Yusuke Sotomaru

Last Updated :2019/12/02

Affiliations, Positions
Natural Science Center for Basic Research and Development, ., Professor
Web Site
E-mail
sotomaruhiroshima-u.ac.jp
Self-introduction
Studies on reproductive developmental engineering technologies in mammals, especially in experimental and domestic animals: Development of animal cloning system using a micromanipulation and nuclear transfer techniques, and investigation of developmental mechanism in the early stage embryos

Basic Information

Major Professional Backgrounds

  • 1995/04/01, 1996/03/30, CLEA Japan, Inc.
  • 1998/04/01, 1999/03/31, Kinki University, Research Associate
  • 2001/04/01, 2004/03/31, Central Institute for Experimental Animals, Researcher
  • 2004/04/01, 2005/02/15, Central Institute for Experimental Animals, Office Director
  • 2005/02/16, 2007/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
  • 2007/04/01, 2011/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
  • 2011/04/01, Hiroshima University, Natural Science Center for Basic Research and Development, Professor
  • 2013/04/01, Hiroshima University, Vice Director, Natural Science Center for Basic Research and Development

Educational Backgrounds

  • Kinki University, Graduate School, Division of Agricultural Science, Japan, 1996/04, 1998/03
  • Tokyo University of Agriculture, Graduate School, Division of Agriculture, Animal Science, Japan, 1991/04, 1993/03
  • Tokyo University of Agriculture, Faculty of Agriculture, Japan, 1987/04, 1991/03

Academic Degrees

  • Doctor of Philosophy, Tokyo University of Agriculture
  • Master, Tokyo University of Agriculture

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

Research Fields

  • Biological Sciences;Laboratory animal science;Laboratory animal science

Affiliated Academic Societies

  • Japan Society for Ova Research

Educational Activity

Course in Charge

  1. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  2. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  3. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  4. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  5. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  6. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  7. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  8. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  9. 2019, Graduate Education (Master's Program) , First Semester, Research
  10. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  11. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  12. 2019, Graduate Education (Master's Program) , Second Semester, Research
  13. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  14. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  15. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  16. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  17. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Life Science
  18. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Life Science
  19. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Life Science
  20. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Life Science
  21. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  22. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B

Research Activities

Academic Papers

  1. XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage., Biol Reprod., 201810
  2. The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38(2), 278-290, 20180110
  3. Quality of common marmoset (Callithrix jacchus) oocytes collected after ovarian stimulation, THERIOGENOLOGY, 106, 221-226, 20180115
  4. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23(3), 136-145, 201803
  5. Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice, HUMAN MOLECULAR GENETICS, 26(19), 3653-3662, 20171001
  6. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer, ONCOGENESIS, 5, 201608
  7. Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-gamma production in iNKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(24), E3394-E3402, 20160614
  8. Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor beta Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation, PLOS ONE, 11(11), 20161111
  9. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10(7), 20150717
  10. Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth, GENES TO CELLS, 19(8), 629-636, 201408
  11. Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli, NEUROBIOLOGY OF DISEASE, 68, 215-227, 201408
  12. A study on cryoprotectant solution suitable for vitrification of rat two-cell stage embryos, CRYOBIOLOGY, 68(1), 147-151, 201402
  13. Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells, FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 51(4), 292-299, 2013
  14. Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 57(9-10), 715-724, 2013
  15. Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8(4), 20130412
  16. Establishment of ES Cells from Inbred Strain Mice by Dual Inhibition (2i), JOURNAL OF REPRODUCTION AND DEVELOPMENT, 58(1), 77-83, 201202
  17. Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks, PLOS GENETICS, 8(1), 201201
  18. Neoplastic transformation by TERT in FGF-2-expanded human mesenchymal stem cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 39(1), 5-11, 201107
  19. Gene Targeting and Subsequent Site-Specific Transgenesis at the beta-actin (ACTB) Locus in Common Marmoset Embryonic Stem Cells, STEM CELLS AND DEVELOPMENT, 20(9), 1588-1600, 201109
  20. Incisor Enamel Formation is Impaired in Transgenic Rats Overexpressing the Type III NaPi Transporter Slc20a1, CALCIFIED TISSUE INTERNATIONAL, 89(3), 192-202, 201109
  21. Identification of Inappropriately Reprogrammed Genes by Large-Scale Transcriptome Analysis of Individual Cloned Mouse Blastocysts, PLOS ONE, 5(6), 20100630
  22. Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages., Immunology., 130(2), 243-253, 20100119
  23. Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus), CLONING AND STEM CELLS, 11(4), 575-583, 200912
  24. Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice, HUMAN MOLECULAR GENETICS, 18(10), 1879-1888, 20090515
  25. Developmental Ability of Trophoblast Stem Cells in Uniparental Mouse Embryos, PLACENTA, 30(5), 448-456, 200905
  26. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2, GENOMICS, 93(5), 461-472, 200905
  27. Generation of transgenic non-human primates with germline transmission, NATURE, 459(7246), 523-U50, 20090528
  28. Protocol for the production of viable bimaternal mouse embryos, NATURE PROTOCOLS, 3(2), 197-209, 2008
  29. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
  30. Identification of genes aberrantly expressed in mouse embryonic stem cell-cloned blastocysts, BIOLOGY OF REPRODUCTION, 78(4), 568-576, 200804

