Koichiro Ozawa
Last Updated :2024/05/07
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
- E-mail
- ozawakhiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 1999/04/01, 2002/03/31, Hiroshima University
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
- Master of Pharmaceutical Science, Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy
- Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
Research Keywords
- drug action
- Exocytosis
- Signal transduction
- Pharnacotherapy
- Tyrosine kinase
- Pharnacotherapy
- Video-enhanced light microscopy
- Clinical Pharmacology
- Mast cell
- Clinical Pharmacology
Educational Activity
Course in Charge
- 2024, Liberal Arts Education Program1, 2Term, Peace Messages from "Kasumi Campus"
- 2024, Liberal Arts Education Program1, 2Term, Foundation physics for life science
- 2024, Liberal Arts Education Program1, 1Term, Foundation biology for life science
- 2024, Undergraduate Education, Intensive, Social Medicine
- 2024, Undergraduate Education, 1Term, Nuclear Pharmacy
- 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
- 2024, Undergraduate Education, First Semester, Research Practice A
- 2024, Undergraduate Education, Second Semester, Research Practice B
- 2024, Undergraduate Education, First Semester, Practice of Clinical Pharmacy
- 2024, Undergraduate Education, Second Semester, Biostatistics
- 2024, Undergraduate Education, 1Term, Pharmacotherapy A
- 2024, Undergraduate Education, 3Term, Clinical Pharmacology A
- 2024, Undergraduate Education, 2Term, Pharmaceutical Affairs Related Laws
- 2024, Undergraduate Education, 1Term, Clinical Pharmacology C
- 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
- 2024, Undergraduate Education, 3Term, Practical English for Pharmaceutical Students
- 2024, Undergraduate Education, 3Term, Pharmacy Practice
- 2024, Undergraduate Education, Year, Clerkship in Clinical Pharmacy A
- 2024, Undergraduate Education, Year, Clerkship in Clinical Pharmacy B
- 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
- 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
- 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
- 2024, Undergraduate Education, 4Term, Seminar on school health II
- 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
- 2024, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacotherapy
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacotherapy
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacotherapy
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacotherapy
- 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
- 2024, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacotherapy
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacotherapy
- 2024, Graduate Education (Master's Program) , First Semester, Research on Pharmacotherapy
- 2024, Graduate Education (Master's Program) , Second Semester, Research on Pharmacotherapy
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacotherapy for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacotherapy for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacotherapy for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacotherapy for Medicinal Sciences
Research Activities
Academic Papers
- Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress, PLOS ONE, 17(12), 20221213
- COOH-terminal fragment of APP interacts with p62, forms an aggregate, and induces autophagic degradation in Alzheimer's cell model, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 323(6), C1633-C1641, 202212
- Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 27(5), 807-819, 202210
- Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli, FRONTIERS IN IMMUNOLOGY, 13, 20220928
- Coagulation factors induce human skin mast cell and basophil degranula-tion via activation of complement 5 and the C5a receptor, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(3), 1101-+, 202103
- Peripheral Immune Activation in Mice Elicits Unfolded Protein Responses Independent on MyD88 Pathway in the Liver but not the Hypothalamus and Hippocampus, FRONTIERS IN PHYSIOLOGY, 13, 20220428
- Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118(1-2), 19-29, 201001
- MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
- MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
- Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 84-90, 201201
- Skin surface electrical potential as an indicator of skin condition: observation of surfactant-induced dry skin and middle-aged skin, EXPERIMENTAL DERMATOLOGY, 20(9), 757-759, 201109
- Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(3), 319-324, 201203
- Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497(2), 340-343, 20120415
- Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7(6), 20120629
- TNF-alpha-857C > T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma, INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 10(12), 1755-1760, 2013
- Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
- Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 123(2), 140-146, 201310
- ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 525-528, 20131115
- ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3, 20131202
- Determination of Insulin Content in Pancreatic B-cell Line MING Cell by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Biol. Pharm. Bull., 1240, 19980401
- 5-HT receptor activation stimulates phospholipid methylation in rat brain, European Journal of Phoracology, 205-206, 19910401
- Different isozymes of protein kinase C show each specific role in RBL-2H3 cells, Bulletin of the Japanese Neurochemical Society, 32(1), 270-271, 19930401
- Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy, The Japanese Journal of Pharmacology, 112pー113p, 19930401
- Antiallergic dimeric prenylbenzoguinones from Ehretia Microphylla, Phytochemistry, 39(1), 105-110, 19950401
- Real-time analysis of PKC-translocation and exocytosis visualized by video-enhanced light/fluorescence microscopy., The Japanese Journal of Pharmacology, 67, 379-389, 19950401
- Real-time analysis of exocytosis and PKC-translocation in RBL-2H3 cells visvalized by video-enhanced light/fluorescence microscopy., Neurochemical Research, 20, 323-324, 19950401
- Real-time analysis of exocytosis and protein kinase C-translocation in RBL0-2H3 cells., The 1st International Symposium on Neuronal Receptor Mechanisms, 1, 61, 19950401
- Different pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope., Biochemical and Biophysical Research Communications, 222, 243-248, 19960401
- Role of calcium, protein kinase C and map kinase in the activation of mast cells. (Review Article), Allergology International, 45, 49-60, 19960401
- Video-microscopy for analysis of molecular dynamics in cells, Journal of Pharmaceutical and Biomedical Analysis, 15, 1483-1488, 19970401
- Simultaneous analysis of membrane potential and calcium mobilization in a pancreatic beta-cell line MIN6 by use of a double-probe imaging microscope-system., Analytica Chimica Acta, 365, 3-7, 19980401
- Analysis of pharmacological and molecular mechanisms underlying insulin-secretion with video-microscopes in a pancreatic beta-cell line MIN6., Japanese Journal of Pharmacology, 76, 32-33, 19980401
- Analysis of pharmacological and molecular mechaisms underlying insulin-secretion with video-microscopes in a pancleatic beta-cell line MIN6., The Japanese Journal of Pharmacology, 76, 38-39, 19980401
- Trapping of secreted molecules at single-cell level using an HPLC resin particle under a videomicroscope., Biological and Pharmacentical Bulletin, 21(8), 886-888, 19980401
- Calcium mobilization in a pancreatic beta-cell line MIN6., The Japanese Journal of Pharmacology, 79, 25, 19990401
- Quantitative analysis of exocytosis visualized by video-microscopes in RBL-2H3 cells., The Japanese Journal of Pharmacology, 85, 12-15, 20010401
- Antiallergic Dimeric Prenylbenzoquinones from Ehretia microphylla, Phytochemistry, 39(1), 105-110, 19950701
- Antihistaminic flavonoids and aliphatic glycosides from Mentha spicata, Phytochemistry, 48(1), 131-136, 19980901
- Mechanism of Cu2+-induced elevation of [3H]cimetidine binding to membranes in rat brain, Neurochemistry International, 7(3), 435-440, 19850301
- Characterization of histamine H2-receptors with [3H]histamine binding in rat brain., Therapeutic Research, 7(1), 9-16, 19870101
- Histamine acting on H2-receptors stimulated phospholipid methylation in synaptic membranes of rat brain., Journal of Neurochemistry, 48(5), 1392-1398, 19870501
- Histamine H2-receptor-induced phospholipid-N-methylation., Neuroscience Research, 5(1), 128-129, 19870701
- Histamine increases phospholipid methylation and H2-receptor-adenylate cyclase coupling in rat brain., Journal of Neurochemistry, 50(5), 1551-1558, 19880501
- Regulation of [3H]histamine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Therapeutic Research, 10(2), 582-587, 19890201
- Regulation of [3H]histamine binding to H2-receptor in rat brain., Neurochemical Research, 14(6), 781-784, 19890601
- Phospholipid methylation participates in histamine H2-receptor-mediated cyclic AMP accumulation and positive chronotropic effect of guinea-pig atrium., Neurochemical Research, 15(3), 325-326, 19900101
