MASANORI SUGIYAMA

Last Updated :2025/06/11

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor, Collaborative Research Laboratory
Web Site
http://en.hiroshima-u.jp/bhs/research/lab/other/Probiotic_Science_for_Preventive_Medicine
E-mail
sugihiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5280 FAX : (+81)82-257-5284
Self-introduction
I (Professor Sugiyama) have studied on the self-resistance mechanisms in antibiotic-producing actinomyces during 40 years. My boss, who had employed me as a assistant professor, has always encouraged me at the following phrase: "If you will continue the study for 10 years, you will be an expert at the microbiology field. Furthermore, if you will continue the study as your lifework, you will become an authority at the scientific field.

Basic Information

Major Professional Backgrounds

  • 1987/05/01, Institute Pasteur Paris, Microbiolgy Unit, Researcher
  • 1992/04/01, Hiroshima University, Faculty of Medicine, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Engineering, Japan, 1974/04, 1976/03
  • Hiroshima University, Faculty of Engineering, Japan, 1971/04, 1974/03

Academic Degrees

  • Doctor of Engineering, Hiroshima University
  • Master of Engineering, Hiroshima University

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • X-ray crystallography
  • three dimensional analysis of protein by X-ray
  • actinomycetes
  • plant-derived lactic acid bacteria
  • molecular microbiology
  • gene regulation sciences
  • antibiotics
  • probiotics
  • secondary metabolite

Affiliated Academic Societies

  • The Society for Biotechnology,Japan
  • The Phamaceutical Society of Japan
  • Japanese Society for Bachteriology
  • The Society for Actinomycetes Japan
  • Japan Society for Lactic Acid Bacteria
  • ASBMB　(The American Society for Biochemistry and Molecular Biology)
  • Japan Bioindustiry Association

Educational Activity

Course in Charge

  1. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  2. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  3. 2025, Graduate Education (Master's Program) , 4Term, Lecture on Probiotic Science for Preventive Medicine
  4. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Probiotic Science for Preventive Medicine
  5. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Probiotic Science for Preventive Medicine
  6. 2025, Graduate Education (Master's Program) , First Semester, Research on Probiotic Science for Preventive Medicine
  7. 2025, Graduate Education (Master's Program) , Second Semester, Research on Probiotic Science for Preventive Medicine
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Probiotic Science for Preventive Medicine
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Probiotic Science for Preventive Medicine

