NOBUYUKI HIROHASHI

Last Updated :2020/11/16

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Professor
Web Site
E-mail
hirohasihiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku, Hiroshima, Japan
TEL : (+81)1 82 257 58 FAX : (+81)
Self-introduction
Radiation Emergency Medicine Radiation Disaster Medicine Emergency and Critical Care Medicine, Acute medicine Aeromedical services Blood Purification in Critical Care

Basic Information

Major Professional Backgrounds

  • 1993/04/01, 1995/05/31, The University of Kansas
  • 1995/06/01, 1997/04/30, Kurume University, Research Associate
  • 1997/04/01, 1999/03/31, Professor
  • 1999/04/01, 2005/03/31, Kurume University, Lecturer
  • 2005/04/01, 2005/07/31, St. Marianna University School of Medicine, Researcher
  • 2005/08/01, 2006/10/31, Kurume University, Lecturer
  • 2006/11/01, 2007/03/31, Kurume University, Associate Professor
  • 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 2012/04/01, 2017/01/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2017/02/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Professor

Educational Backgrounds

  • Kurume University, Japan, 1989/04, 1993/03
  • Kurume University, Japan, 1983/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Kurume University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Emergency medicine

Research Keywords

  • EMERGENCY MEDICINE RADIATION DISASTER MEDICINE CRITICAL CARE MEDICINE ACUTE MEDICINE AEROMEDICAL SERVICES BLOOD PURIFICATION IN CRUTICAL CARE

Affiliated Academic Societies

  • Japanese Association for Acute Medicine, 1989/06
  • Japanese Society for Emergency Medicine, 1998/06
  • Japan Society for Blood Purification in Criticsl Care, 1997/06
  • Japanese Society of Intensive Care Medicine, 1999/04
  • Japanese Asoociation for the Surgery of Trauma, 1997/06
  • Japanese Society for Aeromedical Services, 2003/10
  • Japanese Society of Clinical Toxicology, 1997/06
  • Japanese Society for Burn Injuries, 1997/06
  • Japanese Society of Inflammation and Regeneration, 1992/04
  • Japanese Society for Abdominal Emergency Medicine, 1997/06
  • Japan Endotoxin Society, 1995/11
  • Japan Shock Society, 2007/09
  • Society of Critical Care Medicine, 2007/09
  • International Endotoxin & Innate Immunity Society, 1994/08
  • Japanese Association for Radiation Accident Disaster Medicine, 2013
  • The Japanese Radiation Research Society

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 2Term, War and Peace from the Viewpoint of Medicine
  2. 2020, Undergraduate Education, Year, Systemic Disease Control
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  4. 2020, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  5. 2020, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  6. 2020, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  7. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Radiation Medicine
  8. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Radiation Medicine
  9. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Radiation Medicine
  10. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Radiation Medicine
  11. 2020, Graduate Education (Doctoral Program) , Second Semester, Radiological Disaster Medicine
  12. 2020, Graduate Education (Master's Program) , First Semester, Seminar
  13. 2020, Graduate Education (Master's Program) , Second Semester, Seminar
  14. 2020, Graduate Education (Master's Program) , First Semester, Research
  15. 2020, Graduate Education (Master's Program) , Second Semester, Research
  16. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  17. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  18. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  19. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  20. 2020, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  21. 2020, Graduate Education (Master's Program) , First Semester, Pathophysiology
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Radiation Medicine
  23. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Radiation Medicine
  24. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Radiation Medicine
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Radiation Medicine
  26. 2020, Graduate Education (Doctoral Program) , First Semester, Short-term Fieldwork

