岩本 博志HIROSHI IWAMOTO

Last Updated :2024/02/02

所属・職名
大学院医系科学研究科(医) 准教授
メールアドレス
hirhiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 呼吸器内科学

研究キーワード

  • COPD
  • 気管支喘息

教育活動

授業担当

  1. 2023年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2023年, 学部専門, 集中, 臨床実習I
  3. 2023年, 学部専門, 集中, 臨床実習II
  4. 2023年, 学部専門, セメスター(前期), 内科学II
  5. 2023年, 博士課程・博士課程後期, セメスター(前期), 分子内科学特別研究
  6. 2023年, 博士課程・博士課程後期, セメスター(後期), 分子内科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
  2. ★, Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
  3. Preserved ratio impaired spirometry with or without restrictive spirometric abnormality, SCIENTIFIC REPORTS, 13巻, 1号, 20230220
  4. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes, JOURNAL OF ASTHMA AND ALLERGY, 15巻, pp. 1539-1547, 2022
  5. Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27巻, 11号, pp. 1698-1705, 202211
  6. Hochuekkito Combined with Pulmonary Rehabilitation in Apathetic Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Pilot Trial, JOURNAL OF CLINICAL MEDICINE, 11巻, 19号, 202210
  7. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 13巻, 7号, 202207
  8. Vocal cord dysfunction detected by a three-dimensional image of dynamic change in respiratory resistance in a patient with difficult-to-treat asthma: a case report, JOURNAL OF ASTHMA, 59巻, 6号, pp. 1157-1161, 20220603
  9. ★, Accelerated decline in lung function in adults with a history of remitted childhood asthma, EUROPEAN RESPIRATORY JOURNAL, 59巻, 1号, 20220101
  10. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107巻, 6号, pp. 875-882, 201306
  11. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 43巻, 2号, pp. 421-429, 2014
  12. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67巻, 6号, pp. 1465-9, 20110101
  13. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2巻, pp. 167-170, 20110101
  14. ★, Airflow limitation in smokers is associated with subclinical atherosclerosis., Am J Respir Crit Care Med., 20090101
  15. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20巻, 1号, pp. 87-94, 201501
  16. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106巻, 7号, pp. 921-928, 201507
  17. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, Pharmaceutical Research, 2015
  18. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical & Experimental Allergy, 2009
  19. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulmonary Pharmacology & Therapeutics, 2008
  20. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, european respiratory journal, 2008
  21. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., 301巻, 6号, 2011
  22. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients., Respirology (Carlton, Vic.), 20巻, 1号, 2015
  23. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., 60巻, 1号, 2011
  24. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers., Inhalation toxicology, 2016
  25. Soluble receptor for advanced glycation end-products and progression of airway disease, BMC PULMONARY MEDICINE, 14巻, 2014
  26. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
  27. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28巻, 8号, pp. 343-348, 201607
  28. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11巻, 2016
  29. ★, Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, Respirology, 22巻, pp. 86-92, 2017
  30. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22巻, 1号, pp. 86-92, 201701
  31. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74巻, 5号, pp. 321-327, 201705
  32. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106巻, pp. 1-9, 201705
  33. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22巻, 5号, pp. 965-971, 201707
  34. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 42巻, 2013
  35. Mustard gas exposure causing death due to respiratory tract cancer and chronic bronchitis in the long term, EUROPEAN RESPIRATORY JOURNAL, 42巻, 2013
  36. COPD in Smokers with Atherosclerosis: Are We Missing the Trail?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180巻, 1号, pp. 103-104, 2009
  37. COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18巻, pp. 58-58, 2013
  38. CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18巻, pp. 137-137, 2013
  39. INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18巻, pp. 200-200, 2013
  40. [A case of tumor microembolism diagnosed by perfusion scan and transbronchial lung biopsy]., Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47巻, 8号, 2009
  41. [Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]., Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101巻, 5号, 2012
  42. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18巻, 20170818
  43. CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34巻, 1号, pp. 48-57, 2017
  44. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56巻, 19号, pp. 2627-2631, 2017
  45. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8巻, 55号, pp. 94382-94392, 20171107
  46. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81巻, 1号, pp. 131-139, 201801
  47. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123巻, pp. 105-109, 201702
  48. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119巻, pp. 21-24, 201805
  49. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51巻, 5号, 20180501
  50. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17巻, pp. 263, 2017
  51. 喘息管理手帳を用いた医薬連携の有用性についての検討, 日本病院薬剤師会雑誌, 53巻, pp. 201, 2017
  52. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18巻, 8号, pp. 1215-1218, 201808
  53. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9巻, 5号, pp. 539-544, 201811
  54. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97巻, 49号, 201812
  55. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25巻, 3号, pp. 275-280, 20200301
  56. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15巻, pp. 1049-1059, 20200501
  57. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21巻, 1号, 20200611
  58. Serum high-mobility group box 1 as a predictive marker for cytotoxic chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, RESPIRATORY MEDICINE, 172巻, 20201001
  59. Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma, CLINICAL RESPIRATORY JOURNAL, 15巻, 1号, pp. 48-55, 20210101
  60. Concomitant emphysema might increase the false-negative rate of urinary antigen tests in patients with pneumococcal pneumonia: results from a retrospective study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 40巻, 4号, pp. 871-877, 20210401
  61. IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis, PLOS ONE, 16巻, 6号, 20210604

