Norio Sakai

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), ., Professor
E-mail
nsakaihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1993/04/01, 1994/05/31, Japan Society for the Promotion of Science, Researcher
  • 1999/11/01, 2002/03/31, Kobe University, Associate Professor
  • 1994/06/01, 1999/10/31, Kobe University, Research Associate
  • 2002/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical Sciences , Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences , Professor

Educational Backgrounds

  • Kobe University, Graduate School, Division of Medicine, Dept of Pharmacology, Japan, 1989/04, 1993/03
  • Kobe University, Faculty of Medicine, Japan, 1979/04, 1986/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Kobe University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology

Research Keywords

  • neural plasticity
  • neuropsychiatric disease
  • cell death
  • protein kinase
  • phosphorylation
  • spinno cerebellar ataxia
  • serotonin transporter
  • neurodegenerative disease
  • Protein kinase C

Affiliated Academic Societies

  • society for neuroscience, 1995
  • The Japanese Society of Clinical Pharmacology and Therapeutics
  • Japan Society for Medical education, 2017/04

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, 4Term,
  2. 2019, Undergraduate Education, Year, Biological Responses
  3. 2019, Undergraduate Education, 2Term, Introduction for medical research
  4. 2019, Undergraduate Education, Year, Methodology in advanced medical sciences
  5. 2019, Undergraduate Education, 4Term, Medical Neuroscience I
  6. 2019, Undergraduate Education, First Semester, Medical Neuroscience II
  7. 2019, Undergraduate Education, Intensive, Practice for medical research
  8. 2019, Undergraduate Education, 2Term, Clinical pharmacology
  9. 2019, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  10. 2019, Graduate Education (Master's Program) , 4Term, General phrmacology
  11. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Molecular and pharmacological neuroscience
  12. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular and pharmacological neuroscience
  13. 2019, Graduate Education (Master's Program) , First Semester, Research on Molecular and pharmacological neuroscience
  14. 2019, Graduate Education (Master's Program) , Second Semester, Research on Molecular and pharmacological neuroscience
  15. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Molecular and pharmacological neuroscience
  16. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Molecular and pharmacological neuroscience
  17. 2019, Graduate Education (Master's Program) , First Semester, Research
  18. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Molecular and pharmacological neuroscience
  19. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Molecular and pharmacological neuroscience
  20. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  21. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  22. 2019, Graduate Education (Master's Program) , Second Semester, Research
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  24. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  25. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  26. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  27. 2019, Graduate Education (Master's Program) , 4Term, General Phrmacology
  28. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular and Pharmacological Neuroscience
  29. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular and Pharmacological Neuroscience
  30. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular and Pharmacological Neuroscience
  31. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular and Pharmacological Neuroscience

