HIDENORI AIZAWA

Last Updated :2020/11/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
haizawahiroshima-u.ac.jp
Self-introduction
Our lab works for the brain machinery underlying the mental and neurological disorders. Our interests include the molecular mechanism in the neural circuitry in regulation of the cognitive functions such as learning, memory and emotion.

Basic Information

Academic Degrees

  • MD, PhD, Chiba University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Biological Sciences;Neuroscience;Neurophysiology / General neuroscience

Research Keywords

  • habenula, depression, monoamines, stress, coping, lateralization, asymmetry, zebrafih

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 3Term, Anatomy for understanding human being I
  2. 2020, Liberal Arts Education Program1, 4Term, Anatomy for understanding human being II
  3. 2020, Liberal Arts Education Program1, 2Term, Cell Science
  4. 2020, Undergraduate Education, 2Term, Introduction for medical research
  5. 2020, Undergraduate Education, 4Term, Medical Neuroscience I
  6. 2020, Undergraduate Education, Intensive, Medical Neuroscience II
  7. 2020, Undergraduate Education, Intensive, Practice for medical research
  8. 2020, Undergraduate Education, First Semester, Structure of human body
  9. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Neurobiology
  10. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Neurobiology
  11. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Neurobiology
  12. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Neurobiology
  13. 2020, Graduate Education (Master's Program) , First Semester, Seminar
  14. 2020, Graduate Education (Master's Program) , Second Semester, Seminar
  15. 2020, Graduate Education (Master's Program) , First Semester, Research
  16. 2020, Graduate Education (Master's Program) , Second Semester, Research
  17. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  18. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  19. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  20. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  21. 2020, Graduate Education (Master's Program) , First Semester, Human Anatomy
  22. 2020, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  23. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurobiology
  24. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurobiology
  25. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurobiology
  26. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurobiology

Research Activities

Academic Papers

  1. ★, Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress., The Journal of neuroscience : the official journal of the Society for Neuroscience
  2. ★, Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress, NEUROPHARMACOLOGY, 162, 20200101
  3. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 20200512
  4. Toward an understanding of the habenula's various roles in human depression, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(10), 607-612, 201910
  5. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, NEUROCHEMISTRY INTERNATIONAL, 131, 201912
  6. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, BRAIN RESEARCH, 1680, 13-38, 20180201
  7. Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice, GLIA, 66(4), 777-788
  8. Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice., Hum Mol Genet., 26(16), 3094-3104, 2017
  9. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ, BMC GENOMICS, 17, 20161128
  10. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice, HUMAN MOLECULAR GENETICS, 25(20), 4507-4517, 20161015
  11. Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits, JOURNAL OF NEUROSCIENCE, 35(36), 12432-12445, 20150909
  12. Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice, NEUROPSYCHOPHARMACOLOGY, 40(7), 1569-1579, 2015
  13. ★, Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance, JOURNAL OF NEUROSCIENCE, 34(49), 16273-16285, 2014
  14. The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger, NEURON, 84(5), 1034-1048, 2014
  15. ★, The Synchronous Activity of Lateral Habenular Neurons Is Essential for Regulating Hippocampal Theta Oscillation, JOURNAL OF NEUROSCIENCE, 33(20), 8909-+, 2013
  16. Hyperactivation of the habenula as a link between depression and sleep disturbance, FRONTIERS IN HUMAN NEUROSCIENCE, 7, 2013
  17. Reward-Modulated Motor Information in Identified Striatum Neurons, JOURNAL OF NEUROSCIENCE, 33(25), 10209-10220, 2013
  18. Habenula and the asymmetric development of the vertebrate brain, 88(1), 1-9, 2013
  19. Fear and Anxiety Regulation by Conserved Affective Circuits, NEURON, 78(3), 411-413, 2013
  20. Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program, NEURON, 78(5), 881-894, 2013
  21. Molecular characterization of the subnuclei in rat habenula, JOURNAL OF COMPARATIVE NEUROLOGY, 520(18), 4051-4066, 2012
  22. Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety, DEVELOPMENTAL NEUROBIOLOGY, 72(3), 386-394, 2012
  23. Phylogeny and ontogeny of the habenular structure, FRONTIERS IN NEUROSCIENCE, 5, 2011
  24. The habenula is crucial for experience-dependent modification of fear responses in zebrafish, NATURE NEUROSCIENCE, 13(11), 1354-1356, 2010
  25. Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula, NEUROSCIENCE RESEARCH, 71, E271-E271, 2011
  26. Activation of distinct neural ensemble in zebrafish telencephalon following the go/no-go rule change in the goal directed active avoidance learning, NEUROSCIENCE RESEARCH, 68, E68-E68, 2010
  27. Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula, JOURNAL OF NEUROSCIENCE, 30(4), 1566-1574, 2010
  28. Development of the Mouse Amygdala as Revealed by Enhanced Green Fluorescent Protein Gene Transfer by Means of In Utero Electroporation, JOURNAL OF COMPARATIVE NEUROLOGY, 513(1), 113-128, 2009
  29. Genetic inactivation of the habenulo-interpeduncular projection enhances the conditioned fear response in zebrafish, NEUROSCIENCE RESEARCH, 65, S66-S66, 2009
  30. Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements, NATURE NEUROSCIENCE, 12(12), 1586-U140, 2009
  31. Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish, Development, growth & differentiation, 50, S167-S175, 2008
  32. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures, DEVELOPMENTAL CELL, 12(1), 87-98, 2007
  33. Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems, DEVELOPMENTAL DYNAMICS, 236(3), 706-718, 2007
  34. Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish, JOURNAL OF NEUROSCIENCE, 27(20), 5271-5279, 2007
  35. Development of the mouse amygdala as revealed by labeling with EGFP gene transfer and molecular markers, NEUROSCIENCE RESEARCH, 58, S38-S38, 2007
  36. Fear and anxiety : choice of adaptive behaviors to overcome them, 66(1), 29-32, 201501
  37. Role of the habenula in pathophysiology of the depression, 65(1), 12-15, 201401
  38. Habenula and the Asymmetric Development of the Vertebrate Brain, 87(3), 57-58, 20120901
  39. Development of zebrafish brain asymmetry, Cell technology., 27(6), 576-582, 200806
  40. Visualization and manipulation of the emotional neural circuits in the zebrafish brain: study of mechanisms and roles for the asymmetry in the habenulo-interpeduncular projection, Protein, nucleic acid and enzyme, 53(4), 475-481, 200803