Research Activities

Academic Papers

  1. ★, GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A., CARCINOGENESIS, doi:10.1093/carcin/bgaa010, 20200212
  2. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells, PLOS ONE, 14(7), 20190719
  3. Comparison of Airway Simulators for the AirwayScope Video-Laryngoscope, Emergency Medicine Investigations, 2, DOI: 10.29011/2475-5605. 000074, 20180309
  4. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway, TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 245(3), 193-204, 201807
  5. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13(2), 20180221
  6. Loss of life following evacuation: lessons learned from the Fukushima Daiichi Nuclear Power Plant accident, LANCET, 379, 889-891, 2012
  7. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report, BMC PULMONARY MEDICINE, 16, 20160812
  8. Iwasaki Y, Namera A, Giga H, Kida Y, Ota K, Une K, Otani T, Ohshimo S, Hirohashi N, Tanigawa K: A case of severe puffer fish poisoning: serum tetrodotoxin concentration measurements for 4 days after ingestion J CLIN TOXICOL 5: 226. doi:10.4172/2161-0495.1000226, 2015, J CLIN TOXICOL, 5(226), doi:10.4172/2161-0495.-doi:10.4172/2161-0495., 2015
  9. Influence of clinical experience of the Macintosh laryngoscope on performance with the Pentax-AWS Airway Scope®, a rigid video-laryngoscope, by paramedics in Japan., J ANESTH, 29(5), 672-677-677, 2015
  10. ★, Health effects of radiation and other health problems in the aftermath of nuclear accidents, with an emphasis on Fukushima, LANCET, 386(9992), 479-488, 20150801
  11. A PILOT STUDY: A COMBINED THERAPY USING POLYMYXIN-B HEMOPERFUSION AND EXTRACORPOREAL MEMBRANE OXYGENATION FOR ACUTE EXACERBATION OF INTERSTITIAL PNEUMONIA, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 31(4), 343-349, 2014
  12. Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 108(7), 1031-1039, 201407
  13. KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome, ORPHANET JOURNAL OF RARE DISEASES, 7, 20121217
  14. KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome, RESPIRATORY RESEARCH, 12, 20110322
  15. Tracheal Intubation of a Difficult Airway Using Airway Scope, Airtraq, and Macintosh Laryngoscope: A Comparative Manikin Study of Inexperienced Personnel, ANESTHESIA AND ANALGESIA, 110(4), 1049-1055, 201004

Publications such as books

  1. 2017/08/14, Critical care neurology, Acute central nervous system infectious disease ( encepharitis, meningitis), encepharitis, meningitis, 2017, 8, Scholarly Book, Joint work, 日本語, 9784260017541, 4260017543, 664
  2. 2018/01/10, Today's therapy, Acute radiation syndrome, Acute radiation syndrome, 2018, 1, Dictionary/Encyclopedia, Single work, 日本語, Nobuyuki Hirohashi, 9784260032346, 4260032348, 2066