Research Activities

Academic Papers

  1. Effects of L-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region., Brain Research, 567, 267-273, 19910401
  2. Inhibitory modulation of long-term potentiation via the 5-HT_1A_ receptor in slices of the rat hippocampal dentate gyrus., Brain Research, 613, 326-330, 19930401
  3. A role for potassium and calcium channels in induction of long-lasting synaptic enhancement by calyculin A in rat hippocampal CA1 region., Neurosci. Lett., 176, 181-184, 19940401
  4. Presynaptic and Ca^2+^-independent PKC subspecies modulates NMDAR1 current., NeuroReport, 7, 477-480, 19960401
  5. Neuronal and glial localization of two GABA transporters ( GAT1 and GAT3) in the rat cerebellum., Mol. Brain Res., 37, 309-316, 19960401
  6. Electrophysiological and pharmacological characteristics of ionotropic glutamate receptors in medial vestibular nucleus neurons: A whole cell patch clamp study in acutely dissociated neurons., Jpn J Pharmacol, 72, 335-346, 19960401
  7. Modulation of serotonin transporter activity by a PKC activator and an inhibitor of type1 and 2A serine/threonine phosphatases., J. Neurochem., 68, 2618-2624, 19970401
  8. GABAergic neurotransmission in rat taste buds; Immunocytochemical study for GABA and GABA traspoter subtypes., Mol. Brain Res., 49, 29-36, 19970401
  9. Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABAtransporter., Neurosci. Res., 29, 87-91, 19970401
  10. Three distinct mechanisms for translocation and activation of δ-subspecies of protein kinase C., Mol. Cell. Biol., 18, 5263-5271, 19980401
  11. Transgenic animals with inducible targeted gene expression in brain., Mol Pharmacol, 54, 495-503, 19980401
  12. Subspecies-specific targeting mechanism of protein kinase C., Jpn J Pharmacol, 78, 411-417, 19980401
  13. Association study of a polymorphsim of nonerythroid a-spectrin gene with schizophrenia., Am. J. Med. Genet. (Neuropsychiatr. Genet.), 88, 291-293, 19990401
  14. Advanced glycation end product (AGE) inhibition as a possible pharmacotherapeutic strategy in the treatment of Alzheimer’s disease., Drugs Fut., 24, 411-416, 19990401
  15. Polymorphism of the apolipoproteinE promoter and bleomycin hydrolase gene: Risk factors for Alzheimer’s dementia ?, Neurosci. Lett., 274, 37-40, 19990401
  16. Identification and functional analysis of novel CREB splice variants lacking the bZIP domain., Mol Pharmacol, 56, 917-925, 19990401
  17. Induction of 55 kDa protein of PKN by ischemia/reperfusion model of rat retina., Invest. Ophthal. Vis. Sci., 41, 29-35, 20000401
  18. Involvement of the actin cytoskeleton in the regulation of serotonin transporter (SET) activity: possible mechanism underlying SET regulation by protein kinase C., Neurochem. Int., 36, 567-579, 20000401
  19. Phospholipase A2 and its products are involved in the purinergic receptor-mediated translocation of protein kinase C in CHO-K1 cells., J. Cell Sci., 113, 1335-1343, 20000401
  20. Regulation of GFRα-1 and GFRα-2 mRNAs in rat brain by electroconvulsive seizure., Synapse, 39, 42-50, 20010401
  21. cAMP response element-mediated gene transcription is upregulated by chronic antidepressnt treatment., J. Neurosci., 20, 4030-4036, 20000401
  22. Subtype-specific translocation of diacylglycerol kinase α and γ and its correlation with protein kinase C., J. Biol. Chem., 275, 24760-24766, 20000401
  23. Importance of PKC targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), J. Biol. Chem., 275, 26449-26457, 20000401
  24. Subtype-specific translocation of δ subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in Hela cells., Mol. Cell. Biol., 21, 1769-1783, 20010401
  25. Generation of a constitutively active fragment of PKN in Microglia/Macrophages after Middle Cerebral Artery Occlusion in Rats., J. Neurochem., 79, 903-913, 20010401
  26. Importance of C1B domain for lipid messenger-induced targeting of PKC., J. Biol. Chem., 277, 18037-18045, 20020401
  27. Inducible and brain region specific CREB transgenic mice, Mol Pharmacol, 61, 1453-1464, 20020401
  28. A new neuromodulator pathway with a glial contribution mediated via A2a adrenergic receptors., Glia, 39, 133-147, 20020401
  29. The silencer activity of the novel human serotonin transporter linked polymorphic region., Neurosci. Lett., 327, 13-16, 20020401
  30. Induction of apoptosis by Protein kinase C delta is independent of its kinase activity., J. Biol. Chem., 277, 18037-17045, 20020401
  31. Subtype- and species-specific knockdown of PKC using short interfering RNA., Biochem. Biophys. Res. Commun., 298, 738-743, 20020401
  32. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect., J. Neurosci., 24, 10883-10890, 20020401
  33. Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream site., Neurosci. Lett., 342, 175-178, 20030401
  34. Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 25(12), 1647-1650, 200212
  35. Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder., Neurosci Lett, 328(3), 249-252, 2002
  36. Involvement of Ca(2+) channels in abnormal excitability of hippocampal CA3 pyramidal cells in noda epileptic rats., J. Pharmacol. Sci., 91(2), 2003
  37. Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area., Neurosci. Lett., 347(2), 2003
  38. Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HT1A receptor., J. Pharmacol. Sci., 93(1), 114-117, 2003
  39. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra., J. Pharmacol. Sci., 93(2), 143-148, 2003
  40. Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons., J. Pharmacol. Sci., 1005(1-2), 143-148, 2004
  41. Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats., Neurochem. Int., 45(1), 171-178, 2004
  42. Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats., J. Pharmacol. Sci., 95(3), 355-362, 2004
  43. Propagation of gammaPKC translocation along the dendrites of Purkinje cell in gammaPKC-GFP transgenic mice., Genes to Cells, 9(10), 945-957, 2004
  44. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons., Mol. Brain Res., 129(1-2), 1-7, 2004
  45. Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase C delta in the Golgi complex, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(13), 12668-12676, 20040326
  46. Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia, JOURNAL OF IMMUNOLOGY, 173(7), 4582-4589, 20041001
  47. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT)., Neurochem. Int, 46(2), 93-105, 2005
  48. Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol, GENES TO CELLS, 10(4), 311-319, 200504
  49. Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC., Genes to Cells, 10(3), 225-239, 2005
  50. Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death., J. Biol. Chem, 280(32), 29096-29106, 2005
  51. Maitake D-fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice, NUTRITION, 21(5), 624-629, 200505
  52. Protein kinase C-alpha a mediates TNF release process in RBL-2H3 mast cells, BRITISH JOURNAL OF PHARMACOLOGY, 145(4), 415-423, 200506
  53. Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain, BRAIN RESEARCH, 1053(1-2), 154-161, 20050816