Award of Education

  1. 2014/11/03

Research Activities

Academic Papers

  1. Strategic approach of disease-prevention based upon variability of intestinal microbiota and biological impact induced by ingested sour-bread baked with plant-derived lactic acid bacteria in mice, 106, 31-40, 2024
  2. Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing regulation, J Biosci Bioeng, 137, 445-452, 202403
    Link to Paper Search Results by DOI
  3. Stevia Leaf Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T Displays Anticancer Activity to Pancreatic Cancer PANC-1 Cell Line, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26(9), 20250428
    Link to Paper Search Results by DOI
  4. Atractylodes Japonica Rhizome Extract Fermented with a Plant-Derived Lacticaseibacillus paracasei (Lactobacillus paracasei) IJH-SONE68 Improves the Wheat Gliadin-Induced Food Allergic Reaction in Mice, NUTRIENTS, 17(7), 20250326
    Link to Paper Search Results by DOI
  5. Eriobotrya japonica Fermentation with Plant-Derived Lactiplantibacillus plantarum MSC-5T Ameliorates Antioxidant Activity in HEK293 Cells,, 10(4), 202404
  6. Role of Phenolic Acid Metabolism in Enhancing Bioactivity of Mentha Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T, 16(3), 1052-1064, 202406
  7. Characterization of the Gamma-Aminobutyric Acid (GABA) Biosynthetic Gene Cluster in High GABA-Producing Enterococcus avium G-15, FERMENTATION-BASEL, 10(8), 202408
    Link to Paper Search Results by DOI
  8. Fermented stevia improves alcohol poisoning symptoms associated with changes in mouse gut microbiota, Nutrients, 15(3708), 20230824
  9. Role of phenolic acid metabolism in enhancing bioactivity of mentha extract fermented with plant-derived Lactobacillus plantarum SN13T, Probiotics Antimicrob Proteins, 16(3), 1052-1064, 202306
  10. Awareness Survey on Genetic Testing among Pharmacists in Hiroshima City, JAPANESE JOURNAL OF SOCIAL PHARMACY, Vol 41(No,1), 56-68, 2022
  11. A novel prokaryotic phospholipase A(2) - Characterization, gene cloning, and solution structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20051-20058, 20020531
    Link to Paper Search Results by DOI
  12. Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(1), 33-41, 200801
    Link to Paper Search Results by DOI
  13. Susceptibility of protein synthesis to streptomycin in streptomycin-producing ., FEBS Letters, 250-252, 19800401
  14. Assessment of competitive action of streptomycin 6-kinase and streptomycin 6-phosphatase in the in vitro protein synthesis of a streptomycin-producing microorganism., FEBS Letters, 331-333, 19820401
  15. Molecular cloning and expression in of a streptomycin 6-phosphotransferase gene from a streptomycin-producing microorganism., FEBS Letters, 385-389, 19850401
  16. Susceptibility of protein synthesis to neomycin in neomycin-producing ., Journal of General Microbiology(U. K. )=, 477-478, 19800401
  17. Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin producing microorganism., Journal of General Microbiology(U. K. )=, 1683-1687, 19830401
  18. Mechanism of self-protection in a puromycin-producing microorganism., Journal of General Microbiology(U. K. )=, 1999-2005, 19850401
  19. The nucleotide sequence of a streptomycin 6-phosphotransferase gene from a streptomycin producer., Journal of General Microbiology(U. K. )=, 1289-1296, 19870401
  20. Use of the tyrosinase gene from to probe promoter sequences for ., Plasmid(U. S. A), 237-241, 19900401
  21. Plasmid involvement in the degradation of polycyclic aromatic hydrocarbons by a Beijerinckia species., Biochemical and Biophysical Research Communications, 939-945, 19830401
  22. Biosynthetic correlation between streptomycin and mucopeptide in utilization of D-glucosamine as a common precursor., Journal of Fermentation Technology, 91-96, 19810401
  23. Binding of streptomycin to the teichoic acid of streptomycin-producing ., Journal of Fermentation Technology, 13-17, 19820401
  24. Ribosomal resistance to streptomycin in strains regenerated from protoplasts of a streptomycin-susceptible mutant derived from a streptomycin producer., Journal of Fermentation Technology, 347-351, 19830401
  25. Streptothricin production by a new isolate of from Thailand soil., Journal of Fermentation Technology, 19-28, 19840401
  26. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of ., Agricultural and Biological Chemistry, 1807-1815, 19830401
  27. Intracellular accumulation of trehalose during streptomycin formation by ., Agricultural and Biological Chemistry, 285-290, 19840401
  28. Correlation between intracellular accumulation of peptideglycan precursors and streptomycin formation., Agricultural and Biological Chemistry, 291-297, 19840401
  29. Molecular cloning and expression of a sarcosine oxidase gene in ., Bioscience= Biotechnology and Biochemistry, 432-436, 19920401
  30. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., Journal of Antibiotics, 1183-1188, 19810401
  31. Effect of arginine of gramicidin S biosynthesis by< Bacillus>., Journal of Antibiotics, 615-621, 19820401
  32. Isolation and properties of a puromycin acetyltransferase from puromycin-producing ., Journal of Antibiotics, 1761-1766, 19850401
  33. Acetylation of blasticidin S by its producing actinomycetes., Journal of Antibiotics, 827-832, 19860401
  34. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., Journal of Antibiotics, 135-137, 19890401
  35. The primary structure of an acidic ribosomal protein from ., Biochimica et Biophysica Acta, 164-172, 19820401
