Koichiro Ozawa

Last Updated :2020/12/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
ozawakhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Drug development chemistry

Research Keywords

  • drug action
  • Exocytosis
  • Signal transduction
  • Pharnacotherapy
  • Tyrosine kinase
  • Pharnacotherapy
  • Video-enhanced light microscopy
  • Clinical Pharmacology
  • Mast cell
  • Clinical Pharmacology

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 2Term, Peace Messages from "Kasumi Campus"
  2. 2020, Liberal Arts Education Program1, 2Term, Foundation physics for life science
  3. 2020, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  4. 2020, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  5. 2020, Undergraduate Education, 2Term, Nuclear Pharmacy
  6. 2020, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  7. 2020, Undergraduate Education, First Semester, Research Practice A
  8. 2020, Undergraduate Education, Second Semester, Research Practice B
  9. 2020, Undergraduate Education, Second Semester, Biostatistics
  10. 2020, Undergraduate Education, 1Term, Pharmacotherapy A
  11. 2020, Undergraduate Education, 2Term, Outline of Immunology
  12. 2020, Undergraduate Education, 3Term, Clinical Pharmacology A
  13. 2020, Undergraduate Education, 2Term, Pharmaceutical Affairs Related Laws
  14. 2020, Undergraduate Education, 1Term, Clinical Pharmacology C
  15. 2020, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  16. 2020, Undergraduate Education, 4Term, Practical English for Pharmaceutical Students
  17. 2020, Undergraduate Education, 3Term, Pharmacy Practice
  18. 2020, Undergraduate Education, Year, Clerkship in Clinical Pharmacy A
  19. 2020, Undergraduate Education, Year, Clerkship in Clinical Pharmacy B
  20. 2020, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  21. 2020, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  22. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  23. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  24. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  25. 2020, Undergraduate Education, Second Semester, Seminar on school health
  26. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  27. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  28. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  29. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  30. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pharmacotherapy
  31. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pharmacotherapy
  32. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pharmacotherapy
  33. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pharmacotherapy
  34. 2020, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  35. 2020, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  36. 2020, Graduate Education (Doctoral Program) , 3Term, Pharmacotherapeutic Research
  37. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacotherapy
  38. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacotherapy
  39. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacotherapy
  40. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacotherapy
  41. 2020, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacotherapy
  42. 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacotherapy
  43. 2020, Graduate Education (Master's Program) , First Semester, Research on Pharmacotherapy
  44. 2020, Graduate Education (Master's Program) , Second Semester, Research on Pharmacotherapy

