YOKI NAKAMURA

Last Updated :2024/05/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
Web Site
https://pha.hiroshima-u.ac.jp/
E-mail
nakayokihiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi Minami-ku, Hiroshima, Japan 734-8553, Japan
TEL : (+81)82-257-5312 FAX : (+81)
Self-introduction
I'm conducting research to develop new therapeutic agents based on the elucidation of the pathophysiology of chronic pain and central nervous system diseases.

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant professor
  • 2018/02/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/11/01, 2018/01/22, National Institute on Drug Abuse, Cellular Pathobiology Section, Visiting Fellow
  • 2013/04/01, 2013/10/31, Hiroshima University, Institute of Biomedical & Health Sciences, Post doctoral fellow

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Doctoral Course, Japan, 2010/04, 2013/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Master's Course, Japan, 2008/04, 2010/03
  • Fukuyama University, Japan, 2004/04, 2008/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • Microglia, Neuropathic pain, Trigeminal neuropathy, Cellular senescence, Drug addiction, Psychiatric disorder, Sigma receptor, HMGB1

Affiliated Academic Societies

  • Japanese Pharmacological Society (Scientific council)
  • Pharmaceutical Society of Japan
  • Japanese Association for Study of Pain
  • Japanese Society of Neuropsychopharmacology
  • Japan Society for Biomedical Gerontology
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  2. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  3. 2024, Undergraduate Education, 4Term, Pharmacology IV
  4. 2024, Undergraduate Education, First Semester, Practice of Pharmacology

