YOKI NAKAMURA

Last Updated :2019/11/11

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), ., Assistant Professor
E-mail
nakayokihiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi Minami-ku, Hiroshima, Japan 734-8553, Japan
TEL : (+81)82-257-5312 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant professor
  • 2018/02/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/11/01, 2018/01/22, National Institute on Drug Abuse, Cellular Pathobiology Section, Visiting Fellow
  • 2013/04/01, 2013/10/31, Hiroshima University, Institute of Biomedical & Health Sciences, Post doctoral fellow

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Doctoral Course, Japan, 2010/04, 2013/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Master's Course, Japan, 2008/04, 2010/03
  • Fukuyama University, Japan, 2004/04, 2008/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • Neuropathic pain, Allodynia, Drug addiction, Psychiatric disorder, Sigma receptor, HMGB1

Affiliated Academic Societies

  • Japanese Pharmacological Society (Scientific council)
  • Pharmaceutical Society of Japan
  • Japanese Association for Study of Pain
  • Japanese Society of Neuropsychopharmacology
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, First Semester, Practice of Pharmacology
  2. 2019, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students

Research Activities

Academic Papers

  1. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion., eLife, 8, 2019
  2. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes., European journal of pharmacology, 2019
  3. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1β in activated astrocytes., Journal of neurochemistry, 2019
  4. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics., Biological & pharmaceutical bulletin, 42(6), 2019
  5. High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain., Progress in neuro-psychopharmacology & biological psychiatry, 2019
  6. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice., Brain, behavior, and immunity, 2019
  7. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice., Glia, 66(2), 2018
  8. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice., Molecular and cellular neurosciences, 72, 2016
  9. The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems., Trends in pharmacological sciences, 37(4), 2016
  10. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression., Life sciences, 155, 2016
  11. Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase., Neurochemistry international, 101, 2016
  12. Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia., Journal of neuroscience research, 93(4), 2015
  13. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice., Brain, behavior, and immunity, 49, 2015
  14. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloproteinase-9 upregulation in mice with painful peripheral neuropathy., Journal of neurochemistry, 2015
  15. A β1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes., Journal of cellular physiology, 229(3), 2014
  16. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2., Journal of neurochemistry, 131(6), 2014
  17. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor., Neuroscience, 258, 2014
  18. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., Journal of pharmacological sciences, 121(4), 2013
  19. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons., Brain research, 1509, 2013
  20. The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway., Neuropharmacology, 75, 2013
  21. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1., PloS one, 8(8), 2013
  22. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons., Journal of neurochemistry, 120(6), 2012
  23. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice., Neurochemistry international, 60(8), 2012
  24. Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels., Neuropharmacology, 57(1), 2009

