Yusuke Sotomaru

Last Updated :2024/04/03

Affiliations, Positions
Natural Science Center for Basic Research and Development, Professor
Web Site
http://hiroshima-u.jp/centers/gakunai/nbard
E-mail
sotomaruhiroshima-u.ac.jp
Self-introduction
Studies on reproductive developmental engineering technologies in mammals, especially in experimental and domestic animals: Development of animal cloning system using a micromanipulation and nuclear transfer techniques, and investigation of developmental mechanism in the early stage embryos

Basic Information

Major Professional Backgrounds

  • 1995/04/01, 1996/03/30, CLEA Japan, Inc.
  • 1998/04/01, 1999/03/31, Kinki University, Research Associate
  • 2001/04/01, 2004/03/31, Central Institute for Experimental Animals, Researcher
  • 2004/04/01, 2005/02/15, Central Institute for Experimental Animals, Office Director
  • 2005/02/16, 2007/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
  • 2007/04/01, 2011/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
  • 2011/04/01, Hiroshima University, Natural Science Center for Basic Research and Development, Professor
  • 2013/04/01, Hiroshima University, Vice Director, Natural Science Center for Basic Research and Development

Educational Backgrounds

  • Kinki University, Graduate School, Division of Agricultural Science, Japan, 1996/04, 1998/03
  • Tokyo University of Agriculture, Graduate School, Division of Agriculture, Animal Science, Japan, 1991/04, 1993/03
  • Tokyo University of Agriculture, Faculty of Agriculture, Japan, 1987/04, 1991/03

Academic Degrees

  • Doctor of Philosophy, Tokyo University of Agriculture
  • Master, Tokyo University of Agriculture

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Biological Sciences;Laboratory animal science;Laboratory animal science