Research Activities

Academic Papers

  1. High mobility group box-1: a therapeutic target for analgesia and associated symptoms in chronic pain., Biochemical Pharmacology, 2024
    Link to Paper Search Results by DOI
  2. Perineural treatment with high mobility group box-1 monoclonal antibody prevents initiation of pain-like behaviors in female mice with trigeminal neuropathy, Biological and Pharmaceutical Bulletin, 2024
    Link to Paper Search Results by DOI
  3. Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes, International Immunopharmacology, 127, 111349, 2024
    Link to Paper Search Results by DOI
  4. Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats, Behavioural Brain Research, 459, 114786, 2024
    Link to Paper Search Results by DOI
  5. Investigation of Chronic Pain for the Development of Novel Analgesics Focusing on High Mobility Group Box-1, YAKUGAKU ZASSHI, 144(1), 15-18, 2024
    Link to Paper Search Results by DOI
  6. Inhibition of nuclear receptor ROR gamma ameliorates mechanical hypersensitivity through the suppression of spinal microglial activation, Neuroscience, 2023
    Link to Paper Search Results by DOI
  7. Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain, Experimental Neurology, 2023
    Link to Paper Search Results by DOI
  8. Evaluation of intracellular signal molecules that regulate TLR4-stimulated inflammatory mediator expression in cultured rat chondrocytes, Journal of Pharmacological Sciences, 2023
    Link to Paper Search Results by DOI
  9. Microglia and innate immunity in Alzheimer's disease, Folia Pharmacologica Japonica, 158(2), 211, 2023
    Link to Paper Search Results by DOI
  10. Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy, Neurochemistry International, 163, 2023
    Link to Paper Search Results by DOI
  11. Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation., International Immunopharmacology, 2022
    Link to Paper Search Results by DOI
  12. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, Neurochemistry International, 160, 2022
    Link to Paper Search Results by DOI
  13. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain, Experimental Neurology, 2022
    Link to Paper Search Results by DOI
  14. Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor1/3, Src, and extracellular signal-regulated kinase., European journal of pharmacology, 925, 174986, 2022
    Link to Paper Search Results by DOI
  15. Mirogabalin alleviates nociceptive hypersensitivity without causing sedation in a mouse model of post-traumatic trigeminal neuropathy, Behavioural Brain Research, 425, 113829, 2022
    Link to Paper Search Results by DOI
  16. Pentobarbital may protect against neurogenic inflammation after surgery via inhibition of substance P release from peripheral nerves of rats, Neuroscience Letters, 2022
    Link to Paper Search Results by DOI
  17. Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease, Biomedicine & Pharmacotherapy, 145, 112479, 2022
    Link to Paper Search Results by DOI
  18. Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia, Neurochemistry International, 151, 2021
    Link to Paper Search Results by DOI
  19. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes., Journal of Neurochemistry, 158(4), 849-864, 2021
    Link to Paper Search Results by DOI
  20. p-Nitroterphenyl Units for Near-Infrared Two-Photon Uncaging of Calcium Ions, Journal of Photochemistry and Photobiology A: Chemistry, 409, 113154, 2021
    Link to Paper Search Results by DOI
  21. Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain, Molecular Neurobiology, 58(6), 2523-2541, 2021
    Link to Paper Search Results by DOI
  22. Downregulation of connexin43 potentiates noradrenalineinduced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes., Journal of Cellular Physiology, 2021
    Link to Paper Search Results by DOI
  23. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn., Biochemical Pharmacology, 186, 114496, 2021
    Link to Paper Search Results by DOI
  24. Pretreatment with high mobility group box-1 monoclonal antibody prevents the onset of trigeminal neuropathy in mice with a distal infraorbital nerve chronic constriction injury., 26(7), 2035-2035, 2021
    Link to Paper Search Results by DOI
  25. Treatment with histone deacetylase inhibitor attenuates peripheral inflammation-induced cognitive dysfunction and microglial activation: the effect of SAHA as a peripheral HDAC inhibitor., Neurochemical Research, 2021
    Link to Paper Search Results by DOI
  26. Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice, Biochemical and Biophysical Research Communications, 2021
    Link to Paper Search Results by DOI
  27. Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms., Cells, 9(5), 2020
    Link to Paper Search Results by DOI
