HIROSHI IWAMOTO

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
E-mail
hirhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • asthma
  • COPD

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2025, Undergraduate Education, First Semester, Internal Medicine II
  5. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular and internal Medicine
  6. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular and internal Medicine
  7. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular and internal Medicine
  8. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular and internal Medicine

Research Activities

Academic Papers

  1. High S100A9 level predicts poor survival, and the S100A9 inhibitor paquinimod is a candidate for treating idiopathic pulmonary fibrosis, BMJ OPEN RESPIRATORY RESEARCH, 11(1), 202402
    Link to Paper Search Results by DOI
  2. ★, Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 11(9), 2792-+, 202309
    Link to Paper Search Results by DOI
  3. Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
  4. ★, Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
  5. Preserved ratio impaired spirometry with or without restrictive spirometric abnormality, SCIENTIFIC REPORTS, 13(1), 20230220
    Link to Paper Search Results by DOI
  6. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes, JOURNAL OF ASTHMA AND ALLERGY, 15, 1539-1547, 2022
    Link to Paper Search Results by DOI
  7. Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(11), 1698-1705, 202211
    Link to Paper Search Results by DOI
  8. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 13(7), 202207
    Link to Paper Search Results by DOI
  9. Vocal cord dysfunction detected by a three-dimensional image of dynamic change in respiratory resistance in a patient with difficult-to-treat asthma: a case report, JOURNAL OF ASTHMA, 59(6), 1157-1161, 20220603
    Link to Paper Search Results by DOI
  10. ★, Accelerated decline in lung function in adults with a history of remitted childhood asthma, EUROPEAN RESPIRATORY JOURNAL, 59(1), 20220101
    Link to Paper Search Results by DOI
  11. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107(6), 875-882, 201306
    Link to Paper Search Results by DOI
  12. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 43(2), 421-429, 2014
    Link to Paper Search Results by DOI
  13. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67(6), 1465-9, 20110101
  14. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2, 167-170, 20110101
  15. ★, Airflow limitation in smokers is associated with subclinical atherosclerosis., Am J Respir Crit Care Med., 20090101
  16. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20(1), 87-94, 201501
    Link to Paper Search Results by DOI
  17. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
    Link to Paper Search Results by DOI
  18. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, Pharmaceutical Research, 2015
  19. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical & Experimental Allergy, 2009
  20. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulmonary Pharmacology & Therapeutics, 2008
  21. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, european respiratory journal, 2008
  22. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
    Link to Paper Search Results by DOI
  23. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., 301(6), 2011
  24. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients., Respirology (Carlton, Vic.), 20(1), 2015
  25. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., 60(1), 2011
  26. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers., Inhalation toxicology, 2016
  27. Soluble receptor for advanced glycation end-products and progression of airway disease, BMC PULMONARY MEDICINE, 14, 2014
  28. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
    Link to Paper Search Results by DOI
  29. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28(8), 343-348, 201607
    Link to Paper Search Results by DOI
  30. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76(11), 3285-3294, 20160601
    Link to Paper Search Results by DOI
  31. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 2016
    Link to Paper Search Results by DOI
  32. ★, Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, Respirology, 22, 86-92, 2017
  33. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22(1), 86-92, 201701
    Link to Paper Search Results by DOI
  34. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74(5), 321-327, 201705
    Link to Paper Search Results by DOI
  35. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, 201705
    Link to Paper Search Results by DOI
  36. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22(5), 965-971, 201707
    Link to Paper Search Results by DOI
  37. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
  38. Mustard gas exposure causing death due to respiratory tract cancer and chronic bronchitis in the long term, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
  39. COPD in Smokers with Atherosclerosis: Are We Missing the Trail?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(1), 103-104, 2009
  40. COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18, 58-58, 2013
  41. CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18, 137-137, 2013
  42. INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18, 200-200, 2013
  43. A retrospective study comparing pemetrexed with taxanes as front-line cytotoxic chemotherapy for lung adenocarcinoma, ANNALS OF ONCOLOGY, 26, 123-123, 2015