Invited Lecture, Oral Presentation, Poster Presentation

  1. NHK Documentary Battling a Radiation Emergency: The Doctors at Fukushima, Nobuyuki HIROHASHI et al., NHK Documentary :Battling a Radiation Emergency: The Doctors at Fukushima, 2019/05/11, With Invitation, Japanese, NHK
  2. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima –, Nobuyuki HIROHASHI, 2019/12/17, Without Invitation, English
  3. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima –, Nobuyuki HIROHASHI, 2019/10/28, With Invitation, English
  4. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, 2019/09/02, With Invitation, English
  5. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, 2019/07/23, Without Invitation, English
  6. The role of Hiroshima University as the new radiation/nuclear emergency medical support center for the next disaster, A new horizon of radiation health risk science education from the experience of nuclear disaster, Nobuyuki HIROHASHI, 2019/11/14, With Invitation, Japanese
  7. Code Blue,Black & Yellow - Lessons learned from Fukushima and Hiroshima and More -, Nobuyuki HIROHASHI, Joint meeting(Department of Nursing, U Indonesia and Research Institute for Radiation Biology and Medicine,U Hiroshima), 2019/10/10, With Invitation, English, Department of Nursing, U Indonesia, Depok, Indonesia
  8. The role of Hiroshima University as the new radiation/nuclear emergency medical support center for the next disaster., Nobuyuki HIROHASHI, Crisis in Context: Minding the gaps in medical preparedness for a Rad/Nuke Incident The Radiation Injury Treatment Network Workshop, 2019/07/31, With Invitation, English, The Radiation Injury Treatment Network, Arlington, VA,USA, The Radiation Injury Treatment Network seeks to increase the understanding of and pre-paredness for the tremendous medical, environmental, and psychological consequences of a mass casualty radiological/nuclear incident for healthcare professionals. The 2019 RITN workshop will highlight recent developments in resource-constrained environments: (1) optimizing ARS initial assessment and triage, (2) ensuring the availability and appropriate use of medical and psycho-social supportive care, (3) disseminating the latest research in radiation-specific medical countermeasures, (4) applying technology as a force multiplier for care and education, and (5) enhancing collaboration among burn surgeons and RITN professionals. Additionally, the workshop will encourage open sharing of lessons learned from past efforts.
  9. New Radiation Emergency Medical System in Japan. , Nobuyuki HIROHASHI, Discussion were made involving authorities from the government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia and Radiation Safety Committee of NCC, about how to train doctors and medical professionals for radiation accident medical response, how to organize medical care pathway., 2019/06/14, With Invitation, English, Radiation Safety Committee of National Cancer Center (NCC) Deputy Prime Minister of Mongolia, Ulaanbaatar, Mongolia, discussion were made involving authorities from the government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia and Radiation Safety Committee of NCC, about how to train doctors and medical professionals for radiation accident medical response, how to organize medical care pathway. In this discussion total 20 guests attended: Dr. Hirohashi- Proffessor of Radiation Disaster Medicine Department, Hiroshima University, Toby Lowe- Radiation therapist from St.George Hospital, Australia and representatives from The government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia, National Public Health Center and Second General Hospital as well as Radiation Safety Committee of NCC.
  10. ER(Emergency room) management of Radiation/Nuclear disaster patients, Nobuyuki HIROHASHI, The onsite training, "how to organize emergency response for radiation accident" took place at NCC Conference hall, 2019/06/14, With Invitation, English, Radiation Safety Committee of National Cancer Center (NCC) supported by Deputy Prime Minister of Mongolia, Ulaanbaatar, Mongolia, The onsite training, about how to organize emergency response for radiation accident, took place at NCC Conference hall in the extension building during 09:00 – 12:00, on 14th June 2019 and led by Prof. Hirohashi Nobuyuki. Two radiation accident cases were prepared in advance, in order to show on site medical assistance, including how doctors and nurses should wear the protection suits and undress properly. Total 97 participants from either rural or urban hospitals attended this demonstration training.
  11. New Radiation Emergency Medical System in Japan - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, Radiation Accident Prevention and Medical Response, 2019/06/13, With Invitation, English, the Deputy Prime Minister of Mongolia, Radiation Safety Committee of National Cancer Center (NCC), Ulaanbaatar,Mongolia
  12. Immediate post-accident response, NOBUYUKI HIROHASHI, Consulting meeting on review and future of science and technology studies(STS) Curriculum in Japan, 2017/08/29, With Invitation, English, Consulting meeting on review and future of science and technology studies(STS) Curriculum in Japan, FUKUSHIMA,JAPAN, published
  13. ER(Emergency room) management of Radiation/Nuclear disaster patients, NOBUYUKI HIROHASHI, HICARE INTERNATIONAL TRAINING COURSE on Medical Responses to Radiation Accidents and Disasters, 2018/02/20, Without Invitation, English, HICARE, HIROSHIMA, published
  14. Emergency medical response to radiation and nuclear accidents:Drill, NOBUYUKI HIROHASHI, Emergency Radiation Medicine Promoting Center, Hiroshima University, HICARE INTERNATIONAL TRAINIG COURSE on Medical Responses to Radiation Accidents and Disasters, 2018/02/20, Without Invitation, English, HICARE, HIROSHIMA, published
  15. Radiation/Nuclear Emergency Medical System, NOBUYUKI HIROHASHI, Kick-off Seminar between Soochow University and Hiroshima University, 2018/04/24, Without Invitation, English, Hiroshima University, Soochow University, Hiroshima
  16. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, REAC/TS Advanced Radiation Medicine course, 2018/08/15, With Invitation, English, REAC/TS, Oak Ridge, TN, USA
  17. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, HICARE special seminar, 2018/10/22, With Invitation, English, Kuwakini Medical Center,HICARE, Hawaii, USA.
  18. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, HICARE SEMINAR, 2018/10/23, With Invitation, English, John A.Burns School of Medicine, University of Hawaii HICARE, Hawaii, USA
  19. The role of Hiroshima University as the new radiation/nuclear emergency medical support center on communicating radiation/nuclear emergencies to the public, Nobuyuki HIROHASHI, Kenji Kamiya, International Symposium on Communicating Nuclear and Radiological Emergencies to the Public, 2018/10/04, Without Invitation, English, IAEA, IAEA Headquarters Vienna, Austria
  20. Consultancy meeting on STS education support on return in the context of low-dose radiation, Nobuyuki HIROHASHI, Consultancy meeting on STS education support on return in the context of low-dose radiation, 2018/01/15, With Invitation, English, IAEA, FUKUSHIMA MEDICAL UNIVERSITY, FUKUSHIMA,JAPAN

Social Activities

History as Committee Members

  1. SHAMISEN STAKEHOLDER MEETING MEMBER, 2017/03/23, 2017/03/24