  28. Stimulation of toll-like receptor 4 downregulates the expression of alpha7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia., Neurochemistry International, 138, 2020
    Link to Paper Search Results by DOI
  29. Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors, Behavioural Brain Research, 391, 2020
    Link to Paper Search Results by DOI
  30. TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia, Journal of Pharmacological Sciences, 144(1), 23-29, 2020
    Link to Paper Search Results by DOI
  31. Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freunds adjuvant, Biochemical and Biophysical Research Communications, 533(4), 971-975, 2020
    Link to Paper Search Results by DOI
  32. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion, eLIFE, 8, 20191009
    Link to Paper Search Results by DOI
  33. High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, Neuro-Psychopharmacology & Biological Psychiatry, 92, 347-362, 2019
    Link to Paper Search Results by DOI
  34. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice, Brain, Behavior, and Immunity, 78, 116-130, 2019
    Link to Paper Search Results by DOI
  35. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics, Biological and Pharmaceutical Bulletin, 42(6), 857-866, 2019
    Link to Paper Search Results by DOI
  36. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1 beta in activated astrocytes, Journal of neurochemistry, 150(6), 738-758, 2019
    Link to Paper Search Results by DOI
  37. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes, European Journal of Pharmacology, 860, 2019
    Link to Paper Search Results by DOI
  38. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, Glia, 66(2), 428-444, 2018
    Link to Paper Search Results by DOI
  39. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice., Molecular and cellular neurosciences, 72, 2016
    Link to Paper Search Results by DOI
  40. The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems., Trends in pharmacological sciences, 37(4), 2016
    Link to Paper Search Results by DOI
  41. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression., Life sciences, 155, 2016
    Link to Paper Search Results by DOI
  42. Stimulation of spinal dorsal horn beta2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase., Neurochemistry international, 101, 2016
    Link to Paper Search Results by DOI
  43. Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia., Journal of neuroscience research, 93(4), 2015
    Link to Paper Search Results by DOI
  44. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice., Brain, behavior, and immunity, 49, 2015
    Link to Paper Search Results by DOI
  45. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloproteinase-9 upregulation in mice with painful peripheral neuropathy., Journal of neurochemistry, 2015
    Link to Paper Search Results by DOI
  46. A beta1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes., Journal of cellular physiology, 229(3), 2014
    Link to Paper Search Results by DOI
  47. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2., Journal of neurochemistry, 131(6), 2014
    Link to Paper Search Results by DOI
  48. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the alpha7 nicotinic acetylcholine receptor., Neuroscience, 258, 2014
    Link to Paper Search Results by DOI
  49. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., Journal of pharmacological sciences, 121(4), 2013
    Link to Paper Search Results by DOI
  50. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons., Brain research, 1509, 2013
    Link to Paper Search Results by DOI
  51. The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-kappaB pathway., Neuropharmacology, 75, 2013
    Link to Paper Search Results by DOI
  52. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1., PloS one, 8(8), 2013
    Link to Paper Search Results by DOI
  53. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice., Neurochemistry international, 60(8), 2012
    Link to Paper Search Results by DOI
  54. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons., Journal of neurochemistry, 120(6), 2012
    Link to Paper Search Results by DOI
  55. Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels., Neuropharmacology, 57(1), 2009
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Application in the treatment of central nervous system diseases by delivery of antibody therapeutics via the nose-to-brain pathway, Morioka N, Hisaoka-Nakashima K, Nakamura Y, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/16, With Invitation, English
  2. Influence of mitochondrial DNA- cyclic GMP-AMP synthase pathway on inflammatory response in microglia, Nakano M, Nakamura Y, Iwamoto M, Hisaoka-Nakashima K, Morioka N, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/16, Without Invitation, English
