CHISA SHUKUNAMI

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), ., Professor
Web Site
E-mail
shukunamhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2013/07/23, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2007/04/01, 2013/07/22, KyotoUniversity, Institute for Frontier Medical Sciences, Associate Professor
  • 1998/09/01, 2007/03/31, Kyoto University, Associate Professor

Educational Backgrounds

  • Osaka University, Graduate School, Division of Dental Research, Japan, 1991/04, 1995/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1985/04, 1991/03

Academic Degrees

  • DDS Ph.D, Osaka University

Educational Activity

  • 【Bachelor Degree Program】School of Dentistry : Program of Dentistry

In Charge of Primary Major Programs

  • Dentistry
  • Oral Health Science
  • Oral Engineering

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry
  • Biology;Biological Science;Functional biochemistry
  • Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery
  • Biology;Biological Science;Developmental biology

Research Keywords

  • tenomodulin
  • ligament
  • tendon

Affiliated Academic Societies

  • The Japanese Society for Bone and Mineral Reserach

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2019, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2019, Undergraduate Education, 1Term, Oral biochemistry
  4. 2019, Undergraduate Education, 3Term, Oral biochemistry
  5. 2019, Undergraduate Education, First Semester, Laboratory of Oral Function Sciences-Biochemistry,Physiology,Pharmacology-
  6. 2019, Undergraduate Education, 2Term, Topics in Denral Research
  7. 2019, Undergraduate Education, Intensive, Practice of Molecular Biology and Biochemistry
  8. 2019, Undergraduate Education, 4Term, Start-Up Coursework
  9. 2019, Undergraduate Education, 2Term, Practice on Basic Dental Sciences
  10. 2019, Undergraduate Education, 1Term, Basic Biochemistry
  11. 2019, Undergraduate Education, 4Term, Start-Up Coursework
  12. 2019, Undergraduate Education, 1Term, Basic Biochemistry
  13. 2019, Undergraduate Education, 4Term, Start-Up Coursework
  14. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  15. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  16. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  17. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  18. 2019, Graduate Education (Master's Program) , First Semester, Research on Dental and Medical Biochemistry
  19. 2019, Graduate Education (Master's Program) , Second Semester, Research on Dental and Medical Biochemistry
  20. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  21. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  22. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  24. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Dental and Medical Biochemistry
  25. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Dental and Medical Biochemistry
  26. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  27. 2019, Graduate Education (Master's Program) , First Semester, Research
  28. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Dental and Medical Biochemistry
  29. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Dental and Medical Biochemistry
  30. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Dental and Medical Biochemistry
  31. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Dental and Medical Biochemistry
  32. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  33. 2019, Graduate Education (Master's Program) , Second Semester, Research
  34. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  35. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  36. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  37. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  38. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  39. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  40. 2019, Graduate Education (Doctoral Program) , 3Term, Methodology of Education for Creation and Development of Biomedical Sciences
  41. 2019, Graduate Education (Doctoral Program) , 3Term, Methodology of Education for Creation and Development of Biomedical Sciences
  42. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dental and Medical Biochemistry
  43. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dental and Medical Biochemistry
  44. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dental and Medical Biochemistry
  45. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dental and Medical Biochemistry