- Solubilization and characterization of rat brain histamine H2-receptor., Therapeutic Research, 11(1), 90-95, 19900301
- Signalling mechanism of histamine H2-receptor in guinea-pig right atrium., Therapeutic Research, 11(1), 4-13, 19910301
- Uncoupling of histamine H2-receptors from GTP-binding proteins by sulfhydryl-modifying reagents., Therapeutic Research, 13(1), 191-197, 19920101
- Signalling mechanism of histamine H2-receptor in guinea-pig stomach., European Journal of Pharmacology, 188(1), 136-141, 19910601
- Solubilization and characterization of guinea-pig brain histamine H2-receptor., Therapeutic Research, 13(1), 198-204, 19920101
- Phospholipid methylation participates in H2-receptor mediated stimulation of adenylate cyclase in rat brain., Therapeutic Research, 13(1), 256-263, 19920101
- Regulation of [3H]cimetidine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Neurochemical Research, 15(3), 415-418, 19920101
- Signalling mechanism of histamine H2-receptor in guinea-pig brain., Neurochemical Research, 17(2), 415-418, 19930101
- ★, Ca2+-dependent and Ca2+-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells., The Journal of Biological Chemistry, 268(3), 1749-1756, 19930101
- ★, Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells., The Journal of Biological Chemistry, 268(4), 2280-2283, 19930201
- Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy., Japanese Journal of Pharmacology, 64(2), 112-115, 19940201
- ★, Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C g., Molecular Biology of the Cell, 5(4), 475-484, 19940401
- Each different isozyme of protein kinase C show a specific role in RBL-2H3 cells., Neurochemical Research, 19(8), 877-878, 19940801
- Antiallergic Mimeric Prenylbenzoquinones from Ehretis Microphylia., Phytochemistry, 39(1), 105-110, 19950101
- Real-time analysis of exocytosis and PKC-translocation in RBL-2H3 cells visualized by video-enhanced light/fluorescence microscopy., Neurochemical Research, 20(3), 323-324, 19950401
- Effect of tapsygargin on exocytosis in RBL-2H3 cells., Japanese Journal of Pharmacology, 66(2), 98-101, 19960201
- Effect of extracellular and intracellular calsium on exocytosis in MIN6 cells., Japanese Journal of Pharmacology, 66(2), 121-124, 19960201
- Simultaneous analysis of membrane potential and calcium mobilization in pancreatic ァ-cell line MIN6., Japanese Journal of Pharmacology, 69(1), 114-118, 19960401
- Differemt pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope., Boichemical and Biophyssical Research, 222(2), 243-248, 19960601
- Quantitative analysis of Exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells., FEBS Letters, 398, 67-73, 19961001
- ★, Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate., The Journal of Biological Chemistry, 272(20), 13033-13039, 19970501
- Video-microscopy for analysis of molecular dynamics in cells., Journal of Pharmaceutical and Biomedical Analysis, 15(7), 1483-1488, 19970801
- Release of Ca2+ from intracellular stores is necessary for Ca2+-influx and exocytosis in RBL-2H3 cells., Japanese Journal of Pharmacology, 73(1), 68-69, 19970301
- Effect of Ca2+-channel blocker on elevation of Ca2+ in MIN6 cells., Japanese Journal of Pharmacology, 79(1), 25-26, 19980301
- Effect of thaspygargin on increase of Ca2+ in RBL-2H3 cells., Japanese Journal of Pharmacology, 79(1), 184-185, 19980301
- Overexpression of dominant negative mutant hepatocyte nuclear factor (HNF)-1a inhibits arginine-induced insulin secretion in 6 cells., Diabetologia, 42(8), 887-891, 19990801
- A convenient method for the evaluation of anti-tumor agents affecting the cell cycle., Journal of Bioscience and Bioengineering, 90(5), 574-576, 20000501
- Quantitative analysis of exocytosis visualized by video-microscopesin RBL-2H3 cells., Japanese Journal of Pharmacology, 85(1), 12-15, 20010301
- Antihistaminic flavones and aliphatic glycosides from mentha spicata., Phytochemistry, 48(1), 131-136, 19980501
- Antiallergic Dimeric Prenylbenzoquinones from Ehretia microphylla, Phytochemistry, 39(1), 105-110, 19950501
- Quantitative analysisi of exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells, FEBS Letters, 398(1), 67-73, 19961101
- Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias., Blood, 91(6), 2067-2075, 19980301
- Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec gene., Biochem. Biophys. Res. Commun., 234(2), 376-381, 19970501
- Cloning and characterization of mouse tec promoter., Biochem. Biophys. Res. Commun., 223(2), 422-426, 19980601
- Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway., Kidney Int., 58, 269-282, 20000401
