Last Updated :2018/06/01

Affiliations, Positions
Graduate School of Integrated Arts and Sciences, ., Assistant Professor
Web Site
Other Contact Details
1-7-1,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)82-424-0759

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
  • 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
  • 2007/04/01, 2011/03/31, Part-Time Lecturer
  • 2011/04/01, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2012/07/30, 2012/09/28, University of California, Visiting Scientist

Educational Backgrounds

  • Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03
  • Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03

Academic Degrees

  • Doctor of Science, Osaka University
  • Master of Science, Osaka University

In Charge of Primary Major Programs

  • Integrated Arts and Sciences
  • Life Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • Glia
  • Environmental Chemicals
  • Oxidative Stress
  • Ischemia
  • Steroid hormone

Affiliated Academic Societies

  • The Japanese Pharmacological Society, 2001
  • The Pharmaceutical Society of Japan, 2004
  • The Japanese Biochemical Society, 2004
  • The Society for Free Radical Research Japan, 2007
  • Society for Free Radical Research International, 2007
  • The Japanese Society of Toxicology, 2012
  • The International Society of Endocrinology, 2012
  • The Japan Endocrine Society, 2012
  • The American Society for Biochemistry and Molecular Biology, 2015

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
  2. 2018, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
  3. 2018, Undergraduate Education, 2Term, Introduction to Life Sciences
  4. 2018, Undergraduate Education, 2Term, Fundamental Biochemistry
  5. 2018, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  6. 2018, Undergraduate Education, 1Term, Practical Methods in Life Sciences C

Research Activities

Academic Papers

  1. Effects of sex steroid hormones and their metabolites on neuronal injury elicited by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures., Steroids., 113, 71-77
  2. Ca²⁺/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association., Biochem. Biophys. Res. Commun., 477, 820-825
  3. A simple method for detection of multiple chemical-specific IgGs in serum based on dot blotting., Health., In Press
  4. Involvement of reactive oxygen species amplified in mitochondria in oxidative neuronal injury elicited by methylmercury., J. Clin. Biochem. Nutr, In Press
  5. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65
  6. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy, APPLIED SCIENCES-BASEL, 6(3), MAR 2016
  7. Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, SEP 11 2015
  8. Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 2015 July
  9. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015 July
  10. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015 May
  11. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 2015 March
  12. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015 January
  13. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, APR 2014
  14. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, MAR 18 2014
  15. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  16. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  17. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
  18. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
  19. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  20. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
  21. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  22. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  23. Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
  24. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  25. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
  26. Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
  27. Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., FEBS JOURNAL, 278(11), 1873-1881, 2011
  28. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
  29. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011

Publications such as books

  1. 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Yamazaki T, Ishihara Y


  1. 2012年11月10日, Young Investigator Award of the Pharmaceutical Society of Japan, Chugoku-Shikoku Branch, チトクロムP450阻害によるキノン肝毒性の亢進
  2. 2010年06月, The SFRR Japan Young Investigator Award, 心臓再灌流障害における活性酸素生成源の同定

Social Activities

History as Committee Members

  1. Editorial Board, 2015, Fundamental Toxicological Sciences