Noriyuki Yanaka

Last Updated :2020/08/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Other Contact Details
1-4-4,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-7979 FAX : (+81)82-424-7916
Studies on the relationship between food factors and diseases.

Basic Information

Major Professional Backgrounds

  • 1991/04/07, 2001/11/30, Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory, Researcher
  • 2001/12/01, 2007/03/31, Hiroshima University, Faculty of Applied Biological Science, Associate professor
  • 2020/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • Kyoto University, Graduate School, Division of Agriculture, Japan, 1989/04, 1991/03
  • Kyoto University, Faculty of Agriculture, Japan, 1985/04, 1989/03

Academic Degrees

  • Ph.D. Agriculture, Kyoto University
  • Master of Agriculture, Kyoto University

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • obesity
  • lifestyle diseases
  • gene
  • choline
  • functional food
  • nutrition
  • adipose tissue
  • glycerophosphodiester phosphodiesterase

Affiliated Academic Societies

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2001/10
  • The Molecular Biology Society of Japan, 2001/10
  • Japanese Society of Nutrition and Food Science, 2001/11
  • The Vitamin Society of Japan, 2017/11
  • The Japanese Society for Genome Editing, 2016/04

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 3Term, Food safety and health science
  2. 2020, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2020, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
  4. 2020, Undergraduate Education, 2Term, Reading of Foreign Literature
  5. 2020, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  6. 2020, Undergraduate Education, Intensive, Laboratory work in nutritional biochemistry
  7. 2020, Undergraduate Education, Academic Year, Graduation Thesis
  8. 2020, Undergraduate Education, 1Term, Food and health sciences
  9. 2020, Undergraduate Education, 4Term, Systemic Life Science
  10. 2020, Undergraduate Education, 4Term, Bio-Analytical Science
  11. 2020, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  12. 2020, Undergraduate Education, 3Term, Modern Food Science
  13. 2020, Graduate Education (Doctoral Program) , First Semester, Exercises in Food Science and Biofunctions (B)
  14. 2020, Graduate Education (Doctoral Program) , Second Semester, Exercises in Food Science and Biofunctions (B)
  15. 2020, Graduate Education (Master's Program) , 4Term, Nutritional Biochemistry
  16. 2020, Graduate Education (Master's Program) , 4Term, Health and Nutrition Science
  17. 2020, Graduate Education (Master's Program) , OutOfTerm(1st), Biochemical and Molecular Nutrition
  18. 2020, Graduate Education (Master's Program) , OutOfTerm(1st), Nutrigenomics
  19. 2020, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  20. 2020, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  21. 2020, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  22. 2020, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  23. 2020, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  24. 2020, Graduate Education (Master's Program) , 4Term, Nutrition and Food Functions II
  25. 2020, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  26. 2020, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics
  27. 2020, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models

