Yukio Takeshima

Last Updated :2020/08/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
ykotakehiroshima-u.ac.jp
Self-introduction
We purse a technique for more precise & rapid pathogical diagnosis by fusion of pathological morphology and molecular biology.

Basic Information

Major Professional Backgrounds

  • 2012/07/01, 2019/03/31, Dept of Pathology, Institutes of Biomedical & Health Sciences, Professor
  • 2000/04/07, 2012/06/30, Hiroshima University, Assistant Professor
  • 1995/05/01, 2000/03/31, Hiroshima University, Lecturer
  • 1995/04/01, 1995/04/30, Hiroshima University, Research Associate
  • 1991/04/01, 1995/03/31, Hiroshima University, Research Associate

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Human pathology

Research Keywords

  • Pathology
  • Environmental Carcinogenesis
  • Occupational cancer
  • mesothelioma
  • Lung cancer
  • molecular biology
  • Pathological Diagnosis
  • Autopsy
  • Digital pathology

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 2Term, Peace Messages from "Kasumi Campus"
  2. 2020, Undergraduate Education, Second Semester, Clinical Pathology
  3. 2020, Undergraduate Education, Intensive, Practice for medical research
  4. 2020, Undergraduate Education, 2Term, Introduction for medical research
  5. 2020, Undergraduate Education, First Semester, General Pathology
  6. 2020, Undergraduate Education, First Semester, Pathology
  7. 2020, Undergraduate Education, First Semester, Pathology
  8. 2020, Undergraduate Education, Intensive, Pathology
  9. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pathology
  10. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pathology
  11. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pathology
  12. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pathology
  13. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  14. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  15. 2020, Graduate Education (Master's Program) , First Semester, Seminar
  16. 2020, Graduate Education (Master's Program) , Second Semester, Seminar
  17. 2020, Graduate Education (Master's Program) , First Semester, Research
  18. 2020, Graduate Education (Master's Program) , Second Semester, Research
  19. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  20. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  21. 2020, Graduate Education (Master's Program) , Second Semester, Pathologic Basis of Diseases
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pathology
  23. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pathology
  24. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pathology
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pathology