  54. Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role., J. Neurosci Res., 83(8), 1461-1470, 2006
  55. Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4., Movement Disorders, 21(9), 1355-1360, 2006
  56. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death., J. Neurochem., 98(1), 45-56, 2006
  57. R659S mutation of gammaPKC is susceptible to cell death: implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa., Neurochem. Int., 49(7), 669-675, 2006
  58. Fused protein of delta PKC activation loop and PDK1-interacting fragment (delta AL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells, GENES TO CELLS, 11(9), 1051-1070, 200609
  59. Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats., J. Neurosurg Spine, 6(5), 412-419, 2007
  60. BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures, SPINE, 32(12), 1272-1278, 20070520
  61. Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain., Acta Histochem.Cytochem., 40(4), 113-121, 2007
  62. Spatiotemporal analysis of the molecular interaction between PICK1 and PKC, ACTA HISTOCHEMICA ET CYTOCHEMICA, 39(6), 173-181, 2006
  63. Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures., Spine, 32(21), 2320-2305, 2007
  64. Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress., Eur. J. Neurosci., 26(11), 3126-3140, 2007
  65. Effects of ATP on the release of nitric oxide in microglia, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127, 193-195, 2007
  66. Enzymological analysis of mutant protein kinase C gamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis, JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19854-19863, 20080711
  67. N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations, BRAIN RESEARCH BULLETIN, 75(5), 663-667, 20080328
  68. Signaling and neuroprotective function of alpha 7 nicotinic acetylcholine receptors in microglia, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128, 38-40, 2008
  69. Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma, ONCOGENE, 27(57), 7162-7170, 200812
  70. Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells., Neurobiol. Dis., 33(2), 260-273, 2009
  71. Cell-dependent physiological synaptic action of morphine in the rat habenular nucleus: Morphine both inhibits and facilitates excitatory synaptic transmission, NEUROSCIENCE LETTERS, 451(3), 270-273, 20090227
  72. mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons, NEUROSCIENCE LETTERS, 453(1), 62-67, 20090327
  73. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation., J. Pharmacol. Sci, 111(4), 392-404, 2009
  74. Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy., Genes to Cells, 15(5), 425-437, 2010
  75. Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells., J Biol. Chem., 285(43), 33252-33264, 2010
  76. Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation., J. Pharmacol. Sci., 114(2), 33252-33264, 2010
  77. Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity, MOLECULAR NUTRITION & FOOD RESEARCH, 54(4), 516-524, 201004
  78. A critical role of conventional protein kinase C in morphological changes of rodent mast cells., Immunol. Cell Biol., 89(1), 149-159, 2011
  79. Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia., J. Neurochem., 116(6), 1138-1147, 2011
  80. Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cγ., J. Pharmacol. Sci., 116(3), 239-247, 2011
  81. Molecular pathophysiology of neurodegenerative disease caused by γPKC mutations., World J. Biol. Psychiatry, 12 Suppl 1, 95-98, 2011
  82. Direct binding of RalA to PKC eta and its crucial role in morphological change during keratinocyte differentiation, MOLECULAR BIOLOGY OF THE CELL, 22(8), 1340-1352, 20110415
  83. Mutant PKC gamma in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo, JOURNAL OF NEUROSCIENCE, 31(40), 14324-14334, 20111005
  84. Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival., Neurochem. Int, 60(4), 431-442, 2012
  85. Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron., PLoS ONE, 7(2), e31232, 2012
  86. Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells., J. Pharmacol. Sci., 121(1), 25-38, 2013
  87. Effects of the chemical chaperone 4-phenylbutylate on the function of the serotonin transporter (SERT) expressed in COS-7 cells., J. Pharmacol. Sci., 122(2), 71-83, 2013
  88. JosD1, a Membrane-targeted Deubiquitinating Enzyme, Is Activated by Ubiquitination and Regulates Membrane Dynamics, Cell Motility, and Endocytosis, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(24), 17145-17155, 20130614
  89. A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(41), 29934-29942, 20131011
  90. Principles for the use of in vivo transgene techniques: overview and an introductory practical guide for the selection of tetracycline-controlled transgenic mice., Methods Mol Biol., 1142, 2014
  91. Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14., Frontiers in Physiology, 5, 2014
  92. Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli., Neurobiol. Dis., 68, 2014
  93. The Role of Pak-Interacting Exchange Factor-beta Phosphorylation at Serines 340 and 583 by PKC gamma in Dopamine Release, JOURNAL OF NEUROSCIENCE, 34(28), 9268-9280, 20140709
  94. Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility., Psychopharmacology, 232(1), 2015
  95. Identification and characterization of PKCP gamma, a kinase associated with SCA14, as an amyloidogenic protein, HUMAN MOLECULAR GENETICS, 24(2), 525-539, 20150115
  96. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study, CURRENT MOLECULAR MEDICINE, 15(3), 265-274, 2015
  97. The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons, PLOS ONE, 11(1), 20160122
  98. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, NEUROCHEMISTRY INTERNATIONAL, 93, 82-94, 201602
  99. The Development of Screening Methods to Identify Drugs to Limit ER Stress Using Wild-type and Mutant Serotonin Transporter, ACTA HISTOCHEMICA ET CYTOCHEMICA, 49(6), 197-206, 2016
  100. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4-and 3-repeat tau, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37(7), 2441-2457, 201707
  101. Yokukansan enhances the proliferation of B65 neuroblastoma., J. Traditional Complement. Med., 7, 34-44, 2017
  102. Validation of Anti-CSP alpha, SNAP25, Tyrosine Hydroxylase, Ubiquitin, Cleaved Caspase 3, and pSer PKC Motif Antibodies for Utilization in Western Blotting, ACTA HISTOCHEMICA ET CYTOCHEMICA, 50(6), 177-180, 2017
  103. The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38(2), 278-290, 20180110
  104. Propofol induced diverse and subtype-specific translocation of PKC families, JOURNAL OF PHARMACOLOGICAL SCIENCES, 137(1), 20-29, 201805
  105. Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKC gamma in spinocerebellar ataxia type 14, JOURNAL OF BIOLOGICAL CHEMISTRY, 293(38), 14758-14774, SEP 21 2018
  106. SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism, JOURNAL OF PHARMACOLOGICAL SCIENCES, 139(1), 29-36, 201901
  107. Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene, MOLECULAR AND CELLULAR NEUROSCIENCE, 98, 46-53, 201907