  36. Fate of streptomycin in mycelium of the producer organism., Biotechnology Letters(U. K. ), 239-244, 19810401
  37. Roles of streptomycin 6-kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer., Biotechnology Letters(U. K. ), 357-362, 19810401
  38. Mechanism of resistance to streptothricin of a producing microorganism., Biotechnology Letters(U. K. ), 441-446, 19830401
  39. Protoplast formation and the regeneration of ATCC9999 and its mutants., Biotechnology Letters(U. K. ), 709-714, 19830401
  40. Overproduction of human insulin-like growth factor-(]G0002[) in ., Biotechnology Letters(U. K. ), 839-844, 19890401
  41. Kinetic studies of streptomycin uptake implicated in selfresistance in a streptomycin producer., Biotechnology Letters(U. K. ), 1-6, 19900401
  42. Silence of streptomycin 6-phosphotransferase gene derived by incubation at a high temperature in ., Biotechnology Letters(U. K. ), 537-542, 19910401
  43. Efficient purification and analysis for stability of human secretin precursor-like peptide produced in ., Biotechnology Letters(U. K. ), 603-608, 19910401
  44. Expression of an artificial gene coding for a human secretin precursor-like peptide in ., Journal of Fermentation and Bioengineering, 179-182, 19910401
  45. Two genes for streptomycin phosphotransferase in ., 353-358, 19880401
  46. Isolation and properties of the axopodial cytoskelton of a heliozoan, ., European Journal of Ptotistology, 214-219, 19920401
  47. Electrophoretic migration of the heliozoan, ., Cytobios(U. K. ), 107-114, 19840401
  48. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing ., Actinomycetol., 15-22, 19900401
  49. Resistant mechanism to blasticidin S in ., Korean Biochemical Journal, 327-330, 19910401
  50. Mechanism of self-protection and genes coding for antibiotic biosynthesis , particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis., J. Kor. Agric. Chem. Soc., 371-375, 19880401
  51. Ultrastructure and calcium-dependent contraction of the myonemal network in a heterotrich ciliate, ., European Journal of Ptotistology, 279-287, 19920401
  52. Structure and function of the cytoskeleton in Heliozoa : 2. Measurement of the force of rapid axopodial contraction in Echinosphaerium., European Journal of Ptotistology, 430-433, 19920401
  53. Molecular cloning and high expression of the creatinase gene in ., Journal of Fermentation and Bioengineering, 77-82, 19930401
  54. Susceptibility of methicillin-resistant clinical isolates to various antimicrobial agents. III. Novel. inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima Journal of Medical Sciences, 101-107, 19930401
  55. Cloning, sequencing, and overexpression in of a sarcosine oxidase-encoding gene linked to the creatinase gene., Journal of Fermentation and Bioengineering, 231-234, 19940401
  56. Expression of c-kit ligand in human keratinocytes., Arch Dermatol Res., 273-277, 19940401
  57. Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus, FEMS Microbiology Letters, 121, 81-86, 19940401
  58. Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin, Gene, 11-16, 19940401
  59. Uracil-targeted inhibition of poly(A)-poly(U) hybridization by a zinc(II)-cyclen complex., Chem. Commun., 1747-1748, 19940401
  60. Overproduction of the bleomycin-binding proteins from bleomycin-producing Streptomyces verticillus and a methicillin-resistant Staphylococcus aureus in Escherichia coli andtheir immunological characterisation, FEBS Lett, 80-84, 19950401
  61. Novel assay system favorable for the study of cell-to-cell transmission of HIV-1 and its application to the evaluation of anti-HIV drugs., Biological and Pharmaceutical Bulletin, 18, 920-922, 19950401
  62. Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity., Biological and Pharmaceutical Bulletin, 18, 996-1000, 19950401
  63. Dimeric macrocyclic polyamines with potent inhibitory activity against human immunodeficiency virus., Antiviral Chemistry and Chemotherapy, 6, 337-344, 19950401
  64. The photoreceptor pigment of the unicellular organism Blepharisma generates hydroxyl radicals., Journal of Photochemistry and Photobiology, B:Biology34, 29-33, 19960401
  65. Expression of multiple forms of fetal liver kinase-2 (flk-2/flk-3) ligand in cultured human keratinocytes., Arch Dermatol Res., 289, 177-179, 19970401
  66. Development of a useful vector system that enables visual detection of inhibitor of nucleic acid synthesis, J. Ferment. Bioeng., 84, 155-157, 19970401
  67. Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus, FEMS Microbiol. Lett., 155(67), 71, 19970401
  68. Oxidative and random cleavage of DNA by the novel iron(II)complex capable of yielding an iron(III)hydroperoxide intermediate., Chem. Lett., 39-40, 19980401
  69. Protection of mammalian cells from the toxicity of bleomycin by expression of a bleomycin-binding protein gene from Streptomyces verticillus, J. Biochem., 124, 835-841, 19980401
  70. Characterization of the bleomycin resistance determinant ercoded on the Tn5, FEBS Lett, 442, 34-38, 19990401
  71. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5., Acta Cryst. Sec., D55, 1095-1097, 19990401
  72. Mutation of the N-terminal Proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin, FEBS Lett, 450, 227-230, 19990401
  73. Synthesis, Spectroscopic, Redox Properties, and DNA cleavage Activity of Low-spin Iron((]G0003[))complexes of Bleomycin Analogues., Inorgania Chimica Acta, 294, 56-61, 19990401
  74. Growth of human pancreatic cancer cells, induced by human pancreatic phospholipase A2, is mediated via its specific receptor but not via its catalytic property, INTERNATIONAL JOURNAL OF ONCOLOGY, 9, 1219-1225, 19961201
