KAZUNORI IMAIZUMI

Last Updated :2022/08/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
imaizumihiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5130 FAX : (+81)82-257-5134
Self-introduction
I have consistently promoted "research related to the molecular mechanism of endoplasmic reticulum stress response and physiology and pathophysiology", and have made numerous achievements that have opened the door to elucidation of pathogenic mechanisms of Alzheimer's disease, bone metabolism diseases, rare diseases, etc. (NCB, 1999, NCB, 2005, NCB 2009(2), Nat Commun 2012, Mol Cell 2014, etc.). In addition to working to develop young researchers from the leading position of academic activities in Japan, such as serving as president of the Japanese Society of Neurochemistry and as a collaborative researcher of the Science Council of Japan, I have established university-endowed courses to develop industry-academia collaboration research and contribute widely to local communities and society. I have been recognized as a Distinguished Professor who conducts particularly outstanding research in Hiroshima University.

Basic Information

Academic Degrees

  • Ph.D., Osaka University
  • Master of Agriculture, Tokyo University of Agriculture and Technology

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Biology;Biological Science;Cell biology
  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology

Research Keywords

  • ER stress
  • apoptosis
  • disease
  • Neurodegenerative disease

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2022, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2022, Undergraduate Education, 2Term, Introduction for medical research
  4. 2022, Undergraduate Education, Intensive, Practice for medical research
  5. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2022, Graduate Education (Master's Program) , First Semester, Research
  8. 2022, Graduate Education (Master's Program) , Second Semester, Research
  9. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  10. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  11. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  12. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biochemistry
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biochemistry
  15. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biochemistry
  16. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biochemistry