  3. Involvement of hippocampal microglial activity in persistent pain in a mouse model of knee osteoarthritis, Yamamoto K, Nakamura Y, Hisaoka-Nakashima K, Morioka N, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/15, Without Invitation, Japanese
  4. Development of novel approaches to clarify the age-related changes in microglial function, Nakamura Y, Hisaoka-Nakashima K, Morioka N, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/14, With Invitation, English
  5. Drug developmental strategies based on functional analysis of pain-regulating molecules in astrocytes under chronic pain, Morioka N, Nakamura Y, Hisaoka-Nakashima K, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/14, With Invitation, English
  6. Mitochondrial dysfunction exacerbates inflammatory responses in primary cultured chondrocytes, Motonari H, Tanaka Y, Nakamura Y, Hisaoka-Nakashima K, Morioka N, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/14, Without Invitation, Japanese
  7. Amitriptyline potentiates the expression of brain-derived neurotrophic factor by enhancing downstream signal of lysophosphatidic receptors in connexin43 knockdown astrocyte, Tokunaga N, Nakamura Y, Hisaoka-Nakashima K, Morioka N, The 97th Annual Meeting of the Japanese Pharmacological Society, 2023/12/14, Without Invitation, English
  8. Preventive effect of anti-HMGB1 nAb on the onset of distal infraorbital nerve chronic constriction neuropathy in female mice, Ma S, Nakamura Y, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, Society for Neuroscience Annual Meeting, 2023/11/13, Without Invitation, English
  9. The emerging role of HMGB1 in the brain during chronic pain, Nakamura Y, Nakashima K, Morioka N, 19th World Congress of Basic & Clinical Pharmacology 2023 (WCP2023), 2023/07/04, With Invitation, English
  10. Blockade of high mobility group box-1 function ameriolates mechanical hypersensitivity in a mouse model of Parkinson's disease, Nakamura Y, Sato F, Yamano K, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, IAGG Asia/Oceania Regional Congress 2023, 2023/06/14, Without Invitation, English
  11. Chronic pain model: Effects of intranasal administration of antibody preparation on inflammatory response, pain, and accompanying behavioral abnormalities, Morioka N, Nakmaura Y, Hisaoka-Nakashima K, Nishibori M, Japan Basic and Clinical Pharmacology Week 2022, 2022/12/03, With Invitation, English
  12. Inhibition of histone deacetylase in utero causes spinal microglial activation and mechanical allodynia in mice, Imado E, Samnang S, Tran HNB, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Kiguchi N, Asano S, Ago Y, Japan Basic and Clinical Pharmacology Week 2022, 2022/12/02, Without Invitation, English
  13. Role of mitochondrial DNA leaking into cytosol on inflammatory responses in microglia, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Japan Basic and Clinical Pharmacology Week 2022, 2022/12/02, Without Invitation, English
  14. The effect of REV-ERB agonist on nociceptive hypersensitivity in monoiodoacetate-induced osteoarthritis model, Hashizume H, Motonari H, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Japan Basic and Clinical Pharmacology Week 2022, 2022/11/30, Without Invitation, Japanese
  15. Hippocampal mitochondrial dysfunction induces anxiodepressive-like behaviors in mice with neuropathic pain., Yoshimoto N, Hisaoka-Nakashima K, Nakamura Y, Morioka N, Japan Basic and Clinical Pharmacology Week 2022, 2022/11/30, Without Invitation, Japanese
  16. Effect of intranasal treatment with the anti-HMGB1 neutralizing antibody on mechanical hypersensitivity in a mouse model of hemi-Parkinson's disease, Nakamura Y, Sato F, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, Society for Neuroscience Annual Meeting, 2022/11/15, Without Invitation, English
  17. Downregulation of connexin43 in primary cultured astrocytes potentiates the amitripryline-induced brain-derived neurotrophic factor through lysophosphatidic reecptor1/3, Src, and extraecllular signal-regulated kinase., Tokunaga N, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2022/11/13, Without Invitation, English
  18. Mitochondrial DNA enhances IRF-3 response in BV2 microglial cell line, Yoki Nakamura, Momoka Iwamoto, Keisuke Ikeda, Kazue Hisaoka-Nakashima, Norimitsu Morioka, The 142nd Annual Meeting of the Pharmaceutical Society of Japan, 2022/03/29, Without Invitation, Japanese
  19. Inhibitory effect of REV-ERB agonist on inflammatory responses in primary cultured rat chondrocytes, Hashizume H, Motonari H, Nakamura Y, Nakashima K, Morioka N, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, English