Affiliated Academic Societies

  • Japan Society for Ova Research

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Ethics and regulations in natural science research
  2. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  3. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  4. 2024, Graduate Education (Master's Program) , First Semester, Research
  5. 2024, Graduate Education (Master's Program) , Second Semester, Research
  6. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  7. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  10. 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Life Science
  12. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Life Science
  13. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Life Science
  14. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Life Science
  15. 2024, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. miR-582-5p targets Skp1 and regulates NF-Kappa B signaling-mediated inflammation, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 734, 20230115
    Link to Paper Search Results by DOI
  2. GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice, NEUROBIOLOGY OF DISEASE, 172, 20221001
    Link to Paper Search Results by DOI
  3. In Vitro Transfection of Up-Regulated Genes Identified in Favorable-Outcome Neuroblastoma into Cell Lines, CELLS, 11(19), 202210
    Link to Paper Search Results by DOI
  4. Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 68(2), 125-136, 2022
    Link to Paper Search Results by DOI
  5. Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20220309
    Link to Paper Search Results by DOI
  6. Gene Targeting and Subsequent Site-Specific Transgenesis at the beta-actin (ACTB) Locus in Common Marmoset Embryonic Stem Cells, STEM CELLS AND DEVELOPMENT, 20(9), 1588-1600, 201109
    Link to Paper Search Results by DOI
  7. Incisor Enamel Formation is Impaired in Transgenic Rats Overexpressing the Type III NaPi Transporter Slc20a1, CALCIFIED TISSUE INTERNATIONAL, 89(3), 192-202, 201109
    Link to Paper Search Results by DOI
  8. Protocol for the production of viable bimaternal mouse embryos, NATURE PROTOCOLS, 3(2), 197-209, 2008
    Link to Paper Search Results by DOI
  9. Identification of genes aberrantly expressed in mouse embryonic stem cell-cloned blastocysts, BIOLOGY OF REPRODUCTION, 78(4), 568-576, 200804
    Link to Paper Search Results by DOI
  10. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
    Link to Paper Search Results by DOI
  11. Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice, HUMAN MOLECULAR GENETICS, 18(10), 1879-1888, 20090515
    Link to Paper Search Results by DOI
  12. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2, GENOMICS, 93(5), 461-472, 200905
    Link to Paper Search Results by DOI
  13. Generation of transgenic non-human primates with germline transmission, NATURE, 459(7246), 523-U50, 20090528
    Link to Paper Search Results by DOI
  14. Developmental Ability of Trophoblast Stem Cells in Uniparental Mouse Embryos, PLACENTA, 30(5), 448-456, 200905
    Link to Paper Search Results by DOI
  15. Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus), CLONING AND STEM CELLS, 11(4), 575-583, 200912
    Link to Paper Search Results by DOI
  16. Identification of Inappropriately Reprogrammed Genes by Large-Scale Transcriptome Analysis of Individual Cloned Mouse Blastocysts, PLOS ONE, 5(6), 20100630
    Link to Paper Search Results by DOI
  17. Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks, PLOS GENETICS, 8(1), 201201
    Link to Paper Search Results by DOI
  18. Neoplastic transformation by TERT in FGF-2-expanded human mesenchymal stem cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 39(1), 5-11, 201107
    Link to Paper Search Results by DOI
  19. Establishment of ES Cells from Inbred Strain Mice by Dual Inhibition (2i), JOURNAL OF REPRODUCTION AND DEVELOPMENT, 58(1), 77-83, 201202
    Link to Paper Search Results by DOI
  20. Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8(4), 20130412
    Link to Paper Search Results by DOI
  21. Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 57(9-10), 715-724, 2013
    Link to Paper Search Results by DOI
  22. Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells, FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 51(4), 292-299, 2013
    Link to Paper Search Results by DOI
  23. A study on cryoprotectant solution suitable for vitrification of rat two-cell stage embryos, CRYOBIOLOGY, 68(1), 147-151, 201402
    Link to Paper Search Results by DOI
  24. Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli, NEUROBIOLOGY OF DISEASE, 68, 215-227, 201408
    Link to Paper Search Results by DOI
  25. Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth, GENES TO CELLS, 19(8), 629-636, 201408
    Link to Paper Search Results by DOI
  26. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10(7), 20150717
    Link to Paper Search Results by DOI
  27. Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-gamma production in iNKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(24), E3394-E3402, 20160614
    Link to Paper Search Results by DOI
  28. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer, ONCOGENESIS, 5, 201608
    Link to Paper Search Results by DOI
  29. Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor beta Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation, PLOS ONE, 11(11), 20161111
    Link to Paper Search Results by DOI
  30. Quality of common marmoset (Callithrix jacchus) oocytes collected after ovarian stimulation, THERIOGENOLOGY, 106, 221-226, 20180115
    Link to Paper Search Results by DOI
  31. The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38(2), 278-290, 20180110
    Link to Paper Search Results by DOI
  32. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23(3), 136-145, 201803
    Link to Paper Search Results by DOI
  33. Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice, HUMAN MOLECULAR GENETICS, 26(19), 3653-3662, 20171001
    Link to Paper Search Results by DOI
  34. XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage., Biol Reprod., 201810
  35. Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages., Immunology., 130(2), 243-253, 20100119
    Link to Paper Search Results by DOI
  36. Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure, NUTRITION & METABOLISM, 16, 20190704
    Link to Paper Search Results by DOI
  37. Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model, PLOS ONE, 14(6), 20190626
    Link to Paper Search Results by DOI
  38. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, SCIENTIFIC REPORTS, 9, 20191001
    Link to Paper Search Results by DOI
  39. The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice, COMMUNICATIONS BIOLOGY, 3(1), 20200116
    Link to Paper Search Results by DOI
  40. Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction, CLINICAL CANCER RESEARCH, 26(8), 2065-2079, 202004
    Link to Paper Search Results by DOI
  41. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  42. Oncogenic mutation in RAS-RAF axis leads to increased expression ofGREB1, resulting in tumor proliferation in colorectal cancer, CANCER SCIENCE, 111(10), 3540-3549, 202010
    Link to Paper Search Results by DOI
  43. Effect of Cetrorelix administration on ovarian stimulation in aged mice, EXPERIMENTAL ANIMALS, 70(1), 31-36, 2021
    Link to Paper Search Results by DOI
  44. UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes, BLOOD, 137(7), 908-922, 20210218
    Link to Paper Search Results by DOI
  45. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells, NATURE COMMUNICATIONS, 11(1), 20200917
    Link to Paper Search Results by DOI
  46. Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 22, 202007
    Link to Paper Search Results by DOI
  47. Optineurin defects cause TDP43-pathology with autophagic vacuolar formation, NEUROBIOLOGY OF DISEASE, 148, 202101
    Link to Paper Search Results by DOI
  48. Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice, SCIENTIFIC REPORTS, 11(1), 20210603
    Link to Paper Search Results by DOI
  49. Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13), 202107
    Link to Paper Search Results by DOI
  50. Single-Cell RNA-Sequencing Reveals the Breadth of Osteoblast Heterogeneity, JBMR PLUS, 5(6), 202106
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Stepwise differentiation of ScxGFP iPS cells into mature tenocytes and ligamentocytes, 2019/12/03, Without Invitation, Japanese
  2. Effect of cetrorelix acetate administration on ovarian stimulation in aged mice., Sotomaru Y, Sotomaru Y, Kanda A, Kanzaki M., 14th FELASA Congress, 2019/06/10, Without Invitation, English, FELASA, Prague, Czech Republic
  3. A mutation of the spinocerebellar ataxia gene CACNA1G induces cerebellar Purkinje cell death and ataxia in mice., Y. Matsuda, Y. Matsuda, H. Morino, T. Kurashige, T. Matsuoka, Y. Sotomaru, K. Hashimoto, and H. Kawakami., SFN2017, 2017/11/11, Without Invitation, English
  4. Techniques for creating genetically identical animalsin the non-human primates., Yusuke Sotomaru, 2017 Asia-Oceania Regional Meeting for Marmoset Research, 2017/03/16, With Invitation, English, Seoul, Korea
  5. Characterization of common marmoset (Callithrix jacchus) bone marrow-derived cells., Akifumi Kanda, Akifumi Kanda, Seiji Shiozawa, Asako Nobukiyo, Teruhiko Hatakeyama, Emi Yamaoka, Eiso Hiyama, Yusuke Sotomaru, International Society for Stem Cell Research, 2012/06/14, Without Invitation, English, International Society for Stem Cell Research, Yokohama
  6. Effect of Donor-cell type on developmental potential of clone embryos in the common marmosets, Sotomaru Y, Sotomaru Y, Yoshioka M, Nobukiyo A, Sasaki E., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, English, Tokyo
  7. Use of an adhesion barrier for preventing postoperative adhesion in common marmosets that underwent oocyte collection, Hatakayama T, Hatakayama T, Nobukiyo A, Nishimoto H, Nojiri T, Yoshioka M, Sotomaru Y., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, English, Japan Society for Marmoset Reseach, Tokyo
  8. Application of ES/somatic cell cloning technique to the production of genetically modified marmoset., Sotomaru Y, Sotomaru Y, Sasaki E, Okano H., The 34th Annual Meeting of the Japan Neuroscience Society, 2011/09/17, With Invitation, English, Annual Meeting of the Japan Neuroscience Society, Yokohama
  9. Establishment of ES cells of inbred strain mice by dual inhibition (2i), 2010/12/10, Without Invitation, Japanese
  10. Whole genome bisulphate shotgun sequencing in mouse germ cells, Kobayashi H, Kobayashi　H, Sakurai T, Takahashi N, Obata Y, Nakabayashi K, Hata K, Sotomamru Y, Suzuki Y, Kono T, International Symposium on “Epigenome Network, Development and Reprogramming of Germ Cells”, 2010/11/24, Without Invitation, English, “Epigenome Network, Development and Reprogramming of Germ Cells”, Fukuoka