Research Activities

Academic Papers

  1. Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System, NEUROCHEMICAL RESEARCH, 2022
  2. Advances in understanding the mechanisms of repairing damaged nuclear envelop, JOURNAL OF BIOCHEMISTRY, 171(6), 609-617, 20220527
  3. Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis, FASEB JOURNAL, 35(2), e21158, 202102
  4. Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 202111
  5. Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 2021
  6. Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 2021
  7. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 2020
  8. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 202006
  9. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
  10. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 2020
  11. Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis, FASEB JOURNAL, 35(2), 2021
  12. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
  13. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
  14. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
  15. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, SCIENTIFIC REPORTS, 9(1), 20301, 20191230
  16. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
  17. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
  18. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 20190104
  19. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9, 20180724
  20. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
  21. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
  22. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 20170901
  23. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 37310, 20161117
  24. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
  25. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 30955, 20160803
  26. Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
  27. IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 16580, 20151116
  28. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 16455, 20151112
  29. Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, HUMAN MOLECULAR GENETICS, 24(2), 299-313, 20150115
  30. F-box and WD Repeat Domain-containing-7 (Fbxw7) Protein Targets Endoplasmic Reticulum-anchored Osteogenic and Chondrogenic Transcriptional Factors for Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(40), 28488-28502, 20131004
  31. The roles of endoplasmic reticulum stress in diseases, 37(3), 9-16, 20130920
  32. Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLOS ONE, 8(1), e55155, 20130130
  33. Involvement of endoplasmic reticulum stress in tauopathy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(2), 500-504, 20130111
  34. Activation of OASIS family, ER stress transducers, is dependent on its stabilization, CELL DEATH AND DIFFERENTIATION, 19(12), 1939-1949, 20121219
  35. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, SCIENTIFIC REPORTS, 2, 799, 20121112
  36. The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43), 36190-36200, 20121019
  37. ★, Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 967, 20120724
  38. The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(11), 8144-8153, 20120309
  39. Regulation of osteogenesis and chondrogenesis by unfolded protein response, 84(1), 18-29, 20120125
  40. ★, Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., NATURE CELL BIOLOGY, 11(10), 1197-1204, 20091201
  41. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice, JOURNAL OF NEUROCHEMISTRY, 110(3), 956-965, 20091001
  42. The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury., JOURNAL OF PHARMACOLOGICAL SCIENCES, 109(2), 311-314, 20090701
  43. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 334-344, 20090401
  44. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil, BRAIN RESEARCH, 1208, 217-224, 20080801
  45. Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil, NEUROSCIENCE, 151(1), 111-119, 20080801
  46. A protective role of unfolded protein response in mouse ischemic acute kidney injury, EUROPEAN JOURNAL OF PHARMACOLOGY, 592(1-3), 138-145, 20080601
  47. Nerve fiber analysis on the so-called accessory subscapularis muscle and its morphological significance, ANATOMICAL SCIENCE INTERNATIONAL, 83(1), 55-59, 20080501
  48. A molecular chaperone inducer protects neurons from ER stress, CELL DEATH AND DIFFERENTIATION, 15(2), 364-375, 20080301
  49. The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes, JOURNAL OF IMMUNOLOGY, 179(2), 1210-1224, 20071201
  50. Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice, NEUROSCIENCE, 147(4), 957-967, 20071201
  51. Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle, ACTA NEUROPATHOLOGICA, 114(5), 527-535, 20071001
  52. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1, HUMAN MOLECULAR GENETICS, 16(23), 2834-2843, 20071001
  53. Endoplasmic reticulum stress response in dendrites of cultured primary neurons, NEUROSCIENCE, 146(1), 1-8, 20070901
  54. HMGA1a:Sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of Presenilin-2 pre-mRNA, GENES TO CELLS, 12(10), 1179-1191, 20070801
  55. A novel ER stress transducer, OASIS, expressed in astrocytes, ANTIOXIDANTS & REDOX SIGNALING, 9(5), 563-571, 20070801
  56. Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation, ACTA HISTOCHEMICA ET CYTOCHEMICA, 40(1), 19-26, 20070301
  57. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer, MOLECULAR AND CELLULAR BIOLOGY, 27(5), 1716-1729, 20070201
  58. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 96(4), 1090-1100, 20060901
  59. The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients, NEUROSCIENCE LETTERS, 393(2-3), 102-107, 20060501
  60. Altered localization of amyloid precursor protein under endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 344(2), 525-530, 20060401
  61. Autophagy is activated for cell survival after endoplasmic reticulum stress, MOLECULAR AND CELLULAR BIOLOGY, 26(24), 9220-9231, 20060101
  62. Candidates for tumor-specific alternative splicing, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334(1), 23-29, 20050801
  63. XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(4), 1146-1153, 20050501
  64. ★, OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes, NATURE CELL BIOLOGY, 7(2), 186-194, 20050201
  65. Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex, BRAIN RESEARCH MOLECULAR BRAIN RESEARCH, 127, 128-135, 20041201
  66. Tra2b, SF2/ASF, and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA, GENES TO CELLS, 9, 121-130, 20041201
  67. Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death, JOURNAL OF NEUROSCIENCE, 24(15), 3721-3725, 20041101
  68. Identification of regulatory cis-acting elements for alternative splicing of presenilin-2 exon 5 under hypoxic stress conditions, JOURNAL OF NEUROCHEMISTRY, 91(5), 1191-1198, 20040901
  69. Induction of neuronal death by ER stress in Alzheimer's disease, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 67-78, 20040801
  70. Role of ARF4L in recycling between endosomes and the plasma membrane, CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 137-147, 20040701