  75. Human pancreatic phospholipase A2 stimulates the growth of human pancreatic cancer cell line, FEBS Letters, 373, 85-87, 19951001
  76. Gene technology to overproduce the enzymes useful as diagnostic reagents, 43(8), 765-771, 19950801
  77. Ultrastracture and rapid axopodial contraction of a heliozoa, Raphidiophrys contractilis sp. nov., Journal of Eukaryotic Microbiology, 42(3), 283-288, 19950501
  78. Susceptibility of Methicillin-resistant Staphylococcus aureus clinical isolates to various antimicrobial agents. III. Novel, inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima J. Med. Sci., 42, 101-107, 19930101
  79. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1., J. Basic Microbiol., 42, 190-200, 20020401
  80. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content, Actinomycetologica, 16(2), 17-20, 20020401
  81. Atomic resolution structure of the prokaryotic phospholopase A2: Molecular motion and implication for catalytic mechanism., PROTEINS: Structure= Function= and Genetics, 51(3), 453-469, 20030501
  82. Molecular and structural biology of bleomycin and its resistance determinants., J. Bioscience and Bioengineering, 93, 105-116, 20020401
  83. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, J. Antibiotics, 56, 762-767, 20030401
  84. Physical stress by magnetic force accelerates differentiation of human osteoblasts, Biochem. Biophys. Res. Common, 32-38, 20030401
  85. Molecular cloning and expression of uricase gene from Arthrobactor globiformis in Escherichia coli and characterization of the gene product, J. Biosc. Bioeng.=, 153-158, 20040401
  86. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castanepglobisporus, Protein Expr Purif, 34, 202-207, 20040401
  87. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, Bioscience, Biotechnology, and Biochemistry, 71(11), 2852-2855, 20071101
  88. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat., In Vitro Cell Dev Biol Anim, 39(1-2), 89-97, 20030101
  89. A novel assay method for an amino acid racemase reaction based on circular dichroism, Biochem. J., 389, 491-496, 20050701
  90. Self-protection mechanisms of antibiotic-producing microorganisms, Nippon rinsyo, 65, 669-673, 20070228
  91. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5, Acta Crystallogr. Sect. D, 55, 1095-1097, 19990501
  92. A mammalian vector carrying the bleomycin N-acetyltransferase gene from Streptomyces verticillus as a selective marker, J. Antibiot., 52, 895-899, 19990401
  93. Molecular and structural biology of bleomycin and its resistance determinants, J. Biosci. Bioeng., 93, 105-116, 20020401
  94. Effects of methionine and Cu2+ on the expression of tyrosinase activity in Streptomyces castaneoglobisporus., J. Biochem., 120(6), 1141-1145, 19961201
  95. Molecular cloning and characterization of a gene encoding a novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis., J. Biosci. Bioeng., 101(1), 63-69, 20061101
  96. Establishment of an in vitro Peyer's patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity., Biol. Pharm. Bull., 33(2), 289-293, 20100201
  97. ★, Crystal structure of SCCA1 and insight about the interaction with JNK1., Biochem. Biophys. Res. Commun., 380(1), 143-147, 20090201
  98. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im., Biochem. Biophys. Res. Commun., 378(3), 574-548, 20090101
  99. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS: Structure= Function= and Genetics, 79(10), 2999-3005, 20110901
  100. Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line., FEBS Letters, 407, 343-346, 19970501
  101. The 1.5 angstrom crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus, JOURNAL OF MOLECULAR BIOLOGY, 295(4), 915-925, 20000128
    Link to Paper Search Results by DOI
  102. A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene, PIGMENT CELL RESEARCH, 13(5), 345-351, 200010
    Link to Paper Search Results by DOI
  103. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90(5), 574-576, 200011
    Link to Paper Search Results by DOI
  104. Crystallization and preliminary X-ray diffraction studies of Streptomyces phospholipase A(2) in a calcium-binding form, JOURNAL OF INORGANIC BIOCHEMISTRY, 82(1-4), 221-223, 200011
    Link to Paper Search Results by DOI
  105. Use of bleomycin- and heat shock-induced calreticulin promoter for construction of a mammalian expression vector, JOURNAL OF BIOCHEMISTRY, 129(5), 671-674, 200105
    Link to Paper Search Results by DOI
  106. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 9992-9999, 20010330
    Link to Paper Search Results by DOI
  107. The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(3), 2311-2320, 20020118
    Link to Paper Search Results by DOI
  108. Molecular and structural biology of bleomycin and its resistance determinants, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93(2), 105-116, 200202
    Link to Paper Search Results by DOI
  109. The crystal structure of prokaryotic phospholipase A(2), JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20059-20069, 20020531
    Link to Paper Search Results by DOI
  110. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1, JOURNAL OF BASIC MICROBIOLOGY, 42(3), 190-200, 2002
    Link to Paper Search Results by DOI
  111. Physical stress by magnetic force accelerates differentiation of human osteoblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(1), 32-38, 20031107
    Link to Paper Search Results by DOI
  112. Atomic resolution structure of prokaryotic phospholipase A(2): Analysis of internal motion and implication for a catalytic mechanism, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 51(3), 453-469, 20030515