Research Activities

Academic Papers

  1. Retrospective immunohistological study of autopsied lungs in patients with acute exacerbation of interstitial pneumonia managed with extracorporeal membrane oxygenation, JOURNAL OF THORACIC DISEASE, 11(11), 4436-4443, 201911
  2. Synchronicity of genetic variants between primary sites and metastatic lymph nodes, and prognostic impact in nodal metastatic lung adenocarcinoma, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 145(9), 2325-2333, 201909
  3. Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years, JOURNAL OF CLINICAL MEDICINE, 8(5), 201905
  4. Mucin 21 is a novel, negative immunohistochemical marker for epithelioid mesothelioma for its differentiation from lung adenocarcinoma, HISTOPATHOLOGY, 74(4), 545-554, 201903
  5. Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign", INTERNAL MEDICINE, 58(8), 1157-1162, 2019
  6. Complete Response to Chemotherapy against the Recurrence of Neuroendocrine Carcinoma of the Breast in the Anterior Mediastinal Lymph Nodes of a Patient on Hemodialysis: A Case Report, CASE REPORTS IN ONCOLOGY, 12(1), 205-210, 2019
  7. Immunostaining of Increased Expression of Enhancer of Zeste Homolog 2 (EZH2) in Diffuse Midline Glioma H3K27M-Mutant Patients with Poor Survival, PATHOBIOLOGY, 86(2), 152-161, 2019
  8. Rare Cases of Low-Grade Appendiceal Mucinous Neoplasm: Two Case Reports and a Literature Review, CASE REPORTS IN ONCOLOGY, 12(2), 488-493, 2019
  9. Glypican-1 immunohistochemistry is a novel marker to differentiate epithelioid mesothelioma from lung adenocarcinoma, MODERN PATHOLOGY, 31(5), 809-815, 201805
  10. Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas, WORLD NEUROSURGERY, 112, E84-E94, 201804
  11. MUC4 immunohistochemistry is useful in distinguishing epithelioid mesothelioma from adenocarcinoma and squamous cell carcinoma of the lung, SCIENTIFIC REPORTS, 8, 20180109
  12. miR-182 and miR-183 Promote Cell Proliferation and Invasion by Targeting FOXO1 in Mesothelioma, Front. Oncol., 2018
  13. MUC21 is a novel, negative immunohistochemical marker for epithelioid mesothelioma for its differentiation from lung adenocarcinoma., Histopathology, 2018
  14. Increased risk of recurrence in resected EGFR-positive pN0M0 invasive lung adenocarcinoma., Thorac Cancer., 2018
  15. Characteristics of Benign and Malignant Bone Tumors Registered in the Hiroshima Tumor Tissue Registry, 1973-2012., JB JS Open Access., 29(3), e0064, 2018
  16. Improved differentiation between high- and low-grade gliomas by combining dual-energy CT analysis and perfusion CT., Medicine (Baltimore), 97(32), E11670, 2018
  17. Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: A case report and review of literature, Pathology International, 68, 313-317, 2018
  18. RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging., Brain Tumor Pathol., 35(1), 41-45, 2018
  19. Role for loss of nuclear PTEN in a harbinger of brain metastases., 2018
  20. The differences in histological changes among pulmonary vessels divided with an energy device., Interact Cardiovasc Thorac Surg., 2018
  21. Therapeutic strategies and genetic profile comparisons in small cell carcinoma and large cell neuroendocrine carcinoma of the lung using next-generation sequencing, ONCOTARGET, 8(65), 108936-108945, 20171212
  22. PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 50(3), 1029-1034, 201703
  23. Utility and pitfalls of immunohistochemistry in the differential diagnosis between epithelioid mesothelioma and poorly differentiated lung squamous cell carcinoma, HISTOPATHOLOGY, 70(3), 375-384, 201702
  24. Identification of DAB2 and Intelectin-1 as Novel Positive Immunohistochemical Markers of Epithelioid Mesothelioma by Transcriptome Microarray Analysis for its Differentiation From Pulmonary Adenocarcinoma., Am J Surg Pathol., 2017
  25. MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma., Mod Pathol, 30([Epub ahead of print]), [Epub ahead of print]-[Epub ahead of print], 2017
  26. A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients., Oncol Lett., 14(1), 299-305, 2017
