Yasushi Okinaka

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
okinaka(at)hiroshima-u.ac.jp
Self-introduction
We are studying the infection mechanisms of fish viruses. We model host fishes and viruses for rapid and advanced research. The information obtained is applied to breeding for disease resistance in fish.

Basic Information

Major Professional Backgrounds

  • 1997/04/01, 1999/10/31, Kyoto University., Graduate School of Agriculture, Post-doc
  • 1990/04/01, 1993/03/31, Kyowa Hakko Co., Ltd, Tsukuba Research Laboratories, Researcher
  • 2002/11/01, 2004/03/31, Hiroshima University, Graduate School of Biosphere Science, Lecturer
  • 1999/11/01, 2002/10/31, University of California-Riverside in the U.S.A., Post-doc
  • 2004/04/01, 2007/03/31, Hiroshima University, Graduate School of Biosphere Science, Associate Professor
  • 2007/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Associate Professor

Educational Backgrounds

  • Hokkaido University, Graduate School, Division of Natural Science, Biological Science, Japan, 1993/04, 1997/03
  • Hokkaido University, Graduate School, Division of Agriculture, Agriculture, Japan, 1988/04, 1990/03
  • Hokkaido University, Faculty of Agriculture, Department of Agriculture, Japan, 1984/04, 1988/03

Academic Degrees

  • Ph.D., HOKKAIDO UNIVERSITY
  • Master of Agriculture, HOKKAIDO UNIVERSITY

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Molecular Agro-Life Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

Research Fields

  • Agricultural sciences;Applied aquatic science;Aquatic bioproduction science

Research Keywords

  • Host factor
  • Virulence
  • Fish virus
  • fish disease

Affiliated Academic Societies

  • American Society for Microbiology, 2002
  • The Japanese Society for Virology, 2002
  • The Japanese Society of Fisheries Science, 2002/12
  • The Japanese Society of Fish Pathology, 2002/12
  • Japanese Society of Animal Breeding and Genetics, 2011
    Related URL

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Laboratory Work in General Biology I
  2. 2025, Undergraduate Education, 2Term, Introduction to Microbiology
  3. 2025, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  4. 2025, Undergraduate Education, 2Term, Pathology
  5. 2025, Undergraduate Education, Second Semester, Graduation Thesis I
  6. 2025, Undergraduate Education, First Semester, Graduation Thesis II
  7. 2025, Undergraduate Education, Second Semester, Graduation Thesis III
  8. 2025, Undergraduate Education, Intensive, Problem Based Learning for Molecular Agro-Life ScienceI
  9. 2025, Undergraduate Education, 3Term, Genome Science I
  10. 2025, Undergraduate Education, 4Term, Bio-Analytical Science
  11. 2025, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  12. 2025, Undergraduate Education, Intensive, (AIMS)Molecular Agro-life Science
  13. 2025, Undergraduate Education, Intensive, Molecular Agro-life Science
  14. 2025, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  15. 2025, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  16. 2025, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  17. 2025, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  18. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  19. 2025, Graduate Education (Master's Program) , 1Term, Microbiology for Food Safety I

