TAKUYASUZUKI

Last Updated :2019/08/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Professor
Web Site
E-mail
takuyahiroshima-u.ac.jp
Other Contact Details
1-4-4, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-7984 FAX : (+81)82-424-7916
Self-introduction
*

Basic Information

Major Professional Backgrounds

  • 1998/04/01, 2000/12/03, Meiji Dairies Corporation, Researcher
  • 2000/04/01, 2002/03/31, Meiji Dairies Corporation, Senior Staff
  • 2005/04/01, 2008/06/30, Japan Society for the Promotion of Science, Special Postdoctoral Researcher
  • 2008/07/01, 2009/12/31, Hokkaido University, *
  • 2010/01/01, 2013/03/31, Hiroshima University, Graduate School of Biosphere Science , Associate Professor
  • 2013/04/01, 2016/03/31, Hiroshima University, Graduate School of Biosphere Science , Associate Professor
  • 2016/04/01, Hiroshima University, Graduate School of Biosphere Science , Professor

Educational Backgrounds

  • HOKKAIDO UNIVERSITY, Japan, 2002/04, 2005/03
  • HOKKAIDO UNIVERSITY, Japan, 1996/04, 1998/03
  • HOKKAIDO UNIVERSITY, Japan, 1992/04, 1996/03

Academic Degrees

  • Doctor of Agriculture, HOKKAIDO UNIVERSITY
  • Master of Agriculture, HOKKAIDO UNIVERSITY

Educational Activity

  • 【Bachelor Degree Program】School of Applied Biological Science : Department of Applied Biological Science
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • Functional foods
  • Gastrointestine
  • polyphenol
  • Dietary fiber
  • Zinc
  • Probiotics

Affiliated Academic Societies

  • Japan Society of Nutrition and Food Science
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japanese Biochemial Society
  • Japan Society of Applied Glycoscience
  • Japanese Association for Food Immunology

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 1Term, Life, food, and environmental sciences
  2. 2019, Liberal Arts Education Program1, 3Term, Food safety and health science
  3. 2019, Undergraduate Education, 1Term, Introduction to Applied Biological Sciences
  4. 2019, Undergraduate Education, Intensive, Laboratory Work in General Physics
  5. 2019, Undergraduate Education, 2Term, Reading of Foreign Literature
  6. 2019, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  7. 2019, Undergraduate Education, 4Term, Food Biochemistry
  8. 2019, Undergraduate Education, Intensive, Laboratory Work in Food Chemistry
  9. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  10. 2019, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  11. 2019, Undergraduate Education, Intensive, Agricultural Products and Food Processing
  12. 2019, Undergraduate Education, Intensive, Training for Animal Food Processing
  13. 2019, Undergraduate Education, Intensive, Life, food and agricultural education through experimental studies of dairy farming
  14. 2019, Undergraduate Education, 3Term, Modern Food Science
  15. 2019, Undergraduate Education, Intensive, Laboratory Exercise (2)
  16. 2019, Graduate Education (Master's Program) , Second Semester, Research for Academic Degree Dissertation
  17. 2019, Graduate Education (Doctoral Program) , First Semester, Exercises in Food Science and Biofunctions (B)
  18. 2019, Graduate Education (Doctoral Program) , Second Semester, Exercises in Food Science and Biofunctions (B)
  19. 2019, Graduate Education (Master's Program) , First Semester, Practice in Food Science and Biofunctions
  20. 2019, Graduate Education (Master's Program) , 1Term, Function of Livestock Food Product
  21. 2019, Graduate Education (Master's Program) , 1Term, Exercises in Function of Livestock Food Product
  22. 2019, Graduate Education (Master's Program) , Second Semester, Biochemistry of animal foods I
  23. 2019, Graduate Education (Master's Program) , Second Semester, Biochemistry of animal foods II
  24. 2019, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  25. 2019, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  26. 2019, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  27. 2019, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  28. 2019, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  29. 2019, Graduate Education (Master's Program) , 1Term, Nutrition and Food Functions I