  27. Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of two infantile cases and review of the differential diagnosis of infantile pulmonary lesions., Hum Pathol., 2017, 2017
  28. Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma, PATHOBIOLOGY, 84(2), 99-107, 2017
  29. Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide., J Neurosurg., 2017(21), 2017
  30. Role for loss of nuclear PTEN in a harbinger of brain metastases, Journal of Clinical Neuroscience, 2017
  31. Sellar Atypical Teratoid/Rhabdoid Tumor (AT/RT): A Clinicopathologically and Genetically Distinct Variant of AT/RT, Am J Surg Pathol, 41(7), 932-940, 2017
  32. Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma, ANNALS OF THORACIC SURGERY, 102(5), 1668-1673, 201611
  33. Prognostic significance of vascular invasion in intermediate-grade subtype of lung adenocarcinoma, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46(11), 1015-1021, 201611
  34. Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1, MOLECULAR CELL, 64(1), 176-188, 20161006
  35. Pleural irregularities and mediastinal pleural involvement in early stages of malignant pleural mesothelioma and benign asbestos pleural effusion, EUROPEAN JOURNAL OF RADIOLOGY, 85(9), 1594-1600, 201609
  36. Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma., Pathobiology., 2016 Aug 24. [Epub ahead of print](2016 Aug 24. [Epub ahead of print]), 2016 Aug 24. [Epub ahead of print]-2016 Aug 24. [Epub ahead of print], 20160824
  37. Fatal pleural mesothelioma in Japan (2003-2008): evaluation of computed tomography findings, JAPANESE JOURNAL OF RADIOLOGY, 34(6), 432-438, 201606
  38. Computed Tomographic Features of Malignant Peritoneal Mesothelioma, ANTICANCER RESEARCH, 36(3), 1067-1072, 201603
  39. Differential microRNA expression profiling of mesothelioma and expression analysis of miR-1 and miR-214 in mesothelioma, International Journal of Oncology, 48(4), 1599-1607, 2016
  40. Use of Anti-Noxa Antibody for Differential Diagnosis between Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia., Pathobiology, 83((1):), 33-40, 2016
  41. Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma, JOURNAL OF NEUROSURGERY, 122(6), 1370-1379, 201506
  42. Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature., Childs Nerv Syst, [Epub ahead of print]([Epub ahead of print]), 2015
  43. Propensity score-matched analysis of adjuvant chemotherapy for stage I non-small cell lung cancer, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 148(4), 1179-1185, 201410
  44. Prediction for prognosis of resected pT1a-lbN0M0 adenocarcinoma based on tumor size and histological status: Relationship of TNM and IASLC/ATS/ERS classifications, LUNG CANCER, 85(2), 270-275, 201408
  45. Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma., J Thorac Cardiovasc Surg, 147(6), 1820-1826, 201406
  46. The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 146(3), 580-585, 201309
  47. Treatment and survival analyses of malignant mesothelioma in Japan, ACTA ONCOLOGICA, 52(4), 803-808, 201305
  48. CD9 expression as a favorable prognostic marker for patients with malignant mesothelioma, ONCOLOGY REPORTS, 29(1), 21-28, 201301
  49. Role of perfusion-weighted imaging at 3 T in the histopathological differentiation between astrocytic and oligodendroglial tumors, EUROPEAN JOURNAL OF RADIOLOGY, 81(8), 1863-1869, 201208
  50. CD26 Overexpression Is Associated with Prolonged Survival and Enhanced Chemosensitivity in Malignant Pleural Mesothelioma, CLINICAL CANCER RESEARCH, 18(5), 1447-1456, 20120301
  51. National survey of malignant mesothelioma and asbestos exposure in Japan, CANCER SCIENCE, 103(3), 483-490, 201203
  52. Lymphomas and glioblastomas: Differences in the apparent diffusion coefficient evaluated with high b-value diffusion-weighted magnetic resonance imaging at 3 T, EUROPEAN JOURNAL OF RADIOLOGY, 81(2), 339-344, 201202
  53. Role of PROPELLER diffusion-weighted imaging and apparent diffusion coefficient in the evaluation of pituitary adenomas, EUROPEAN JOURNAL OF RADIOLOGY, 80(2), 412-417, 201111
  54. Clinical, Radiological, and Pathological Investigation of Asbestosis, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 8(3), 899-912, 2011