  20. Pretreatment with RAGE inhibitor prevents the onset of nociceptive behavior in mice with distal infraorbital nerve chronic constriction injury, Ma S, Nakamura Y, Kochi T, Nakashima K, Morioka N, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, English
  21. Involvement of microglia in mechanical allodynia in a mouse model of neurodevelopmental disorder, Imado E, Sun S, Abawa A, Asano S, Nakamura Y, Nakashima K, Morioka N, Tsuga K, Irifune M, Takuma K,Kiguchi N, Ago Y, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, English
  22. The effect of neutralizing antibody against high-mobility group box 1 on cognitive impairment in mice with neuropathic pain, Yoshimoto N, Nakashima K, Ohata K, Nakamura Y, Wang D, Liu K, Wake H, Ago Y, Nishibori M, Morioka N, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, English
  23. Mitochondrial dysfunction in microglia enhances inflammation-induced production of interferon-beta via mitochondrial DNA leakage and enhanced activity of TBK1-IRF3 signaling, Nakamura Y, Ikeda K, Iwamoto M, Hisaoka-Nakashima K, Morioka N, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/07, Without Invitation, English
  24. Downregulation of astrocytic connexin43 potentiates the antidepressantinduced brain-derived neurotrophic factor expression, Tokunaga N, Nakamura Y, Nakashima K, Morioka N, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/07, Without Invitation, English
  25. High mobility group box 1 evokes mechanical hypersensitivity in Parkinson disease mouse model, Nakamura Y, Satoh F, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M,, Morioka N, The 43rd Annual Meeting of Japanese Association for the Study of Pain, 2021/12/11, Without Invitation, Japanese
  26. Role of peripheral histone deacetylase in inflammation-induced cognitive impairment, Keisuke Ikeda, Yoki Nakamura, Kazue Nakashima, Naoki Takaoka, Seigo Sanoh, Yaichiro Kotake, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/29, Without Invitation, Japanese
  27. Nuclear receptor RORg regulates inflammatory responses in microglia, Maho Tsuruta, Youki Nakamura, Kazue Nakashima, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/29, Without Invitation, Japanese
  28. The role of high mobility group box-1 in hypersensitivity associated with Parkinson's disease, Fumiaki Sato, Yoki Nakamura, Simeng Ma, Takahiro Kochi, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/28, Without Invitation, Japanese
  29. Mitochondria dysfunction upregulates lipopolysaccharide-induced interferon-beta expression in BV2 microglial cell line, Momoka Iwamoto, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/28, Without Invitation, Japanese
  30. Downregulation of connexin43 leads to upregulation of amitriptyline-induced brain-derived neurotrophic factor expression in cultured cortical astrocytes, Nozomi Tokunaga, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/28, Without Invitation, Japanese
  31. Investigation into mitochondrial damage-associated molecular patterns in neuropathic pain model mouse, Natsuki Yoshimoto, Kazue Nakashima, Youki Nakamura, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/28, Without Invitation, Japanese
  32. Effects of anti-interleukin-6 receptor antibody on mechanical hypersensitivity and cognitive dysfunction in mice with neuropathic pain, Kodai Moriwaki, Kazue Hisaoka-Nakashima, Toshiki Yoshi, Yoki Nakamura, Norimitsu Morioka, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/27, Without Invitation, Japanese
  33. Alpha-7 nicotinic acetylcholine receptor physically interacts with sigma-1 receptor, Nakamura Y, Takemura M, Ikeda K, Nakashima K, Morioka N, The 94th Annual Meeting of the Japanese Pharmacological Society, 2021/03/09, Without Invitation, English
  34. Treatment with anti-interleukin-6 receptor antibody improves mechanical hypersensitivity and cognitive dysfunction in mice with neuropathic pain, Moriwaki K, Hisaoka-Nakashima K, Yoshii T, Nakamura Y, Morioka N, The 94th Annual Meeting of the Japanese Pharmacological Society, 2021/03/09, Without Invitation, English
  35. Inhibitory effects of anti-high mobility group box-1 neutralizing antibody on nociceptive hypersensitivity in Parkinson's disease, Satoh F, Nakamura Y, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M,, Morioka N,, The 94th Annual Meeting of the Japanese Pharmacological Society, 2021/03/09, Without Invitation, English
  36. Influence of mitochondria dysfunction in microglia on inflammation-evoked type I interferon expression, Iwamoto M, Nakamura Y, Hisaoka-Nakashima K, Morioka N, The 94th Annual Meeting of the Japanese Pharmacological Society, 2021/03/09, Without Invitation, English
  37. Pretreatment with a high mobility group box-1 neutralizing antibody inhibits trigeminal neuropathy in rat, Yoki Nakamura, Takahiro Kochi, Kazue Hisaoka-Nakashima, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Masahiro Irifune, Norimitsu Morioka, The 42nd Annual Meeting of Japanese Association for the Study of Pain, 2020/12/04, Without Invitation, Japanese