Research Activities

Academic Papers

  1. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118(1-2), 19-29, 201001
  2. MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
  3. MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
  4. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 84-90, 201201
  5. Skin surface electrical potential as an indicator of skin condition: observation of surfactant-induced dry skin and middle-aged skin, EXPERIMENTAL DERMATOLOGY, 20(9), 757-759, 201109
  6. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(3), 319-324, 201203
  7. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497(2), 340-343, 20120415
  8. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7(6), 20120629
  9. TNF-alpha-857C > T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma, INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 10(12), 1755-1760, 2013
  10. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
  11. Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 123(2), 140-146, 201310
  12. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 525-528, 20131115
  13. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3, 20131202
  14. Determination of Insulin Content in Pancreatic B-cell Line MING Cell by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Biol. Pharm. Bull., 1240, 19980401
  15. 5-HT receptor activation stimulates phospholipid methylation in rat brain, European Journal of Phoracology, 205-206, 19910401
  16. Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy, The Japanese Journal of Pharmacology, 112pー113p, 19930401
  17. Antiallergic dimeric prenylbenzoguinones from Ehretia Microphylla, Phytochemistry, 39(1), 105-110, 19950401
  18. Real-time analysis of PKC-translocation and exocytosis visualized by video-enhanced light/fluorescence microscopy., The Japanese Journal of Pharmacology, 67, 379-389, 19950401
  19. Real-time analysis of exocytosis and PKC-translocation in RBL-2H3 cells visvalized by video-enhanced light/fluorescence microscopy., Neurochemical Research, 20, 323-324, 19950401
  20. Real-time analysis of exocytosis and protein kinase C-translocation in RBL0-2H3 cells., The 1st International Symposium on Neuronal Receptor Mechanisms, 1, 61, 19950401
  21. Role of calcium, protein kinase C and map kinase in the activation of mast cells. (Review Article), Allergology International, 45, 49-60, 19960401
  22. Video-microscopy for analysis of molecular dynamics in cells, Journal of Pharmaceutical and Biomedical Analysis, 15, 1483-1488, 19970401
  23. Simultaneous analysis of membrane potential and calcium mobilization in a pancreatic beta-cell line MIN6 by use of a double-probe imaging microscope-system., Analytica Chimica Acta, 365, 3-7, 19980401
  24. Analysis of pharmacological and molecular mechanisms underlying insulin-secretion with video-microscopes in a pancreatic beta-cell line MIN6., Japanese Journal of Pharmacology, 76, 32-33, 19980401
  25. Quantitative analysis of exocytosis visualized by video-microscopes in RBL-2H3 cells., The Japanese Journal of Pharmacology, 85, 12-15, 20010401
  26. Antiallergic Dimeric Prenylbenzoquinones from Ehretia microphylla, Phytochemistry, 39(1), 105-110, 19950701
  27. Histamine H2-receptor-induced phospholipid-N-methylation., Neuroscience Research, 5(1), 128-129, 19870701
  28. Histamine increases phospholipid methylation and H2-receptor-adenylate cyclase coupling in rat brain., Journal of Neurochemistry, 50(5), 1551-1558, 19880501
  29. Regulation of [3H]histamine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Therapeutic Research, 10(2), 582-587, 19890201
  30. Regulation of [3H]histamine binding to H2-receptor in rat brain., Neurochemical Research, 14(6), 781-784, 19890601
  31. Phospholipid methylation participates in histamine H2-receptor-mediated cyclic AMP accumulation and positive chronotropic effect of guinea-pig atrium., Neurochemical Research, 15(3), 325-326, 19900101
  32. Solubilization and characterization of rat brain histamine H2-receptor., Therapeutic Research, 11(1), 90-95, 19900301
  33. Uncoupling of histamine H2-receptors from GTP-binding proteins by sulfhydryl-modifying reagents., Therapeutic Research, 13(1), 191-197, 19920101
  34. Signalling mechanism of histamine H2-receptor in guinea-pig stomach., European Journal of Pharmacology, 188(1), 136-141, 19910601
  35. Solubilization and characterization of guinea-pig brain histamine H2-receptor., Therapeutic Research, 13(1), 198-204, 19920101
  36. Phospholipid methylation participates in H2-receptor mediated stimulation of adenylate cyclase in rat brain., Therapeutic Research, 13(1), 256-263, 19920101
  37. Regulation of [3H]cimetidine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Neurochemical Research, 15(3), 415-418, 19920101
  38. Signalling mechanism of histamine H2-receptor in guinea-pig brain., Neurochemical Research, 17(2), 415-418, 19930101
  39. ★, Ca2+-dependent and Ca2+-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells., The Journal of Biological Chemistry, 268(3), 1749-1756, 19930101
  40. ★, Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells., The Journal of Biological Chemistry, 268(4), 2280-2283, 19930201
  41. Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy., Japanese Journal of Pharmacology, 64(2), 112-115, 19940201
  42. ★, Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C g., Molecular Biology of the Cell, 5(4), 475-484, 19940401
  43. Antiallergic Mimeric Prenylbenzoquinones from Ehretis Microphylia., Phytochemistry, 39(1), 105-110, 19950101
  44. Differemt pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope., Boichemical and Biophyssical Research, 222(2), 243-248, 19960601
  45. Quantitative analysis of Exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells., FEBS Letters, 398, 67-73, 19961001
  46. ★, Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate., The Journal of Biological Chemistry, 272(20), 13033-13039, 19970501
  47. Video-microscopy for analysis of molecular dynamics in cells., Journal of Pharmaceutical and Biomedical Analysis, 15(7), 1483-1488, 19970801
  48. Release of Ca2+ from intracellular stores is necessary for Ca2+-influx and exocytosis in RBL-2H3 cells., Japanese Journal of Pharmacology, 73(1), 68-69, 19970301
  49. Effect of Ca2+-channel blocker on elevation of Ca2+ in MIN6 cells., Japanese Journal of Pharmacology, 79(1), 25-26, 19980301
  50. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle., Journal of Bioscience and Bioengineering, 90(5), 574-576, 20000501
  51. Quantitative analysisi of exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells, FEBS Letters, 398(1), 67-73, 19961101
  52. Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias., Blood, 91(6), 2067-2075, 19980301
  53. Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec gene., Biochem. Biophys. Res. Commun., 234(2), 376-381, 19970501
  54. Cloning and characterization of mouse tec promoter., Biochem. Biophys. Res. Commun., 223(2), 422-426, 19980601
  55. Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway., Kidney Int., 58, 269-282, 20000401
  56. Novel approaches using video techniques for dynamic analysis, 299-314, 19990301
  57. Different changes of disuse atrophy with normally temperature and low-temperature environment on hindlimb unloadong syrian hamster., Cryoletters, 215-222, 20021201
  58. Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients., The Japanese Journal of Toxicology, 16(4), 105-124, 20030901
  59. Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients in the intensive care unit., Chudoku Kenkyu, 16(3), 433-440, 20031201
  60. Energy metabolism and nutritional support in the early phase of severely burned patients., Jap. J. Burn Injur., 23(7), 223-230, 20040701
  61. Augmentation of serotonin-induced inhibition of neuronal activity in the hippocampus following repeated treatment with methamphetamine., Annals of New York Academy of Sciences, 1025, 242-247, 20041001
  62. Early apoptosis signals in hindlimb unloading-induced muscle atrophy., Journal of Pharmacological Sciences, 94, 142, 20040301
