YOKI NAKAMURA

Last Updated :2020/08/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
Web Site
E-mail
nakayokihiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi Minami-ku, Hiroshima, Japan 734-8553, Japan
TEL : (+81)82-257-5312 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant professor
  • 2018/02/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/11/01, 2018/01/22, National Institute on Drug Abuse, Cellular Pathobiology Section, Visiting Fellow
  • 2013/04/01, 2013/10/31, Hiroshima University, Institute of Biomedical & Health Sciences, Post doctoral fellow

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Doctoral Course, Japan, 2010/04, 2013/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Master's Course, Japan, 2008/04, 2010/03
  • Fukuyama University, Japan, 2004/04, 2008/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • Neuropathic pain, Trigeminal neuropathy, Drug addiction, Psychiatric disorder, Sigma receptor, HMGB1

Affiliated Academic Societies

  • Japanese Pharmacological Society (Scientific council)
  • Pharmaceutical Society of Japan
  • Japanese Association for Study of Pain
  • Japanese Society of Neuropsychopharmacology
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, First Semester, Practice of Pharmacology
  2. 2020, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science

Research Activities

Academic Papers

  1. TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia, Journal of Pharmacological Sciences, 2020
  2. Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors, Behavioural Brain Research, 391, 2020
  3. Stimulation of toll-like receptor 4 downregulates the expression of alpha7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia., Neurochemistry International, 2020
  4. Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms., Cells, 9(5), 2020
  5. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion, eLIFE, 8, 20191009
  6. High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, Neuro-Psychopharmacology & Biological Psychiatry, 92, 347-362, 2019
  7. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice, Brain, Behavior, and Immunity, 78, 116-130, 2019
  8. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics, Biological and Pharmaceutical Bulletin, 42(6), 857-866, 2019
  9. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1 beta in activated astrocytes, Journal of neurochemistry, 150(6), 738-758, 2019
  10. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes, European Journal of Pharmacology, 860, 2019
  11. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, Glia, 66(2), 428-444, 2018
  12. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice., Molecular and cellular neurosciences, 72, 2016
  13. The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems., Trends in pharmacological sciences, 37(4), 2016
  14. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression., Life sciences, 155, 2016
  15. Stimulation of spinal dorsal horn beta2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase., Neurochemistry international, 101, 2016
  16. Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia., Journal of neuroscience research, 93(4), 2015
  17. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice., Brain, behavior, and immunity, 49, 2015
  18. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloproteinase-9 upregulation in mice with painful peripheral neuropathy., Journal of neurochemistry, 2015
  19. A beta1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes., Journal of cellular physiology, 229(3), 2014
  20. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2., Journal of neurochemistry, 131(6), 2014
  21. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the alpha7 nicotinic acetylcholine receptor., Neuroscience, 258, 2014
  22. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., Journal of pharmacological sciences, 121(4), 2013
  23. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons., Brain research, 1509, 2013
  24. The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-kappaB pathway., Neuropharmacology, 75, 2013
  25. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1., PloS one, 8(8), 2013
  26. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons., Journal of neurochemistry, 120(6), 2012
  27. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice., Neurochemistry international, 60(8), 2012
  28. Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels., Neuropharmacology, 57(1), 2009