Research Activities

Academic Papers

  1. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142(4), 787-796, 20150215
  2. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells, Stem Cells and Development, 24(5), 597-609, 201501
  3. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis, AMERICAN JOURNAL OF HUMAN GENETICS, 97(2), 337-342, 20150806
  4. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change, Biochem Biophys Rep., 175-189, 2015
  5. Tenomodulin, 108-109, 2015
  6. Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures, Journal of Cardiovascular Development and Disease, 1(2), 163-176, 20140826
  7. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PLoS One, 8, e60203, 2013
  8. Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament, DEVELOPMENT, 140(11), 2280-2288, 2013
  9. Direct conversion of tenocytes into chondrocytes by Sox9., Exp Cell Res, 318, 1492-1507, 2012
  10. Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer Sci, 103, 1311-1318, 2012
  11. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis., Stem Cells Dev, 21, 846-858, 2012
  12. TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene, GENE, 587(1), 1-17, AUG 1 2016
  13. Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells, STEM CELLS INTERNATIONAL, 2016
  14. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system, SCIENTIFIC REPORTS, 7, MAR 22 2017
  15. Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load, EBIOMEDICINE, 20, 240-254, JUN 2017
  16. Host defense against oral microbiota by bone-damaging T cells, NATURE COMMUNICATIONS, 9, FEB 16 2018
  17. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes, SCIENTIFIC REPORTS, 8, FEB 16 2018
  18. TGF-beta 1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 45(10), 2394-2404, AUG 2017
  19. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis, JOURNAL OF BONE AND MINERAL METABOLISM, 36(4), 410-419, JUL 2018
  20. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., J Cell Biol., 133, 457-468, 1996
  21. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, CELL REPORTS, 29(3), 603-+, 20191015
  22. Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue., Current pharmaceutical design, 13(20), 2007
  23. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development., Cell and tissue research, 332(1), 2008
  24. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(10), 2008
  25. Altered fracture callus formation in chondromodulin-I deficient mice., Bone, 43(6), 2008
  26. Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis., Circulation, 118(17), 2008
  27. Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation., Developmental biology, 332(2), 2009
  28. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription., The international journal of biochemistry & cell biology, 42(1), 2010
  29. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor., Experimental cell research, 316(5), 2010
  30. A functional role of the glycosylated N-terminal domain of chondromodulin-I., Journal of bone and mineral metabolism, 29(1), 2011
  31. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents., The Journal of clinical investigation, 120(7), 2010
  32. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro., BMC cell biology, 12, 2011
  33. Generation and characterization of ScxCre transgenic mice., Genesis (New York, N.Y. : 2000), 51(4), 2013
  34. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PloS one, 8(4), 2013
  35. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis., Nature genetics, 45(6), 2013
  36. Pax1 acts as a negative regulator of chondrocyte maturation., Experimental cell research, 319(20), 2013
  37. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development., PloS one, 9(4), 2014
  38. Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components, JAPANESE DENTAL SCIENCE REVIEW, 52(4), 84-92, 2016
  39. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis., American journal of human genetics, 97(2), 2015
  40. FGF-2 Stimulates the Growth of Tenogenic Progenitor Cells to Facilitate the Generation of Tenomodulin-Positive Tenocytes in a Rat Rotator Cuff Healing Model., The American journal of sports medicine, 43(10), 2015
  41. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis., Scientific reports, 5, 2015
  42. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation., PLoS genetics, 12(1), 2016
  43. [Integration of the musculoskeletal components by tendons and ligaments.], Clinical calcium, 27(3)
  44. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears, AMERICAN JOURNAL OF SPORTS MEDICINE, 47(7), 1701-1712, 2019
  45. Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage., Acta histochemica, 104(2), 2002
  46. Chondromodulin I is a bone remodeling factor., Molecular and cellular biology, 23(2), 2003
  47. Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 442(5), 2003
  48. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes., Investigative ophthalmology & visual science, 44(5), 2003
  49. Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4., Genomics, 83(1), 2004
  50. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis, NATURE MEDICINE, 12(10), 1151-1159, 2006
  51. Disruption of chondromodulin-I gene, a potent angioinhibitory factor, causes aortic valve stenosis in mice, CIRCULATION, 114(18), 326-326, 2006
  52. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells, JOURNAL OF CELL SCIENCE, 120(5), 849-857, 2007
  53. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force, BIOMEDICAL MICRODEVICES, 9(2), 105-111, 2007
  54. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(23), 17289-17296, 2007
  55. Realignment process of actin stress fibers in single living cells studied by focused femtosecond laser irradiation, APPLIED SURFACE SCIENCE, 253(15), 6416-6419, 2007
  56. Chondromodulin-I and tenomodulin: The negative control of angiogenesis in connective tissue, CURRENT PHARMACEUTICAL DESIGN, 13(20), 2101-2112, 2007
  57. The anti-angiogenic factor, tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis, CIRCULATION, 116(16), 234-234, 2007
  58. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development, CELL AND TISSUE RESEARCH, 332(1), 111-122, 2008
  59. Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 93(1), 39-43, 2008
  60. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules, MODERN PATHOLOGY, 21(10), 1282-1292, 2008
  61. Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis, CIRCULATION, 118(17), 1737-1747, 2008
  62. Chordae tendineae cordis are covered and protected by the anti-angiogenic factor, Tenomodulin, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45, S26-S26, 2008
  63. Altered fracture callus formation in chondromodulin-I deficient mice, BONE, 43(6), 1047-1056, 2008
  64. Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation, DEVELOPMENTAL BIOLOGY, 332(2), 196-211, 2009
  65. Gene delivery process in a single animal cell after femtosecond laser microinjection, APPLIED SURFACE SCIENCE, 255(24), 9880-9884, 2009
  66. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(1), 148-156, 2010
  67. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor, EXPERIMENTAL CELL RESEARCH, 316(5), 775-788, 2010