Research Activities

Academic Papers

  1. Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats, NUTRITION & METABOLISM, 7, 20100312
  2. Ingestion of Epilactose, a Non-digestible Disaccharide, Improves Postgastrectomy Osteopenia and Anemia in Rats through the Promotion of Intestinal Calcium and Iron Absorption, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(19), 10787-10792, 20101013
  3. Phytate hydrolysate induces circumferential F-actin ring formation at cell-cell contacts by a Rho-associated kinase-dependent mechanism in colorectal cancer HT-29 cells, MOLECULAR NUTRITION & FOOD RESEARCH, 54(12), 1807-1818, 2010
  4. Kaempferol Enhances Intestinal Barrier Function through the Cytoskeletal Association and Expression of Tight Junction Proteins in Caco-2 Cells, JOURNAL OF NUTRITION, 141(1), 87-94, 2011
  5. Role of flavonoids in intestinal tight junction regulation, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 22(5), 401-408, 2011
  6. Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(36), 31263-31271, 20110909
  7. Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-gamma, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28(5), 817-822, 2011
  8. Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011
  9. Effect of D-Alanine in Teichoic Acid from the Streptococcus thermophilus Cell Wall on the Barrier-Protection of Intestinal Epithelial Cells, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(2), 283-288, 2012
  10. Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(18), 4628-4633, 20120509
  11. Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms, BRAIN BEHAVIOR AND IMMUNITY, 26(7), 1061-1065, 2012
  12. Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-alpha-induced Inflammatory Response in Endothelial Cells, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 18(5), 667-671, 2012
  13. Effects of a Chicken Collagen Hydrolysate on the Circulation System in Subjects with Mild Hypertension or High-Normal Blood Pressure, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(4), 691-696, 2013
  14. Regulation of intestinal epithelial permeability by tight junctions, CELLULAR AND MOLECULAR LIFE SCIENCES, 70(4), 631-659, 2013
  15. Comparative Analyses of Anti-hypertensive Effects of Commercial Collagen Peptides in Spontaneously Hypertensive Rats, JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 60(3), 142-147, 2013
  16. Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammation in Colitic Mice, JOURNAL OF NUTRITION, 143(6), 827-834, 2013
  17. Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis, JOURNAL OF FUNCTIONAL FOODS, 5(2), 949-955, 2013
  18. Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules, PLOS ONE, 8(11), 20131108
  19. Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells, MOLECULAR NUTRITION & FOOD RESEARCH, 57(11), 2019-2028, 2013
  20. Fructooligosaccharide augments benefits of quercetin-3-O-beta-glucoside on insulin sensitivity and plasma total cholesterol with promotion of flavonoid absorption in sucrose-fed rats, EUROPEAN JOURNAL OF NUTRITION, 53(2), 457-468, 2014
  21. Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity, JOURNAL OF FUNCTIONAL FOODS, 5(4), 1633-1641, 2013
  22. Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 10, 112-116, 2014
  23. Regulation of intestinal barrier function by dietary polyphenols., Current Nutrition and Food Science, 9, 85-92, 2013
  24. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 2902-2918, 20150130
  25. Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology, IMMUNOBIOLOGY, 220(6), 701-710, 2015
  26. Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets, BRITISH JOURNAL OF NUTRITION, 114(11), 1774-1783, 20151214
  27. High-fat Diet-induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice, JOURNAL OF FOOD SCIENCE, 81(1), H216-H222, 2016
  28. Ingestion of epilactose, a non-digestible saccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal mineral absorption. - Comparative analyses of two non-digestible saccharides, epilactose and fructooligosaccharide -, Journal of Applied Glycoscience Supplement, 2011(0), 74-74, 2011
  29. Effects of DFA IV in Rats : Calcium Absorption and Metabolism of DFA IV by Intestinal Microorganisms, Bioscience, biotechnology, and biochemistry, 63(4), 655-661, 19990423
  30. In vivo dose response and in vitro mechanistic analysis of enhanced immunoglobulin A production by Lactobacillus plantarum AYA., Biosci Microbiota Food Health, 34(3), 53-58, 20150314
  31. Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, JOURNAL OF NUTRITION, 146(10), 1970-1979, 2016
  32. Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression., Am J Physiol Gastrointest Liver Physiol., 311(1), G105-G116, 20160701
  33. Regulation of the intestinal tight junction by natural polyphenols: a mechanistic perspective., Crit Rev Food Sci Nutr, 2017
  34. Dietary psyllium fiber increases intestinal heat shock protein 25 expression in mice, NUTRITION RESEARCH, 39, 25-33, 2017
  35. A novel whey tetrapeptide IPAV reduces interleukin-8 production induced by TNF-alpha in human intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 35, 376-383, 2017
  36. Guar gum fiber increases suppressor of cytokine signaling-1 expression via toll-like receptor 2 and dectin-1 pathways, regulating inflammatory response in small intestinal epithelial cells, MOLECULAR NUTRITION & FOOD RESEARCH, 61(10), 201710
  37. Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 68(8), 941-951, 2017
  38. Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice, BRITISH JOURNAL OF NUTRITION, 118(9), 661-672, 20171114
  39. Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(1), 108-117, 20180110
  40. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective, CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 57(18), 3830-3839, 2017
  41. Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier, JOURNAL OF NUTRITION, 148(4), 552-561, 201804

