TAKAHIRO CHIHARA

Last Updated :2017/11/01

Affiliations, Positions
Graduate School of Science, ., Professor
E-mail
tchiharahiroshima-u.ac.jp
Self-introduction
I am trying to reveal the molecular mechanism underlying neural network formation by using fruit fly, Drosophila melanogaster.

Basic Information

Major Professional Backgrounds

  • 2016/03, Hiroshima University, Graduate School of Science, Department of Biological Science, Professor
  • 2013/10, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor
  • 2010/08, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Lecturer
  • 2009/10, 2013/03, JST, PRESTO, PRESTO Researcher
  • 2007/04, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2006/04, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2006/02, Stanford University, Department of Biological Science, Stanford University postdoc fellow
  • 2004/02, Stanford University, Department of Biological Science, JSPS Research Fellow abroad
  • 2002/02, Stanford University, Department of Biological Science, JST young scientist abroad
  • 2001/04, National Institute of Genetics, Lab for Invertebrate Genetics, JSPS Research Fellow (PD)

Academic Degrees

  • Kumamoto University
  • The Graduate University for Advanced Studies

Research Fields

  • Biology;Biological Science;Developmental biology
  • Biology;Biological Science;Cell biology
  • Biological Sciences;Neuroscience;Neurophysiology / General neuroscience

Research Keywords

  • Neural Development, animal behavior, Neural network, Synapse, Olfactory system, dendrite, Meigo, Unfolded Stress Response, Hippo, Strip, Vesicle trafficking, Genetic mosaic method, Drosophila

Affiliated Academic Societies

  • Japanese Society for Developmental Society, The Japan Society for Neurochemistry, The Japan Neuroscience Society, The Molecular Biology Society of Japan, The Japanese Biochemical Society, Japan Society for Cell Biology, Society for Neuroscience, Genetic Society of America

Educational Activity

Course in Charge

  1. 2017, Liberal Arts Education Program1, First Semester, Fundamentals of Biology
  2. 2017, Liberal Arts Education Program1, Second Semester, Introduction to Biological Sciences B
  3. 2017, Liberal Arts Education Program1, First Semester, Introductory Seminar for First-Year Students
  4. 2017, Undergraduate Education, First Semester, Advanced Biology
  5. 2017, Undergraduate Education, Second Semester, Seminar for cell biology
  6. 2017, Undergraduate Education, Year, Biology Internship
  7. 2017, Undergraduate Education, First Semester, Special Study for Graduation
  8. 2017, Undergraduate Education, Second Semester, Special Study for Graduation
  9. 2017, Undergraduate Education, First Semester, Molecular Cell Biology
  10. 2017, Undergraduate Education, First Semester, Recent Developments in Biological Sciences
  11. 2017, Graduate Education (Master's Program) , Second Semester, Genetics and Evolution
  12. 2017, Graduate Education (Master's Program) , First Semester, Seminar for cell biology
  13. 2017, Graduate Education (Master's Program) , Second Semester, Seminar for cell biology
  14. 2017, Graduate Education (Master's Program) , First Semester, Special Research for Thesis
  15. 2017, Graduate Education (Master's Program) , Second Semester, Special Research for Thesis
  16. 2017, Graduate Education (Doctoral Program) , First Semester, Seminar for cell biology
  17. 2017, Graduate Education (Doctoral Program) , Second Semester, Seminar for cell biology

Research Activities

Academic Papers

  1. Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila, GENES & DEVELOPMENT, 31(10), 1054-1065, MAY 15 2017
  2. Role of the STRIPAK complex and the Hippo pathway in synaptic terminal formation, Neural Regen Res, 12, 578-579
  3. The Strip-Hippo pathway regulates synaptic terminal formation by modulating actin organization at the Drosophila neuromuscular synapses, Cell Reports, 16, 2289-2297, 2016
  4. Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy, Am J Hum Genet, 99(4), 950-961, OCT 6 2016
  5. Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43., J Biol Chem, 291, 23464-23476
  6. Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development., Neural Regen Res, 11, 1394-1395, 2016
  7. Tissue non-autonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila., Proc Natl Acad Sci U S A, 113, 1835-1840, 2016
  8. Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos., Genes to Cells, 21, 53-64, 2016
  9. A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability., Scientific Reports, 5, 17769, 2015
  10. The roles of tubulin-folding cofactors in neuronal morphogenesis and disease., Neural Regeneration Research, 10(9), 1388-1389, 2015
  11. Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis., The Journal of Neuroscience, 35(5), 1979-1990, 2015
  12. Drosophila Strip serves as a platform for early endosome organization during axon elongation., Nature Communications, 5, 5180, 2014
  13. Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila., PLOS Genetics, 10(6), e1004437, 2014
  14. Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit., Genes and Genetic Systems, 89(1), 17-26, 2014
  15. RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy, Hum. Mol. Genet., 22, 4474-4484, 2013
  16. Meigo governs dendrite targeting specificity by modulating Ephrin level and N-glycosylation, Nature Neuroscience, 16, 683-689, 2013
  17. Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster, PLOS ONE, 7, e30265, 2012
  18. Histon deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero, The Journal of Neuroscience, 21, 9939-9946, 2010
  19. Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain, Development, 137, 43-51, 2010
  20. Organelles in developing neurons: essential regulators of neuronal morphogenesis and function, Int. J. Dev. Biol., 53, 19-27, 2009
  21. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization, Nature Neuroscience, 10, 828-837, 2007
  22. Wiring stability of the adult Drosophila olfactory circuit after lesion, The Journal of Neuroscience, 26, 3367-3376, 2006
  23. Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea, Development, 131, 5253-5261, 2004
  24. Like poles repel: Molecular mechanisms of dendritic tiling, Cell, 119, 148-149, 2004
  25. Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila, Development, 130, 1419-1428, 2003
  26. Control of tracheal tubulogenesis by Wingless signaling, Development, 127, 4433-4442, 2000
  27. Myeloid ELF-1-like factor up-regulates lysozyme transcription in epithelial cells, The Journal of Biological Chemistry, 274, 20098-20102, 1999