  63. Model core curriculum for pharmaceutical education in Japan., FIP Abstracts 2004, 22, 20040901
  64. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
  65. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070604
  66. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070324
  67. Nanokinetics of drug molecule transport into a single cell., Nanomedicine, 1(3), 345-350, 20061001
  68. Determination of insulin content in pancreatic beta cell line MIN6 cells by matrix-assisted laser desorption ionization time-of-flight mass spectrometry., Biol. Pharm. Bull., 21(11), 1240-1241, 19981101
  69. Trapping of secreted molecules at single-cell level using an HPLC resin particle under a videomicroscope., Biol. Pharm. Bull., 21(8), 886-888, 19980801
  70. ★, Endoplasmic Reticulum Stress Induces Leptin Resistanc, Molecular Pharmacology, 74(6), 1610-1619, 20080828
  71. The activation of apoptosis factor in hindlimb unloading-induced mescle atrophy under normal and low^temperature environmental conditions., acta histochemica, 110, 505-518, 20080101
  72. TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress., Journal of Pharmacological Sciences, 114, 230-233, 20100201
  73. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537, 20100901
  74. Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 724-734, 20101101
  75. A unique modulator of endoplasmic reticulum stress-signaling pathways: the novel pharmacological properties of amiloride., British Journal of Pharmacology, 159(2), 428-437, 20100501
  76. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance (Mini-Review)., The Journal of Medical Investigation, 56, 296-298, 20091001
  77. Vanadate inhibits endoprasmic reticulum stress responses., European Journal of Pharmacology, 594, 44-48, 20080101
  78. Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression., European Journal of Pharmacology, 554, 8*11, 20071001
  79. Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17, 184-186, 20071101
  80. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070901
  81. Development of clinical application for a nutritional prescription support system for total parenteral/enteral nutrition., YAKUGAKU ZASSHI, 129(9), 1077-1086, 20090901
  82. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells., Neurochemistry International, 54, 1-6, 20090101
  83. Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition., Experimental Dermatology, 17, 688-692, 20080901
  84. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 12, 20120401
  85. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells., Biochemical and Biophysical Research Communications, 1, 286-90, 20060201
  86. 2-Aminopurine inhibits leptin receptor signal transduction., European Journal of Pharmacology, 1-3, 61-66, 20061201
  87. LPS induces stefin A3 expression in mouse primary cultured glial cells., Molecular Brain Research, 1-2, 138-41, 20051001
  88. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140(1-2), 138-141, 20051031
  89. A low temperature environment delays the changes in muscle fiber type composition induced by unloading, ACTA HISTOCHEMICA ET CYTOCHEMICA, 38(5), 305-312, 2005
  90. ★, Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress., EMBO Molecular Medicine, 6(3), 335-346, 2014
  91. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells., PLoS ONE, 7, e40144, 2012
  92. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 3, 1-5, 2012
  93. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537
  94. Endoplasmic reticulum stress induces leptin resistance., Molecular Pharmacology, 74, 1610-1619, 2008
  95. Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 230-233, 2010
  96. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. S. Yokoyama, T. Hosoi, and K. Ozawa., GENE, 497, 340-343, 2012
  97. ER stress upregulated PGE2/IFNg-induced IL-6 expression and down-regulated iNOS expression in glial cells., Scientific Reports, 3, DOI 10.1038/srep03388, 2013
  98. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, Nov 18;4, 7096
  99. Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 343-351, 2015
  100. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
  101. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance, The Journal of Medical Investigation, 56, 19-29, 2009
  102. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632
  103. Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
  104. Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
  105. TNF-alpha -857C>T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma., International Journal of Medical Sciences, 10(12), 1755-1760
  106. Serotonergic modulation of neuronal activity in the nucleus accumbens following repeated methamphetamine administration in rats., Journal of Pharmacological Sciences, 123, 140-146
  107. Differential activation of the ER stress factor XBP1 by oligomeric assemblies., Neurochemical Research, 37, 1834-1837
  108. Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis., Frontiers in Endocrinology, 10.3389/fendo.2016.00138, 2016
  109. Flurbiprofen ameliorates glucose deprivation-induced leptin resistance., Frontiers in Pharmacology, doi: 10.3389/fphar.2016.00354, 2016
  110. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. (Mini Review), Scientific Reports, 6, 34312, 2016
  111. Mechanisms and pharmacological strategy targeting dysfunction of endoplasmic reticulum., YAKUGAKU ZASSHI, 136(6), 827-830, 2016
  112. The mechanisms and pharmacological strategy for treatment on ER stress-iduced metabolic syndrome., YAKUGAKU ZASSHI, 136(6), 799-800, 2016
  113. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death., Neuroscience Letters, 629, 241-244, 2016
  114. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 716-720, 2016
  115. Unique pharmacological property of ISRIB in inhibition of Ab-induced neuronal cell death., Journal of Pharmacological Sciences, 131(4), 292-295, 2016
  116. Possible pharmacological approach targeting endoplasmic reticulum stress to ameliorate leptin resistance in obesity., Frontiers in Endocrinology, 10.3389/fendo.2016.00059, 2016
  117. Key role of HSP90 in leptin-induced STAT3 activation and feeding regulation., British Journal of Pharmacology, 173, 2434-2445, 2016
  118. Implementation and evaluation of genetic testing seminars on lifestyle-related disease prevention for pharmacy students., YAKUGAKU ZASSHI, 136(2), 337-350, 2016
  119. Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 345-351, 2015
  120. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
  121. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, doi: 10.1038/srep07096, 2014
  122. Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
  123. Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
  124. TERT attenuated ER stress-induced cell death., Biochemical and Biophysical Research Communications, 447, 378-382, 2014
  125. Caffeine attenuated ER stress-induced leptin resistance in neurons., Neuroscience Letters, 569, 23-26, 2014
  126. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress., EMBO Molecular Medicine, 6(3), 335-346, 2014
  127. Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases. (Review), Journal of Health Science, 5, 9-17, 2017
  128. Link between endoplasmic reticulum stress and autophagy in neurodegenerative disesases. (Review), Endoplasimic Reticulum Stress in Diseases, 4, 37-45, 2017
  129. Alteration of the composition of memberane lipid on endplasmic reticulum stress and phathophysiology of obesity., 50(3), 154-156, 2018
  130. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 292-295, 2016
  131. Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis, CYTOTECHNOLOGY, 71(4), 769-783, 201908
  132. Progress of Pharmacy Education in Japan —MODEL CORE CURRICULUM FOR PHARMACY EDUCATION and THE EVALUATION STANDARDS— (Review), Journal of Asian Association of Schools of Pharmacy, 7, 8-14, 2018
  133. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3., Pharmacological Reports, 71(2), 289-298
  134. Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity., American Journal of Physiology, 316, C641-C648
  135. Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis., Cytotechnology, 71, 769-783