Research Activities

Academic Papers

  1. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, Scientific Reports, 9, 20191001
  2. GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage, Am. J. Physiol. Cell Physiol., 316(2), C162-C174, 201902
  3. Novel metabolic disturbances in marginal vitamin B6-deficient rat heart., J. Nutr. Biochem., 65, 26-34, 201903
  4. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, Genes Cells, 23(3), 136-145, 201803
  5. Beneficial effects of dietary tempeh prepared with Rhizopus stolonifer on liver function in rats fed with a high-fat diet, J. Nutr. Sci. Vitaminol. (Tokyo)., 64(5), 379-383, 2018
  6. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, Journal of Functional Foods, 49, 162-167, 201810
  7. Gender difference and dietary supplemental vitamin B-6: Impact on colon luminal environment, J. Nutr. Sci. Vitaminol (Tokyo)., 64(2), 116-128, 2018
  8. Production of isoflavone aglycone-enriched tempeh with Rhizopus stolonifer, Food Sci. Technol. Res., 24(3), 493-499, MAR 2018
  9. Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, Life Sciences, 184, 103-111, 20170901
  10. Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats, Exp. Ther. Med., 14(4), 3239-3246, 201710
  11. Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet, Journal of Functional Foods, 39, 250-256, 201712
  12. Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells, Biosci. Biotechnol. Biochem., 81(3), 534-540, 2017
  13. Molecular characterization of aspartylglucosaminidase, a lysosomal hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita, Biosci. Biotechnol. Biochem., 81(5), 938-950, 2017
  14. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, Biosci. Biotechnol. Biochem., 81(11), 2164-2167, 2017
  15. Serum amyloid A3 gene expression in adipocytes is an indicator of the interaction with macrophages, Scientific Reports, 6, 20161208
  16. Time course analysis of skeletal muscle pathology of GDE5 transgenic mouse, PLoS One, 11(9), 20160922
  17. CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation, Int. Immunol., 28(6), 267-282, 20160101
  18. Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice, Biol. Open, 5(8), 1142-1148, 20160815
  19. De novo-synthesized retinoic acid in ovarian antral follicles enhances FSH-mediated ovarian follicular cell differentiation and female fertility, Endocrinology, 157(5), 2160-2172, 20160501
  20. Carnosine content in skeletal muscle Is dependent on vitamin B6 status in rats, Front. Nutr., 2, 20160119
  21. New members of the mammalian glycerophosphodiester phosphodiesterase family : GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity., J. Biol. Chem., 290(7), 4260-4271, 20150213
  22. Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats, Springerplus, 4, 280, 20150501
  23. Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle, J. Muscle Res. Cell Motil., 36(3), 275-286, 20150601
  24. I kappa B kinase epsilon expression in adipocytes is upregulated by interaction with macrophages, Biosci. Biotechnol. Biochem., 78(8), 1357-1362, 20140801
  25. Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis, J. Agrc. Food Chem., 62(24), 5589-5594, 20140618
  26. Vitamin B-6 activates p53 and elevates p21 gene expression in cancer cells and the mouse colon, Oncol. Rep., 31(5), 2371-2376, 20140501
  27. Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions, J. Muscle Res. Cell Motil., 35(2), 179-189, 20140401
  28. The emerging physiological roles of the glycerophosphodiesterase family, FEBS J., 281(4), 998-1016, 20140201
  29. High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway, Mol. Med. Rep., 8(4), 973-978, 20131001
  30. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages, PLoS One, 8(4), e61931, 20130423
  31. Comparative study on the responses of concentrations of B-6-vitamers in several tissues of mice to the dietary level of pyridoxine, J. Nutr. Sci. Vitaminol (Tokyo)., 58(6), 446-451, 20121201
  32. Consumption of vitamin B-6 reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet, J. Nutr. Sci. Vitaminol (Tokyo)., 58(5), 366-370, 20121001
  33. Regulation of colon gene expression by vitamin B6 supplementation, Mol. Nutr. Food Res., 56(4), 641-652, 20120401
  34. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-alpha-stimulated HT-29 cells, Mol. Nutr. Food Res., 55(4), 635-643, 20110401
  35. Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1,2-dimethylhydrazine, Oncol. Lett., 2(6), 1243-1246, 20111101
  36. Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain, Biosci. Biotechnol. Biochem., 75(7), 1383-1385, 20110701
  37. Vitamin B6 regulates mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, Exp. Ther. Med., 2(3), 419-424, 20110501
  38. A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism, J. Biol. Chem., 285(36), 27652-27663, 20100903
  39. The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle, Eur. J. Appl. Physiol., 110(5), 943-952, 20101101
  40. Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents, Biosci. Biotechnol. Biochem., 74(1), 185-187, 20100101
  41. Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer, Bioorg. Med. Chem., 17(1), 25-28, 20090101
  42. Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha., Biosci. Biotechnol. Biochem., 73(12), 2809-2811, 20091201
  43. The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth., J. Biol. Chem., 284(37), 24848-24856, 20090901
  44. Mammalian glycerophosphodiester phosphodiesterases, Biosci. Biotechnol. Biochem., 71(8), 1811-1818, 20070401