External Funds

Acceptance Results of Competitive Funds

  1. 2018/04/03, 2020
  2. Strategic Research Programs for Brain Science(ACT-C), 2017/04/01, 2018/03/31
  3. 2017/03/30, 2019
  4. Strategic Research Program for Brain Sciences , 2016/04/01, 2017/03/31
  5. 2016, 2018
  6. Strategic Research Program for Brain Sciences, 2015/04/01, 2016/03/31
  7. KAKENHI, 2015, 2018
  8. KAKENHI, 2015, 2018
  9. KAKENHI, 2015
  10. Strategic Research Programs for Brain Science(ACT-C), 2014/04/01, 2015/03/31
  11. KAKENHI, 2013, 2014
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  12. KAKENHI, 2013, 2015
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  13. KAKENHI, 2012, 2014
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  14. KAKENHI, 2010, 2014
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  15. KAKENHI, Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis, 2010, 2013
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  16. KAKENHI, Molecular analysis for developing the newtargeting therapy in Japanese Pediatric Liver Tumor study group, 2010, 2012
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  17. KAKENHI, 2010, 2010
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  18. KAKENHI, Elucidation of development mechanism and molecular targets in neuroblastoma and hepatoblastoma using genomics and cellomics, 2009, 2011
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  19. 2008, 2012
  20. KAKENHI, 2007, 2008
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  21. KAKENHI, Regulation of germ line function and development by genomic imprinting, 2006, 2008
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  22. KAKENHI, Establishment of preclinical study system for regenerative medicine using somatic nuclear transferred embryonic stem cells, 2006, 2007
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  23. KAKENHI, 2004, 2005
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  24. KAKENHI, Studies on developmental aberration of somatic clones by global gene expression analysis, 2004, 2005
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  25. KAKENHI, Basic studies on animal model for regenerative medicine using severe immunodeficient mice., 2003, 2004
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  26. KAKENHI, Development of genetic and microbiological quality control system of mouse embryonic stem cell lines., 2003, 2005
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