  68. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents, JOURNAL OF CLINICAL INVESTIGATION, 120(7), 2292-2306, 2010
  69. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents (vol 120, pg 2292, 2010), JOURNAL OF CLINICAL INVESTIGATION, 121(1), 454-454, 2011
  70. A functional role of the glycosylated N-terminal domain of chondromodulin-I, JOURNAL OF BONE AND MINERAL METABOLISM, 29(1), 23-30, 2011
  71. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro, BMC CELL BIOLOGY, 12, 2011
  72. Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis, STEM CELLS AND DEVELOPMENT, 21(6), 846-858, 2012
  73. Direct conversion of tenocytes into chondrocytes by Sox9, EXPERIMENTAL CELL RESEARCH, 318(13), 1492-1507, 2012
  74. Generation and characterization of ScxCre transgenic mice, GENESIS, 51(4), 275-283, 2013
  75. Pax1 acts as a negative regulator of chondrocyte maturation, EXPERIMENTAL CELL RESEARCH, 319(20), 3128-3139, 2013
  76. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development, PLOS ONE, 9(4), 2014
  77. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142(4), 787-796, 2015
  78. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12(1), 2016
  79. Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein., Journal of biochemistry, 125(3), 1999
  80. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells., European journal of biochemistry, 260(3), 1999
  81. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation., The International journal of developmental biology, 43(1), 1999
  82. Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development., FEBS letters, 456(1), 1999
  83. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo., FEBS letters, 458(3), 1999
  84. Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells., FEBS letters, 469(1), 2000
  85. Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 2000
  86. A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification., Bone, 27(1), 2000
  87. Chondromodulin-I as a novel cartilage-specific growth-modulating factor., Pediatric nephrology (Berlin, Germany), 14(7), 2000
  88. Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells., Cell structure and function, 25(3), 2000
  89. [Angiogenic inducers and inhibitors]., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 45(13 Suppl), 2000
  90. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells., The Journal of biological chemistry, 276(14), 2001
  91. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene., Biochemical and biophysical research communications, 280(5), 2001
  92. Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis., The American journal of pathology, 158(4), 2001
  93. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye., Investigative ophthalmology & visual science, 42(6), 2001
  94. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis., Mechanisms of development, 105(1-2), 2001
  95. Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage., Osteoarthritis and cartilage, 9 Suppl A, 2001
  96. Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation., Osteoarthritis and cartilage, 9 Suppl A, 2001
  97. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis., Arthritis and rheumatism, 50(3), 2004
  98. Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I., Journal of cell science, 117(Pt 13), 2004
  99. Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 446(1), 2005
  100. [Differentiation of cartilage stem cells and their clinical applications]., Clinical calcium, 12(2), 2002
  101. [Chondromodulin-I and its related gene Tenomodulin]., Clinical calcium, 12(3), 2002
  102. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues., Biochemical and biophysical research communications, 333(2), 2005
  103. Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin., Connective tissue research, 46(1), 2005
  104. [Vascular development and cartilage formation]., Clinical calcium, 16(4), 2006
  105. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes., Developmental biology, 298(1), 2006
  106. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis., Nature medicine, 12(10), 2006
  107. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force., Biomedical microdevices, 9(2), 2007
  108. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells., Journal of cell science, 120(Pt 5), 2007
  109. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment., The Journal of biological chemistry, 282(23), 2007
  110. Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination., Histopathology, 51(2), 2007
  111. Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells., Tissue & cell, 42(2), 2010
  112. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system., Scientific reports, 7, 2017
  113. TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model., The American journal of sports medicine, 45(10), 2017
  114. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells., PloS one, 12(7), 2017
  115. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis., Journal of bone and mineral metabolism, 36(4), 2018
  116. [Homeostasis and Disorder of Musculoskeletal System.Enthesis formation and repair:Current understanding and perspectives for the future regenerative therapy.], Clinical calcium, 28(3)
  117. Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., Scientific reports, 9(1), 2019
  118. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears., The American journal of sports medicine, 47(7), 2019
  119. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., The Journal of cell biology, 133(2), 1996
  120. 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11(1), 1996
  121. A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence., The Journal of biological chemistry, 271(37), 1996
  122. [Effect of collagen on magnetization transfer contrast assessed in cultured cartilage]., Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 56(12), 1996
  123. Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II., FEBS letters, 406(3), 1997
  124. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5., Biochemical and biophysical research communications, 235(1), 1997
  125. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(8), 1997
  126. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I., FEBS letters, 415(3), 1997
  127. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage., The Journal of biological chemistry, 272(51), 1997
  128. Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture., Biochemical and biophysical research communications, 241(2), 1997
  129. Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans., The Journal of biological chemistry, 273(20), 1998
  130. Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5., Experimental cell research, 241(1), 1998
  131. Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro., Biochemical and biophysical research communications, 249(3), 1998

Awards

  1. 1995年12月, The 3rd Pan Pacific Connective Tissue Societies Symposium Young Investigator Award

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016

Social Activities

Organizing Academic Conferences, etc.

  1. 2017/09