  45. Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells., FEBS Lett., 581(4), 712-718, 20070220
  46. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase, Biochimie, 89, 581-590, 20070501
  47. Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet., Biosci. Biotechnol. Biochem., 581(4), 712-718, 20060701
  48. Expression of zinc finger protein ZPR1 mRNA in brain is up-regulated in mice fed a high-fat diet., Int. J. Mol. Med., 17(3), 491-496, 20060301
  49. High protein buckwheat flour suppresses hypercholesterolemia in rats and gallstone formation in mice by hypercholesterolemic diet and body fat in rats because of its low protein digestibility., Nutrition, 22, 166-173, 20060101
  50. Vitamin B6 suppresses NF-kappaB activation in LPS-stimulated mouse macrophages., Int. J. Mol. Med., 16(6), 1071-1075, 20051201
  51. A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice, Oncology Reports, 14, 265-269, 20050501
  52. Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice, Biosci. Biotechnol. Biochem., 69, 209-211, 20050201
  53. Short-term feeding of fish oil down-regulates the expression of pyruvate dehydrogenase E1 alpha subunit mRNA in mouse brain., Biosci. Biotechnol. Biochem., 69(2), 301-306, 20050201
  54. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6., Gene, 337, 173-179, 20040804
  55. Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation., J. Biol. Chem., 278(44), 43595-43602, 20031031
  56. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles., Biosci. Biotechnol. Biochem., 67(5), 973-979, 20030501
  57. Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hair less mouse., J. Photochem. Photobiol. B: Biology, 71, 11-17, 20030401
  58. Antitumor effect of vitamin B6 and its mechanism, Biochim. Biophys. Acta, 1647, 127-130, 20030401
  59. Developmental expression of Na+/Ca2+ exchanger (NCX1) gene in the mouse embryo, Comp. Biochem. Physiol., 130(2), 191-198, 20010901
  60. Human Ca(2+)/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization, Biochim. Biophys. Acta, 1517(2), 278-287, 20010101
  61. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat, J. Biol. Chem., 275(47), 36991-36998, 20001101
  62. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis, J. Biol. Chem., 275(20), 14791-14794, 20000501
  63. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha, J. Biol. Chem., 275(7), 4897-4905, 20000201
  64. The specific domain of cGMP -dependent protein kinase Ibeta but not Ialpha functions as a transcriptional activator in yeast, IUBMB Life, 49(1), 17-22, 20000101
  65. Identification of a conserved residue responsible for the autoinhibition of cGMP-dependent protein kinase Ialpha and beta, FEBS Lett., 466(1), 175-178, 20000101
  66. Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice, DNA Seq., 11(42737), 75-81, 20000101
  67. A novel interaction of cGMP-dependent protein kinase I with troponin T, J. Biol. Chem., 274(52), 37429-37434, 19991201
  68. Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5, Biochim. Biophys. Acta, 1452(3), 219-227, 19991201
  69. Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases, Eur. J. Biochem., 262(3), 866-873, 19990101
  70. 1,25-Dihydroxyvitamin D3 upregulates natriuretic peptide receptor-C expression in mouse osteoblasts, Am. J. Physiol., 275(42887), E965-973, 19981201
  71. Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase, J. Biol. Chem., 273(41), 26982-26990, 19981001
  72. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene, Eur. J. Biochem., 255(2), 391-399, 19980701
  73. Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation, Am. J. Physiol., 274(42795), L425-431, 19980501
  74. Isolation and characterization of the 5’-flanking regulatory region of the human natriuretic peptide receptor C gene, Endocrinology, 139(3), 1389-1400, 19980301
  75. TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345., J. Antibiot. (Tokyo), 51, 111-111, 1998
  76. Protein kinase C activation down-regulates natriuretic peptide receptor C expression via transcriptional and post-translational pathways., FEBS Lett., 418(3), 333-336, 19971201
  77. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development., Eur. J. Biochem., 249(2), 434-442, 19971015
  78. Structure of the 5'-flanking regulatory region of the mouse gene encoding the clearance receptor for atrial natriuretic peptide., Eur. J. Biochem., 237(1), 25-34, 19960401
  79. Nitrilase from Rhodococcus rhodochrous J1. Sequencing and overexpression of the gene and identification of an essential cysteine residue., J. Biol. Chem., 267, 20746-20751, 1992
  80. Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue., Biochemistry, 31, 9000-9007, 1992
  81. Hyperinduction of an aliphatic nitrilase by Rhodococcus rhodochrous K22., FEMS Microbiol. Lett., 77, 121-123, 1991
  82. Monohydrolysis of an aliphatic dinitrile compound by nitrilase from Rhodococcus rhodochrous K22., Tetrahedron, 46, 5587-5590, 1990
  83. Nitrilase-catalyzed production of pyrazinoic acid, an antimycobacterial agent, from cyanopyrazine by resting cells of Rhodococcus rhodochrous J1., J. Antibiot. (Tokyo), 43, 1316-1320, 1990
  84. Purification and characterization of a novel nitrilase of Rhodococcus rhodochrous K22 that acts on aliphatic nitriles., J. Bacteriol., 172, 4807-4815, 1990
  85. Nitrilase-catalyzed production of para-aminobenzoic acid from para-aminobenzonitorile with Rhodococcus rhodochrous J1., Biotechnol. lett., 11, 27-30, 1989

