Norimitsu Morioka

Last Updated :2020/09/11

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
mnorihiroshima-u.ac.jp
Other Contact Details
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5310 FAX : (+81)82-257-5314
Self-introduction
I specialize in the research for Neuroprharmacology, especially pain and depression.

Basic Information

Major Professional Backgrounds

  • 2002/04/01, 2007/03/31, Hiroshima University, Graduate School of Biomedical Sciences , Research Associate
  • 2007/04/01, 2009/09/30, Hiroshima University, Graduate School of Biomedical Sciences , Research associate
  • 2009/10/01, 2013/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/04/01, 2016/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate professor
  • 2016/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences , Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1999/04, 2002/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1997/04, 1999/03
  • Hiroshima University, Faculty of Medicine, Japan, 1993/04, 1997/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology

Research Keywords

  • neuropathic pain
  • allodynia
  • connexin/gap junction
  • clock genes
  • HMGB1
  • astrocytes
  • microglia
  • nicotine/nACh receptor

Affiliated Academic Societies

  • The Society for Neuroscience

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  2. 2020, Undergraduate Education, 3Term, Pharmacology I
  3. 2020, Undergraduate Education, First Semester, Practice of Biochemical Pharmacology
  4. 2020, Undergraduate Education, 1Term, Pharmacology II
  5. 2020, Undergraduate Education, 2Term, Pharmacology III
  6. 2020, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  7. 2020, Undergraduate Education, First Semester, Practice of Pharmacology
  8. 2020, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  9. 2020, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  10. 2020, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  11. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  12. 2020, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  13. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on pharmacology
  14. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on pharmacology
  15. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on pharmacology
  16. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on pharmacology
  17. 2020, Graduate Education (Master's Program) , Second Semester, Clinical Pharmacology
  18. 2020, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacology
  19. 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacology
  20. 2020, Graduate Education (Master's Program) , First Semester, Research on Pharmacology
  21. 2020, Graduate Education (Master's Program) , Second Semester, Research on Pharmacology
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacology
  23. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacology
  24. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacology
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacology
  26. 2020, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Pharmacology
  27. 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Pharmacology