  38. Inflammatory stimulation downregulates expression of sigma-1 receptor via p38 MAP kinase and HDAC6 in primary cultured rat microglia, Takemura M, Iwamoto M, Nakamura Y, Nakashima K, Morioka N, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/27, Without Invitation, Japanese
  39. The diverse roles of high mobility group box-1 in regulation of glial functions under neuropathic pain state, Morioka N, Nakamura Y, Hisaoka-Nakashima K, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/27, Without Invitation, Japanese
  40. High mobility group box-1 leaked around injured-trigeminal nerves evokes nociceptive-like responses in trigeminal neuropathy model mouse, Nakamura Y, Kochi T, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/26, Without Invitation, Japanese
  41. Activation of toll-like receptor 4 induces downregulation of sigma-1 receptor in microglia, Iwamoto M, Takemura M, Nakamura Y, Nakashima K, Morioka N, The 93rd Annual Meeting of the Japanese Pharmacological Society, 2020/03/18, Without Invitation, English
  42. Perineural treatment with anti-HMGB1 antibody alleviates nociceptive-like behaviors in mice with chronic constriction injury of distal infraorbital nerve, Kochi T, Nakamura Y, Nakashima K, Liu K, Waki H, Nishibori M, Irifune M, Morioka N, The 93rd Annual Meeting of the Japanese Pharmacological Society, 2020/03/16, Without Invitation, English
  43. The possibility of HMGB1 as a therapeutic target for neuropathic pain., Nakamura Y, Nakashima K, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11/06, With Invitation, English
  44. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N., 9th International DAMPs and Alarmins Symposium, 2019/11/06, Without Invitation, English
  45. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10/23, Without Invitation, English
  46. Sigma-1 receptor control of cocaine-induced endocannabinoid signaling via inhibition of extracellular vesicle release in the ventral tegmental area, Dryanovski D, Nakamura Y, Su TP, Lupica C, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation, English
  47. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia, Kodama K,Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka M, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation, English
  48. Cocaine Increases Endocannabinoids-Containing Extracellular Vesicles Release from Dopaminergic Neurons via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Lupica C, Su TP, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/13, Without Invitation, English
  49. Systemic inflammation-induced memory disfunction is prevented by blockade either microglia activation or histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/12, Without Invitation, English
  50. The mechanisms underlying cocaine-evoked extracellular vesicles release via sigma-1 receptor-ARF6 pathway, Nakamura Y, Su TP, The 139th Annual Meeting of the Pharmaceutical Society of Japan, 2019/03/21, Without Invitation, Japanese
  51. The nuclear receptor REV-ERBs suppress the pro-inflammatory responses in cultured microglia, Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation, English
  52. Effects of histone deacetylase inhibitor on lipopolysaccharide-induced cognitive impairment., Takada N, Nakashima K, Nakamura Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation, English
  53. Activation of toll-like receptor 4 induces downregulation of alpha 7 nicotinic acetylcholine receptor in microglia, Nakamura Y, Kimura S, Takemura M, Kodama K, Iwamoto M, Nakashima K, Nakata Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/14, Without Invitation, English
  54. Sigma-1 Receptor Control of Extracellular Vesicle Release and Cocaine-Induced Endocannabinoid Signaling in the Ventral Tegmental Area (VTA), Dryanovski D, Nakamura Y, Su TP, Lupica C, 2019 WINTER CONFERENCE ON BRAIN RESEARCH, 2019/01/31, Without Invitation, English
  55. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Morioka N, Kondo S, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation, English
  56. The analysis of anxiety-and depression-related behaviors in neuropathic pain of mice -possible involvement of brain inflammation, Hisaoka-Nakashima K, Tomimura Y, Yoshii T, Zhang FF, Nakamura Y, Liu K, Nishibori M, Nakata Y, Morioka N, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation, English
  57. Cocaine Regulates Endocannabinoids-Containing Extracellular Vesicles Release in Ventral Tegmental Area via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Jackson S, Tsai SY, Woods A, Lupica C, Su TP, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/02, Without Invitation, English