  71. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Ab-induced cell death, JOURNAL OF CELL BIOLOGY, 165(3), 347-356, 20040601
  72. Endoplasmic reticulum stress and neuronal death, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 49-50, 20040301
  73. JAB1 participates in unfolded protein responses by association and dissociation with IRE1, NEUROCHEMISTRY INTERNATIONAL, 45, 765-772, 20040201
  74. Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12, NEUROSCIENCE LETTERS, 357, 127-130, 20040101
  75. The unfolded protein response is involved in the pathology of Alzheimer's disease, Annals of the New York Academy of Sciences , 977, 349-355, 20040101
  76. MDG1/ERdj4, an ER-resident DnaJ family member, suppresses cell death induced by ER stress, GENES TO CELLS, 8, 189-202, 20031001
  77. An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 15825-15831, 20030801
  78. Endoplasmic reticulum stress and Alzheimer's disease, Mapping the Progress of Alzheimer's and Parkinson's Disease. Mizuno, Y., Fisher, A., Hanin, I. (eds), 95-100, 20030101
  79. FAD-linked presenilin-1 mutants impede translation regulation under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296, 313-318, 20021101
  80. Identification of a Cis-acting elements for the regulation of SMN exon 7 splicing, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 23271-23277, 20021001
  81. The cytosolic inclusion bodies that consist of splice variants that lack exon of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients, NEUROSCIENCE LETTERS, 328, 198-200, 20020601
  82. Inter-changeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling, ONCOGENE, 20, 4317-4323, 20010901
  83. Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor-2 (TRAF2) dependent mechanisms in response to ER stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 13935-13940, 20010801
  84. Upregulation of the pro-apoptotic BH3-only peptide Harakiri (HRK) in spinal neurons of amyotrophiclateral sclerosis patients, NEUROSCIENCE LETTERS, 313, 153-157, 20010501
  85. Impairment of response to ER stress in presenilin 1 mutant, Neuroscientific Basis of Dementia. Tanaka, C., McGeer, P., Ihara, Y. (eds), 193-199, 20010101
  86. Are cerebrovascular factors involved in Alzheimer's disease?, NEUROBIOLOGY OF AGING, 21, 215-224, 20000701
  87. Molecular cloning of a novel membrane glycoprotein, Pal, specifically expressed inphotoreceptor cells of the retina and containing leucine-rich repeat, JOURNAL OF NEUROSCIENCE, 20, 3206-3213, 20000601
  88. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, MALT lymphoma-associated protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 11114-11120, 20000201
  89. ★, Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response, NATURE CELL BIOLOGY, 1, 479-485, 19991201
  90. A novel presenilin-2 (PS-2) splice variant in human Alzheimer's disease brain tissue, JOURNAL OF NEUROCHEMISTRY, 72, 2498-2505, 19990501
  91. IPP isomerase, an enzyme of mevalonate pathway, is preferentially expressed in postnatal cortical neurons and induced after nerve transection, MOLECULAR BRAIN RESEARCH, 67, 231-238, 19990401
  92. Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the girbil, MOLECULAR BRAIN RESEARCH, 56, 66-75, 19980901
  93. Expression of pattern of a novel death-promoting gene, DP5, in the developing murine nervous system, MOLECULAR BRAIN RESEARCH, 54, 316-320, 19980501
  94. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 18842-18848, 19971001
  95. Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the girbil, JOURNAL OF NEUROSCIENCE, 17, 6678-6684, 19970801
  96. Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models, ENDOCRINOLOGY, 160(11), 2673-2691, 201911
  97. The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis, Neurochemistry International, 119, 26-34, 201810
  98. Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 3215, 201810
  99. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
  100. 60th Anniversary of the Japanese Society for Neurochemistry, Journal of Neurochemistry, 141, 788-789, 201706
  101. The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy, Medical Research Archives, 4(4), 201611
  102. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
  103. Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics, FEBS JOURNAL, 283(8), 1475-1487, 201604
  104. Physiological Unfolded Protein Response Regulated by OASIS Family Members, Transmembrane bZIP Transcription Factors, IUBMB LIFE, 63(4), 233-239, 201104
  105. Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), e0125982, 2015
  106. OASIS is a Novel Cofactor of HIF1 alpha to Promote the Transcription Dependence on Hypoxia Response Element under the Hypoxic Condition, FASEB JOURNAL, 29, 2015
  107. An ER stress sensor PERK is involved in Post-operative Subcojunctival Scarring in a Mouse Model of Glaucoma Filtration Surgery, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7), 2015
  108. ★, Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, MOLECULAR CELL, 53(1), 127-139, 2014
  109. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLOS ONE, 9(2), e88048, 2014
  110. Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 13810-13820, 2014
  111. OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex, JOURNAL OF NEUROCHEMISTRY, 130(5), 612-625, 2014
  112. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor, CELL DEATH & DISEASE, 5, e1332, 2014
  113. The biological regulation by the endoplasmic reticulum stress response, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S79-S79, 2013
  114. [Endoplasmic reticulum stress response in osteogenesis]., Clinical calcium, 23(11), 2013
  115. [Endoplasmic reticulum stress response involved in osteogenesis and chondrogenesis]., Clinical calcium, 23(12), 2013
  116. The roles of unfolded protein response in osteogenesis and chondrogenesis, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 53P-53P, 2012
  117. [Regulation of osteogenesis and chondrogenesis by unfolded protein respone]., Seikagaku. The Journal of Japanese Biochemical Society, 84(1), 2012
  118. Roles of endoplasmic reticulum stress transducer OASIS in fracture healing, BONE, 49(4), 724-732, 2011
  119. ★, Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation., NATURE CELL BIOLOGY, 11(10), 1205-1211, 2009
  120. Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2 alpha-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4809-4818, 2011
  121. Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice, BONE, 48(3), 514-523, 2011
  122. The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology, JOURNAL OF BIOCHEMISTRY, 149(5), 507-518, 2011
  123. ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type, MAMMALIAN GENOME, 22(5-6), 318-328, 2011
  124. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice, JOURNAL OF BONE AND MINERAL METABOLISM, 28(4), 384-394, 2010
  125. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis, JOURNAL OF BONE AND MINERAL METABOLISM, 28(2), 131-138, 2010
  126. Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice, NEUROSCIENCE LETTERS, 484(1), 43-46, 2010