Invited Lecture, Oral Presentation, Poster Presentation

  1. A mutation of the spinocerebellar ataxia gene CACNA1G induces cerebellar Purkinje cell death and ataxia in mice., Y. Matsuda, Y. Matsuda, H. Morino, T. Kurashige, T. Matsuoka, Y. Sotomaru, K. Hashimoto, and H. Kawakami., SFN2017, 2017/11/11, Without Invitation
  2. Techniques for creating genetically identical animalsin the non-human primates., Yusuke Sotomaru, 2017 Asia-Oceania Regional Meeting for Marmoset Research, 2017/03/16, With Invitation, Seoul, Korea
  3. Characterization of common marmoset (Callithrix jacchus) bone marrow-derived cells., Akifumi Kanda, Akifumi Kanda, Seiji Shiozawa, Asako Nobukiyo, Teruhiko Hatakeyama, Emi Yamaoka, Eiso Hiyama, Yusuke Sotomaru, International Society for Stem Cell Research, 2012/06/14, Without Invitation, International Society for Stem Cell Research, Yokohama
  4. Effect of Donor-cell type on developmental potential of clone embryos in the common marmosets, Sotomaru Y, Sotomaru Y, Yoshioka M, Nobukiyo A, Sasaki E., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, Tokyo
  5. Use of an adhesion barrier for preventing postoperative adhesion in common marmosets that underwent oocyte collection, Hatakayama T, Hatakayama T, Nobukiyo A, Nishimoto H, Nojiri T, Yoshioka M, Sotomaru Y., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, Japan Society for Marmoset Reseach, Tokyo
  6. Application of ES/somatic cell cloning technique to the production of genetically modified marmoset., Sotomaru Y, Sotomaru Y, Sasaki E, Okano H., The 34th Annual Meeting of the Japan Neuroscience Society, 2011/09/17, With Invitation, Annual Meeting of the Japan Neuroscience Society, Yokohama
  7. Establishment of ES cells of inbred strain mice by dual inhibition (2i), 2010/12/10, Without Invitation
  8. Whole genome bisulphate shotgun sequencing in mouse germ cells, Kobayashi H, Kobayashi H, Sakurai T, Takahashi N, Obata Y, Nakabayashi K, Hata K, Sotomamru Y, Suzuki Y, Kono T, International Symposium on “Epigenome Network, Development and Reprogramming of Germ Cells”, 2010/11/24, Without Invitation, “Epigenome Network, Development and Reprogramming of Germ Cells”, Fukuoka

External Funds

Acceptance Results of Competitive Funds

  1. 2018/04/03, 2020
  2. Strategic Research Programs for Brain Science(ACT-C), 2017/04/01, 2018/03/31
  3. 2017/03/30, 2019
  4. Strategic Research Program for Brain Sciences , 2016/04/01, 2017/03/31
  5. 2016, 2018
  6. Strategic Research Program for Brain Sciences, 2015/04/01, 2016/03/31
  7. KAKENHI, 2015, 2018
  8. KAKENHI, 2015, 2018
  9. KAKENHI, 2015
  10. Strategic Research Programs for Brain Science(ACT-C), 2014/04/01, 2015/03/31
  11. KAKENHI, 2013, 2014
  12. KAKENHI, 2013, 2015
  13. KAKENHI, 2012, 2014
  14. KAKENHI, 2010, 2014
  15. KAKENHI, Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis, 2010, 2013
  16. KAKENHI, Molecular analysis for developing the newtargeting therapy in Japanese Pediatric Liver Tumor study group, 2010, 2012
  17. KAKENHI, 2010, 2010
  18. KAKENHI, Elucidation of development mechanism and molecular targets in neuroblastoma and hepatoblastoma using genomics and cellomics, 2009, 2011
  19. 2008, 2012
  20. KAKENHI, 2007, 2008
  21. KAKENHI, Regulation of germ line function and development by genomic imprinting, 2006, 2008
  22. KAKENHI, Establishment of preclinical study system for regenerative medicine using somatic nuclear transferred embryonic stem cells, 2006, 2007
  23. KAKENHI, 2004, 2005
  24. KAKENHI, Studies on developmental aberration of somatic clones by global gene expression analysis, 2004, 2005
  25. KAKENHI, Basic studies on animal model for regenerative medicine using severe immunodeficient mice., 2003, 2004
  26. KAKENHI, Development of genetic and microbiological quality control system of mouse embryonic stem cell lines., 2003, 2005