Hideki Shiba

Last Updated :2025/06/25

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
E-mail
bashihihiroshima-u.ac.jp
Self-introduction
In January 2015, I succeeded the former Professor. At the same time, the name of the Department was changed to Biological Endodontics. The pursuit of this Department is to establish a new treatment for endodontic diseases by removal of bacteria and regulation of host cell function.

Basic Information

Major Professional Backgrounds

  • 1993/04/01, Hiroshima University, Dental Hospital, Clinical Fellow
  • 1993/11/01, Hiroshima University, Faculty of Dentistry, Research Associate
  • 2002/04/01, Hiroshima University, Graduate School of Biomedical Sciences, Research Associate
  • 2005/05/01, Hiroshima University Hospital, Lecturer
  • 2012/04/01, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2015/01/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2019/05/01, 2022/03/31, Hiroshima University Hospital, Chief Deputy of Director

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 1989/04, 1993/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1983/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Conservative dentistry

Research Keywords

  • regulation of cell function
  • prevention
  • regeneration
  • Biological Endodontics

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2025, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2025, Undergraduate Education, 2Term, Topics in Dental Research II
  4. 2025, Undergraduate Education, 3Term, Endodontics I
  5. 2025, Undergraduate Education, 4Term, Endodontics II
  6. 2025, Undergraduate Education, 3Term, Operative Dentistry I
  7. 2025, Undergraduate Education, 4Term, Operative Dentistry II
  8. 2025, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  9. 2025, Undergraduate Education, 1Term, Basic Practice of Endodontics and Operative Dentistry I
  10. 2025, Undergraduate Education, 2Term, Basic Practice of Endodontics and Operative Dentistry II
  11. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  12. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  13. 2025, Undergraduate Education, 2Term, Advanced Course in Functional and Regenerative Oral Medicine
  14. 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  15. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  16. 2025, Undergraduate Education, Year, Clinical Practice (Endodontics and Operative Dentistry)
  17. 2025, Undergraduate Education, 3Term, Endodontology
  18. 2025, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  19. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health
  20. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  21. 2025, Undergraduate Education, 3Term, Endodontorogy
  22. 2025, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  23. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biological Endodontics
  24. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biological Endodontics
  25. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biological Endodontics
  26. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biological Endodontics