  55. Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines, ONCOLOGY REPORTS, 26(6), 1369-1375, 2011
  56. Clinical Study on Mesothelioma in Japan: Relevance to Occupational Asbestos Exposure, AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 53(11), 1081-1087, 201011
  57. Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma, ONCOLOGY REPORTS, 24(2), 423-431, 201008
  58. Evaluation of apoptosis and immunohistochemical expression of the apoptosis-related proteins in mesothelioma., Hiroshima Journal of Medical Sciences, 59(2), 27-33, 20100601
  59. Myogenic antigen expression is useful for differentiation between epithelioid mesothelioma and non-neoplastic mesothelial cells., Histopathology, 56(7), 969-74, 20100601
  60. Role of PROPELLER diffusion weighted imaging and apparent diffusion coefficient in the diagnosis of sellar and parasellar lesions, EUROPEAN JOURNAL OF RADIOLOGY, 74(3), 420-427, 201006
  61. TRIGEMINAL NEUROPATHY FROM PERINEURAL SPREAD OF AN AMYLOIDOMA DETECTED BY BLINK REFLEX AND THIN-SLICE MAGNETIC RESONANCE IMAGING, MUSCLE & NERVE, 41(6), 875-878, 201006
  62. Glioblastoma treated with postoperative radio-chemotherapy: Prognostic value of apparent diffusion coefficient at MR imaging, EUROPEAN JOURNAL OF RADIOLOGY, 73(3), 532-537, 201003
  63. Clinical Study on Mesothelioma in Japan: Relevance to Occupational Asbestos Exposure, AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 53(11), 1081-1087, 2010
  64. Accuracy of pathological diagnosis of mesothelioma cases in Japan: Clinicopathological analysis of 382 cases, LUNG CANCER, 66(2), 191-197, 200911
  65. Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma, HISTOPATHOLOGY, 55(1), 10-19, 200907
  66. Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma, HISTOPATHOLOGY, 54(6), 667-676, 200905
  67. Letter to the Editor, PATHOLOGY INTERNATIONAL, 59(4), 274-274, 20090401
  68. Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas: Comparative study with 11 pilocytic astrocytomas, PATHOLOGY INTERNATIONAL, 59(2), 80-85, 200902
  69. WIF1 expression is down-regulated by its promoter methylation in mesothelioma, JOURNAL OF THORACIC ONCOLOGY, 4(9), S767-S767, 2009
  70. Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry, PATHOLOGY INTERNATIONAL, 58(2), 75-83, 200802
  71. Familial occurrence of dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: Case report, NEUROSURGERY, 63(2), 370-372, 2008
  72. Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma, PATHOLOGY INTERNATIONAL, 57(4), 190-199, 200704
  73. Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast, PATHOLOGY INTERNATIONAL, 56(5), 256-261, MAY 2006
  74. Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer, CANCER SCIENCE, 97(8), 737-745, AUG 2006
  75. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma, JOURNAL OF PATHOLOGY, 207(2), 185-198, OCT 2005
  76. Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung, JOURNAL OF CLINICAL PATHOLOGY, 58(10), 1076-1080, OCT 2005
  77. Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers, CANCER RESEARCH, 65(20), 9176-9184, OCT 15 2005
  78. Aberrant methylation and loss of expression of O-6-methylguanine-DNA methyltransferase in pulmonary squamous cell carcinoma and adenocarcinoma, PATHOLOGY INTERNATIONAL, 55(6), 303-309, JUN 2005
  79. Loss of expression of E-cadherin and beta-catenin is associated with progression of pulmonary adenocarcinoma, PATHOLOGY INTERNATIONAL, 55(1), 14-18, JAN 2005
  80. Esophageal carcinosarcoma with basaloid squamous carcinoma and rhabdomyosarcoma components with TP53 mutation, PATHOLOGY INTERNATIONAL, 54(10), 803-809, OCT 2004
  81. Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 121(5), 644-653, MAY 2004
  82. Methylation of p14(ARF) gene in meningiomas and its correlation to the p53 expression and mutation, MODERN PATHOLOGY, 17(6), 705-710, JUN 2004
  83. Inactivation of the p16 gene by hypermethylation and loss of heterozygosity in adenocarcinoma of the lung, PATHOLOGY INTERNATIONAL, 54(7), 486-489, JUL 2004
  84. Meningioma in mature cystic teratoma of the ovary, PATHOLOGY INTERNATIONAL, 54(7), 543-548, JUL 2004
  85. Aberrant methylation of p14(ARF), p15(INK4b) and p16(INK4a) genes and location of the primary site in pulmonary squamous cell carcinoma, PATHOLOGY INTERNATIONAL, 54(8), 549-555, AUG 2004
