to: Comment on: Non-invasive measurement of intestinal tissue oxygen saturation for evaluation of reconstructed blood flow in rectal cancer surgery: HiSCO-09 study., British Journal of Surgery, 111(1), 20240103
    Link to Paper Search Results by DOI
  6. Association between social background and implementation of postoperative adjuvant chemotherapy for older patients undergoing curative resection of colorectal cancers, sub-analysis of the HiSCO-04 study., International Journal of Colorectal Diseseas, 39(1), 20231228
  7. Non-invasive measurement of intestinal tissue oxygen saturation for evaluation of reconstructed blood flow in rectal cancer surgery: HiSCO-09 study., Birish Journal of Surgery, 9(110), 1769-1773, 20231109
    Link to Paper Search Results by DOI
  8. Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II-III: A retrospective cohort study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 38(1), 20230121
    Link to Paper Search Results by DOI
  9. Laparoscopic repair of Morgagni hernia with extra-abdominal sutures and ileocecal resection for colon cancer: a case report., Journal of Surgical Case Report, 12, 572-572, 20221220
  10. Ischemic Necrosis of the Gastric Remnant Treated Successfully Using Total Remnant Gastrectomy, Case Report in Gastroenterology, 16(2), 507-514, 20220829
  11. Castleman's Disease Arising from the Hepatoduodenal Ligament Mimicking a Duodenal Gastrointestinal Stromal Tumor, Case Report in Gastroenterology, 15(1), 424-430, 20210419
  12. Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report, Asian Journal of Endoscopic Surgery, 2, 271-274, 20210414
  13. Mucinous nonneoplastic cyst of the pancreas penetrates the colon causing infection: a case report, Journal of Medical Case Reports, 13(1), 264, 20190810
    Link to Paper Search Results by DOI
  14. Initial experiences of robotic versus conventional laparoscopic surgery for colorectal cancer, focusing on short-term outcomes: a matched case-control study., World Journal of Surgical Oncology, 13, 103, 20150512
    Link to Paper Search Results by DOI
  15. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results., World Journal of Surgical Oncology, 10, 61, 20120424
  16. Survival outcomes of patients with stage III colorectal cancer aged ≥ 80 years who underwent curative resection: the HiSCO-04 prospective cohort study, International Journal of Clinical Oncology, 15, 202312
  17. A prospective feasibility study of uracil-tegafur and leucovorin as adjuvant chemotherapy for patients aged >= 80 years after curative resection of colorectal cancer, the HiSCO-03 study, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 91(4), 317-324, 202304
    Link to Paper Search Results by DOI
  18. Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras., Journal of gastroenterology, 51(5), 447-457, 201605
    Link to Paper Search Results by DOI
  19. The modified Glasgow prognostic score for early mortality in patients with synchronous peritoneal carcinomatosis from colorectal cancer., Surgery Today, 45(11), 1396-1403, 201511
    Link to Paper Search Results by DOI
  20. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases., World Journal of Surgical Oncology, 201504
  21. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer., International Journal of Cancer, 201404
  22. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, International Journal of Colorectal Diseases, 29(2), 217-223, 201402
  23. Effect of left colonic artery preservation on anastomotic leakage in laparoscopic anterior resection for middle and low rectal cancer., World Journal of Surgery, 37(12), 2935-2943, 201312
    Link to Paper Search Results by DOI
  24. Submucosal invasive micropapillary carcinoma of the colon with massive lymph node metastases: a case report., Case Rep Oncol, 201209
  25. Abscess in the inguinal hernial sac after peritonitis surgery: a case report., World Journal of Gastroenterology, 200902
  26. Success rate of acquiring informed consent and barriers to participation in a randomized controlled trial of laparoscopic versus open surgery for non-curative stage IV colon cancer in Japan (JCOG1107)., Jpn J Clin Oncol, 112, 2022
  27. Ischemic Necrosis of the Gastric Remnant Treated Successfully Using Total Remnant Gastrectomy., Case Rep Gastroenterol., 16(2), 507-514, 2022
  28. Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report., Asian J Endosc Surg, 14(2), 271-274, 2021
  29. Castleman's Disease Arising from the Hepatoduodenal Ligament Mimicking a Duodenal Gastrointestinal Stromal Tumor., Case Rep Gastroenterol, 15(1), 424-430, 2021
  30. A safe and reliable technique for fascial closure without special devices after laparoscopic surgery., Asian J Endosc Surg, 14(1), 149-153, 2021
  31. Long-term outcomes of laparoscopic surgery in elderly patients with colorectal cancer: A single institutional matched case-control study., Asian J Endosc Surg., 14(2), 200-206, 2021
