YAICHIRO KOTAKE

Last Updated :2019/04/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), ., Professor
E-mail
yaichirohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., The University of Tokyo
  • MSc., The University of Tokyo

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy

Research Keywords

  • neurotoxicity

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, 2Term, Public Health Chemistry II
  2. 2019, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  3. 2019, Undergraduate Education, 1Term, Public Health Chemistry I
  4. 2019, Undergraduate Education, 3Term, Public Health Chemistry III
  5. 2019, Undergraduate Education, First Semester, Experiments of Public health Chemistry
  6. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  7. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  8. 2019, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  9. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  10. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  11. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  12. 2019, Graduate Education (Master's Program) , First Semester, Advanced lecture on molecula toxicology and drug metabolism
  13. 2019, Graduate Education (Master's Program) , First Semester, Seminar on molecula toxicology and drug metabolism
  14. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on molecula toxicology and drug metabolism
  15. 2019, Graduate Education (Master's Program) , First Semester, Research on molecula toxicology and drug metabolism
  16. 2019, Graduate Education (Master's Program) , Second Semester, Research on molecula toxicology and drug metabolism
  17. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Xenobiotic Metabolism and Molecular Toxicology
  18. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Xenobiotic Metabolism and Molecular Toxicology
  19. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Xenobiotic Metabolism and Molecular Toxicology
  20. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Xenobiotic Metabolism and Molecular Toxicology
  21. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences
  22. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurochemistry and Environmental Health Sciences
  24. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurochemistry and Environmental Health Sciences
  25. 2019, Graduate Education (Master's Program) , 1Term, Lecture on Neurochemistry and Environmental Health Sciences
  26. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Neurochemistry and Environmental Health Sciences
  27. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Neurochemistry and Environmental Health Sciences
  28. 2019, Graduate Education (Master's Program) , First Semester, Research on Neurochemistry and Environmental Health Sciences
  29. 2019, Graduate Education (Master's Program) , Second Semester, Research on Neurochemistry and Environmental Health Sciences
  30. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Neurotoxicology
  31. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Neurotoxicology