  86. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo, GENES & DEVELOPMENT, 18(8), 877-888, APR 15 2004
  87. Myxopapillary ependymoma with anaplastic features, PATHOLOGY INTERNATIONAL, 53(10), 700-703, OCT 2003
  88. Meningioangiomatosis occurring in a young male without neurofibromatosis - With special reference to its histogenesis and loss of heterozygosity in the NF2 gene region, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 26(1), 125-129, JAN 2002
  89. Heterogeneity of expression of cytokeratin subtypes in squamous cell carcinoma of the lung: With special reference to CK14 overexpression in cancer of high-proliferative and lymphogenous metastatic potential, PATHOLOGY INTERNATIONAL, 52(4), 286-293, APR 2002
  90. Co-existence of Carcinosarcoma and Adenoid Basal Carcinoma of the Uterine Cervix with Special Reference toits Correlation with Human Papilloma Virus Infection., Int. J Gynecol Pathol., 21(2), 186-190, 20020401
  91. Co-existent carcinosarcoma and adenoid basal carcinoma of the uterine cervix and correlation with human papilloma virus infection, International Journal of Gynecological Pathology, 21(2), 186-190, 20020401
  92. Co-existent carcinosarcoma and adenoid basal carcinoma of the uterine cervix and correlation with human papillomavirus infection., Int. J Gynecol Pathol., 21(2), 186-90, 20020401
  93. Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast, Journal of Experimental Therapeutics and Oncology, 2(1), 9-18, 20020401
  94. Meningioangiomatosis Occurring in a Young Male without Neurofibromatosis -With Special Reference to its Histogenesis and LOH in the NF2 Gene Region-, Am. J. Surg. Pathol., 26(1), 125-126, 20020101
  95. Meningioangiomatosis occurring in a young male without neurofibromatosis: with special reference to its histogenesis and loss of heterozygosity in the NF2 gene region., Am. J. Surg. Pathol., 26(1), 125-129, 20020101
  96. A case of micronodular pneumocyte hyperplasia diagnosed through lung biopsy using thoracoscopy, RESPIRATION, 69(3), 277-279, 2002
  97. In vivo histological changes occurring in hydroxyapatite cranial reconstruction - Case report, NEUROLOGIA MEDICO-CHIRURGICA, 41(2), 100-104, FEB 2001
  98. Heterogeneous Genetic Alterations in Ovarian Mucinous Tumors-Application and Usefulness of Laser Capture Microdissection-, Human Pathology, 32(11), 1203-1208, 20011101
  99. An Extraabdominal Desmoid Tumor Presenting as an Intrathoracic Tumor (Intrathoracic Desmoid Tumor): A Case Report and Review of Literature., Pathol. Int., 824-828, 20011001
  100. Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast, J. Exp. Ther. Oncol., 2(1), 1-10, 20010901
  101. Extra-abdominal desmoid tumor presenting as an intrathoracic tumor: Case report and literature review, PATHOLOGY INTERNATIONAL, 51(10), 824-828, 2001
  102. Correlation between genetic alterations and histopathological subtypes in bronchiolo-alveolar carcinoma and atypical adenomatous hyperplasia of the lung, PATHOLOGY INTERNATIONAL, 50(10), 778-785, OCT 2000
  103. Correlation between morphological heterogeneity and genetic alteration within one tumor in adenocarcinomas of the lung, PATHOLOGY INTERNATIONAL, 50(11), 891-896, NOV 2000
  104. 'Adenomyomatous' hamartoma of the lung, PATHOLOGY INTERNATIONAL, 50(12), 984-986, DEC 2000
  105. Genetic Alterations in Ovarian Mucinous Tumors -with Special Reference to the Histogenesis-, Acta Histochem Cytochem, 123-129, 20000201
  106. Genetic alterations in ovarian mucinous tumors - With special reference to the histogenesis, ACTA HISTOCHEMICA ET CYTOCHEMICA, 33(2), 123-129, 2000
  107. Idiopathic granulomatous meningoencephalitis presenting as an intracranial tumor., Pathol. Int., 49(12), 1084-1088, 19991201
  108. p21WAF1/CIP1 Expression in Primary Lung Adenocarcinomas: Heterogeneous Expression in Tumor Tissues and Correlation with p53 Expression and Proliferative Activities., Carcinogenesis, 19(10), 1755-1761, 19981001
  109. Angiomyofibroblastoma of the vulva : A mitotically active variant?, Pathology International, 48, 292-296, 19980401