招待講演、口頭・ポスター発表等

  1. COPDと心血管疾患, 岩本 博志, 第51回日本呼吸器学会総会, 2011年, 招待, 日本語
  2. Mild obesity is correlated with desaturation in voluntary breath-holding,, Iwamoto et al, European respiratory society, 2006年, 通常, 日本語
  3. 高齢者喘息の治療状況についての実態調査, 岩本 博志, 日本呼吸器学会総会, 2010年, 通常, 日本語
  4. COPD as a systemic disease. Subclinical atherosclerosis in COPD, Iwamoto H, 日本呼吸器学会, 2008年, 通常, 日本語
  5. 気管支喘息合併のGERDの実態と診断についての検討‐FSSGを用いた検討‐, 岩本 博志, アレルギー学会春季臨床大会, 2006年, 通常, 日本語
  6. Airway resistance assessed by impulse oscillometry at varying respiratory rate and the effect of pretreatment with short-acting beta2 agonist in COPD patients., Iwamoto et al, European respiratory society, 2010年, 通常, 日本語
  7. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap., Iwamoto H, Gao J, Koskela J, Kobayashi H, Laitinen T, Mazur W., European respiratory society, 2013年, 通常, 英語
  8. Soluble receptor for advanced glycation end-products and progression of airway disease, Iwamoto H, Gao J, Pulkkinen V, Toljamo T, Nieminen P, Mazur W, 2014年05月, 通常, 日本語
  9. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, 2014年09月, 通常, 英語
  10. 重症喘息のフェノタイプ -広島末梢気道研究会の喘息コホート研究よりー, 岩本博志, 第65回日本アレルギー学会学術大会, 2016年06月19日, 招待, 日本語, 東京
  11. ACOSのバイオマーカー, 岩本博志, 第56回日本呼吸器学会学術講演会, 2016年04月08日, 招待, 日本語, 東京
  12. HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis, 第55回日本呼吸器学会学術講演会, 2015年04月17日, 通常, 英語, 東京
  13. Long-term pulmonary complications of sulfur mustard exposure in former poison gas factory workers, e 1st Asia Oceania Workshop of Pulmonary Functional Imaging (1st AOWPFI) and 8th meeting of the Japanese Society of Pulmonary Functional Imaging (8th JSPFI), 2016年01月29日, 通常, 日本語, awaji
  14. Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, 2015年09月26日, 通常, 英語
  15. 小児喘息の既往を有する中年成人の肺機能と呼吸器症状についての検討, 大森慶太郎 岩本博志 春田吉則 山根高 佐々木英夫 倉岡敏彦 佐久間和代 伊藤千賀子 山根公則 服部登 横山彰仁 河野修興, 第55回日本呼吸器学会学術講演会, 2015年04月17日, 通常, 日本語

外部資金

競争的資金等の採択状況

  1. 基盤研究(C), 身体活動量の低下が喘息の病態に及ぼす影響とそのメカニズムの解明, 2023年04月01日, 2026年03月31日
  2. 科学研究費助成事業(若手研究(B)), I型肺胞上皮由来の新規特発性肺線維症バイオマーカーRAGEの開発と創薬の試み, 2013年, 2015年
  3. 科学研究費助成事業(若手研究(B)), 気管支喘息・間質性肺炎モデルマウスにおける亜鉛キレート剤の効果の検討, 2010年, 2012年
  4. 科学研究費助成事業(基盤研究(C)), セレクチンリガンドを有するKL-6/MUC1分子の臨床病理学的意義, 2007年, 2009年
  5. 科学研究費助成事業(基盤研究(A)), 国際共同研究による間質性肺炎の新規バイオマーカーの開発と創薬の試み, 2013年, 2016年
  6. 基盤研究(C), Ⅰ型肺胞上皮由来物質RAGEを用いた特発性肺線維症の病態解明の試み, 2017年, 2019年
  7. 科学研究費助成事業(基盤研究(C)), Ⅰ型肺胞上皮由来物質RAGEを用いた特発性肺線維症の病態解明の試み, 2017年, 2019年

社会活動

委員会等委員歴

  1. 閉塞性肺疾患学術部会, 2019年, 日本呼吸器学会
  2. 代議員, 2016年, 日本呼吸器学会