Research Activities

Academic Papers

  1. Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons, ARCHIVES OF TOXICOLOGY, 92(1), 401-409, 201801
  2. Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1, METALLOMICS, 10(2), 337-345, 201802
  3. Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions, BIOCHEMICAL PHARMACOLOGY, 154, 28-38, 201808
  4. Neurotoxicity Mechanism of Environmental Chemicals and Its Evaluation System, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 138(10), 1227-1233, 201810
  5. Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression, ARCHIVES OF TOXICOLOGY, 91(2), 885-895, 201702
  6. Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(3), 303-309, 201703
  7. Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 486(3), 639-644, 20170506
  8. Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation, SCIENTIFIC REPORTS, 7, 20170426
  9. Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(7), 1121-1124, 201707
  10. Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), E1754, 201708
  11. Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver, JOURNAL OF TOXICOLOGICAL SCIENCES, 42(5), 589-596, 201710
  12. Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis, JOURNAL OF TOXICOLOGICAL SCIENCES, 42(5), 605-613, 201710
  13. Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(1), 155-164, 201602
  14. Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction, SCIENTIFIC REPORTS, 6, 20160222
  15. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 207-215, 201604
  16. Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 255-264, 201604
  17. Protein extracts from cultured cells contain nonspecific serum albumin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(6), 1164-1167, 2016
  18. Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism, JOURNAL OF NEUROCHEMISTRY, 139(2), 294-308, 201610
  19. Tributyltin induces mitochondrial fission through NAD-IDH dependent mitofusin degradation in human embryonic carcinoma cells, METALLOMICS, 7(8), 1240-1246, 2015
  20. Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver., Xenobiotica, 45(7):605-14(7), 605-614, 2015
  21. Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability., Toxicology Reports, 2, 450-460, 2015
  22. Development of a simple measurement method for GluR(2) protein expression as an index of neuronal vulnerability, TOXICOLOGY REPORTS, 2, 450-460, 2015
  23. NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells, SCIENTIFIC REPORTS, 4, 20140805
  24. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function, JOURNAL OF NEUROCHEMISTRY, 130(6), 826-838, 201409
  25. Detection of a novel neurotoxic metabolite of Parkinson's disease-related neurotoxin, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, JOURNAL OF TOXICOLOGICAL SCIENCES, 39(5), 749-754, 201410
  26. Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates, Toxicology in Vitro, 28(6), 1176-1182, 201409
  27. AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells, METALLOMICS, 5(5), 484-491, 2013
  28. Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 38(3), 513-521, 201306
  29. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
  30. Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver, DRUG METABOLISM AND DISPOSITION, 40(2), 322-328, 201202
  31. Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2), 257-259, 201202
  32. Three new megastigmanes from the leaves of Annona muricata, JOURNAL OF NATURAL MEDICINES, 66(2), 284-291, 201204
  33. Guidelines for the use and interpretation of assays for monitoring autophagy, AUTOPHAGY, 8(4), 445-544, 201204
  34. Molecular Mechanisms of Environmental Organotin Toxicity in Mammals, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(11), 1876-1880, 201211
  35. Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes, DRUG METABOLISM AND DISPOSITION, 40(12), 2267-2272, 201212
  36. Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 36(1), 1-7, 201102
  37. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination, JOURNAL OF NEUROCHEMISTRY, 114(5), 1291-1301, 201009
  38. Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 35(2), 245-251, 201004
  39. MODULATION OF CONNEXIN 43 IN ROTENONE-INDUCED MODEL OF PARKINSON'S DISEASE, NEUROSCIENCE, 160(1), 61-68, 20090421
  40. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate, TOXICOLOGY AND APPLIED PHARMACOLOGY, 240(2), 292-298, 20091015
  41. Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death, TOXICOLOGY AND APPLIED PHARMACOLOGY, 230(3), 358-363, 20080801
  42. Concentration dependence of the mechanisms of tributyltin-induced apoptosis, TOXICOLOGICAL SCIENCES, 97(2), 438-447, 200706
  43. Neurotoxicity induced by environmental low-molecular-weight substances, JOURNAL OF HEALTH SCIENCE, 53(6), 639-643, 200712
  44. Neurotoxicity of an endogenous amine in the brain, 1BnTIQ in organotypic slice co-culture of ventral mecensephalon and striatum., Neuroscience, 117(1), 63-70, 20030101
  45. Determination method of 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay., Life Sci., 70, 2871-2883, 20020401
  46. Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity., Bioorg.Med.Chem.Lett., 10, 1669-1771, 20000401
  47. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine trnsporter expressed in HEK293 cells., Neurosci. Res., 30, 87-90, 19980401
  48. Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes., J.Neural.Transm., 105(6-7), 677-688, 19980401
  49. Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate., Neurosci. Lett., 217, 69-71, 19960401
  50. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF., J. Neurochem., 65(6), 2633-2638, 19950401
  51. Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity., Bioorg.Med.Chem.Lett., 1669-1771, 99990101
  52. Regional distribution of parkinsonism-preventing endogenous tetrahydro-isoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain., Neurosci. Lett., 68-70, 99990101

Invited Lecture, Oral Presentation, Poster Presentation

  1. Environmental organotin and its mammalian neurotoxicity, Yaichiro Kotake, Graduate School Lecture, GIP-TRIAD, University of Tsukuba, 2018/11/07, With Invitation, Tsukuba
  2. PFOS Increases Neuronal Vulnerability to Excitotoxicity via Decrease of AMPA receptor Subunit GluR2 expression, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Seigo Sanoh, Shigeru Ohta, Society of Toxicology 56th Annual Meeting, 2017/03, Without Invitation, Baltimore, USA
  3. Neurotoxicity of perfluorooctane sulfonate (PFOS) via GluR2 decrease, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Takashi Saiki, Seigo Sanoh, Shigeru Ohta, 2016 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology, 2016/09, Without Invitation, Tokyo
  4. Organotin decreases GluR2 expression in nuclear respiratory factor-1-dependent manner., Yaichiro Kotake, Keishi Ishida, Kaori Aoki, Tomoko Takishita, Tomoki Kimura, Yasunari Kanda, Shigeru Ohta, International Society for Trace Element Research in Humans (ISTERH) 2015, 2015/10, Without Invitation, International Society for Trace Element Research in Humans (ISTERH), Dubrovnik, Croatia
  5. Increased expression of glutamate transporter EAAT3 by rotenone, Yaichiro Kotake, Tomomi Yamamoto, Satoshi Adachi, Kouta Kouno, Shigeru Ohta, 50th Congress of the European Societies of Toxicology, 2014/09, Without Invitation, the European Societies of Toxicology, Edinburgh

Social Activities

History as Committee Members

  1. Frontiers in Cellular Endocrinology Review Editor, 2011/01, 2019/03