  110. Tubular Seminoma of the testis : Report of a Case, Patholgy International, 49, 676-679, 19980401
  111. Solitary fibrous tumor of the prostate, Pathology International, 47, 713-717, 19970401
  112. p16/CDKN2 gene and p53 gene alterations in Japanese non-smoking female lung adenocarcinoma, Jpn.J.Cancer Res., 87, 134-140, 19960401
  113. p16/CDKN2 Gene and p53 Gene Alterations in Japanese Non-smoking Female Lung Adenocarcioma., Jpn.J.Cancer Res., 134-140, 19960201
  114. Primary Carcinoid Tumor of the Kidney with Special Reference to its Histogenesis., Pathol. Int., 894-900, 19960101
  115. p53 mutations in lung cancers from Japanese mustard gas workers., Carcinogenesis, 15(10):2075-9.(10), 2075-2079, 199412
  116. p53 mutations in lung cancers from non-smoking atomic-bomb survivors., 342, 1520-1521, 199312
  117. p53 Protein Accumulates Frequently in Early Bronchial Neoplasia., Cancer Res., 1-6, 19930701
  118. Ovarian Sex Cord Tumor with Annular Tubules - A Case Report and Review of the Literature in Japanese., Hiroshima J. Med. Sci., 37-42, 19920201
  119. Quantitative risk assessment of carcinogenicity of urethane (ethyl carbamate) on the basis of long-term oral administration to B6C3F1 mice, 380-385, 19910401
  120. Nonenhancing peritumoral hyperintense lesion on diffusion-weighted imaging in glioblastoma: a novel diagnostic and specific prognostic indicator., J Neurosurg, 2017
  121. Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma., Ann Thorac Surg., 102(5), 1668-1673., 2017
  122. Evaluation of Apoptosis and Immunohistochemical Expression of the Apoptosis-related Proteins in Mesothelioma, Hiroshima Journal of Medical Sciences, 59(2), 27-33, 201006
  123. A case of nodular female breast fasciitis, J. Jpn. Soc. Clin. Cytol., 48(4), 201-205, 20090722
  124. Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas : Comparative study with 11 pilocytic astrocytomas, 59(2), 80-85, 20090201
  125. Asbestos and lung cancer, 57(9), 2274-2277, 200809
  126. Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer, Cancer Sci, 99(8), 1570-1577, 20080810
  127. Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry, Pathol Int, 58(2), 75-83, 20080201
  128. A Useful Antibody Panel for Differential Diagnosis Between Peritoneal Mesothelioma and Ovarian Serous Carcinoma in Japanese Cases, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 130(5), 771-779, 2008
  129. Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma, PATHOLOGY INTERNATIONAL, 57(4), 190-199, 2007
  130. Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer, Cancer Sci, 97(8), 737-745, 20060810
  131. Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast, 56(5), 256-261, 20060501
  132. The Reversed Apical Pattern of MUC1 Expression Is Characteristics of Invasive Micropapillary Carcinoma of the Breast, Breast Cancer, 13(1), 58-63, 20060105
  133. A Case of Desmoplastic Malignant Pleural Mesothelioma Treated With Induction Chemotherapy and Subsequent Extrapleural Pneumonectomy, Japanese Journal of Lung Cancer, 45(7), 851-856, 20051220
  134. Loss of expression of E-cadherin and β-catenin is associated with progression of pulmonary adenocarcinoma, 55(1), 14-18, 20050101
  135. Esophageal carcinosarcoma with basaloid squamous carcinoma and rhabdomyosarcoma components with TP53 mutation, Pathol Int, 54(10), 803-809, 20041001
  136. Inactivation of the p16 gene by hypermethylation and loss of heterozygosity in adenocarcinoma of the lung, Pathol Int, 54(7), 486-489, 20040701
  137. Meningioma in mature cystic teratoma of the ovary, Pathol Int, 54(7), 543-548, 20040701
  138. Granulocyte-Macrophage Colony-Stimulating Factor and Granulocyte Colony-Stimulating Factor-Producing Malignant Pleural Mesothelioma Accompanied by Eosinophilic Pleural Fluid, Japanese Journal of Lung Cancer, 44(1), 25-30, 20040220
  139. Myxopapillary ependymoma with anaplastic features, 53(10), 700-703, 20031001
  140. Case of clear cell ependymoma of medulla oblongata : Clinicopathological and immunohistochemical study with literature review, Pathol Int, 53(5), 297-302, 20030501
  141. Heterogeneity of expression of cytokeratin subtypes in squamous cell carcinoma of the lung : With special reference to CK14 overexpression in cancer of high-proliferative and lymphogenous metastatic potential, 52(4), 286-293, 20020401