Research Activities

Academic Papers

  1. Clinical and genetic analysis of oral and nasal staphylococcus aureus isolates in dental patients, SCIENTIFIC REPORTS, 15(1), 20250416
    Link to Paper Search Results by DOI
  2. Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status, SCIENTIFIC REPORTS, 15(1), 20250217
    Link to Paper Search Results by DOI
  3. Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/ cementogenic differentiation abilities, JOURNAL OF DENTAL SCIENCES, 20(1), 560-568, 202501
    Link to Paper Search Results by DOI
  4. Comprehensive analysis of bacteriocins produced by clinical enterococcal isolates and their antibacterial activity against Enterococci including VRE, SCIENTIFIC REPORTS, 15(1), 20250209
    Link to Paper Search Results by DOI
  5. The oral cavity is a potential reservoir of gram-negative antimicrobial-resistant bacteria, which are correlated with ageing and the number of teeth., Heliyon., 10(21), e39827.-e39827., 20241028
  6. Bactericidal activity of slightly acidic electrolyzed water against the cariogenic bacterium Streptococcus mutans and other oral bacteria, ORAL SCIENCE INTERNATIONAL, 21(3), 344-351, 202409
    Link to Paper Search Results by DOI
  7. Ursoricin, a bacteriocin of Streptococcus ursoris, has potent activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(6), 20240618
    Link to Paper Search Results by DOI
  8. Antibiotic susceptibility and genome analysis of Enterococcus species isolated from inpatients in one hospital with no apparent outbreak of vancomycin-resistant Enterococcus in Japan, MICROBIOLOGY AND IMMUNOLOGY, 68(8), 254-266, 202408
    Link to Paper Search Results by DOI
  9. Opposing genetic polymorphisms of two ABC transporters contribute to the variation of nukacin resistance in Streptococcus mutans, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(3), 20240320
    Link to Paper Search Results by DOI
  10. Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells, SCIENTIFIC REPORTS, 13(1), 20230920
    Link to Paper Search Results by DOI
  11. Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
    Link to Paper Search Results by DOI
  12. Rare root canal morphology of maxillary second molars: A report of three cases, CLINICAL CASE REPORTS, 11(7), 202307
    Link to Paper Search Results by DOI
  13. In Situ Raman Analysis of Biofilm Exopolysaccharides Formed in Streptococcus mutans and Streptococcus sanguinis Commensal Cultures, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7), 202304
    Link to Paper Search Results by DOI
  14. Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis, CELLS, 12(8), 202304
    Link to Paper Search Results by DOI
  15. Retrospective study on the therapeutic efficacy of zinc acetate hydrate administration to patients with hypozincemia-induced dysgeusia, BMC ORAL HEALTH, 23(1), 20230318
    Link to Paper Search Results by DOI
  16. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
    Link to Paper Search Results by DOI
  17. Successful regenerative response of a severe bone defect in a right lower central incisor affected by a cemental tear, CLINICAL CASE REPORTS, 10(11), 202211
    Link to Paper Search Results by DOI
  18. Oxidative stress impairs the calcification ability of human dental pulp cells, BMC ORAL HEALTH, 22(1), 20221003
    Link to Paper Search Results by DOI
  19. Loss of I kappa B zeta Drives Dentin Formation via Altered H3K4me3 Status, JOURNAL OF DENTAL RESEARCH, 101(8), 951-961, 202207
    Link to Paper Search Results by DOI
  20. Oxytocin suppresses CXCL10 production in TNF-alpha-stimulated human dental pulp stem cells, CELL BIOLOGY INTERNATIONAL, 46(9), 1530-1535, 202209
    Link to Paper Search Results by DOI
  21. Impact of Maximum Tongue Pressure in Patients with Jaw Deformities Who Underwent Orthognathic Surgery, DIAGNOSTICS, 12(2), 202202
    Link to Paper Search Results by DOI
  22. Transforming Growth Factor-beta-1 Reduces Alkaline Phosphatase mRNA and Activity and Stimulates Cell Proliteration in Cultures of Human Pulp Cells, Journal of Dental Research, 73(9), 1509-1514, 19940401
  23. Effects of basic fibroblast growth factor on proliferation, the expression of osteonectin (SPARC) and alkaline phosphatase, and calcification in cultures of human pulp cells, Dev Biol, 170(2), 457-466, 19950801
  24. Cellular immuno-competence of infected root canal contents in pathogesesis of periapiacl lesion., J. Endodontics, 23, 213-216, 19970401
  25. Differential effects of various growth factos and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC) , and alkaline phosphatase by human pulp cells in culture, J Cell Physiol, 174(2), 194-205, 19980201
  26. Periodontal Tissue Regeneration Therapy, The Journal of Hiroshima Dental Association, 26(1), 1-14, 19980401
  27. Adherence of Bacteroides forsythus to host cells, Microbios, 101, 115-126, 19990401
  28. ★, Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells, J. Bone Miner. Res., 14(9), 1486-1492, 19990901
  29. Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclasogenesis inhibitory factor) in cultures of human periodontal ligament cells, Mech. Ageing Dev., 117(1-3), 69-77, 20000801
  30. Transforming growth factor-b1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin D-activated pulp cells, J. Dent. Res., 80(7), 1653-1659, 20010701
  31. SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 31(6), 345-352, 200207
    Link to Paper Search Results by DOI
  32. Expression of endothelins and their receptors in cells from human periodontal tissues, J. Periodontal. Res., 38(3), 269-275, 20030301
  33. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J. Endodontics, 29, 104-107, 20030401
  34. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, Molecular Microbiology, 50(4), 1125-1139, 20030901
  35. Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., Inflammation., 27(6), INFLAMMATION. 2003 DEC;27(6):341-9., 20031231