Publications such as books

  1. 2017/11, Science within Food: Up-to-date Advances on Research and Educational Ideas., Vitamin B6: a heart-protective molecule through a novel mechanism of increasing histidine-related compounds., Formatex Research Center., 2017, 11, Kumrungsee T, Nirmagustina DE, Kato N, Yanaka N, and Lai HC:, 292-299

Invited Lecture, Oral Presentation, Poster Presentation

  1. Dietary supplemental vitamin B6 increases concentrations of carnosine and anserine in the skeletal muscles and heart of rats., Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato., Jan Stautemas, Wim Derave, The 6th International Conference on Food Factors, 2015/11/22, Without Invitation, ICoFF, Seoul
  2. Carnosine and anserine in skeletal muscles and heart are dependent on vitamin B6 status., Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato, Wim Derave, 12th European Nutrition Conference (FENS 2015), 2015/10/23, Without Invitation, FENS, Berlin
  3. In vivo imaging model mice for assessing obese adipose inflammation and DSS-induced colon inflammation, Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato and Noriyuki Yanaka, 17th International Conference of FFC, 2015/09/15, Without Invitation, Functional food center, Massachusetts
  4. GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity., Isaji C, Kudo T, Ohshima N, Yamashita Y, Araki M, Honda A, Nagano T, Kato N, Konishi A, Kishimoto K, Tatei K, Yanaka N, Izumi T, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015), 2015/02/12, Without Invitation, Tokyo
  5. Transcriptomic analysis identities novel genes expression in response to choline deficiency in rat liver and in rat primary hepatocytes., Rina Watanabe, Kouji Mitsumoto, Hisaki Yonenaka, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, Federation of Asian Nutrition Societies, Yokohama
  6. In vivo imaging of adipose tissue inflammation by using Saa3 promoter activity., Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, Federation of Asian Nutrition Societies, Yokohama
  7. Maternal choline deficiency affects offspring health., Yoshiko Tsukuda, Yukino Miyachi, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, Federation of Asian Nutrition Societies, Yokohama
  8. Effect of vitamin B6 on the expression of IGFBPs, anti-disease factors, in HepG2 cells, Sofya Suidasari, Peipei Zhang, Tomomi Hasegawa, Noriyuki Yanaka, Norihisa Kato, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, Federation of Asian Nutrition Societies, Yokohama
  9. Dietary supplemental vitamin B6 to a low vitamin B6 diet modulates gene expression of myokines in skeletal muscle of rats., Shinji Uragami, Sofya Suidasari, Noriyuki Yanaka, Norihisa Kato, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, Federation of Asian Nutrition Societies, Yokohama


  1. 2005, The Japan Bioscience, Biotechnology, and Agrochemistry Society Award for the Encouragement of Young Scientists in 2005., 日本農芸化学会, 動物の新規酵素の探索とホスホジエステラーゼ類に関する基盤的研究

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  2. KAKENHI, 2014, 2016
  3. KAKENHI, Cellular functions of a cytosolic glycerophosphocholine phosphodiesterase GDE5, 2011, 2013
  4. KAKENHI, Study on the antitumor effect of vitamin B6, 2009, 2011
  5. KAKENHI, Physiological functions of novel mammalian glycerophosphodiester phosphodiesterases, 2008, 2010
  6. KAKENHI, Isolation and characterization of mammalian glycerophosphodiester phosphodiesterases, 2006, 2007
  7. KAKENHI, 2015, 2018
  8. KAKENHI, 2012, 2014
  9. KAKENHI, 2006, 2008
  10. KAKENHI, Study on vitamin B6 as an anti-ageing factor, 2005, 2007
  11. KAKENHI, 2003, 2004

Social Activities

Organizing Academic Conferences, etc.

  1. 2007/11
  2. 2004/03
  3. 2004/03