Publications such as books

  1. 2000, Analysis of pharmacological and molecular mechanisms underlying histamine-secretion with video-microscopes in RBL-2H3 cells. , Histamine Research in the New Millenium, 2000
  2. 1988/10, Neuroreceptors and Signal Transduction , Plenum Press, 1988, 10, Joint work
  3. 1989/07, Biosignalling in Cardiac and Vascular Systems , Pergamon press, 1989, 07, Joint work
  4. 1990/02, The Biology and Medicine of Signal Transduction , Raven Press, 1990, 02, Joint work
  5. 2001/03, Histamine Research in the New Millennium , Pergamon press, 2001, 03, Scholarly Book, Cocompilation, 521
  6. 2004/10, Current status of drug dependence/abuse studies , Annals New York Academy of Sciences, 2004, 10, Scholarly Book, Cocompilation, 642

Invited Lecture, Oral Presentation, Poster Presentation

  1. Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 3rd AASP Pharmacy Deans Forum, With Invitation, English, TOKYO
  2. Accreditation of Pharmacy School in Japan., Koichiro Ozawa, 7TH Asian Association of Schools of Pharmacy (AASP), 2015/10/30, With Invitation, English
  3. Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 7rd Asian Association of Schools of Pharmacy, 2015/10/30, With Invitation, English, Taipei
  4. Accreditation for Pharmaceutical Education in Japan, Koichiro Ozawa, Symposium of Accreditation for Pharmaceutical Education in Korea, 2015/05/21, With Invitation, English, Seoul, Korea
  5. Possible involvement of 4-hydroxy-2-nonenal on development of leptin resistance., Toru Hosoi, Ayaka Kuwamura, and Koichiro Ozawa, The 90th Annual Meeting of the Japanese Pharmacological Society, 2017/03/15, Without Invitation, Japanese, the Japanese Pharmacological Society, Nagasaki
  6. Comparing the pharmacy education between Japan and the foreign countries., Koichiro Ozawa, 137th Annual Meeting of the Pharmaceutical Society of Japan, 2017/03/26, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Sendai
  7. Harmonization of pharmaceutical education in the world - A PROJECT COMMISSIONED TO PSJ FROM THE MEXT, Koichiro Ozawa, 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/27, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Kanazawa