  36. Actinobacillus actinomycetemcomitans CDT insuces cell cycle arrest in primary culture of human gingival fibroblasts. M.Ohara, Y.Ueno, H.Shiba, S.Nishikubo, M.Ikura, H.Kurihara, H.Komatsuzawa, M.Sugai. Dentistry in Japan. 40: 18-22. 2004., Dentistry in Japan, 40, 18-22, 20040401
  37. Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells., Cell. Biol. Int., 28, 281-286, 20040401
  38. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells, J. Periodontol, 75(9), 1281-1287, 20040401
  39. Effect of bone morphogenetic proteins -4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells, Cell Biol. Int., 28(10), 675-682, 20041001
  40. The genetic basis of periodontitis, Periodontol 2000, 39, 91-117, 20050101
  41. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins, Cell Biol Int., 29(2), 111-117, 20050201
  42. Parotid secretory protein is expressed and inducible in human gingival keratinocytes, JOURNAL OF PERIODONTAL RESEARCH, 40(2), 153-157, 200504
    Link to Paper Search Results by DOI
  43. ★, Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., Biochem. Biophys. Res. Commun., 333, 502-507, 20050401
  44. ★, Brain-derived neurotrophic factor enhances periodontal tissue regeneration:, Tissue eng., 11(9-10), 1619-1630, 20051101
  45. An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells, MYCOSES, 49(1), 14-17, 200601
    Link to Paper Search Results by DOI
  46. An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells., Mycoses, 49(1), 14-17, 20060101
  47. Porphyromonas gingivalis enhances FasL expression via up-regulation of NF?B-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells, Microbiology, 152(3), 797-806, 20060301
  48. Characteristics of periodontal ligament subpopulations obtained by sequential enzymatic digestion of rat molar periodontal ligament., BONE, 38, 420-426, 20060401
  49. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 20060401
  50. Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Glp and Thr399Ile are hypo-responsive to Porphyromonas gingivalis, Genes Immun, 7(3), 190-200, 20060401
  51. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., J. Periodontol., 77(5), 800-807, 20060501
  52. Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biol. Int., 30(6), 521-524, 20060601
  53. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine., 34(5-6), 271-7, 20060630
  54. Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells., Infect. Immun., 74(9), 5211-5220, 20060901
  55. Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases, Curr Pham Des, 13(30), 3084-3095, 20070101
  56. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal Res., 42(3), 283-6, 20070601
  57. Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases., Curr Pharm Des., 13(30), 3084-3095, 20071001
  58. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 31(12), 1462-1469, 20071201
  59. Irsogladine maleate counters the IL-1b-induced suppression in gap-junctional intercellular communication without affecting increased ZO-1 levels by IL-1b in human gingival epithelial cells., Journal of Periodontal Research, 43(1), 96-102, 20080201
  60. ★, Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, The Journal of Biological Chemistry, 283(23), 16259-16267, 20080601
  61. Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells, Journal of Periodontal Research, 43(5), 508-513, 20081001
  62. Effect of Neurotrophin-4/5 on Bone/Cementum-Related Protein Expressions and DNA Synthesis in Cultures of Human Periodontal Ligament Cells, Journal of Periodontology, 79(11), 2182-2189, 20081101
  63. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells, Journal of Periodontology, 79(12), 2361-2370, 20081201
  64. Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells, Journal of Endodontics, 35(3), 373-376, 20090301
  65. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, BIOCHEMICAL PHARMACOLOGY, 79(10), 1496-1505, 20100515
    Link to Paper Search Results by DOI
  66. The Antimicrobial Peptide LL37 Induces the Migration of Human Pulp Cells: A Possible Adjunct for Regenerative Endodontics, JOURNAL OF ENDODONTICS, 36(6), 1009-1013, 201006
    Link to Paper Search Results by DOI
  67. The expressions of claudin-1 and E-cadherin in junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 45(4), 579-582, 201008
    Link to Paper Search Results by DOI
  68. Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, TISSUE ENGINEERING PART A, 17(7-8), 955-967, 201104
    Link to Paper Search Results by DOI
  69. Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 47(1), 55-61, 201202
    Link to Paper Search Results by DOI
  70. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201205
    Link to Paper Search Results by DOI
  71. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
    Link to Paper Search Results by DOI
  72. Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48(2), 228-234, 201304
    Link to Paper Search Results by DOI
  73. The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
    Link to Paper Search Results by DOI
  74. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201404
    Link to Paper Search Results by DOI
  75. miR-584 Expressed in Human Gingival Epithelial Cells Is Induced by Porphyromonas gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor, JOURNAL OF PERIODONTOLOGY, 85(6), E198-E204, 201406
    Link to Paper Search Results by DOI
  76. Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290(2), 201-208, 201408
    Link to Paper Search Results by DOI
  77. Smad2 is Involved in Aggregatibacter actinomycetemcomitans-induced Apoptosis, JOURNAL OF DENTAL RESEARCH, 93(11), 1148-1154, 201411
    Link to Paper Search Results by DOI
  78. Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86(3), 456-464, 201503
    Link to Paper Search Results by DOI
  79. Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10(1), 88-94, 201503
    Link to Paper Search Results by DOI
  80. The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21(5), 626-633, 201507
    Link to Paper Search Results by DOI
  81. ★, Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
    Link to Paper Search Results by DOI