Invited Lecture, Oral Presentation, Poster Presentation

  1. OASIS in podocytes promoted tubular injury by suppressing PRKCI expression, Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Takeo Harada, Takafumi Nakae, Shunsuke Noda, Sayuri Mitsuoka, Koki Tanaka, Shota Tanaka, Makiko Maeda, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio, American Society of Nephrology Kidney Week 2020, 2020/10/22, Without Invitation, English, Denver, USA(web)
  2. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, Wu Y, Okamoto T, Imaizumi K, Kaneko M, ASCB|EMBO2019 meeting, 2019/12/08, Without Invitation, English, Washington, USA
  3. Suppression of transcription factor OASIS ameliorated kidney fibrosis, Masanori Obana, Ayaha Yamamoto, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Sayuri Mitsuoka, Shunsuke Noda, Makiko Maeda, Kazunori Imaizumi, Kotaro Matsumoto, Yasushi Fujio, The American Society of Nephrology, 2019/11/07, Without Invitation, English, Washington, USA
  4. Recovery of lysosomal functions by the shutdown of ER-associated degradation and therapy of mucopolysaccharidosis, Saito A, Osaki Y, Imaizumi K, NEURO2019, 2019/07/28, With Invitation, English
  5. The roles of ER-resident transmembrane transcription factor OASIS in cellular senescence of astrocytes, Matsuhisa K, Saito A, Asada R, Kaneko M, Imaizumi K, NEURO2019, 2019/07/26, Without Invitation, English
  6. The roles of an ER-resident transmembrane transcription factor OASIS in the response to impairment of nuclear envelope integrity., Imaizumi K, Joint Annual Meeting of 71st JSCB & 19th PSSJ, 2019/06/24, Without Invitation, English, Kobe, Japan
  7. ER-resident transmembrane transcription factor OASIS accumulates in the nuclear bleb in response to the disruption of the nuclear lamina, Matsuhisa K, Asada R, Kaneko M, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/11, Without Invitation, English, San Diego, USA
  8. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, Osaki Y, Saito A, Masaaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/09, Without Invitation, English, San Diego, USA
  9. Neuronal activity-dependent formation of ER-PM contact sites in spines regulates spine formation and dendritic extension via local manipulation of unfolded protein response, Saito A, Imaizumi K, Society for Neuroscience 2018, 2018/11/04, Without Invitation, English, San Diego, USA
  10. Lysosomal ubiquitin ligase RNF182 regulates mTORC1 signaling and neuronal differentiation, Kaneko M, Kanemoto S, Guo X, Imaizumi K, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/05, Without Invitation, English, Kyoto, Japan
  11. Suppression of expression of ubiquitin ligase RNF183 ameliorates dextran sodium sulfate-induced colitis, Wu Y, Imaizumi K, Kaneko M, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation, English, Kyoto, Japan