  44. [A case of tumor microembolism diagnosed by perfusion scan and transbronchial lung biopsy]., Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(8), 2009
  45. [Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]., Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101(5), 2012
  46. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18, 20170818
    Link to Paper Search Results by DOI
  47. CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34(1), 48-57, 2017
  48. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
    Link to Paper Search Results by DOI
  49. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, 20171107
    Link to Paper Search Results by DOI
  50. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
    Link to Paper Search Results by DOI
  51. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, 201801
    Link to Paper Search Results by DOI
  52. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 201702
    Link to Paper Search Results by DOI
  53. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, 201805
    Link to Paper Search Results by DOI
  54. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), 20180501
    Link to Paper Search Results by DOI
  55. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263, 2017
  56. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263, 2017
  57. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis., Intern Med., 56, 3327, 2017
  58. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, 2018
    Link to Paper Search Results by DOI
  59. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18(8), 1215-1218, 201808
    Link to Paper Search Results by DOI
  60. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, 20180907
    Link to Paper Search Results by DOI
  61. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, 201810
    Link to Paper Search Results by DOI
  62. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
    Link to Paper Search Results by DOI
  63. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
    Link to Paper Search Results by DOI
  64. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 20190201
    Link to Paper Search Results by DOI
  65. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 20200301
    Link to Paper Search Results by DOI
  66. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15, 1049-1059, 20200501
    Link to Paper Search Results by DOI
  67. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611
    Link to Paper Search Results by DOI
  68. Concomitant emphysema might increase the false-negative rate of urinary antigen tests in patients with pneumococcal pneumonia: results from a retrospective study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 40(4), 871-877, 20210401
    Link to Paper Search Results by DOI
  69. Association between glucose intolerance and chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 88(5), 857-865, 202111
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Mild obesity is correlated with desaturation in voluntary breath-holding,, Iwamoto et al, European respiratory society, 2006, Without Invitation, Japanese
  2. COPD as a systemic disease. Subclinical atherosclerosis in COPD, Iwamoto H, Japanese respiratory society, 2008, Without Invitation, Japanese
  3. Airway resistance assessed by impulse oscillometry at varying respiratory rate and the effect of pretreatment with short-acting beta2 agonist in COPD patients., Iwamoto et al, European respiratory society, 2010, Without Invitation, Japanese
  4. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap., Iwamoto H, Gao J, Koskela J, Kobayashi H, Laitinen T, Mazur W., European respiratory society, 2013, Without Invitation, English, Barcelona
  5. Soluble receptor for advanced glycation end-products and progression of airway disease, Iwamoto H, Gao J, Pulkkinen V, Toljamo T, Nieminen P, Mazur W, American thoracic society, 2014/05, Without Invitation, Japanese
  6. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, Iwamoto H, Horimasu Y, Nakashima T, Senoo T, Ohshimo S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hattori N, Mazur W, Kohno N,, European respiratory society, 2014/09, Without Invitation, English
  7. HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis, Chihiro Yamaoka, Yasushi Horimasu, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hiroshi Murai, Noboru Hattori, Hironobu Hamada, Nobuoki Kohno, 2015/04/17, Without Invitation, English
  8. Long-term pulmonary complications of sulfur mustard exposure in former poison gas factory workers, Nishimura Y, Iwamoto H, Ishikawa N, Hattori N, Horimasu Y, Ohshimo S, Fujitaka K, Kondo K, Hamada H, Awai K, Kohno N, e 1st Asia Oceania Workshop of Pulmonary Functional Imaging (1st AOWPFI) and 8th meeting of the Japanese Society of Pulmonary Functional Imaging (8th JSPFI), 2016/01/29, Without Invitation, Japanese, awaji
  9. Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, European respiratory society annual congress, 2015/09/26, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2015
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  2. KAKENHI, Effects of zincchelator in asthma and interstitialpneumonia model mouse, 2010, 2012
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  3. KAKENHI, Clinicopathological role of kl-6/muc1 with selectin ligand, 2007, 2009
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  4. KAKENHI, 2013, 2016
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  5. 2017, 2019
  6. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019