HIROSHI IWAMOTO
Last Updated :2023/09/06
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
- E-mail
- hir
hiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine
Research Keywords
Educational Activity
Course in Charge
- 2023, Undergraduate Education, Year, Clinical diagnosis and treatment I
- 2023, Undergraduate Education, Intensive, Practice of Medicine I
- 2023, Undergraduate Education, Intensive, Practice of Medicine II
- 2023, Undergraduate Education, First Semester, Internalz Medicine II
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular and internal Medicine
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular and internal Medicine
Research Activities
Academic Papers
- Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
- ★, Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, J Allergy Clin Immunol Pract, 2023
- Preserved ratio impaired spirometry with or without restrictive spirometric abnormality, SCIENTIFIC REPORTS, 13(1), 20230220
- Association Between Patient Preference for Inhaler Medications and Asthma Outcomes, JOURNAL OF ASTHMA AND ALLERGY, 15, 1539-1547, 2022
- Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(11), 1698-1705, 202211
- Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 13(7), 202207
- Vocal cord dysfunction detected by a three-dimensional image of dynamic change in respiratory resistance in a patient with difficult-to-treat asthma: a case report, JOURNAL OF ASTHMA, 59(6), 1157-1161, 20220603
- ★, Accelerated decline in lung function in adults with a history of remitted childhood asthma, EUROPEAN RESPIRATORY JOURNAL, 59(1), 20220101
- Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107(6), 875-882, 201306
- Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 43(2), 421-429, 2014
- Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67(6), 1465-9, 20110101
- Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2, 167-170, 20110101
- ★, Airflow limitation in smokers is associated with subclinical atherosclerosis., Am J Respir Crit Care Med., 20090101
- Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20(1), 87-94, 201501
- MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
- Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, Pharmaceutical Research, 2015
- IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical & Experimental Allergy, 2009
- Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulmonary Pharmacology & Therapeutics, 2008
- Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, european respiratory journal, 2008
- Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
- Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., 301(6), 2011
- Effect of increasing respiratory rate on airway resistance and reactance in COPD patients., Respirology (Carlton, Vic.), 20(1), 2015
- Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., 60(1), 2011
- Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers., Inhalation toxicology, 2016
- Soluble receptor for advanced glycation end-products and progression of airway disease, BMC PULMONARY MEDICINE, 14, 2014
- Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
- Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28(8), 343-348, 201607
- Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76(11), 3285-3294, 20160601
- Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 2016
- ★, Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, Respirology, 22, 86-92, 2017
- Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22(1), 86-92, 201701
- Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74(5), 321-327, 201705
- Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, 201705
- AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22(5), 965-971, 201707
- Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
- Mustard gas exposure causing death due to respiratory tract cancer and chronic bronchitis in the long term, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
- COPD in Smokers with Atherosclerosis: Are We Missing the Trail?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(1), 103-104, 2009
- COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18, 58-58, 2013
- CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18, 137-137, 2013
- INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18, 200-200, 2013
- A retrospective study comparing pemetrexed with taxanes as front-line cytotoxic chemotherapy for lung adenocarcinoma, ANNALS OF ONCOLOGY, 26, 123-123, 2015
- [A case of tumor microembolism diagnosed by perfusion scan and transbronchial lung biopsy]., Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(8), 2009
- [Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]., Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101(5), 2012
- Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18, 20170818
- CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34(1), 48-57, 2017
- Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
- AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, 20171107
- Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
- The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, 201801
- FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 201702
- Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, 201805
- Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), 20180501
- MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263, 2017
- MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263, 2017
- Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis., Intern Med., 56, 3327, 2017
- Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, 2018
- Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18(8), 1215-1218, 201808
- Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, 20180907
- Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, 201810
- Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
- Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
- Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 20190201
- Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 20200301
- Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15, 1049-1059, 20200501
- Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611
- Concomitant emphysema might increase the false-negative rate of urinary antigen tests in patients with pneumococcal pneumonia: results from a retrospective study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 40(4), 871-877, 20210401
- Association between glucose intolerance and chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 88(5), 857-865, 202111
Invited Lecture, Oral Presentation, Poster Presentation
- Mild obesity is correlated with desaturation in voluntary breath-holding,, Iwamoto et al, European respiratory society, 2006, Without Invitation, Japanese
- COPD as a systemic disease. Subclinical atherosclerosis in COPD, Iwamoto H, Japanese respiratory society, 2008, Without Invitation, Japanese
- Airway resistance assessed by impulse oscillometry at varying respiratory rate and the effect of pretreatment with short-acting beta2 agonist in COPD patients., Iwamoto et al, European respiratory society, 2010, Without Invitation, Japanese
- Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap., Iwamoto H, Gao J, Koskela J, Kobayashi H, Laitinen T, Mazur W., European respiratory society, 2013, Without Invitation, English, Barcelona
- Soluble receptor for advanced glycation end-products and progression of airway disease, Iwamoto H, Gao J, Pulkkinen V, Toljamo T, Nieminen P, Mazur W, American thoracic society, 2014/05, Without Invitation, Japanese
- Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, Iwamoto H, Horimasu Y, Nakashima T, Senoo T, Ohshimo S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hattori N, Mazur W, Kohno N,, European respiratory society, 2014/09, Without Invitation, English
- HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis, Chihiro Yamaoka, Yasushi Horimasu, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hiroshi Murai, Noboru Hattori, Hironobu Hamada, Nobuoki Kohno, 2015/04/17, Without Invitation, English
- Long-term pulmonary complications of sulfur mustard exposure in former poison gas factory workers, Nishimura Y, Iwamoto H, Ishikawa N, Hattori N, Horimasu Y, Ohshimo S, Fujitaka K, Kondo K, Hamada H, Awai K, Kohno N, e 1st Asia Oceania Workshop of Pulmonary Functional Imaging (1st AOWPFI) and 8th meeting of the Japanese Society of Pulmonary Functional Imaging (8th JSPFI), 2016/01/29, Without Invitation, Japanese, awaji
- Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, European respiratory society annual congress, 2015/09/26, Without Invitation, English
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, 2013, 2015
- KAKENHI, Effects of zincchelator in asthma and interstitialpneumonia model mouse, 2010, 2012
- KAKENHI, Clinicopathological role of kl-6/muc1 with selectin ligand, 2007, 2009
- KAKENHI, 2013, 2016
- 2017, 2019
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019