Research Activities

Academic Papers

  1. Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms, CELLS, 9(5), 202005
  2. Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors, BEHAVIOURAL BRAIN RESEARCH, 391, 20200805
  3. Stimulation of toll-like receptor 4 downregulates the expression of alpha 7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia, NEUROCHEMISTRY INTERNATIONAL, 138, 202009
  4. TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 144(1), 23-29, 202009
  5. High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 92, 347-362, 20190608
  6. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 857-866, 201906
  7. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice, BRAIN BEHAVIOR AND IMMUNITY, 78, 116-130, 201905
  8. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes, EUROPEAN JOURNAL OF PHARMACOLOGY, 860, 20191005
  9. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1 beta in activated astrocytes, JOURNAL OF NEUROCHEMISTRY, 150(6), 738-758, 201909
  10. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, GLIA, 66(2), 428-444, 201802
  11. Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(10), 1759-1766, 201710
  12. Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(53), 27364-+, 20161230
  13. Stimulation of spinal dorsal horn beta 2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase, NEUROCHEMISTRY INTERNATIONAL, 101, 144-155, 201612
  14. The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 479(4), 907-912, 20161028
  15. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression, LIFE SCIENCES, 155, 116-122, 20160615
  16. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice, MOLECULAR AND CELLULAR NEUROSCIENCE, 72, 72-83, 201604
  17. Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia, BRAIN RESEARCH, 1634, 57-67, 20160301
  18. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy, JOURNAL OF NEUROCHEMISTRY, 136(4), 837-850, 201602
  19. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2), 151-157, 20160108
  20. Stimulation of alpha 7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia, BRAIN RESEARCH, 1625, 111-120, 20151102
  21. The induction of Pen1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes, NEUROCHEMISTRY INTERNATIONAL, 90, 9-19, 201511
  22. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice, BRAIN BEHAVIOR AND IMMUNITY, 49, 293-310, 201510
  23. Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes, JOURNAL OF NEUROCHEMISTRY, 135(1), 27-37, 201510
  24. Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1202-1208, 20150904
  25. Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G alpha(i/o) Activation in Astroglial Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(22), 13678-13691, 20150529
  26. Downregulation of Connexin36 in Mouse Spinal Dorsal Horn Neurons Leads to Mechanical Allodynia, JOURNAL OF NEUROSCIENCE RESEARCH, 93(4), 584-591, 201504
  27. Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility, PSYCHOPHARMACOLOGY, 232(1), 39-46, 201501
  28. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2, JOURNAL OF NEUROCHEMISTRY, 131(6), 755-766, 201412
  29. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay, JOURNAL OF PHARMACOLOGICAL SCIENCES, 126(4), 302-309, 201412
  30. Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway, BRITISH JOURNAL OF PHARMACOLOGY, 171(11), 2854-2867, 201406
  31. Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappa B activation in spinal astrocytes, MOLECULAR AND CELLULAR NEUROSCIENCE, 59, 37-46, 201403
  32. PRIMARY CULTURES OF RAT CORTICAL MICROGLIA TREATED WITH NICOTINE INCREASES IN THE EXPRESSION OF EXCITATORY AMINO ACID TRANSPORTER 1 (GLAST) VIA THE ACTIVATION OF THE alpha 7 NICOTINIC ACETYLCHOLINE RECEPTOR, NEUROSCIENCE, 258, 374-384, 20140131
  33. Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1, PLOS ONE, 8(8), 20130821
  34. Spinal astrocytes stimulated by tumor necrosis factor- and/or interferon- attenuate connexin 43-gap junction via c-jun terminal kinase activity, JOURNAL OF NEUROSCIENCE RESEARCH, 91(6), 745-756, 201306
  35. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons, BRAIN RESEARCH, 1509, 20-31, 20130506
  36. Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121(4), 257-271, 201304
  37. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., J. Pharmacol. Sci., 20130301
  38. Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline, PLOS ONE, 7(12), 20121205
  39. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice, NEUROCHEMISTRY INTERNATIONAL, 60(8), 817-826, 201206
  40. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons, JOURNAL OF NEUROCHEMISTRY, 120(6), 1036-1047, 201203
  41. The Roles of ATP Receptors in the Regulation of Various Functions in Spinal Microglia, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131(7), 1047-1052, 20110701
  42. Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production., Journal of Biological Chemistry, 20110601
  43. Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3, Neurochem. Int., 57(8), 923-934, 20101001
  44. Cannabis use disorder and treatment of dependence, 68(8), 1475, 20100801
  45. Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with PKA-CREB and Src-GSK-3beta., J. Pharmacol. Sci., 113(3), 234-245, 20100601
  46. Paclitax and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels, Neuropharmacology, 57(1), 25, 20090701
  47. Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain, Pharmacology and Therapeutics, 123, 54-79, 20090701
  48. The regulation of glycine transporter GlyT1 is mainly mediated by protein kinase Calpha in C6 glioma cells., Neurochemical International, 53, 248-254, 20081201
  49. Involvement of Voltage-Gated Sodium Channel Na(v)1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons, J. Pharmacol. Sci., 108(2), 190-197, 200810
  50. Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signaling in spinal cord in mice., Pain, 138, 525-536, 20080901
  51. Spinal anti-allodynia action of glycine transporter inhibitors in neuropathic pain models in mice., J. Pharmacol. Exp. Ther., 326, 633-645, 20080801
  52. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamates transporter., Glia, 56, 528-538, 20080401
  53. Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils., J. Pharmacol. Sci., 106, 492-504, 20080301
  54. Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice., Neurochemistry International, IN PRESS, 20071201
  55. Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice, 130(6), 458-463, 20071201
  56. Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with localanesthetics., Brain Res., 1096, 97-103, 20061001
  57. Analgesic action of nicotine on tibial nervw transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord., Life. Sci., 80, 9-16, 20061001
  58. Transport of dopamine and levodopa and their interaction in COS-7 cells heterologously expressing monoamine neurotransmitter transporters and in monoaminergic cell lines PC12 and SK-N-SH, Life Sciences, 76(1), 1603-1612, 20050101
  59. Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice, Pain, 111(3), 351-359, 20041001
  60. Non-steroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells, The Journal of Pharmacology and Experimental Therapeutics, 310(2), 800-807, 20040801

