YAICHIRO KOTAKE

Last Updated :2018/07/02

Affiliations, Positions
Graduate School of Biomedical & Health Sciences (Medicinal Sciences Major), ., Professor
E-mail
yaichirohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., The University of Tokyo
  • MSc., The University of Tokyo

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy

Research Keywords

  • neurotoxicity

Educational Activity

Course in Charge

  1. 2018, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  2. 2018, Undergraduate Education, 1Term, Public Health Chemistry I
  3. 2018, Undergraduate Education, 2Term, Public Health Chemistry II
  4. 2018, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  5. 2018, Undergraduate Education, 3Term, Public Health Chemistry III
  6. 2018, Undergraduate Education, First Semester, Experiments of Public health Chemistry
  7. 2018, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  8. 2018, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  9. 2018, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  10. 2018, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  11. 2018, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  12. 2018, Graduate Education (Master's Program) , First Semester, Advanced lecture on molecula toxicology and drug metabolism
  13. 2018, Graduate Education (Master's Program) , First Semester, Seminar on molecula toxicology and drug metabolism
  14. 2018, Graduate Education (Master's Program) , Second Semester, Seminar on molecula toxicology and drug metabolism
  15. 2018, Graduate Education (Master's Program) , First Semester, Research on molecula toxicology and drug metabolism
  16. 2018, Graduate Education (Master's Program) , Second Semester, Research on molecula toxicology and drug metabolism
  17. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Xenobiotic Metabolism and Molecular Toxicology
  18. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Xenobiotic Metabolism and Molecular Toxicology
  19. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced research on Xenobiotic Metabolism and Molecular Toxicology
  20. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Xenobiotic Metabolism and Molecular Toxicology

Research Activities

Academic Papers

  1. Concentration dependence of the mechanisms of tributyltin-induced apoptosis, TOXICOLOGICAL SCIENCES, 97(2), 438-447, JUN 2007
  2. Neurotoxicity induced by environmental low-molecular-weight substances, JOURNAL OF HEALTH SCIENCE, 53(6), 639-643, DEC 2007
  3. Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death, TOXICOLOGY AND APPLIED PHARMACOLOGY, 230(3), 358-363, AUG 1 2008
  4. MODULATION OF CONNEXIN 43 IN ROTENONE-INDUCED MODEL OF PARKINSON'S DISEASE, NEUROSCIENCE, 160(1), 61-68, APR 21 2009
  5. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate, TOXICOLOGY AND APPLIED PHARMACOLOGY, 240(2), 292-298, OCT 15 2009
  6. Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 35(2), 245-251, APR 2010
  7. Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver, DRUG METABOLISM AND DISPOSITION, 40(2), 322-328, FEB 2012
  8. Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2), 257-259, FEB 2012
  9. Three new megastigmanes from the leaves of Annona muricata, JOURNAL OF NATURAL MEDICINES, 66(2), 284-291, APR 2012
  10. Guidelines for the use and interpretation of assays for monitoring autophagy, AUTOPHAGY, 8(4), 445-544, APR 2012
  11. Molecular Mechanisms of Environmental Organotin Toxicity in Mammals, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(11), 1876-1880, NOV 2012
  12. Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes, DRUG METABOLISM AND DISPOSITION, 40(12), 2267-2272, DEC 2012
  13. AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells, METALLOMICS, 5(5), 484-491, 2013
  14. Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 38(3), 513-521, JUN 2013
  15. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, OCT 1 2013
  16. NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells, SCIENTIFIC REPORTS, 4, AUG 5 2014
  17. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function, JOURNAL OF NEUROCHEMISTRY, 130(6), 826-838, SEP 2014
  18. Detection of a novel neurotoxic metabolite of Parkinson's disease-related neurotoxin, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, JOURNAL OF TOXICOLOGICAL SCIENCES, 39(5), 749-754, OCT 2014
  19. Tributyltin induces mitochondrial fission through NAD-IDH dependent mitofusin degradation in human embryonic carcinoma cells, METALLOMICS, 7(8), 1240-1246, 2015
  20. Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates, Toxicology in Vitro, 28(6), 1176-1182, 201409
  21. Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(1), 155-164, FEB 2016
  22. Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction, SCIENTIFIC REPORTS, 6, FEB 22 2016
  23. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 207-215, APR 2016
  24. Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 255-264, APR 2016
  25. Protein extracts from cultured cells contain nonspecific serum albumin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(6), 1164-1167, 2016
  26. Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver., Xenobiotica, 45(7):605-14(7), 605-614, 2015
  27. Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability., Toxicology Reports, 2, 450-460, 2015
  28. Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism, JOURNAL OF NEUROCHEMISTRY, 139(2), 294-308, OCT 2016

Invited Lecture, Oral Presentation, Poster Presentation

  1. Increased expression of glutamate transporter EAAT3 by rotenone, Yaichiro Kotake, Tomomi Yamamoto, Satoshi Adachi, Kouta Kouno, Shigeru Ohta, 50th Congress of the European Societies of Toxicology, 2014/09, Without Invitation, the European Societies of Toxicology, Edinburgh
  2. Organotin decreases GluR2 expression in nuclear respiratory factor-1-dependent manner., Yaichiro Kotake, Keishi Ishida, Kaori Aoki, Tomoko Takishita, Tomoki Kimura, Yasunari Kanda, Shigeru Ohta, International Society for Trace Element Research in Humans (ISTERH) 2015, 2015/10, Without Invitation, International Society for Trace Element Research in Humans (ISTERH), Dubrovnik, Croatia
  3. Neurotoxicity of perfluorooctane sulfonate (PFOS) via GluR2 decrease, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Takashi Saiki, Seigo Sanoh, Shigeru Ohta, 2016 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology, 2016/09, Without Invitation, Tokyo
  4. PFOS Increases Neuronal Vulnerability to Excitotoxicity via Decrease of AMPA receptor Subunit GluR2 expression, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Seigo Sanoh, Shigeru Ohta, Society of Toxicology 56th Annual Meeting, 2017/03, Without Invitation, Baltimore, USA