TOSHINORI HAYASHI

Last Updated :2025/06/25

Affiliations, Positions
Amphibian Research Center, Professor
E-mail
toshih2hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Nagoya University
  • Nagoya University

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Developmental biology

Research Keywords

  • Regeneration Biology, Organ Regeneration, Genome Editing, Model Organisms, Pleurodeles waltl

Affiliated Academic Societies

  • JAPANESE SOCIETY of DEVELOPMENTAL BIOLOGISTS

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
  2. 2025, Liberal Arts Education Program1, 3Term, Introduction to Biology
  3. 2025, Liberal Arts Education Program1, 3Term, The life science of amphibians
  4. 2025, Undergraduate Education, 4Term, Introduction to Biological Sciences B
  5. 2025, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  6. 2025, Undergraduate Education, 2Term, Advanced Biology
  7. 2025, Undergraduate Education, 1Term, Regeneration Biology
  8. 2025, Undergraduate Education, First Semester, Special Study for Graduation
  9. 2025, Undergraduate Education, Second Semester, Special Study for Graduation
  10. 2025, Undergraduate Education, Second Semester, Seminar for Amphibian Biology
  11. 2025, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  12. 2025, Undergraduate Education, First Semester, Practice for Fundamental Biology IV
  13. 2025, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  14. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Basic Biology
  15. 2025, Graduate Education (Master's Program) , 4Term, Cell Dynamics and Genomics
  16. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  17. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  18. 2025, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  19. 2025, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  20. 2025, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  21. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Biomedial Science
  22. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  23. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  24. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  25. 2025, Graduate Education (Doctoral Program) , Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  26. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  27. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  28. 2025, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics

Research Activities

Academic Papers

  1. Effect of Cdk1 gene disruption on cell cycle progression in newt cells, DEVELOPMENT GROWTH & DIFFERENTIATION, 67(2), 85-93, 202502
    Link to Paper Search Results by DOI
  2. Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration, CELL GENOMICS, 5(2), 20250212
    Link to Paper Search Results by DOI
  3. Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4, DEVELOPMENT GROWTH & DIFFERENTIATION, 67(1), 10-22, 202501
    Link to Paper Search Results by DOI
  4. Sustained induction of autophagy enhances survival during prolonged starvation in newt cells, LIFE SCIENCE ALLIANCE, 8(4), 20250204
    Link to Paper Search Results by DOI
  5. Development of an AI-Assisted Embryo Selection System Using Iberian Ribbed Newts for Embryo-Fetal Development Toxicity Testing, YONAGO ACTA MEDICA, 67(3), 233-241, 202408
    Link to Paper Search Results by DOI
  6. Biomechanical analysis of tendon regeneration capacity of Iberian ribbed newts following transection injury: Comparison to a mouse model, JOURNAL OF ORTHOPAEDIC RESEARCH, 42(3), 607-617, 202403
    Link to Paper Search Results by DOI
  7. Amphibian newts as experimental models for studying weight gain after castration, ENDOCRINE JOURNAL, 71(2), 181-191, 2024
    Link to Paper Search Results by DOI
  8. Phenotype-genotype relationships in Xenopus sox9 crispants provide insights into campomelic dysplasia and vertebrate jaw evolution, DEVELOPMENT GROWTH & DIFFERENTIATION, 65(8), 481-497, 202310
    Link to Paper Search Results by DOI
  9. Step-by-step protocol for alternative injury models in newt cardiac regeneration, DEVELOPMENT GROWTH & DIFFERENTIATION, 65(5), 266-271, 202306
    Link to Paper Search Results by DOI
  10. Appendage-restricted gene induction using a heated agarose gel for studying regeneration in metamorphosed Xenopus laevis and Pleurodeles waltl, DEVELOPMENT GROWTH & DIFFERENTIATION, 65(2), 86-93, 202302
    Link to Paper Search Results by DOI
  11. Cryo-injury procedure-induced cardiac regeneration shows unique gene expression profiles in the newt Pleurodeles waltl, DEVELOPMENTAL DYNAMICS, 251(5), 864-876, 202205
    Link to Paper Search Results by DOI
  12. An approach for elucidating dermal fibroblast dedifferentiation in amphibian limb regeneration, ZOOLOGICAL LETTERS, 8(1), 20220428
    Link to Paper Search Results by DOI
  13. Cranial skeletogenesis of one of the largest amphibians, Andrias japonicus, provides insight into ontogenetic adaptations for feeding in salamanders, ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, 195(1), 299-314, 20220507
    Link to Paper Search Results by DOI
  14. Newt Hoxa13 has an essential and predominant role in digit formation during development and regeneration, DEVELOPMENT, 149(5), 202203
    Link to Paper Search Results by DOI
  15. Insights regarding skin regeneration in non-amniote vertebrates: Skin regeneration without scar formation and potential step-up to a higher level of regeneration, Seminars in Cell & Developmental Biology, 100, 109-121, 2019
  16. Advanced microinjection protocol for gene manipulation using the model newt Pleurodeles waltl, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 63(6-7), 281-286, 2019
    Link to Paper Search Results by DOI
  17. A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology., DNA research : an international journal for rapid publication of reports on genes and genomes, 26(3), 217-229, 2019
  18. Newts can normalize duplicated proximal-distal disorder during limb regeneration., Developmental dynamics : an official publication of the American Association of Anatomists, 247(12), 1276-1285, 2018
  19. Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration., Developmental biology, 443(2), 127-136, 2018
  20. Effects of cadmium exposure on Iberian ribbed newt (Pleurodeles waltl) testes., Journal of toxicologic pathology, 30(4), 345-350, 2017
  21. Application of local gene induction by infrared laser-mediated microscope and temperature stimulator to amphibian regeneration study., Development, growth & differentiation, 57(9), 601-613, 2015
  22. Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration., Development, growth & differentiation, 56(1), 115-121, 2014
  23. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis., Mechanisms of development, 130(11-12), 519-531, 2013
  24. Molecular genetic system for regenerative studies using newts., Development, growth & differentiation, 55(2), 229-236, 2013
  25. Cell cycle regulation in mouse heart during embryonic and postnatal stages., Development, growth & differentiation, 54(8), 731-738, 2012
  26. Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20., The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(37), 12876-12884, 2012
  27. Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea., Journal of the Association for Research in Otolaryngology : JARO, 12(4), 455-469, 2011
  28. A method for stabilizing RNA for transfection that allows control of expression duration., Developmental dynamics : an official publication of the American Association of Anatomists, 239(7), 2034-2040, 2010
  29. Expression patterns of FGF receptors in the developing mammalian cochlea., Developmental dynamics : an official publication of the American Association of Anatomists, 239(3), 1019-1026, 2010
  30. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development., Developmental dynamics : an official publication of the American Association of Anatomists, 238(9), 2163-2178, 2009
  31. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation., Human molecular genetics, 18(15), 2748-2760, 2009
  32. CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development., PLoS genetics, 5(8), e1000607, 2009
  33. Fgf20 is required for sensory epithelial specification in the developing cochlea., The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(23), 5991-5999, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Study of the stem cell system from organ regeneration in the newt., Hayashi T, Kyakuno M, Ikuta H, Manabe I, Takeuchi T, International Symposium: Principles of pluriopotent stem cells underlying plant vitality, 2019/05/13, With Invitation, English