MAKOTO HIRAYAMA

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Associate Professor or Lecturer
Web Site
E-mail
hirayamahiroshima-u.ac.jp
Other Contact Details
1-4-4, Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8528, JAPAN, Japan
TEL : (+81) FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2005/04/01, 2006/03/31, Japan Society for the Promotion of Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Special Postdoctoral Researcher
  • 2006/04/01, 2007/03/31, Japan Society for the Promotion of Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Special Postdoctoral Researcher
  • 2007/04/01, 2008/10/31, Japan Society for the Promotion of Science, Graduate School of Frontier Sciences, The University of Tokyo (20070401-20070831)/ Hopkins Marine Station, Stanford University (20070901-20081031), Special Postdoctoral Researcher
  • 2008/11/01, 2016/03/31, Hiroshima University, Graduate School of Biosphere Science, Assistant Professor
  • 2016/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Associate Professor

Educational Backgrounds

  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Department of Aquatic Bioscience, Japan, 2003/04, 2006/03
  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Department of Aquatic Bioscience, Japan, 2001/04, 2003/03
  • The University of Tokyo, Faculty of Agriculture, Major in Aquatic Life Sciences, Japan, 1999/04, 2001/03

Academic Degrees

  • Doctor of Agriculture, The University of Tokyo
  • Master of Agriculture, The University of Tokyo

Educational Activity

  • 【Bachelor Degree Program】School of Applied Biological Science : Department of Applied Biological Science
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science

Research Fields

  • Agricultural sciences;Applied aquatic science;Aquatic life science

Research Keywords

  • Algae, Bioactive compound, Lectin, Glycobiology, Molecular Biology, Anti-cancer, Anti-virus

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 4Term, Biological production and natural environment
  2. 2019, Liberal Arts Education Program1, 3Term, Cell Science
  3. 2019, Liberal Arts Education Program1, 3Term, Food safety and health science
  4. 2019, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  5. 2019, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
  6. 2019, Undergraduate Education, 2Term, Reading of Foreign Literature
  7. 2019, Undergraduate Education, 4Term, Introduction to Applied Biological Science II
  8. 2019, Undergraduate Education, 4Term, Marine Bioresources Chemistry
  9. 2019, Undergraduate Education, Intensive, Laboratory Work in Marine Bioresources Chemistry
  10. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  11. 2019, Undergraduate Education, Intensive, Training for Marine Food Processing
  12. 2019, Undergraduate Education, Intensive, Food factory inspection
  13. 2019, Undergraduate Education, 3Term, Modern Food Science
  14. 2019, Graduate Education (Master's Program) , First Semester, Research for Academic Degree Dissertation
  15. 2019, Graduate Education (Master's Program) , First Semester, Practice in Food Science and Biofunctions
  16. 2019, Graduate Education (Master's Program) , 2Term, Aquatic Bioresource Chemistry
  17. 2019, Graduate Education (Master's Program) , 4Term, Glycobiology and Glycotechnology
  18. 2019, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  19. 2019, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  20. 2019, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  21. 2019, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  22. 2019, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  23. 2019, Graduate Education (Master's Program) , 2Term, Bioactive Natural Products Chemistry I
  24. 2019, Graduate Education (Master's Program) , 4Term, Bioactive Natural Products Chemistry II

Research Activities

Academic Papers

  1. High mannose-specific lectin (KAA-2) from the red alga Kappaphycus alvarezii potently inhibits influenza virus infection in a strain-independent manner, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 291-296, FEB 11 2011
  2. High Mannose-binding Lectin with Preference for the Cluster of alpha 1-2-Mannose from the Green Alga Boodlea coacta Is a Potent Entry Inhibitor of HIV-1 and Influenza Viruses, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(22), 19446-19458, JUN 3 2011
  3. Purification, Characterization, and cDNA Cloning of a Novel Lectin from the Green Alga, Codium barbatum, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(4), 805-811, 42837
  4. Purification , primary structure, and bioilogical activity of the high-mannose N-glycan specific lectin from cultivated Eucheuma denticulatum, JOURNAL OF APPLIED PHYCOLOGY, 27(4), 1657-1669, 42962
  5. Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin, MARINE DRUGS, 13(6), 3454-3465, 42901
  6. Biological activity, cDNA cloning and primary structure of lectin KSA-2 from the cultivated red alga Kappaphycus striatum (Schmitz) Doty ex Silva, PHYTOCHEMISTRY LETTERS, 14, 99-105, 42339