  58. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and neuropathic pain, Morioka N, Fujii S, Kondo S, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y., 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/26, Without Invitation, Japanese
  59. Cocaine regulates extracellular vesicle release in mouse midbrain, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation, English
  60. Sigma1 receptor modulates cocaine-induced endocannabinoid signaling in the mouse ventral tegmental area, Dryanovski DI, Nakamura Y, Su TP, Lupica CR, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation, English
  61. Cocaine stimulation causes the release of the sigma-1receptor chaperone into the extracellular space, Nakamura Y, Tsai SY, Su TP, KEYSTONE SYMPOSIA-Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication (E4)-, 2016, Without Invitation, English
  62. Psychostimulant cocaine causes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2016, Without Invitation, English
  63. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission, Fukushige R, Nakamura Y, Morioka N, Nakata Y, The 89th Annual Meeting of The Japanese Pharmacological Society, 2016, Without Invitation, Japanese
  64. Cocaine evokes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Li Y, Lin DT, and Su TP, Society for Neuroscience Annual Meeting, 2015, Without Invitation, English
  65. The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, Society for Neuroscience Annual Meeting, 2015, Without Invitation, English
  66. Cocaine stimulation causes the release of the sigma-1 receptor into the extracellular space, Nakamura Y, Tsai SY, Su TP, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015, Without Invitation, Japanese
  67. Cocaine stimulating the release of the ER chaperone sigma-1 receptor into the extracellular vesicles as an emerging role in cocaine-induced neuroplasticity, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2014, Without Invitation, English
  68. The involvement of beta-adrenergic receptors in the regulation of c-jun N-terminal kinase and CCL2 production in TNF-stimulated spinal astrocytes, Morioka N, Abe H, Araki R, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 87th Annual Meeting of The Japanese Pharmacological Society, 2014, Without Invitation, Japanese
  69. Increased high mobility group box 1 in spinal dorsal horn plays a critical role in the maintenance of neuropathic pain in rats with partial sciatic nerve ligation, Nakamura Y, Morioka N, Abe H, Zhang FF, Hisaoka-Nakashima K, Liu K, Nishibori M, Nakata Y, The 86th Annual Meeting of The Japanese Pharmacological Society, 2013, Without Invitation, Japanese
  70. Cytokines induce a down-regulation of connexin 43-gap junction in spinal astrocytes, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, 2013, Without Invitation, Japanese
  71. Substance P release occurs from the rat striatum after intraplantar formalin injection to suppress nociceptive responses via activation of neurokinin 1 receptor, Nakamura Y, Izumi H, Morioka N, Hisaoka-Nakashima K, Takebayashi M, Nakata Y, Society for Neuroscience Annual Meeting, 2012, Without Invitation, English
  72. Activation of transient receptor potential ankyrin 1 evokes nociception through phosphorylation of p38 mitogen-activated protein kinase and subsequent substance P release, Nakamura Y, Morioka N, Nakata Y, The 34th annual meeting of Japanese association for the study of pain, 2012, Without Invitation, Japanese
  73. Transient receptor potential ankyrin 1 mediated release of substance P in primary sensory neurons is dependent on calcium and p38 mitogen activated protein kinase activation, Nakamura Y, Une Y, Abe H, Miyano K, Hisaoka K, Morioka N, Nakata Y, Society for Neuroscience Annual Meeting, 2011, Without Invitation, English
  74. The activation of transient receptor potential ankirin 1 evokes substance P release from rat dorsal root ganglion neurons through the phosphorylation of p38 mitogen-activated protein kinase, Nakamura Y, Une Y, Abe H, Hisaoka K, Morioka N, Nakata Y, The 84th Annual Meeting of The Japanese Pharmacological Society, 2011, Without Invitation, Japanese
  75. Influence of continuous administration of SP into the rat striatum on formalin-induced pain behaviors, Nakamura Y, Une Y, Abe H, Miyano K, Morioka N, Nakata Y, The 83rd Annual Meeting of The Japanese Pharmacological Society, 2010, Without Invitation, Japanese
  76. Effects of anti-mitotic drugs on the release of substrance P from cultured dorsal root ganglion cells, Miyano K, Nakamura Y, Tang HB , Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation, Japanese
  77. Functional analysis of substance P release in rat brain, Nakamura Y, Tang HB , Miyano K, Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation, Japanese

