Last Updated :2019/02/01

Affiliations, Positions
Graduate School of Biomedical & Health Sciences (Biomedical Sciences Major), Professor
Web Site
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5130 FAX : (+81)82-257-5134

Basic Information

Academic Degrees

  • Ph.D., Osaka University
  • Master of Agriculture, Tokyo University of Agriculture and Technology

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Biology;Biological Science;Cell biology
  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology

Research Keywords

  • ER stress
  • apoptosis
  • disease
  • Neurodegenerative disease

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2018, Undergraduate Education, Second Semester, Early exposure of undergraduates to medicine
  3. 2018, Undergraduate Education, Year, Physiology and Biochemistry
  4. 2018, Undergraduate Education, 2Term, Introduction for medical research
  5. 2018, Undergraduate Education, Intensive, Practice for medical research
  6. 2018, Graduate Education (Master's Program) , First Semester, Physiology and biological chemistry
  7. 2018, Graduate Education (Master's Program) , First Semester, Seminar on Biochemistry
  8. 2018, Graduate Education (Master's Program) , Second Semester, Seminar on Biochemistry
  9. 2018, Graduate Education (Master's Program) , First Semester, Research on Biochemistry
  10. 2018, Graduate Education (Master's Program) , Second Semester, Research on Biochemistry
  11. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Biochemistry
  12. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Biochemistry
  13. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced research on Biochemistry
  14. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Biochemistry