- Involvement of mTOR/Bim, not Akt/Bad pathway in cytokine-mediated cells survival signaling downstream of PI3-kinase in murine hematopoietic progenitors., Blood 96 Suppl., 1, 568A, 20000401
- Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3(E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes., Mol. Cell. Biol., 19, 2754-2762, 19990401
- SLUG, a ces-1-related zinc-finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein., Mol. Cell, 4, 343-352, 19990401
- Essential role of the BH3 factor, Bim, in the cytokine-mediated apoptosis program: Implications in the antiapoptotic Ras pathways and in leukemogenesis., Blood 94 Suppl., 1, 688A, 19990401
- Involvement of Bim, the BH3-containing cell death activator, in cytokine-mediated apoptosis program and in leukemogenesis by the E2A-HLF chimera, Blood 92 Suppl., 1, 199A, 19980401
- Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells., Blood, 90, 3884-3892, 19970401
- Ras-dependent and -independent regulation of E4BP4/NFIL3 transcription factor in cytokine-mediated cell survival of pro-B lymphocytes: the target gene program for oncogenic Ras, Bcr-Abl and E2A-HLF chimeras in leukemogenesis., Blood 90 Suppl., 1, 47A, 19970401
- Novel approaches using video techniques for dynamic analysis, 299-314, 19990301
- Role of calcium, protein kinase C and MAP kinase in the activation of mast cells., Allergology International, 73-84, 19960901
- Different changes of disuse atrophy with normally temperature and low-temperature environment on hindlimb unloadong syrian hamster., Cryoletters, 215-222, 20021201
- Analysis of pharmacological and molecural mechanisms underlying histamine-secretion with video-micorscopes in RBL-2H3 cells., Histamine Research in the New Millennium, 103, 20011001
- Caspase 3-activating Factor and Early Apoptosis Signaling in Hindlimb Unloading-induced Muscle Atrophy, European Journal of Applied Physiology, 38(3), 115-122, 20030801
- Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients., The Japanese Journal of Toxicology, 16(4), 105-124, 20030901
- Disuse atrophy alterations in normal and low temperature environments during hindlimb unloading in Syrian hamsters., Cryoletters, 24(4), 245-252, 20031101
- Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients in the intensive care unit., Chudoku Kenkyu, 16(3), 433-440, 20031201
- Energy metabolism and nutritional support in the early phase of severely burned patients., Jap. J. Burn Injur., 23(7), 223-230, 20040701
- Augmentation of serotonin-induced inhibition of neuronal activity in the hippocampus following repeated treatment with methamphetamine., Annals of New York Academy of Sciences, 1025, 242-247, 20041001
- Early apoptosis signals in hindlimb unloading-induced muscle atrophy., Journal of Pharmacological Sciences, 94, 142, 20040301
- Model core curriculum for pharmaceutical education in Japan., FIP Abstracts 2004, 22, 20040901
- Environmental factors and lifestyles as risk facters for Japanese ceder pollinosis in recent urban areas
- Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Res., 17(2), 184-186, 20070201
- Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
- Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070604
- Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
- Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070324
- Nanokinetics of drug molecule transport into a single cell., Nanomedicine, 1(3), 345-350, 20061001
- Determination of insulin content in pancreatic beta cell line MIN6 cells by matrix-assisted laser desorption ionization time-of-flight mass spectrometry., Biol. Pharm. Bull., 21(11), 1240-1241, 19981101
- Trapping of secreted molecules at single-cell level using an HPLC resin particle under a videomicroscope., Biol. Pharm. Bull., 21(8), 886-888, 19980801
- ★, Endoplasmic Reticulum Stress Induces Leptin Resistanc, Molecular Pharmacology, 74(6), 1610-1619, 20080828
- The activation of apoptosis factor in hindlimb unloading-induced mescle atrophy under normal and low^temperature environmental conditions., acta histochemica, 110, 505-518, 20080101
- TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress., Journal of Pharmacological Sciences, 114, 230-233, 20100201
- Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537, 20100901
- Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 724-734, 20101101
- A unique modulator of endoplasmic reticulum stress-signaling pathways: the novel pharmacological properties of amiloride., British Journal of Pharmacology, 159(2), 428-437, 20100501
- Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance (Mini-Review)., The Journal of Medical Investigation, 56, 296-298, 20091001
