Norimitsu Morioka

Last Updated :2019/04/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), ., Professor
E-mail
mnorihiroshima-u.ac.jp
Self-introduction
I specialize in the research for Neuroprharmacology, especially pain and depression.

Basic Information

Major Professional Backgrounds

  • 2002/04/01, 2007/03/31, Hiroshima University, Graduate School of Biomedical Sciences , Research Associate
  • 2007/04/01, 2009/09/30, Hiroshima University, Graduate School of Biomedical Sciences , Research associate
  • 2009/10/01, 2013/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/04/01, 2016/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate professor
  • 2016/04/01, Hiroshima University, Institute of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1999/04, 2002/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1997/04, 1999/03
  • Hiroshima University, Faculty of Medicine, Japan, 1993/04, 1997/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • School of Pharmaceutical Sciences:Program of Pharmaceutical Sciences, Graduate School of Biomedical & Health Sciences:Medicinal Sciences Major, Graduate School of Biomedical & Health Sciences:Medicinal Sciences Major

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology

Research Keywords

  • neuropathic pain
  • allodynia
  • connexin/gap junction
  • clock genes
  • HMGB1
  • astrocytes
  • microglia
  • glutamate transporter
  • nicotine/nACh receptor

Affiliated Academic Societies

  • The Society for Neuroscience

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, 3Term, Pharmacology I
  2. 2019, Undergraduate Education, First Semester, Practice of Biochemical Pharmacology
  3. 2019, Undergraduate Education, 1Term, Pharmacology II
  4. 2019, Undergraduate Education, 4Term, Pharmacology III
  5. 2019, Undergraduate Education, First Semester, Practice of Pharmacology
  6. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  7. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  8. 2019, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  9. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  10. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  11. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  12. 2019, Graduate Education (Master's Program) , Second Semester, Advanced lecture on pharmacology
  13. 2019, Graduate Education (Master's Program) , First Semester, Seminar on pharmacology
  14. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on pharmacology
  15. 2019, Graduate Education (Master's Program) , First Semester, Seminar on molecular pharmacology
  16. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on molecular pharmacology
  17. 2019, Graduate Education (Master's Program) , First Semester, Research on pharmacology
  18. 2019, Graduate Education (Master's Program) , Second Semester, Research on pharmacology
  19. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on pharmacology
  20. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on pharmacology
  21. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on pharmacology
  22. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on pharmacology
  23. 2019, Graduate Education (Master's Program) , 3Term, Lecture on Pharmacology
  24. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacology
  25. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacology
  26. 2019, Graduate Education (Master's Program) , First Semester, Research on Pharmacology
  27. 2019, Graduate Education (Master's Program) , Second Semester, Research on Pharmacology
  28. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacology
  29. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacology
  30. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacology
  31. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacology
  32. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Pharmacology
  33. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Pharmacology

Research Activities

Academic Papers

  1. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, GLIA, 66(2), 428-444, 201802
  2. Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(10), 1759-1766, 201710
  3. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2), 151-157, 20160108
  4. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy, JOURNAL OF NEUROCHEMISTRY, 136(4), 837-850, 201602
  5. Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia, BRAIN RESEARCH, 1634, 57-67, 20160301
  6. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice, MOLECULAR AND CELLULAR NEUROSCIENCE, 72, 72-83, 201604
  7. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression, LIFE SCIENCES, 155, 116-122, 20160615
  8. The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 479(4), 907-912, 20161028
  9. Stimulation of spinal dorsal horn beta 2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase, NEUROCHEMISTRY INTERNATIONAL, 101, 144-155, 201612
  10. Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(53), 27364-+, 20161230
  11. Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility, PSYCHOPHARMACOLOGY, 232(1), 39-46, 201501
  12. Downregulation of Connexin36 in Mouse Spinal Dorsal Horn Neurons Leads to Mechanical Allodynia, JOURNAL OF NEUROSCIENCE RESEARCH, 93(4), 584-591, 201504
  13. Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G alpha(i/o) Activation in Astroglial Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(22), 13678-13691, 20150529
  14. Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1202-1208, 20150904
  15. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice, BRAIN BEHAVIOR AND IMMUNITY, 49, 293-310, 201510
  16. Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes, JOURNAL OF NEUROCHEMISTRY, 135(1), 27-37, 201510
  17. Stimulation of alpha 7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia, BRAIN RESEARCH, 1625, 111-120, 20151102
  18. The induction of Pen1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes, NEUROCHEMISTRY INTERNATIONAL, 90, 9-19, 201511
  19. PRIMARY CULTURES OF RAT CORTICAL MICROGLIA TREATED WITH NICOTINE INCREASES IN THE EXPRESSION OF EXCITATORY AMINO ACID TRANSPORTER 1 (GLAST) VIA THE ACTIVATION OF THE alpha 7 NICOTINIC ACETYLCHOLINE RECEPTOR, NEUROSCIENCE, 258, 374-384, 20140131
  20. Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappa B activation in spinal astrocytes, MOLECULAR AND CELLULAR NEUROSCIENCE, 59, 37-46, 201403
  21. Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway, BRITISH JOURNAL OF PHARMACOLOGY, 171(11), 2854-2867, 201406
  22. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2, JOURNAL OF NEUROCHEMISTRY, 131(6), 755-766, 201412
  23. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay, JOURNAL OF PHARMACOLOGICAL SCIENCES, 126(4), 302-309, 201412
  24. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., J. Pharmacol. Sci., 20130301
  25. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons, BRAIN RESEARCH, 1509, 20-31, 20130506
  26. Spinal astrocytes stimulated by tumor necrosis factor- and/or interferon- attenuate connexin 43-gap junction via c-jun terminal kinase activity, JOURNAL OF NEUROSCIENCE RESEARCH, 91(6), 745-756, 201306
  27. Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1, PLOS ONE, 8(8), 20130821
  28. Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121(4), 257-271, 201304
  29. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons, JOURNAL OF NEUROCHEMISTRY, 120(6), 1036-1047, 201203
  30. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice, NEUROCHEMISTRY INTERNATIONAL, 60(8), 817-826, 201206
  31. Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline, PLOS ONE, 7(12), 20121205
  32. Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production., Journal of Biological Chemistry, 20110601
  33. The Roles of ATP Receptors in the Regulation of Various Functions in Spinal Microglia, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131(7), 1047-1052, 20110701
  34. Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3, Neurochem. Int., 57(8), 923-934, 20101001
  35. Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with PKA-CREB and Src-GSK-3beta., J. Pharmacol. Sci., 113(3), 234-245, 20100601
  36. Cannabis use disorder and treatment of dependence, 68(8), 1475, 20100801
  37. Paclitax and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels, Neuropharmacology, 57(1), 25, 20090701
  38. Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain, Pharmacology and Therapeutics, 123, 54-79, 20090701
  39. Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils., J. Pharmacol. Sci., 106, 492-504, 20080301
  40. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamates transporter., Glia, 56, 528-538, 20080401
  41. Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signaling in spinal cord in mice., Pain, 138, 525-536, 20080901
  42. Spinal anti-allodynia action of glycine transporter inhibitors in neuropathic pain models in mice., J. Pharmacol. Exp. Ther., 326, 633-645, 20080801
  43. Involvement of Voltage-Gated Sodium Channel Na(v)1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons, J. Pharmacol. Sci., 108(2), 190-197, 200810
  44. The regulation of glycine transporter GlyT1 is mainly mediated by protein kinase Calpha in C6 glioma cells., Neurochemical International, 53, 248-254, 20081201
  45. Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice., Neurochemistry International, IN PRESS, 20071201
  46. Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice, 130(6), 458-463, 20071201
  47. Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with localanesthetics., Brain Res., 1096, 97-103, 20061001
  48. Analgesic action of nicotine on tibial nervw transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord., Life. Sci., 80, 9-16, 20061001
  49. Transport of dopamine and levodopa and their interaction in COS-7 cells heterologously expressing monoamine neurotransmitter transporters and in monoaminergic cell lines PC12 and SK-N-SH, Life Sciences, 76(1), 1603-1612, 20050101
  50. Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice, Pain, 111(3), 351-359, 20041001
  51. Non-steroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells, The Journal of Pharmacology and Experimental Therapeutics, 310(2), 800-807, 20040801