Publications such as books

  1. 2014/07, Centrifugal Ultrafiltration-HPLC Method for Interaction Analysis Between Lectins and Sugars, in: Jun Hirabayashi (Ed.), Lectins-Methods and Protocols, Springer New York, E

Invited Lecture, Oral Presentation, Poster Presentation

  1. A lectin-device is effective for trapping and clearance of HIV-1, Kanji Hori, Makoto Hirayama, Takemasa Sakaguchi, Hiroshi Kurokawa, Hiroyoshi Minakuchi, Kiyonori Hirota, Masahiro Iwakura, 23rd International Symposium on Glycoconjugates, 2015/09/17, Without Invitation, International Glycoconjugate Organization, Split, Croatia
  2. A novel high-mannose specific lectin from the calcareous green alga Halimeda renschii exhibits a strong anti-influenza virus activity, Jinmin Mu, Makoto Hirayama, Yuichiro Sato, Kinjiro Morimoto, Kanji Hori, Yuichiro Sato, Kinjiro Morimoto, The 2017 spring meeting of the Japanese Society of Fisheries Science, 2017/03/28, Without Invitation, Japanese Society of Fisheries Science, Tokyo University of Marine Science and Technology
  3. Structural and functional analyses of the lectins from the green algae Codium subtubulosum and C. latum, Makoto Hirayama, Haruka Shimazaki, Kanji Hori, 11th Asia Pacific Marine Biotechnology Conference, 2017/05/24, Without Invitation, The Asia Pacific Society of Marine Biotechnology, University of Hawaii at Manoa, Hawaii, USA
  4. Structural and functional analyses of a novel high-mannose specific lectin from an edible red alga Meristotheca papulosa, Makoto Hirayama, Suwako Chinen, Nana Kameda, Kanji Hori, International Symposium "Fisheries Science for Future Generations", 2017/09/24, Without Invitation, The Japanese Society of Fisheries Science, Tokyo University of Marine Science and Technology, Tokyo, Japan
  5. Diversity, Structure, Biological Functions of Algal Lectins, Makoto Hirayama, 36th Symposium and Annual Meeting of the Association of Sydtematic Biologists of the Philippines, 2018/05/31, With Invitation, Association of Systematic Biologists of the Philippines, Butuan City, Philippines
  6. Structure, Function and Diversity of Seaweed Lectins as Potential Taxonomic Markers, Makoto Hirayama, 2018/06/04, With Invitation, University of San Carlos, Cebu City, Philippines
  7. Diversity, Structure, and Biological Fucntions of Algal Lectins, Makoto Hirayama, 2018/06/01, With Invitation, Caraga State University, Butuan City, Philippines
  8. A novel complex type N-glycan-specific lectin from the calcareous green alga Halimeda borneensis exhibits a strong anti-influenza virus activity, Jinmin Mu, Makoto Hirayama, Kanji Hori (Graduate School of Biosphere Science, Hiroshima Univ.), Yuichiro Sato, Kinjiro Morimoto (Faculty of Pharmacy, Yasuda Women's Univ.), Yuichiro Sato, Kinjiro Morimoto (Faculty of Pharmacy, Yasuda Women's Univ.), 2018/09/16, Without Invitation

Patented

  1. 5892489, 2016/03/04

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Study of a transgenic technique in coenocytic green algae for the production of useful proteins, 2012, 2013
  2. KAKENHI, Study of a new transgenic technique in coenocytic green algae utilizing their protoplast regeneration ability, 2009, 2010
  3. KAKENHI, Characterization of coralline algae growth using genetic markers, 2011, 2013
  4. KAKENHI(Grant-in-Aid for Young Scientists (B)), 2017, 2019

Social Activities

History as Peer Reviews of Academic Papers

  1. 2014, Fish Sci, 1
  2. 2014, Fish Physiol Biochem, 1
  3. 2013, Fish Sci, 1
  4. 2015, Phycological Research
  5. 2017, Aquaculture
  6. 2018, Fisheries Science, 1