Invited Lecture, Oral Presentation, Poster Presentation

  1. Deciphering the heterogeneous symptoms of depression by the habenular pathways, Hidenori Aizawa, Neuro2019, 2019/07/27, With Invitation, English, Niigata
  2. Wide-field serial block-face fluorescence microscope using deep ultraviolet light for whole-brain imaging, Kasaragod Deepa Kamath, Zhu Meina, Takemoto Hidenori, Aizawa Hidenori, Neuro2020, 2020/07/31, Without Invitation, English, Kobe
  3. A novel microcontroller-based system for the wheel running activity in mice, Meina Zhu and Hidenori Aizawa, Neuro2020, 2020/07/29, Without Invitation, English, Kobe
  4. Dopamine metabolism and coping behaviors under the tail suspension stress, Hidenori. Aizawa, Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Takashi Nakano, Shigeki Kato, Kohichi Tanaka, Kazuto Kobayashi, Tadashi Isa, Neuro2017, 2017/07/21, Without Invitation, English, The Japan Neuroscience Society, Chiba
  5. Effect of TSPO-targeting compound ONO-2952 on the mouse behaviors under the chronic social defeat stress, Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Takahiro Kato, Takashi Kitajima, Seishi Katsumata, Yousuke Yamawaki, Shigeto Yamawaki, Hidenori Aizawa, Neuro2018, 2018/07/28, Without Invitation, English, Japan Neuroscience Society, Kobe
  6. Anatomical proximity and concordance of laterality in the organs of developing zebrafish, Kei Taguchi, Masahi Akieda, Haruhi Terai, Hidenori Aizawa, The 41st Annual Meeting of the Japan Neuroscience Society (Neuroscience 2018), 2018/07/27, Without Invitation, English, Japan Neuroscience Society, Kobe
  7. TSPO-targeting compound ameliorates the abnormal behaviors of mice received social defeat stress, Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro Kato, Hidenori Aizawa, 9th Fedaration of the Asian and Oceanian Physiological Societies, 2019/03/29, Without Invitation, English, Asian and Oceanian Physiological Societies, Kobe

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, a Grant-in-Aid for Scientific Research on Innovative Areas, 2014, 2018
  2. KAKENHI, a Grant-in-Aid for Scientific Research (C), 2014, 2016
  3. KAKENHI, Grant-in-Aid for Scientific Research on Innovative Areas, 2014
  4. Mitsui Life Social Welfare Foundation, 2014
  5. Brain Science Foundation, 2014
  6. Inamori Foundation, 2014
  7. KAKENHI, 2015, 2019

Social Activities

History as Peer Reviews of Academic Papers

  1. 2015, Development, Growth and Differentiation, Others, Reviewer, 1
  2. 2015, Journal of Physiology, Others, Reviewer, 1