Publications such as books

  1. 2018/, /Ja, Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection, Springer, 2018, 01, English, Morioka N, Hisaoka-Nakashima K, Nakata Y., 978-981-10-8487-4
  2. 2000/03, Neural-immune interactions in dorsal root ganglia , Folia Pharmacol. Jpn, 2000, 03

Invited Lecture, Oral Presentation, Poster Presentation

  1. The possibility of HMGB1 as a therapeutic target for neuropathic pain., Nakamura Y, Nakashima K, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11, With Invitation
  2. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11, Without Invitation
  3. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase., Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10, Without Invitation
  4. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia., Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10, Without Invitation
  5. Systemic inflammation-induced memory dysfunction is prevented by blockade either microglia activation or histone deacetylase., Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of AsCNP, 2019/10, Without Invitation
  6. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Morioka N., Kondo S., Nakamura Y., Hisaoka-Nakashima K., Nakata Y, WCP2018, 2018/07, Without Invitation, Kyoto, Japan
  7. The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation, Hisaoka-Nakashima K., Tomimura Y., Yoshii T., Zhang F.F., Nakamura Y., Liu K., Nishibori M., Nakata Y., Morioka N., WCP2018, 2018/07, Without Invitation, Kyoto, Japan
  8. Downregulation of astocytic connexin43 leads to enhancement of neurotrophic factor production in cortical astrocytes, Kondo S., Hisaoka-Nakashima K., Nakata Y., Morioka N., WCP2018, 2018/07, Without Invitation, Kyoto, Japan
  9. The analysis of depression-related behaviors in neuropathic pain of mice―possible involvement of brain microglia, Tomimura Y., Nakashima K., Yoshii Y., Zhang F.F., Nakata Y., Morioka N., 2017/03, Without Invitation
  10. Mechanism for the high mobility group box-1-induced mechanical hypersensitivity in spinal dorsal horn of mice, Miyauchi K., Zhang F.F., Nakashima K., Nakata Y., Morioka N., 2017/03, Without Invitation
  11. A role of spinal astrocytic connexin43 in maintenance of neuropathic pain., 2016/03, Without Invitation
  12. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission., 2016/03, Without Invitation
  13. The downregulation of connexin43 expression in spinal astrocytes contributes to the maintenance of neuropathic pain, 2015/03/28, Without Invitation
  14. Induction of neuropathic pain in mice by clock gene Per1, 2015/03/20, Without Invitation
  15. Role of HMGB1 in neuropathic pain and anti-HMGB1 therapy for neuropathic pain, Norimitsu MORIOKA, Yoshihiro NAKATA, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015/03/18, Without Invitation
  16. Tricyclic antidepressant amitriptyline acts on astrocytes leading to the increase in the FGF2 expression: A role of early growth response 1 signaling., Kajitani N, Hisaoka-Nakashima K, Okada-Tsuchioka M, Hosoi M, Shibasaki C, Morioka N, Nakata Y, Takebayashi M., Neuroscience 2014, 2014/11/17, Without Invitation
  17. The role of clock gene Per1 in the regulation of nociceptive transduction in spinal astrocytes, 2014/03/28, Without Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  2. 2016
  3. 2016, 2018
  4. KAKENHI, 2015, 2018
  5. KAKENHI, 2014, 2016
  6. KAKENHI, The role of astroglial gap juncton in the regulation of chronic pain, 2012, 2013
  7. 2011
  8. 2011
  9. KAKENHI, A crosstalk between sensory neurons and surrounding cells, 2009, 2011
  10. 2009
  11. KAKENHI, The modulation of pain transduction mechanism through circadian clock, 2007, 2008
  12. KAKENHI, Role of glycine signal in the mechanism of neuropathic pain and development using siRNA for medicament., 2007, 2008
  13. KAKENHI, 2006, 2008
  14. KAKENHI, Evidence of a role for cyclic ADP-ribose in pain transduction in spinal cord, 2006, 2007
  15. KAKENHI, 2005, 2006
  16. KAKENHI, 2004, 2006
  17. 2004
  18. KAKENHI, 2003, 2004
  19. KAKENHI, The role of Platelet-Activating Factor (PAF) on the mechanisms of development of neuropathic pain. And its regulation, 2003, 2005
  20. KAKENHI, Evidence of a role for cyclic ADP-ribose in calcium signaling and migration in human neutrophils, 2003, 2004