Invited Lecture, Oral Presentation, Poster Presentation

  1. The possibility of HMGB1 as a therapeutic target for neuropathic pain., Nakamura Y, Nakashima K, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11/06, With Invitation
  2. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N., 9th International DAMPs and Alarmins Symposium, 2019/11/06, Without Invitation
  3. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10/23, Without Invitation
  4. Sigma-1 receptor control of cocaine-induced endocannabinoid signaling via inhibition of extracellular vesicle release in the ventral tegmental area, Dryanovski D, Nakamura Y, Su TP, Lupica C, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation
  5. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia, Kodama K,Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka M, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation
  6. Cocaine Increases Endocannabinoids-Containing Extracellular Vesicles Release from Dopaminergic Neurons via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Lupica C, Su TP, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/13, Without Invitation
  7. Systemic inflammation-induced memory disfunction is prevented by blockade either microglia activation or histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/12, Without Invitation
  8. The mechanisms underlying cocaine-evoked extracellular vesicles release via sigma-1 receptor-ARF6 pathway, Nakamura Y, Su TP, The 139th Annual Meeting of the Pharmaceutical Society of Japan, 2019/03/21, Without Invitation
  9. The nuclear receptor REV-ERBs suppress the pro-inflammatory responses in cultured microglia, Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation
  10. Effects of histone deacetylase inhibitor on lipopolysaccharide-induced cognitive impairment., Takada N, Nakashima K, Nakamura Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation
  11. Activation of toll-like receptor 4 induces downregulation of alpha 7 nicotinic acetylcholine receptor in microglia, Nakamura Y, Kimura S, Takemura M, Kodama K, Iwamoto M, Nakashima K, Nakata Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/14, Without Invitation
  12. Sigma-1 Receptor Control of Extracellular Vesicle Release and Cocaine-Induced Endocannabinoid Signaling in the Ventral Tegmental Area (VTA), Dryanovski D, Nakamura Y, Su TP, Lupica C, 2019 WINTER CONFERENCE ON BRAIN RESEARCH, 2019/01/31, Without Invitation
  13. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Morioka N, Kondo S, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation
  14. The analysis of anxiety-and depression-related behaviors in neuropathic pain of mice -possible involvement of brain inflammation, Hisaoka-Nakashima K, Tomimura Y, Yoshii T, Zhang FF, Nakamura Y, Liu K, Nishibori M, Nakata Y, Morioka N, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation
  15. Cocaine Regulates Endocannabinoids-Containing Extracellular Vesicles Release in Ventral Tegmental Area via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Jackson S, Tsai SY, Woods A, Lupica C, Su TP, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/02, Without Invitation
  16. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and neuropathic pain, Morioka N, Fujii S, Kondo S, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y., 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/26, Without Invitation
  17. Cocaine regulates extracellular vesicle release in mouse midbrain, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation
  18. Sigma1 receptor modulates cocaine-induced endocannabinoid signaling in the mouse ventral tegmental area, Dryanovski DI, Nakamura Y, Su TP, Lupica CR, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation
  19. Cocaine stimulation causes the release of the sigma-1receptor chaperone into the extracellular space, Nakamura Y, Tsai SY, Su TP, KEYSTONE SYMPOSIA-Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication (E4)-, 2016, Without Invitation
  20. Psychostimulant cocaine causes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2016, Without Invitation
  21. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission, Fukushige R, Nakamura Y, Morioka N, Nakata Y, The 89th Annual Meeting of The Japanese Pharmacological Society, 2016, Without Invitation
  22. Cocaine evokes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Li Y, Lin DT, and Su TP, Society for Neuroscience Annual Meeting, 2015, Without Invitation
  23. The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, Society for Neuroscience Annual Meeting, 2015, Without Invitation
  24. Cocaine stimulation causes the release of the sigma-1 receptor into the extracellular space, Nakamura Y, Tsai SY, Su TP, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015, Without Invitation
  25. Cocaine stimulating the release of the ER chaperone sigma-1 receptor into the extracellular vesicles as an emerging role in cocaine-induced neuroplasticity, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2014, Without Invitation
  26. The involvement of beta-adrenergic receptors in the regulation of c-jun N-terminal kinase and CCL2 production in TNF-stimulated spinal astrocytes, Morioka N, Abe H, Araki R, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 87th Annual Meeting of The Japanese Pharmacological Society, 2014, Without Invitation
  27. Increased high mobility group box 1 in spinal dorsal horn plays a critical role in the maintenance of neuropathic pain in rats with partial sciatic nerve ligation, Nakamura Y, Morioka N, Abe H, Zhang FF, Hisaoka-Nakashima K, Liu K, Nishibori M, Nakata Y, The 86th Annual Meeting of The Japanese Pharmacological Society, 2013, Without Invitation
  28. Cytokines induce a down-regulation of connexin 43-gap junction in spinal astrocytes, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, 2013, Without Invitation
  29. Substance P release occurs from the rat striatum after intraplantar formalin injection to suppress nociceptive responses via activation of neurokinin 1 receptor, Nakamura Y, Izumi H, Morioka N, Hisaoka-Nakashima K, Takebayashi M, Nakata Y, Society for Neuroscience Annual Meeting, 2012, Without Invitation
  30. Activation of transient receptor potential ankyrin 1 evokes nociception through phosphorylation of p38 mitogen-activated protein kinase and subsequent substance P release, Nakamura Y, Morioka N, Nakata Y, The 34th annual meeting of Japanese association for the study of pain, 2012, Without Invitation
  31. Transient receptor potential ankyrin 1 mediated release of substance P in primary sensory neurons is dependent on calcium and p38 mitogen activated protein kinase activation, Nakamura Y, Une Y, Abe H, Miyano K, Hisaoka K, Morioka N, Nakata Y, Society for Neuroscience Annual Meeting, 2011, Without Invitation
  32. The activation of transient receptor potential ankirin 1 evokes substance P release from rat dorsal root ganglion neurons through the phosphorylation of p38 mitogen-activated protein kinase, Nakamura Y, Une Y, Abe H, Hisaoka K, Morioka N, Nakata Y, The 84th Annual Meeting of The Japanese Pharmacological Society, 2011, Without Invitation
  33. Influence of continuous administration of SP into the rat striatum on formalin-induced pain behaviors, Nakamura Y, Une Y, Abe H, Miyano K, Morioka N, Nakata Y, The 83rd Annual Meeting of The Japanese Pharmacological Society, 2010, Without Invitation
  34. Effects of anti-mitotic drugs on the release of substrance P from cultured dorsal root ganglion cells, Miyano K, Nakamura Y, Tang HB , Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation
  35. Functional analysis of substance P release in rat brain, Nakamura Y, Tang HB , Miyano K, Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation

Awards

  1. 2013年, The JPS Prize 2014 Awards, The Japanese Pharmacological Society

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Research Activity start-up, 2018/08/24, 2020/03/31
  2. JSPS-NIH Fellowship, 2015/01/01, 2016/12/31

Social Activities

History as Peer Reviews of Academic Papers

  1. 2019, YAKUGAKU ZASSHI, Reviewer, 1
  2. 2019, Biological and Pharmaceutical Bulletin, Reviewer, 1
  3. 2018, Biological and Pharmaceutical Bulletin, Reviewer, 1
  4. 2017, Biological and Pharmaceutical Bulletin, Reviewer, 1