Invited Lecture, Oral Presentation, Poster Presentation

  1. The subcellular localization and local function of Gs-linked receptor GPR3 in neuronal cells, Miyagi T, Tanaka S, Sakai N et.al, Neuroscience meeting 2014 , 2014/11/18, Without Invitation
  2. SKF-10047, a prototype Sigma-1 receptor agonist, accelerated the membrane trafficking and uptake activity of serotonin transporter and its mutant via the mechanism independent of Sigma-1receptor., Norio Sakai, Masaya Asano, Chika Yokota, Naoto Usuki, Hikaru Yamamoto, Izumi Hide, Shigeru Tanaka, 2018/07/02, Without Invitation
  3. Purinergic receptor is involved in dying cell phagocytosisi and mediator production in Toll-like receptor 4-activated microglia, Izumi Hide, Hiroko Shiraki,, Yuhki Yanase, Toshihiko Shirafuji, Shigeru, Tanaka, Norio Sakai, 2018/07/02, Without Invitation
  4. Potential role of G-protein-coupled receptor 3 in mast cells following brain ischemia., Shigeru Tanaka, Yuhki Yanase, Masahiro Yamamoto, Tatsuhiro Miyagi, Hiroko, Shiraki, Izumi Hide, Norio Sakai, 2018/07/03, Without Invitation
  5. Intrinsic expression of G protein-coupled receptor 3 facilitates formation of neuronal polarity in hippocampal neurons., Shigeru Tanaka, Naoto Shimada, Masahiro Yamamoto, Tatsuhiro Miyagi, Hiroko, Shiraki, Isumi Hide Norio Sakai, Neuroscience meeting 2018, 2018/11/04, Without Invitation, Society for Neuroscience, San Diego
  6. SKF-10047, a prototype Sigma-1 receptor agonist, facilitated the membrane trafficking and uptake activity of serotonin transporter and its mutant through thesigma-1 receptor-independent mechanism., Masaya Asano, Hikaru Yamamoto, Izumi Hide, Shigeru Tanaka, Norio Sakai, Neuroscience meeting 2018, 2018/11/04, Without Invitation, Society for Neuroscience, San Diego

Social Activities

Organizing Academic Conferences, etc.

  1. 第133回日本薬理学会近畿部会, 1806/01, 1806/01