Awards

  1. 2020, Featured Paper of the Month – Apil 2020, National Institute on Drug Abuse IRP
  2. 2013, The JPS Prize 2014 Awards, The Japanese Pharmacological Society

External Funds

Acceptance Results of Competitive Funds

  1. Pharmaceutical Research Grant from Takeda Science Foundation, 2023
  2. Research Grant from The Nakatomi Foundation, 2023
  3. KAKENHI (Grant-in-Aid for Scientific Research (C)), 2022, 2024
  4. Young Research Grant from Smoking Research Foundation, 2021, 2023
  5. KAKENHI (Grant-in-Aid for Early-Career Scientists), 2020, 2021
  6. KAKENHI (Grant-in-Aid for Research Activity Start-up), 2018, 2019
  7. JSPS-NIH Fellowship, 2015, 2016
  8. KAKENHI (Grant-in-Aid for Scientific Research (C)), 2023, 2026
  9. KAKENHI (Grant-in-Aid for Scientific Research (C)), 2022, 2024
  10. KAKENHI (Grant-in-Aid for Scientific Research (C)), 2020, 2023

Social Activities

History as Committee Members

  1. Associate Editor for Pain Mechanisms and Modulators, 2022/08, Frontiers in Molecular Neuroscience
  2. Full Membership, 2024, SIGMA XI

History as Peer Reviews of Academic Papers

  1. 2024, Scientific Reports, Reviewer, 1
  2. 2024, Molecular Neurobiology, Reviewer, 1
  3. 2023, Scientific Reports, Reviwer, 1
  4. 2023, Journal of Visualized Experiments, Reviewer, 1
  5. 2023, Journal of Neuroinflammation, Reviewer, 3
  6. 2023, Journal of Pharmacological Sciences, Reviewer, 2
  7. 2023, Biological and Pharmaceutical Bulletin, Reviewer, 8
  8. 2023, Journal of Neuroimmune Pharmacology, Reviewer, 1
  9. 2023, International Immunopharmacology, Reviewer, 3
  10. 2023, Heliyon, Reviewer, 1
  11. 2023, European Journal of Pharmacology, Reviewer, 6
  12. 2023, Frontiers in Molecular Neuroscience, Editor, Associate Editor, 6
  13. 2023, Epigenetics, Reviewer, 1
  14. 2023, YAKUGAKU ZASSHI, Reviewer, 1
  15. 2023, Neurochemical Research, Reviewer, 2
  16. 2022, Journal of Pharmacological Sciences, Reviewer, 1
  17. 2022, Frontiers in Molecular Neuroscience, Editor, Associate Editor, 3
  18. 2022, Neurochemical Research, Reviewer, 2
  19. 2022, Frontiers in Pharmacology, Reviewer, 1
  20. 2022, Journal of Clinical Biochemistry and Nutrition, Reviewer, 1
  21. 2022, Cellular and Molecular Neurobiology, Reviewer, 1
  22. 2022, European Journal of Pharmacology, Reviewer, 1
  23. 2021, International Journal of Molecular Sciences, Reviewer, 1
  24. 2021, Journal of Neuroimmunology, Reviewer, 1
  25. 2021, Frontiers in Cell and Developmental Biology, Reviewer, 1
  26. 2021, Cellular and Molecular Neurobiology, Reviewer, 1
  27. 2020, Frontiers in Molecular Neuroscience, Reviewer, 1
  28. 2020, European Journal of Pharmacology, Reviewer, 2
  29. 2020, International Journal of Molecular Sciences, Reviewer, 1
  30. 2020, J—Multidisciplinary Scientific Journal, Reviewer, 1
  31. 2020, Biological and Pharmaceutical Bulletin, Reviewer, 1
  32. 2019, Journal of Pharmacological Sciences, Reviewer, 1
  33. 2019, YAKUGAKU ZASSHI, Reviewer, 1
  34. 2019, Biological and Pharmaceutical Bulletin, Reviewer, 1
  35. 2018, Biological and Pharmaceutical Bulletin, Reviewer, 1
  36. 2017, Biological and Pharmaceutical Bulletin, Reviewer, 1