Research Activities

Academic Papers

  1. Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 3215, 201810
  2. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9, 20180724
  3. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
  4. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
  5. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
  6. The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis, Neurochemistry International, 119, 26-34, 20170628
  7. 60th Anniversary of the Japanese Society for Neurochemistry, Journal of Neurochemistry, 141, 788-789, 2017
  8. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 20170901
  9. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 37310, 20161117
  10. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 30955, 20160803
  11. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
  12. The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy, Medical Research Archives, 4(4), 201611
  13. Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics, FEBS JOURNAL, 283(8), 1475-1487, 201604
  14. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
  15. Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
  16. IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 16580, 20151116
  17. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 16455, 20151112
  18. Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), e0125982, 2015
  19. Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, HUMAN MOLECULAR GENETICS, 24(2), 299-313, 20150115
  20. OASIS is a Novel Cofactor of HIF1 alpha to Promote the Transcription Dependence on Hypoxia Response Element under the Hypoxic Condition, FASEB JOURNAL, 29, 2015
  21. Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, MOLECULAR CELL, 53(1), 127-139, 2014
  22. Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 13810-13820, 2014
  23. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLOS ONE, 9(2), e88048, 2014
  24. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor, CELL DEATH & DISEASE, 5, e1332, 2014
  25. OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex, JOURNAL OF NEUROCHEMISTRY, 130(5), 612-625, 2014
  26. Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLOS ONE, 8(1), e55155, 2013
  27. F-box and WD Repeat Domain-containing-7 (Fbxw7) Protein Targets Endoplasmic Reticulum-anchored Osteogenic and Chondrogenic Transcriptional Factors for Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(40), 28488-28502, 2013
  28. Involvement of endoplasmic reticulum stress in tauopathy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(2), 500-504, 2013
  29. The roles of endoplasmic reticulum stress in diseases, 37(3), 9-16, 20130920
  30. Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 967, 2012
  31. Activation of OASIS family, ER stress transducers, is dependent on its stabilization, CELL DEATH AND DIFFERENTIATION, 19(12), 1939-1949, 2012
  32. The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43), 36190-36200, 2012
  33. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, SCIENTIFIC REPORTS, 2, 799, 2012
  34. The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(11), 8144-8153, 2012
  35. Regulation of osteogenesis and chondrogenesis by unfolded protein response, 84(1), 18-29, 20120125
  36. The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology, JOURNAL OF BIOCHEMISTRY, 149(5), 507-518, 2011
  37. Physiological Unfolded Protein Response Regulated by OASIS Family Members, Transmembrane bZIP Transcription Factors, IUBMB LIFE, 63(4), 233-239, 2011
  38. Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2 alpha-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4809-4818, 2011
  39. Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice, BONE, 48(3), 514-523, 2011
  40. Roles of endoplasmic reticulum stress transducer OASIS in fracture healing, BONE, 49(4), 724-732, 2011
  41. ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type, MAMMALIAN GENOME, 22(5-6), 318-328, 2011
  42. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis, JOURNAL OF BONE AND MINERAL METABOLISM, 28(2), 131-138, 2010
  43. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice, JOURNAL OF BONE AND MINERAL METABOLISM, 28(4), 384-394, 2010
  44. Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice, NEUROSCIENCE LETTERS, 484(1), 43-46, 2010
  45. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation., NATURE CELL BIOLOGY, 11(10), 1205-1211, 2009
  46. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., NATURE CELL BIOLOGY, 11(10), 1197-1204, 2009
  47. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice, JOURNAL OF NEUROCHEMISTRY, 110(3), 956-965, 2009
  48. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 334-344, 2009
  49. The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury., JOURNAL OF PHARMACOLOGICAL SCIENCES, 109(2), 311-314, 2009
  50. A molecular chaperone inducer protects neurons from ER stress, CELL DEATH AND DIFFERENTIATION, 15(2), 364-375, 2008
  51. A protective role of unfolded protein response in mouse ischemic acute kidney injury, EUROPEAN JOURNAL OF PHARMACOLOGY, 592(1-3), 138-145, 2008
  52. Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil, NEUROSCIENCE, 151(1), 111-119, 2008
  53. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil, BRAIN RESEARCH, 1208, 217-224, 2008
  54. Nerve fiber analysis on the so-called accessory subscapularis muscle and its morphological significance, ANATOMICAL SCIENCE INTERNATIONAL, 83(1), 55-59, 2008
  55. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer, MOLECULAR AND CELLULAR BIOLOGY, 27(5), 1716-1729, 2007
  56. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1, HUMAN MOLECULAR GENETICS, 16(23), 2834-2843, 2007
  57. Endoplasmic reticulum stress response in dendrites of cultured primary neurons, NEUROSCIENCE, 146(1), 1-8, 2007
  58. A novel ER stress transducer, OASIS, expressed in astrocytes, ANTIOXIDANTS & REDOX SIGNALING, 9(5), 563-571, 2007
  59. HMGA1a:Sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of Presenilin-2 pre-mRNA, GENES TO CELLS, 12(10), 1179-1191, 2007
  60. Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice, NEUROSCIENCE, 147(4), 957-967, 2007
  61. Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle, ACTA NEUROPATHOLOGICA, 114(5), 527-535, 2007