Publications such as books

  1. 2018/, /Ja, Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection, Springer, 2018, 01, English, Morioka N, Hisaoka-Nakashima K, Nakata Y., 978-981-10-8487-4
  2. 2000/03, Neural-immune interactions in dorsal root ganglia , Folia Pharmacol. Jpn, 2000, 03

Invited Lecture, Oral Presentation, Poster Presentation

  1. The analysis of depression-related behaviors in neuropathic pain of mice―possible involvement of brain microglia, Tomimura Y., Nakashima K., Yoshii Y., Zhang F.F., Nakata Y., Morioka N., 2017/03, Without Invitation
  2. Mechanism for the high mobility group box-1-induced mechanical hypersensitivity in spinal dorsal horn of mice, Miyauchi K., Zhang F.F., Nakashima K., Nakata Y., Morioka N., 2017/03, Without Invitation
  3. A role of spinal astrocytic connexin43 in maintenance of neuropathic pain., 2016/03, Without Invitation
  4. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission., 2016/03, Without Invitation
  5. The downregulation of connexin43 expression in spinal astrocytes contributes to the maintenance of neuropathic pain, 2015/03/28, Without Invitation
  6. Induction of neuropathic pain in mice by clock gene Per1, 2015/03/20, Without Invitation
  7. Role of HMGB1 in neuropathic pain and anti-HMGB1 therapy for neuropathic pain, Norimitsu MORIOKA, Yoshihiro NAKATA, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015/03/18, Without Invitation
  8. Tricyclic antidepressant amitriptyline acts on astrocytes leading to the increase in the FGF2 expression: A role of early growth response 1 signaling., Kajitani N, Hisaoka-Nakashima K, Okada-Tsuchioka M, Hosoi M, Shibasaki C, Morioka N, Nakata Y, Takebayashi M., Neuroscience 2014, 2014/11/17, Without Invitation
  9. The role of clock gene Per1 in the regulation of nociceptive transduction in spinal astrocytes, 2014/03/28, Without Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  2. 2016
  3. 2016, 2018
  4. KAKENHI, 2015, 2018
  5. KAKENHI, 2014, 2016
  6. KAKENHI, The role of astroglial gap juncton in the regulation of chronic pain, 2012, 2013
  7. 2011
  8. 2011
  9. KAKENHI, A crosstalk between sensory neurons and surrounding cells, 2009, 2011
  10. 2009
  11. KAKENHI, The modulation of pain transduction mechanism through circadian clock, 2007, 2008
  12. KAKENHI, Role of glycine signal in the mechanism of neuropathic pain and development using siRNA for medicament., 2007, 2008
  13. KAKENHI, 2006, 2008
  14. KAKENHI, Evidence of a role for cyclic ADP-ribose in pain transduction in spinal cord, 2006, 2007
  15. KAKENHI, 2005, 2006
  16. KAKENHI, 2004, 2006
  17. 2004
  18. KAKENHI, 2003, 2004
  19. KAKENHI, The role of Platelet-Activating Factor (PAF) on the mechanisms of development of neuropathic pain. And its regulation, 2003, 2005
  20. KAKENHI, Evidence of a role for cyclic ADP-ribose in calcium signaling and migration in human neutrophils, 2003, 2004