  82. LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
    Link to Paper Search Results by DOI
  83. Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 444-451, 201508
    Link to Paper Search Results by DOI
  84. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
    Link to Paper Search Results by DOI
  85. Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 486-493, 201508
    Link to Paper Search Results by DOI
  86. Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75(1), 165-173, 201509
    Link to Paper Search Results by DOI
  87. Relationship between length variations in Ser/Asp-rich repeats in phosphophoryn and in vitro precipitation of calcium phosphate, ARCHIVES OF ORAL BIOLOGY, 60(9), 1263-1272, 201509
    Link to Paper Search Results by DOI
  88. Aggregatibacter actinomycetemcomitans outer membrane protein 29 induces TGF-β-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrinβ1/FAK cascade, Cell Microbiol, 18(18), 1723-1738, 2016
  89. Dentin sialophosphoproteinisapotentiallylatentbioactiveprotein in dentin, Journal of Oral Biosciences, 58(58), 134-142, 2016
  90. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62, 64-69, 201602
    Link to Paper Search Results by DOI
  91. Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
    Link to Paper Search Results by DOI
  92. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
    Link to Paper Search Results by DOI
  93. Dentin sialophosphoprotein is a potentially latent bioactive protein in dentin, Journal of Oral Biosciences, 58(4), 134-142, 201611
    Link to Paper Search Results by DOI
  94. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF--regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin1/FAK cascade, CELLULAR MICROBIOLOGY, 18(12), 1723-1738, 201612
    Link to Paper Search Results by DOI
  95. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation, JOURNAL OF IMMUNOLOGICAL METHODS, 445, 31-36, 201706
    Link to Paper Search Results by DOI
  96. Useful immunochromatographic assay of calprotectin in gingival crevicular fluid for diagnosis of diseased sites in patients with periodontal diseases, JOURNAL OF PERIODONTOLOGY, 89(1), 67-75, 2018
    Link to Paper Search Results by DOI
  97. Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 495(3), 2303-2309, 20180115
    Link to Paper Search Results by DOI
  98. Combined endodontic and periodontal management of a class 3 invasive cervical resorption in a mandibular first molar, CLINICAL CASE REPORTS, 6(10), 2005-2010, 201810
    Link to Paper Search Results by DOI
  99. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
    Link to Paper Search Results by DOI
  100. Dental pulp cell-derived powerful inducer of TNF-alpha comprises PKR containing stress granule rich microvesicles, SCIENTIFIC REPORTS, 9, 20190307
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  101. Interleukin (IL)-35 Suppresses IL-6 and IL-8 Production in IL-17A-Stimulated Human Periodontal Ligament Cells, INFLAMMATION, 42(3), 835-840, 201906
    Link to Paper Search Results by DOI
  102. Heparin-LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities, INTERNATIONAL ENDODONTIC JOURNAL, 52(9), 1327-1343, 201909
    Link to Paper Search Results by DOI
  103. Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital, CURRENT HIV RESEARCH, 18(6), 475-479, 2020
    Link to Paper Search Results by DOI
  104. Dentin phosphoprotein inhibits lipopolysaccharide-induced macrophage activation independent of its serine/aspartic acid-rich repeats, ARCHIVES OF ORAL BIOLOGY, 110, 202002
    Link to Paper Search Results by DOI
  105. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  106. A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-alpha inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-kappa B p65 complex to Smad binding element, MOLECULAR AND CELLULAR BIOCHEMISTRY, 469(1-2), 133-142, 202006
    Link to Paper Search Results by DOI
  107. A mandibular second molar with a middle mesial root canal, CLINICAL CASE REPORTS, 8(6), 1015-1020, 202006
    Link to Paper Search Results by DOI
  108. Oral environment and taste function of Japanese HIV-infected patients treated with antiretroviral therapy, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 32(7), 829-834, 20200702
    Link to Paper Search Results by DOI
  109. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
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  110. Surgical Sealing of Laterally Localized Accessory Root Canal with Resin Containing S-PRG Filler in Combination with Non-Surgical Endodontic Treatment: A Case Report, DENTISTRY JOURNAL, 8(4), 202012
    Link to Paper Search Results by DOI
  111. Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear, INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, 41(5), E205-E212, 2021
    Link to Paper Search Results by DOI
  112. Semaphorin3A released from human dental pulp cells inhibits the increase in interleukin-6 and CXC chemokine ligand 10 production induced by tumor necrosis factor-alpha through suppression of nuclear factor-kappa B activation, CELL BIOLOGY INTERNATIONAL, 45(1), 238-244, 202101
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  113. DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration, MOLECULAR AND CELLULAR BIOCHEMISTRY, 476(4), 1673-1690, 202104
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  114. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
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  115. PPAR gamma-Induced Global H3K27 Acetylation Maintains Osteo/Cementogenic Abilities of Periodontal Ligament Fibroblasts, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(16), 202108
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Aiming for the realization of Biological Endodontics, Hideki Shiba, the International Federation of Endodontic Associations 12th World Endodontic Congress, 2021/08, With Invitation, English
  2. Proposal for Biological Endodontics, Hideki shiba, Stovit Online Series (TADS), Universitas Airlangga, 2022/07, With Invitation, English