  32. Successful surgical management of non-perforating acute appendicitis with septic disseminated intravascular coagulation: A case report and review of the literature., International Journal of Surgical Case Reports, 55, 103-106, 2019
    Link to Paper Search Results by DOI
  33. Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review., World J Surg Oncol, 15(17), 2019
  34. Is laparoscopic colorectal surgery with continuation of antiplatelet therapy safe without increasing bleeding complications?, Surg Today, 49(11), 948-957, 2019
  35. Surgical Venous Cutdown for the Insertion of Totally Implantable Venous Access Devices., Int Surg, 103, 415-421, 2018
  36. Successful resection of liver metastasis detected by exacerbation of skin symptom in a patient with dermatomyositis accompanied by rectal cancer: a case report and literature review., Surg Case Rep, 3(1), 3, 2017
  37. possible role of soluble fibrin monomer complex after gastroenterological surgery., World J Gastroenterol., 23(12), 2209-2216, 2017
  38. Chemotherapeutic outcomes for metastatic colorectal cancer in elderly patients aged ≥75 years: A single-institutional retrospective analysis., Asia Pac J Clin Oncol, 12(2), 151-158, 2016
  39. Clinical Significance of Pharmacological Prophylaxis based on the Original Risk Classification of Venous Thromboembolism after Lower Abdominal Surgery., Hiroshima Journal of medical sciences, 65(3-4), 53-59, 2016
  40. A multi-institutional feasibility study of S-1/oxaliplatin plus bevacizumab in patients with advanced/metastatic colorectal cancer: the HiSCO-02 prospective phase II study., Springerplus, 18(5), 1800, 2016
  41. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery., Surgery Today, 2015
    Link to Paper Search Results by DOI
  42. Total colectomy for multiple metachronous colon cancers in a patient with Lynch syndrome. Kochi M, Shimomura M, Hinoi T, Niitsu H, Yano T, Mukai S, Sawada H, Miguchi M, Saito Y, Adachi T, Ishizaki Y, Egi H, Ohdan H., Surg Case Rep, 26(13), 123, 2015
  43. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery., Langenbecks Arch Surg, 2013
  44. A case of advanced colorectal carcinoma with aggressively growing liver metastases successfully managed with the induction of cetuximab single-agent therapy., Gan To Kagaku Ryoho, 2013
  45. Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases., 20(Suppl 3), 527-536, 2013
  46. Single-incision laparoscopic colectomy using the Gelport system for early colon cancer., Scandinavian Journal of Surgery, 101(1), 16-20, 2012
  47. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer., Int J Colorectal Dis., 27(10), 1339-1346, 2012
  48. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer., Surg Today, 41(10), 1370-1379, 2011
  49. Alterations in portal vein blood pH, hepatic functions, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model., Surgical Endoscopy, 2010
  50. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review., Pediatr Surg Int., 26(6), 649-654, 2010
  51. Surgical techniques for prevention of recurrence after total enterolysis in encapsulating peritoneal sclerosis., Adv Perit Dial., 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Phase  two multi-institutional prospective feasibility study of uracil-tegafur and leucovorin (UFT/LV) as adjuvant chemotherapy for patients aged 80 years or more after curative resection of colorectal cancer The HiSCO-03 study, Manabu Shimomura, Satoshi Ikeda, Masahiro Nakahara, Tomohiro Adachi, Yasuyo Ishizaki, Yasuhumi Saitoh, Kazuhiro Toyota, Daisuke Sumitani, Yosuke Shimizu, Yuji Takakura, Wataru Shimizu, Masanori Yoshimitsu, Shinya Kodama Masahiko Fujimori, Mamoru Oheda, Hironori Kobayashi, and Hideki Ohdan, 2023 the Japanese Society of Medical Oncology Annual Meeting, 2023/03/16, Without Invitation, English
  2. Prospective cohort study of patients with stage III colorectal cancer aged ≥80 years who underwent curative resection: the HiSCO-04 study, Manabu Shimomura, Satoshi Ikeda, Masahiro Nakahara, Tomohiro Adachi, Yasufumi Saitoh, Yosuke Shimizu, Kazuhiro Toyota, Yasuyo Ishizaki, Masanori Yoshimitsu, Yuji Takakura, Wataru Shimizu, Daisuke Sumitani, Shinya Kodama, Masahiko Fujimori, Mamoru Oeda, Hironori Kobayashi, Hideki Ohdan; H, ASCO Gastrointestinal Cancers Symposium, 2023/01/19, Without Invitation, English
  3. Phase two multi-institutuional prospective feasibility study of uracil-tegafur and leucovotrin as adjuvant chemotherapy for patiensts aged 80 yeas or more after curatrive resectrion of colorectal cancer: The HiSCO-03 study, Masashi Miguchi, Satoshi Ikeda, Manabu Shimomura, Masahiro Nakahara, Tomohiro Adachi, Yasuyo Ishizaki, Yasuhumi Saitoh, Kazuhiro Toyota, Daisuke Sumitani, Yosuke Shimizu, Yuji Takakura, Wataru Shimizu, Masanori Yoshimitsu, Shinya Kodama Masahiko Fujimori, Mamoru Oheda, Hironori Kobayashi, and Hideki Ohdan, ASCO Gastrointestinal Cacners Symposium, 2023/01/19, Without Invitation, English
  4. Experiences of robotic assisted rectal cancer surgery in our institution, The 77th general meeting of the japanese society of gastroenterological surgery, 2022, Without Invitation, Japanese