Research Activities

Academic Papers

  1. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18(6), 20230623
    Link to Paper Search Results by DOI
  2. Multiple isoforms of HSP70 and HSP90 required for betanodavirus multiplication in medaka cells, ARCHIVES OF VIROLOGY, 167(10), 1961-1975, 202210
    Link to Paper Search Results by DOI
  3. Establishing an effective gene knockdown system using cultured cells of the model fish medaka (Oryzias latipes), BIOLOGY METHODS & PROTOCOLS, 7(1), 20220110
    Link to Paper Search Results by DOI
  4. Aquabirnavirus-induced protection of marine fish against piscine nodavirus infection., Fish Pathology, 40(2), 125-131, 20050601
  5. Characterization of Striped jack nervous necrosis virus subgenomic RNA3 and biological activities of its encoded protein B2, J. Gen. Virol., 86, 2807-2816, 20050601
  6. Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kB target genes protecting the macrophage from staurosporine-induced apoptosis., Microbial Pathogensis, 41(6), 226-240, 20061201
  7. Identification of host-specificity determinants in betanodaviruses using reassortants between striped jack nervous necrosis virus and sevenband grouper nervous necrosis virus., J. Virol., 78(3), 1256-1262, 20040201
  8. In vivo and in vitro analysis of the resistance against viral haemorrhagic septicaemia virus in Japanese flounder (Paralichthys olivaceus ) precedingly infected with aquabirnavirus., Fish Shellfish Immuno., 17, 1-11, 20040401
  9. Identification of potential virulence genes in Erwinia chrysanthemi 3937: Transposon insertion into plant up-regulated genes., J. Gen. Plant Pathol., 72, 360-368, 20061201
  10. A structural model for the mechanisms of elicitor release from fungal cell walls by plant s-1,3-endoglucanase., Plant Physiol., 109, 839-845, 19951001
  11. Syringolide derivatives for receptor studies., Molecular Genetics of Host-Specific Toxins in Plant Disease= eds. Kohmoto= K.= and Yoder= O. C. (Kluwer Academic Publishers= Dordrecht), 139-140, 19970401
  12. A specific binding site(s) in soybean soluble protein fraction for syringolide, an elicitor controlled by avirulence gene D from Pseudomonas syringae., Actual and Future Perspectives in Physiological Plant Pathology= eds. Ehara= Y.= and Hashiba= T. (Phytopathol. Soc. Japan), 77-83, 19960701
  13. The syringolide elicitors specified by avirulence gene D and their specific perception by Rpg4 soybean cells., Molecular Aspects of Pathogenicity and Resistance: Requirement for Signal Transduction= eds. Millis= D. et al. (APS PRESS= St. Paul), 139-148, 19950601
  14. Trash fish can be a source of betanodaviruses for cultured marine fish, AQUACULTURE, 302(42798), 158-163, 20100423
    Link to Paper Search Results by DOI
  15. Susceptibilities of medaka (Oryzias latipes) cell lines to a betanodavirus, VIROLOGY JOURNAL, 7, 20100712
    Link to Paper Search Results by DOI
  16. Production of biologically active Atlantic salmon interferon in transgenic potato and rice plants, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 110(2), 201-207, 2010
    Link to Paper Search Results by DOI
  17. Identification of RNA regions that determine temperature sensitivities in betanodaviruses, ARCHIVES OF VIROLOGY, 155(10), 1597-1606, 2010
    Link to Paper Search Results by DOI
  18. Genetic heterogeneity of betanodaviruses in juvenile production trials of Pacific bluefin tuna, Thunnus orientalis (Temminck & Schlegel), JOURNAL OF FISH DISEASES, 32(10), 815-823, 2009
    Link to Paper Search Results by DOI
  19. Phylogenetic Analysis of Betanodavirus RNA2 Identified from Wild Marine Fish in Oceanic Regions, FISH PATHOLOGY, 43(1), 19-27, 2008
    Link to Paper Search Results by DOI
  20. Comparison among the complete genomes of the four types of betanodaviruses, Diseases of Aqucitic Organisms, 80, 113-121, 20080707
  21. Variable region of RNA2 is sufficient to determine host specificity in betanodaviruses, Diseases of Aqucitic Organisms, 79, 199-205, 20080508
  22. Screening of freshwater fish species for their susceptibility to a betanodavirus, Diseases of Aqucitic Organisms, 77, 119-125, 20070914
  23. Screening of freshwater fish species for their susceptibility to a betanodavirus., Dis. Aquat. Org., 77, 119-125, 20070901
  24. Plylogenetic analysis of betanodavirus RNA2 identified from wild marine fish in oceanic region, Fish Pathology, 43(1), 19-27, 20070501
  25. Upper temperature limits for the multiplication of betanodaviruses, Fish Pathology, 42, 225-228, 20070524
  26. Upper temperature limits for the multiplication of betanodaviruses., Fish Pathol., 42(4), 20071215
  27. Betanodavirus infection in the freshwater model fish medaka (Oryzias latipes)., J. Gen. Virol., 87, 2333-2339, 20060801
  28. Development of betanodavirus infection systems in the freshwater model fish medaka (Oryzias latipes)., Innovative Technology for the Sustained Development of Fishery and Agriculture, 20061212
  29. Characterization of a novel barley protein, HCP1, that interacts with the Brome mosaic virus coat protein., Mol. Plant-Microbe Interact., 16, 352-259, 20030401
  30. The P34 syringolide elicitor receptor interacts with a soybean photorespiration enzyme, NADH-dependent hydroxypyruvate reductase., Mol. Plant-Microbe Interact., 15, 1213-1218, 20021101
  31. Microarray profiling of Erwinia chrysanthemi 3937 genes that are regulated during plant infection., Mol. Plant-Microbe Interact., 15, 619-629, 20020401
  32. hrp genes of Erwinia chrysanthemi 3937 are important virulence factors., Mol. Plant-Microbe Interact., 15, 472-480, 20020401
  33. The C terminus of brome mosaic virus coat protein controls viral cell-to-cell and long-distance movement., J. Virol., 75, 5385-5390, 20010601
  34. Characterization of a 34-kDa soybean binding protein for the syringolide elicitors., Proc. Natl. Acad. Sci. USA, 95, 3306-3311, 19980601
  35. Specific binding of the syringolode elicitors to a soluble protein fraction from soybean leaves., Plant Cell, 9, 1425-1433, 19970801
  36. Genome-wide identification of plant up-regulated genes of Erwinia chrysanthemi 3937 using GFP based IVET leaf array., Mol. Plant-Microbe Interact., 17, 999-1008, 20041001
  37. PCR-based detection of betanodaviruses from cultured and wild marine fish with no clinical signs., J. Fish Dis., 27, 603-608, 20041001

Awards

  1. 2006, Best Presentation Award, The First International Symposium on Viral Nervous Necrosis of Fish, Establishment of betanodavirus infection systems in small freshwater fish

Patented

  1. Patent, JP5421901, 2013/11/29
  2. Patent, JP5571577, 2014/07/04
  3. 5571577, 2014/07/04
  4. 5670201, 2014/12/26
  5. Patent, 9445605, 2016//9//2
  6. Patent, 2719358, 2017//1/0/