    Link to Paper Search Results by DOI
  113. Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureus, FEBS LETTERS, 546(2-3), 401-406, 20030710
    Link to Paper Search Results by DOI
  114. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 89-97, 2003
    Link to Paper Search Results by DOI
  115. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, JOURNAL OF ANTIBIOTICS, 56(9), 762-767, 200309
    Link to Paper Search Results by DOI
  116. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castaneoglobisporus, PROTEIN EXPRESSION AND PURIFICATION, 34(2), 202-207, 200404
    Link to Paper Search Results by DOI
  117. Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46153-46161, 20041029
    Link to Paper Search Results by DOI
  118. Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae - Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46143-46152, 20041029
    Link to Paper Search Results by DOI
  119. Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98(3), 153-158, 200409
    Link to Paper Search Results by DOI
  120. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
    Link to Paper Search Results by DOI
  121. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
    Link to Paper Search Results by DOI
  122. ★, The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
    Link to Paper Search Results by DOI
  123. ★, Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
    Link to Paper Search Results by DOI
  124. ★, Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
    Link to Paper Search Results by DOI
  125. ★, Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
    Link to Paper Search Results by DOI
  126. ★, Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
    Link to Paper Search Results by DOI
  127. ★, Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
    Link to Paper Search Results by DOI
  128. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
    Link to Paper Search Results by DOI
  129. Crystal structure of SCCA1 and insight about the interaction with JNK1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(1), 143-147, 20090227
    Link to Paper Search Results by DOI
  130. A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
    Link to Paper Search Results by DOI
  131. ★, Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
    Link to Paper Search Results by DOI
  132. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
    Link to Paper Search Results by DOI
  133. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
    Link to Paper Search Results by DOI
  134. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
    Link to Paper Search Results by DOI
  135. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
    Link to Paper Search Results by DOI
  136. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
    Link to Paper Search Results by DOI
  137. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
    Link to Paper Search Results by DOI
  138. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
    Link to Paper Search Results by DOI
  139. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
    Link to Paper Search Results by DOI
  140. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
    Link to Paper Search Results by DOI
  141. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
    Link to Paper Search Results by DOI
  142. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
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  143. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
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  145. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
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  147. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
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  148. Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes, JOURNAL OF ANTIBIOTICS, 68(9), 543-550, 201509
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  149. The structural and mutational analyses of O-ureido-l-serine synthase necessary for d-cycloserine biosynthesis, FEBS JOURNAL, 282(20), 3929-3944, 201510
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  150. High-Level Heterologous Production of D-Cycloserine by Escherichia coli, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(22), 7881-7887, 201511
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  151. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 201511
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  152. Characterization and Mutational Analysis of a Two-Polypeptide Bacteriocin Produced by Citrus Iyo-Derived Lactobacillus brevis 174A, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(12), 1902-1909, 201512
  153. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
  154. Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 70(5), 582-587, 201605
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  195. Activation of the ERKs pathway prevents susceptibility to the H_2O_2-induced apoptosis in human pancreatic cancer cell line., 11, 19990816
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  219. Blasticidin S-producing Streptomyces morookaensis possesses a novel enzyme which hydrolyzes puromycin., 7, 19950915
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  236. 3F11-4 The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin, 18, 20060803
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    Link to Paper Search Results by DOI