  142. Extra-abdominal desmoid tumor presenting as an intrathoracic tumor : Case report and literature review, Pathol Int, 51(10), 824-828, 20011001
  143. PARAGANGLIOMA OF THE URINARY BLADDER : A CASE REPORT, 63(3), 151-153, 20010320
  144. In Vivo Histological Changes Occurring in Hydroxyapatite Cranial Reconstruction, 神経外科, 41(2), 100-104, 20010215
  145. Correlation between morphological heterogeneity and genetic alteration within one tumor in adenocarcinomas of the lung, Pathology International, 50(11), 891-896, 20001101
  146. Correlation between genetic alterations and histopathological subtypes in bronchiolo-alveolar carcinoma and atypical adenomatous hyperplasia of the lung, Pathology International, 50(10), 778-785, 20001001
  147. A case of malignant pericardial mesothelioma with secondary pulmonary hypertension due to pulmonary vein occulusion:Comprehensive review of 56 cases reported in Japan, Shinzo, 32(5), 438-445, 2000
  148. Idiopathic granulomatous meningoencephalitis presenting as an intracranial tumor, Pathology International, 49(12), 1084-1088, 19991201
  149. Correlation Among Histological Subtypes, Clinicopathological Factors, Expression of p53 Protein and Proliferative Activity in Adenocarcinoma of the Lung, Japanese Journal of Lung Cancer, 39(7), 995-1000, 19991201
  150. Down-regulation of KAI1 Messenger RNA Expression Is Not Associated with Loss of Heterozygosity of the KAI1 Gene Region in Lung Adenocarcinoma, Jpn J Cancer Res, 90(9), 970-976, 19990930
  151. Tubular seminoma of the testis, Pathology International, 49(7), 676-679, 199907
  152. Abstracts:THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY, Proceedings of the Japanese Histochemical Association, 32(6), 502-516, 1999
  153. Immunohistochemical and Molecular Pathological Analysis of Cell Cycle-related Factors in Human Multistep Carcinogenesis, Acta histochemica et cytochemica, 32(6), 1999
  154. Angiomyofibroblastoma of the vulva : A mitotically active variant?, Pathology International, 48(4), 292-296, 199804
  155. Histopathological and Immunohistochemical Analysis of 6 Cases of Solitary Fibrous Tumor of the Pleura, Japanese Journal of Lung Cancer, 38(2), 117-122, 199804
  156. Solitary fibrous tumor of the prostate, Pathology International, 47(10), 713-717, 199710
  157. Primary carcinoid tumor of the kidney with special reference to its histogenesis, Pathology International, 46(11), 894-900, 199611
  158. p16/CDKN2 Gene and p53 Geno Alteration in Japanese Non-smoking Female Lung Adenocarcinoma, Jpn J Cancer Res, 87(2), 134-140, 19960229
  159. Effects of K-ras Gene Mutations in the Development of Lung Lesions Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J Mice, Jpn J Cancer Res, 87(1), 44-50, 19960101
  160. Alteration of the p53 gene of lung carcinomas with sarcomatous transformation (spindle cell carcinoma) : Analysis of four cases, Pathol Int., 46(1), 38-45, 199601
  161. PATHOLOGY OF RESPIRATORY TRACT IN FORMER WORKERS IN MUSTARD GAS FACTORY : A REVIEW, J Toxicol Pathol, 8(4), 343-353, 19951201
  162. An Autopsy Case of Malignant Pleural Mesothelioma with Prominent Deposition of Chrysotile in the Lung, Japanese Journal of Lung Cancer, 35(6), 783-788, 19951020
  163. Pathological Findings of Atypical Carcinoid Tumors of the Thymus, Japanese Journal of Lung Cancer, 34(7), 1093-1098, 19941220
  164. A Clinicopathological Study of Carcinoembryonic Antigen (CEA) Expression Patterns in Small-sized Adenocarcinomas of the Lung, Japanese Journal of Lung Cancer, 32(7), 1049-1057, 19921220
  165. A Clinicopathological Study of Adenosquamous Carcinoma of the Lung, Japanese Journal of Lung Cancer, 32(4), 543-551, 19920820
  166. Histopathological former workers engaged in mustard gas factory, Med J Hiroshima Univ, 38, 853-863, 1990
  167. Idipatic granulomatous meningoencepalitis presenting as an intracranial tumor, Pathology International, 49, 1084-1088
  168. Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, p27KIP1expression in benign, atypical, and anplastic meningiomas, Human Pathology, 32, 970-975