- Vanadate inhibits endoprasmic reticulum stress responses., European Journal of Pharmacology, 594, 44-48, 20080101
- Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression., European Journal of Pharmacology, 554, 8*11, 20071001
- Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17, 184-186, 20071101
- Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070901
- Development of clinical application for a nutritional prescription support system for total parenteral/enteral nutrition., YAKUGAKU ZASSHI, 129(9), 1077-1086, 20090901
- Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells., Neurochemistry International, 54, 1-6, 20090101
- Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition., Experimental Dermatology, 17, 688-692, 20080901
- Development of advanced pharmacy practoce experience in national unibersities., Yakugaku Zassi, 3, 345-350, 20120301
- Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 12, 20120401
- PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells., Biochemical and Biophysical Research Communications, 1, 286-90, 20060201
- 2-Aminopurine inhibits leptin receptor signal transduction., European Journal of Pharmacology, 1-3, 61-66, 20061201
- LPS induces stefin A3 expression in mouse primary cultured glial cells., Molecular Brain Research, 1-2, 138-41, 20051001
- Improvement of the Teaching Method for Active Learning-Introduction of Problem-based Learning to the first-year seminar ―, in press, 20131201
- Augmentation of serotonin-induced inhibition of neuronal activity in the hippocampus following repeated treatment with methamphetamine, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 242-247, 2004
- LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140(1-2), 138-141, 20051031
- A low temperature environment delays the changes in muscle fiber type composition induced by unloading, ACTA HISTOCHEMICA ET CYTOCHEMICA, 38(5), 305-312, 2005
- PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340(1), 286-290, 20060203
- Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152, 27-31, 20070604
- 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553(1-3), 61-66, 20061228
- Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression, EUROPEAN JOURNAL OF PHARMACOLOGY, 554(1), 8-11, 20070105
- Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition, EXPERIMENTAL DERMATOLOGY, 17(8), 688-692, 200808
- Comparative study of drug efficacy and drug additives between generic drugs and original drugs, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127(12), 2035-2044, 200712
- Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594(1-3), 44-48, 20081010
- Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74(6), 1610-1619, 200812
- The activation of apoptosis factor in hindlimb unloading-induced muscle atrophy under normal and low-temperature environmental conditions, ACTA HISTOCHEMICA, 110(6), 505-518, 2008
- Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54(1), 1-6, 200901
- Development of Clinical Application for a Nutritional Prescription Support System for Total Parenteral/Enteral Nutrition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 129(9), 1077-1086, 200909
- Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177(2), 724-734, 201008
- A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 428-437, 201001
- Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56(2), 216-220, 201001
- Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5(9), 20100902
- TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(2), 230-233, 201010
- Development of Advanced Pharmacy Practice Experience in National Universities, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 132(3), 345-350, 201203
- Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6(3), 335-346, 201403
- TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
- Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558, 11-17, 20140416
- Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569, 23-26, 20140521
- Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449(1), 132-134, 20140620
- Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4, 20141118
- Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133(3), 343-351, 201505
- Synthesis of a peptide that can translocate to the endoplasmic reticulum, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 460(3), 628-632, 20150508
- Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
- ★, Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress., EMBO Molecular Medicine, 6(3), 335-346, 2014
- Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells., PLoS ONE, 7, e40144, 2012
- Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 3, 1-5, 2012
- Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537
- Endoplasmic reticulum stress induces leptin resistance., Molecular Pharmacology, 74, 1610-1619, 2008
- Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 230-233, 2010
- Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. S. Yokoyama, T. Hosoi, and K. Ozawa., GENE, 497, 340-343, 2012
- ER stress upregulated PGE2/IFNg-induced IL-6 expression and down-regulated iNOS expression in glial cells., Scientific Reports, 3, DOI 10.1038/srep03388, 2013
- Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, Nov 18;4, 7096
- Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 343-351, 2015
- Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
- Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance, The Journal of Medical Investigation, 56, 19-29, 2009
- Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
- Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
- Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
- TNF-alpha -857C>T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma., International Journal of Medical Sciences, 10(12), 1755-1760, 2013
- Serotonergic modulation of neuronal activity in the nucleus accumbens following repeated methamphetamine administration in rats., Journal of Pharmacological Sciences, 123, 140-146, 2013
- Improvement of the Teaching Method for Active Learning-Introduction of Problem-based Learning to the first-year seminar-, 19, 25-36
- Differential activation of the ER stress factor XBP1 by oligomeric assemblies., Neurochemical Research, 37, 1834-1837, 2012
- The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(6), 827-830, 201606
- Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7, 20160608
- Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173(15), 2434-2445, 201608
- Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27(13), 974-977, 20160907
- Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
- Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131(4), 292-295, 201608
- Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(2), 716-720, 20160916
- Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6, 20160928
- Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7, 20160930
- Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis., Frontiers in Endocrinology, 10.3389/fendo.2016.00138, 2016
- Flurbiprofen ameliorates glucose deprivation-induced leptin resistance., Frontiers in Pharmacology, doi: 10.3389/fphar.2016.00354, 2016
- Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. (Mini Review), Scientific Reports, 6, 34312, 2016
- Mechanisms and pharmacological strategy targeting dysfunction of endoplasmic reticulum., YAKUGAKU ZASSHI, 136(6), 827-830, 2016
- The mechanisms and pharmacological strategy for treatment on ER stress-iduced metabolic syndrome., YAKUGAKU ZASSHI, 136(6), 799-800, 2016
- Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death., Neuroscience Letters, 629, 241-244, 2016
- Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 716-720, 2016
- Unique pharmacological property of ISRIB in inhibition of Ab-induced neuronal cell death., Journal of Pharmacological Sciences, 131(4), 292-295, 2016
- Possible pharmacological approach targeting endoplasmic reticulum stress to ameliorate leptin resistance in obesity., Frontiers in Endocrinology, 10.3389/fendo.2016.00059, 2016
- Key role of HSP90 in leptin-induced STAT3 activation and feeding regulation., British Journal of Pharmacology, 173, 2434-2445, 2016
- Implementation and evaluation of genetic testing seminars on lifestyle-related disease prevention for pharmacy students., YAKUGAKU ZASSHI, 136(2), 337-350, 2016
- Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 345-351, 2015
- Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
- Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, doi: 10.1038/srep07096, 2014
- Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
- Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
- TERT attenuated ER stress-induced cell death., Biochemical and Biophysical Research Communications, 447, 378-382, 2014
- Caffeine attenuated ER stress-induced leptin resistance in neurons., Neuroscience Letters, 569, 23-26, 2014
- Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress., EMBO Molecular Medicine, 6(3), 335-346, 2014
- Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6(1), 159-172, 201701
- Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(8), 1161-1164, 201708
- Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(12), 1517-1531, 201712
- Mechanisms of the action of adenine on anti-allergic effects in mast cells, IMMUNITY INFLAMMATION AND DISEASE, 6(1), 97-105, 201803
- TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
- Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases. (Review), Journal of Health Science, 5, 9-17, 2017
- Link between endoplasmic reticulum stress and autophagy in neurodegenerative disesases. (Review), Endoplasimic Reticulum Stress in Diseases, 4, 37-45, 2017
- Alteration of the composition of memberane lipid on endplasmic reticulum stress and phathophysiology of obesity., 50(3), 154-156, 2018
- Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 292-295, 2016
- Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes, FRONTIERS IN PHYSIOLOGY, 9, 20180926
- Immobilization stress induces XBP1 splicing in the mouse brain, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 508(2), 516-520, 20190108
- Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kappa B, and STAT3, PHARMACOLOGICAL REPORTS, 71(2), 289-298, 201904
- Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 316(5), C641-C648, 201905
- Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease, ENDOPLASMIC RETICULUM STRESS IN DISEASES, 2(1), 107-118, 201501
- Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases, ENDOPLASMIC RETICULUM STRESS IN DISEASES, 4(1), 37-45, 201704
- Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis, CYTOTECHNOLOGY, 71(4), 769-783, 201908
- Progress of Pharmacy Education in Japan —MODEL CORE CURRICULUM FOR PHARMACY EDUCATION and THE EVALUATION STANDARDS— (Review), Journal of Asian Association of Schools of Pharmacy, 7, 8-14, 2018
- Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3., Pharmacological Reports, 71(2), 289-298, 2019
- Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity., American Journal of Physiology, 316, C641-C648, 2019
- Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis., Cytotechnology, 71, 769-783, 201908
- Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1 beta, JOURNAL OF DERMATOLOGY, 47(11), 1293-1300, 202011
- Possible Involvement of MyD88 in Regulating Stress Response in Mice, FRONTIERS IN NEUROSCIENCE, 15, 20210312
- Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus, ANTIOXIDANTS, 10(5), 202105
- The possible role of biochanin A in ameliorating endoplasmic reticulum stress-induced leptin resistance, NEUROREPORT, 32(12), 983-987, 20210811
- The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria, CELLS, 10(7), 202107
- Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline, MOLECULAR PHARMACOLOGY, 100(3), 181-192, 20210901
Publications such as books
- 2000, Analysis of pharmacological and molecular mechanisms underlying histamine-secretion with video-microscopes in RBL-2H3 cells. , Histamine Research in the New Millenium, 2000
- 1988/10, Neuroreceptors and Signal Transduction , Plenum Press, 1988, 10, Joint work
- 1989/07, Biosignalling in Cardiac and Vascular Systems , Pergamon press, 1989, 07, Joint work
- 1990/02, The Biology and Medicine of Signal Transduction , Raven Press, 1990, 02, Joint work
- 2001/03, Histamine Research in the New Millennium , Pergamon press, 2001, 03, Scholarly Book, Cocompilation, 521
- 2004/10, Current status of drug dependence/abuse studies , Annals New York Academy of Sciences, 2004, 10, Scholarly Book, Cocompilation, 642
Invited Lecture, Oral Presentation, Poster Presentation
- Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 3rd AASP Pharmacy Deans Forum, With Invitation, English, TOKYO
- Accreditation of Pharmacy School in Japan., Koichiro Ozawa, 7TH Asian Association of Schools of Pharmacy (AASP), 2015/10/30, With Invitation, English
- Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 7rd Asian Association of Schools of Pharmacy, 2015/10/30, With Invitation, English, Taipei
- Accreditation for Pharmaceutical Education in Japan, Koichiro Ozawa, Symposium of Accreditation for Pharmaceutical Education in Korea, 2015/05/21, With Invitation, English, Seoul, Korea
- Possible involvement of 4-hydroxy-2-nonenal on development of leptin resistance., Toru Hosoi, Ayaka Kuwamura, and Koichiro Ozawa, The 90th Annual Meeting of the Japanese Pharmacological Society, 2017/03/15, Without Invitation, Japanese, the Japanese Pharmacological Society, Nagasaki
- Comparing the pharmacy education between Japan and the foreign countries., Koichiro Ozawa, 137th Annual Meeting of the Pharmaceutical Society of Japan, 2017/03/26, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Sendai
- Harmonization of pharmaceutical education in the world - A PROJECT COMMISSIONED TO PSJ FROM THE MEXT, Koichiro Ozawa, 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/27, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Kanazawa