Publications such as books

  1. 1994/12/14, Antibiotics produced by ┣DBStreptomyces(/)-┫DB host-vector systems. , In Recombinant Microbes for industrial and agricultural applications, marcel dekker= inc., 1994, 12, Scholarly Book, Joint work, en, 896
  2. 2012/09, Advanced Technology for Microbiological Production in Japan, 微生物の物質資産について，その技術，応用の最新の状況, 2012, 10, Scholarly Book, Joint work, jp, ISBN-10:4781306586,ISBN-13:978-4781306582, 223, p186-193
  3. 2014, Microbiol Production , From Genome Design to Cell Engineering Structure of Tyrosinase and Its Inhibitor from Sake Lees, Springer, 2014, Scholarly Book, Joint work, en, Anazawa, H. ; Shimizu, S. (Eds.) , 978-4-431-54606-1, 306, pp.243-249

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名, 植物乳酸菌が便秘と肝機能の改善に優れていることのヒト臨床試験による実証

Patented

  1. Patent, TW：I727293, 2021/05/11, COMPOSITION FOR TYPE IV ALLERGY
  2. Patent, CA：3086031, 2021/11/23, COMPOSITION FOR TYPE IV ALLERGY
  3. Patent, AU：2019260953, 2021/05/06, COMPOSITION FOR TYPE IV ALLERGY
  4. Patent, KR：10-2368628, 2022/02/23, COMPOSITION FOR TYPE IV ALLERGY
  5. Patent, EP：3714701, 2022/08/10, COMPOSITION FOR TYPE IV ALLERGY
  6. Patent, 6679202, 2020/03/23, COMPOSITION FOR TYPE IV ALLERGY
  7. Patent, TW：I739078, 2021/09/11, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  8. Patent, CA：3086024, 2022/02/08, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  9. Patent, AU：2019260952, 2021/02/25, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  10. Patent, KR：10-2368627, 2022/02/23, COMPOSITION FOR SUPPRESSING FAT ACCUMULATION
  11. Patent, 6649539, 2020/01/21, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  12. Patent, TW：I746955, 2021/11/21, COMPOSITION FOR TYPE I ALLERGY
  13. Patent, CA：3085995, 2022/03/08, COMPOSITION FOR TYPE I ALLERGY
  14. Patent, AU：2019260951, 2021/03/25, COMPOSITION FOR TYPE I ALLERGY
  15. Patent, KR：10-2368626, 2022/02/23, COMPOSITION FOR TYPE I ALLERGY
  16. Patent, 6648348, 2020/01/17, COMPOSITION FOR TYPE I ALLERGY
  17. Patent, TW：I713850, 2020/12/21, Nobel lactic acid bacteria and use thereof
  18. Patent, NZ：750198, 2022/10/04, Nobel lactic acid bacteria and use thereof
  19. Patent, CA：3032579, 2020/06/16, Nobel lactic acid bacteria and use thereof
  20. Patent, AU:2018281512, 2020/07/09, Nobel lactic acid bacteria and use thereof
  21. Patent, KR：10-2361556, 2022/02/07, Nobel lactic acid bacteria and use thereof
  22. Patent, 6523579, 2019/05/10, Nobel lactic acid bacteria and use thereof
  23. Patent, TW:I696465, 2020/06/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  24. Patent, NZ: 750188, 2022/08/02, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  25. Patent, CA:3032572, 2020/04/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  26. Patent, AU:2018281511, 2020/07/30, NEW LACTIC ACID BACTERIUM AND THEREOF
  27. Patent, KR:10-2313677, 2021/10/12, NEW LACTIC ACID BACTERUM AND USE THEREOF
  28. Patent, US:11447740, 2022/09/20, NEW LACTIC ACID BACTERUM AND USE THEREOF

Social Activities

Organizing Academic Conferences, etc.

  1. Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/03, 2009/03
  2. The 2nd International Symposium for Lactic Acid Bacteria to Prevented to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/12, 2009/12
  3. The 3rd International Symposium for Lactic Acid Bacteria to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2010/12, 2010/12
  4. The 4th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2011/12, 2011/12
  5. The 5th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2012/12, 2012/12
  6. The 2013 Annual Meeting of the Society for Actinomycetes Japan Abstracts, 2013/09, 2013/09
  7. The 6th International Symposium for Probiotics to preventive & Pre-symptomatic Medicine, Representative, 2014/03, 2014/03
  8. 2014 Annual Meeting of The Japan Society for Lactic Acid Bacteria, 2014/07, 2014/07