Publications such as books

  1. 1991, Sporadic, Late-Onset Case of Familial Amyloid Polyneuropathy Type I (Andrade), A Clinical Study. , Kluwer Academic Publ., 1991

Invited Lecture, Oral Presentation, Poster Presentation

  1. Pathological Diagnosis of Mesothelioma Using Immunohistochemistry, Yukio Takeshima, JICA project "The improvement of diagnostic ability in early phase of pneumoconiosis and asbestosis-exposure related respiratory disease", 2019/11/19, Without Invitation
  2. Pathological diagnosis of lung cancer, Yukio Takeshima, JICA project "The improvement of diagnostic ability in early phase of pneumoconiosis and asbestosis-exposure related respiratory disease", 2019/06/27, Without Invitation
  3. Practice and Utility of Immunohistochemistry and genetic analysis for Pathological Diagnosis, Yukio Takeshima, JICA project "The improvement of diagnostic ability in early phase of pneumoconiosis and asbestosis-exposure related respiratory disease", 2019/06/27, Without Invitation, Ulaanbaatar, Mongolia
  4. Diagnostic utility of MUC4 expression to differentiate epithelioid mesothelioma from lung adenocarcinoma and squamous cell carcinoma, Amatya V.J., Mawas A.S., Kushitani K., Kai Y., Miyata Y., Okada M. and Takeshima Y., IASLC 18th World Conference on Lung Cancer, 2017/10/15, Without Invitation
  5. Identification of DAB2 and Intelection-1 as novel positive immunohistochemical markers of epithelioid mesothelioma, Kushitani K., Amatya V.J., Okada Y., Katayama Y., Mawas A.S., Miyata Y., Okada M., Inai K., Kishimoto T. and Takeshima Y., IASLC 18th World Conference on Lung Cancer, 2017/10/15, Without Invitation
  6. Usefulness of immunohistochemistry in the differential diagnosis of epithelioid mesothelioma and lung squamous cell carcinoma, Kushitani K., Amatya V.J., Okada Y., Katayama Y., Mawas A.S., Miyata Y., Okada M., Inai K., Kishimoto T. and Takeshima Y., IASLC 18th World Conference on Lung Cancer, 2017/10/15, Without Invitation
  7. Therapeutic strategies and genetic comparisons in SCLC and LCNEC of the lung using next-generation sequencing, Ito M., Miyata Y., Hirano S., Kimura S., Irisuna F., Kushitani K., Tsutani Y., Takeshima Y. and Okada M., IASLC 18th World Conference on Lung Cancer, 2017/10/15, With Invitation

Social Activities

History as Peer Reviews of Academic Papers

  1. 2014, Pathology International, Editorial board
  2. 2015, Pathology International, Editorial board
  3. 2015, Hiroshima J Medical Sciences
  4. 2016, Pathobiology, Reviewer, 2
  5. 2016, Cancer Science, Reviewer, 1
  6. 2016, Pathology International
  7. 2016, Pathology International, reviwer, 1
  8. 2016, Hiroshima J Medical Sciences
  9. 2017, Pathology International, Editor, 1