Invited Lecture, Oral Presentation, Poster Presentation

  1. Intestinal barrier regulation by dietary polyphenols., Takuya Suzuki, International Society Nutraceuticals and Food Factors Annual conference, 2012, With Invitation, Hawai, USA
  2. Novel functional food factors to regulate intestinal barrier function, Takuya Suzuki, 2015/07/03, With Invitation
  3. Regulation of intestinal barrier by dietary polyphenols, Takuya Suzuki, 2015/09/09, With Invitation
  4. Intestinal barrier and the regulation by food factors, Takuya Suzuki, Ajinomoto seminar, 1509/29, With Invitation, Ajinomoto
  5. Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice., Hung TV, Takuya S, International Society of Nutraceuticals and Functional Foods, 2016/10/09, Without Invitation
  6. Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression., Yuka M, Takuya S, United European Gastroenterology Week, 2016/10, Without Invitation, Austria
  7. Barrier Recovering-function of a Gut Microbial Metabolite of Linoleic Acid, Junki Miyamoto, Shigenobu Kishino, Takuya Suzuki, Jun Ogawa, Ikuo Kimura, Soichi Tanabe, 107th AOCS Annual Meeting & Expo, 2016/05, Without Invitation
  8. A gut microbial metabolite of linoleic acid and gut homeostasis, Junki Miyamoto, Shigenobu Kishino, Takuya Suzuki, Jun Ogawa, Ikuo Kimura, Soichi Tanabe,, Experimental Biology, 2016/04, Without Invitation
  9. Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, Hung TV and Takuya S, 2016/11, Without Invitation
  10. Resveratrol Enhances Intestinal Barrier Function and Ameliorates the Hydrogen Peroxide-Induced Epithelial Barrier Disruption., Mayangsari Y,Suzuki T, Indonesian society for functional food and nutraceutical, 2017/03, With Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2015
  2. KAKENHI, 2012, 2014
  3. KAKENHI, Protective role of flavonoids in the stress-induced intestinal barrier dysfunction, 2011, 2012
  4. KAKENHI, Analysis of impairment and recovery mechanism of intestinal barrier and its application for design of foods with barrier-protectingactivity, 2010, 2012
  5. KAKENHI, Characterization of intestinal barrier defect in metabolic syndrome and the ameliorative effect of food factors, 2009, 2010
  6. KAKENHI, 2016, 2018