  62. The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes, JOURNAL OF IMMUNOLOGY, 179(2), 1210-1224, 2007
  63. Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation, ACTA HISTOCHEMICA ET CYTOCHEMICA, 40(1), 19-26, 2007
  64. Autophagy is activated for cell survival after endoplasmic reticulum stress, MOLECULAR AND CELLULAR BIOLOGY, 26(24), 9220-9231, 2006
  65. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 96(4), 1090-1100, 2006
  66. Altered localization of amyloid precursor protein under endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 344(2), 525-530, 2006
  67. The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients, NEUROSCIENCE LETTERS, 393(2-3), 102-107, 2006
  68. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes, NATURE CELL BIOLOGY, 7(2), 186-194, 2005
  69. XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(4), 1146-1153, 2005
  70. Candidates for tumor-specific alternative splicing, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334(1), 23-29, 2005
  71. Identification of regulatory cis-acting elements for alternative splicing of presenilin-2 exon 5 under hypoxic stress conditions, JOURNAL OF NEUROCHEMISTRY, 91(5), 1191-1198, 2004
  72. Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death, JOURNAL OF NEUROSCIENCE, 24(15), 3721-3725, 2004
  73. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Ab-induced cell death, JOURNAL OF CELL BIOLOGY, 165(3), 347-356, 2004
  74. Endoplasmic reticulum stress and neuronal death, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 49-50, 2004
  75. Induction of neuronal death by ER stress in Alzheimer's disease, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 67-78, 2004
  76. Tra2b, SF2/ASF, and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA, GENES TO CELLS, 9, 121-130, 2004
  77. Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex, BRAIN RESEARCH MOLECULAR BRAIN RESEARCH, 127, 128-135, 2004
  78. Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12, NEUROSCIENCE LETTERS, 357, 127-130, 2004
  79. Role of ARF4L in recycling between endosomes and the plasma membrane, CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 137-147, 2004
  80. JAB1 participates in unfolded protein responses by association and dissociation with IRE1, NEUROCHEMISTRY INTERNATIONAL, 45, 765-772, 2004
  81. An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 15825-15831, 2003
  82. MDG1/ERdj4, an ER-resident DnaJ family member, suppresses cell death induced by ER stress, GENES TO CELLS, 8, 189-202, 2003
  83. Identification of a Cis-acting elements for the regulation of SMN exon 7 splicing, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 23271-23277, 2002
  84. FAD-linked presenilin-1 mutants impede translation regulation under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296, 313-318, 2002
  85. The cytosolic inclusion bodies that consist of splice variants that lack exon of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients, NEUROSCIENCE LETTERS, 328, 198-200, 2002
  86. The unfolded protein response is involved in the pathology of Alzheimer's disease, Annals of the New York Academy of Sciences , 977, 349-355, 2002
  87. Endoplasmic reticulum stress and Alzheimer's disease, Mapping the Progress of Alzheimer's and Parkinson's Disease. Mizuno, Y., Fisher, A., Hanin, I. (eds), 95-100, 2002
  88. Inter-changeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling, ONCOGENE, 20, 4317-4323, 2001
  89. Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor-2 (TRAF2) dependent mechanisms in response to ER stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 13935-13940, 2001
  90. Upregulation of the pro-apoptotic BH3-only peptide Harakiri (HRK) in spinal neurons of amyotrophiclateral sclerosis patients, NEUROSCIENCE LETTERS, 313, 153-157, 2001
  91. Impairment of response to ER stress in presenilin 1 mutant, Neuroscientific Basis of Dementia. Tanaka, C., McGeer, P., Ihara, Y. (eds), 193-199, 2001
  92. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, MALT lymphoma-associated protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 11114-11120, 2000
  93. Molecular cloning of a novel membrane glycoprotein, Pal, specifically expressed inphotoreceptor cells of the retina and containing leucine-rich repeat, JOURNAL OF NEUROSCIENCE, 20, 3206-3213, 2000
  94. Are cerebrovascular factors involved in Alzheimer's disease?, NEUROBIOLOGY OF AGING, 21, 215-224, 2000
  95. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response, NATURE CELL BIOLOGY, 1, 479-485, 1999
  96. A novel presenilin-2 (PS-2) splice variant in human Alzheimer's disease brain tissue, JOURNAL OF NEUROCHEMISTRY, 72, 2498-2505, 1999
  97. IPP isomerase, an enzyme of mevalonate pathway, is preferentially expressed in postnatal cortical neurons and induced after nerve transection, MOLECULAR BRAIN RESEARCH, 67, 231-238, 1999
  98. Expression of pattern of a novel death-promoting gene, DP5, in the developing murine nervous system, MOLECULAR BRAIN RESEARCH, 54, 316-320, 1998
  99. Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the girbil, MOLECULAR BRAIN RESEARCH, 56, 66-75, 1998
  100. Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the girbil, JOURNAL OF NEUROSCIENCE, 17, 6678-6684, 1997
  101. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 18842-18848, 1997
  102. An ER stress sensor PERK is involved in Post-operative Subcojunctival Scarring in a Mouse Model of Glaucoma Filtration Surgery, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7), 2015
  103. The biological regulation by the endoplasmic reticulum stress response, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S79-S79, 2013
  104. [Endoplasmic reticulum stress response in osteogenesis]., Clinical calcium, 23(11), 2013
  105. [Endoplasmic reticulum stress response involved in osteogenesis and chondrogenesis]., Clinical calcium, 23(12), 2013
  106. The roles of unfolded protein response in osteogenesis and chondrogenesis, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 53P-53P, 2012
  107. [Regulation of osteogenesis and chondrogenesis by unfolded protein respone]., Seikagaku. The Journal of Japanese Biochemical Society, 84(1), 2012