Invited Lecture, Oral Presentation, Poster Presentation

  1. Inflammatory stimulation downregulates expression of sigma-1 receptor via p38 MAP kinase and HDAC6 in primary cultured rat microglia, Takemura M, Iwamoto M, Nakamura Y, Nakashima K, Morioka N, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/27, Without Invitation
  2. The diverse roles of high mobility group box-1 in regulation of glial functions under neuropathic pain state, Morioka N, Nakamura Y, Hisaoka-Nakashima K, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/27, Without Invitation
  3. High mobility group box-1 leaked around injured-trigeminal nerves evokes nociceptive-like responses in trigeminal neuropathy model mouse, Nakamura Y, Kochi T, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/26, Without Invitation
  4. Activation of toll-like receptor 4 induces downregulation of sigma-1 receptor in microglia, Iwamoto M, Takemura M, Nakamura Y, Nakashima K, Morioka N, The 92rd Annual Meeting of the Japanese Pharmacological Society, 2020/03/18, Without Invitation
  5. Perineural treatment with anti-HMGB1 antibody alleviates nociceptive-like behaviors in mice with chronic constriction injury of distal infraorbital nerve, Kochi T, Nakamura Y, Nakashima K, Liu K, Waki H, Nishibori M, Irifune M, Morioka N, The 93rd Annual Meeting of the Japanese Pharmacological Society, 2020/03/16, Without Invitation
  6. The possibility of HMGB1 as a therapeutic target for neuropathic pain., Nakamura Y, Nakashima K, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11/06, With Invitation
  7. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N., 9th International DAMPs and Alarmins Symposium, 2019/11/06, Without Invitation
  8. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10/23, Without Invitation
  9. Sigma-1 receptor control of cocaine-induced endocannabinoid signaling via inhibition of extracellular vesicle release in the ventral tegmental area, Dryanovski D, Nakamura Y, Su TP, Lupica C, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation
  10. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia, Kodama K,Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka M, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation
  11. Cocaine Increases Endocannabinoids-Containing Extracellular Vesicles Release from Dopaminergic Neurons via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Lupica C, Su TP, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/13, Without Invitation
  12. Systemic inflammation-induced memory disfunction is prevented by blockade either microglia activation or histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/12, Without Invitation
  13. The mechanisms underlying cocaine-evoked extracellular vesicles release via sigma-1 receptor-ARF6 pathway, Nakamura Y, Su TP, The 139th Annual Meeting of the Pharmaceutical Society of Japan, 2019/03/21, Without Invitation
  14. The nuclear receptor REV-ERBs suppress the pro-inflammatory responses in cultured microglia, Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation
  15. Effects of histone deacetylase inhibitor on lipopolysaccharide-induced cognitive impairment., Takada N, Nakashima K, Nakamura Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/16, Without Invitation
  16. Activation of toll-like receptor 4 induces downregulation of alpha 7 nicotinic acetylcholine receptor in microglia, Nakamura Y, Kimura S, Takemura M, Kodama K, Iwamoto M, Nakashima K, Nakata Y, Morioka N, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/14, Without Invitation
  17. Sigma-1 Receptor Control of Extracellular Vesicle Release and Cocaine-Induced Endocannabinoid Signaling in the Ventral Tegmental Area (VTA), Dryanovski D, Nakamura Y, Su TP, Lupica C, 2019 WINTER CONFERENCE ON BRAIN RESEARCH, 2019/01/31, Without Invitation
  18. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Morioka N, Kondo S, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation
  19. The analysis of anxiety-and depression-related behaviors in neuropathic pain of mice -possible involvement of brain inflammation, Hisaoka-Nakashima K, Tomimura Y, Yoshii T, Zhang FF, Nakamura Y, Liu K, Nishibori M, Nakata Y, Morioka N, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation
  20. Cocaine Regulates Endocannabinoids-Containing Extracellular Vesicles Release in Ventral Tegmental Area via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway, Nakamura Y, Dryanovski D, Jackson S, Tsai SY, Woods A, Lupica C, Su TP, The 91st Annual Meeting of The Japanese Pharmacological Society/The 18th World Congress of Basic and Clinical Pharmacology, 2018/07/02, Without Invitation
  21. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and neuropathic pain, Morioka N, Fujii S, Kondo S, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y., 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/26, Without Invitation
  22. Cocaine regulates extracellular vesicle release in mouse midbrain, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation
  23. Sigma1 receptor modulates cocaine-induced endocannabinoid signaling in the mouse ventral tegmental area, Dryanovski DI, Nakamura Y, Su TP, Lupica CR, Society for Neuroscience Annual Meeting, 2017/11/13, Without Invitation
  24. Cocaine stimulation causes the release of the sigma-1receptor chaperone into the extracellular space, Nakamura Y, Tsai SY, Su TP, KEYSTONE SYMPOSIA-Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication (E4)-, 2016, Without Invitation
  25. Psychostimulant cocaine causes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2016, Without Invitation
  26. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission, Fukushige R, Nakamura Y, Morioka N, Nakata Y, The 89th Annual Meeting of The Japanese Pharmacological Society, 2016, Without Invitation
  27. Cocaine evokes microvesicle release by activating sigma-1 receptor and ARF6, Nakamura Y, Tsai SY, Li Y, Lin DT, and Su TP, Society for Neuroscience Annual Meeting, 2015, Without Invitation
  28. The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, Society for Neuroscience Annual Meeting, 2015, Without Invitation
  29. Cocaine stimulation causes the release of the sigma-1 receptor into the extracellular space, Nakamura Y, Tsai SY, Su TP, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015, Without Invitation
  30. Cocaine stimulating the release of the ER chaperone sigma-1 receptor into the extracellular vesicles as an emerging role in cocaine-induced neuroplasticity, Nakamura Y, Tsai SY, Su TP, Society for Neuroscience Annual Meeting, 2014, Without Invitation
  31. The involvement of beta-adrenergic receptors in the regulation of c-jun N-terminal kinase and CCL2 production in TNF-stimulated spinal astrocytes, Morioka N, Abe H, Araki R, Zhang FF, Nakamura Y, Hisaoka-Nakashima K, Nakata Y, The 87th Annual Meeting of The Japanese Pharmacological Society, 2014, Without Invitation
  32. Increased high mobility group box 1 in spinal dorsal horn plays a critical role in the maintenance of neuropathic pain in rats with partial sciatic nerve ligation, Nakamura Y, Morioka N, Abe H, Zhang FF, Hisaoka-Nakashima K, Liu K, Nishibori M, Nakata Y, The 86th Annual Meeting of The Japanese Pharmacological Society, 2013, Without Invitation
  33. Cytokines induce a down-regulation of connexin 43-gap junction in spinal astrocytes, Zhang FF, Morioka N, Nakamura Y, Fujii S, Hisaoka-Nakashima K, Nakata Y, 2013, Without Invitation
  34. Substance P release occurs from the rat striatum after intraplantar formalin injection to suppress nociceptive responses via activation of neurokinin 1 receptor, Nakamura Y, Izumi H, Morioka N, Hisaoka-Nakashima K, Takebayashi M, Nakata Y, Society for Neuroscience Annual Meeting, 2012, Without Invitation
  35. Activation of transient receptor potential ankyrin 1 evokes nociception through phosphorylation of p38 mitogen-activated protein kinase and subsequent substance P release, Nakamura Y, Morioka N, Nakata Y, The 34th annual meeting of Japanese association for the study of pain, 2012, Without Invitation
  36. Transient receptor potential ankyrin 1 mediated release of substance P in primary sensory neurons is dependent on calcium and p38 mitogen activated protein kinase activation, Nakamura Y, Une Y, Abe H, Miyano K, Hisaoka K, Morioka N, Nakata Y, Society for Neuroscience Annual Meeting, 2011, Without Invitation
  37. The activation of transient receptor potential ankirin 1 evokes substance P release from rat dorsal root ganglion neurons through the phosphorylation of p38 mitogen-activated protein kinase, Nakamura Y, Une Y, Abe H, Hisaoka K, Morioka N, Nakata Y, The 84th Annual Meeting of The Japanese Pharmacological Society, 2011, Without Invitation
  38. Influence of continuous administration of SP into the rat striatum on formalin-induced pain behaviors, Nakamura Y, Une Y, Abe H, Miyano K, Morioka N, Nakata Y, The 83rd Annual Meeting of The Japanese Pharmacological Society, 2010, Without Invitation
  39. Effects of anti-mitotic drugs on the release of substrance P from cultured dorsal root ganglion cells, Miyano K, Nakamura Y, Tang HB , Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation
  40. Functional analysis of substance P release in rat brain, Nakamura Y, Tang HB , Miyano K, Morioka N, Inoue A, Nakata Y, The 82nd Annual Meeting of The Japanese Pharmacological Society, 2009, Without Invitation

Awards

  1. 2013, The JPS Prize 2014 Awards, The Japanese Pharmacological Society

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI (Grant-in-Aid for Early-Career Scientists), 2020, 2021
  2. KAKENHI (Grant-in-Aid for Research Activity Start-up), 2018, 2019
  3. JSPS-NIH Fellowship, 2015, 2016

Social Activities

History as Peer Reviews of Academic Papers

  1. 2019, Journal of Pharmacological Sciences, Reviewer, 1
  2. 2019, YAKUGAKU ZASSHI, Reviewer, 1
  3. 2019, Biological and Pharmaceutical Bulletin, Reviewer, 1
  4. 2018, Biological and Pharmaceutical Bulletin, Reviewer, 1
  5. 2017, Biological and Pharmaceutical Bulletin, Reviewer, 1