KAZUNORI IMAIZUMI
Last Updated :2025/02/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Professor
- Web Site
- E-mail
- imaizumi
hiroshima-u.ac.jp
- Other Contact Details
- 1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5130 FAX : (+81)82-257-5134
- Self-introduction
- I have consistently promoted "research related to the molecular mechanism of endoplasmic reticulum stress response and physiology and pathophysiology", and have made numerous achievements that have opened the door to elucidation of pathogenic mechanisms of Alzheimer's disease, bone metabolism diseases, rare diseases, etc. (NCB, 1999, NCB, 2005, NCB 2009(2), Nat Commun 2012, Mol Cell 2014, etc.). In addition to working to develop young researchers from the leading position of academic activities in Japan, such as serving as president of the Japanese Society of Neurochemistry and as a collaborative researcher of the Science Council of Japan, I have established university-endowed courses to develop industry-academia collaboration research and contribute widely to local communities and society. I have been recognized as a Distinguished Professor who conducts particularly outstanding research in Hiroshima University.
Basic Information
Academic Degrees
- Ph.D., Osaka University
- Master of Agriculture, Tokyo University of Agriculture and Technology
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
- Biology;Biological Science;Cell biology
- Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology
Research Keywords
- ER stress
- apoptosis
- disease
- Neurodegenerative disease
Educational Activity
Course in Charge
- 2024, Liberal Arts Education Program1, 2Term, Cell Science
- 2024, Undergraduate Education, Year, Physiology and Biochemistry
- 2024, Undergraduate Education, 2Term, Introduction for medical research
- 2024, Undergraduate Education, Intensive, Practice for medical research
- 2024, Graduate Education (Master's Program) , First Semester, Seminar
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar
- 2024, Graduate Education (Master's Program) , First Semester, Research
- 2024, Graduate Education (Master's Program) , Second Semester, Research
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biochemistry
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biochemistry
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biochemistry
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biochemistry
Research Activities
Academic Papers
- VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma, NUCLEUS, 15(1), 20241231
- CREB3L1 /OASIS: cell cycle regulator and tumor suppressor, FEBS JOURNAL, 291(22), 4853-4866, 202411
- AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer, MOLECULAR CANCER RESEARCH, 22(4), 373-385, 20240402
- Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co- ordinating insulin biosynthesis with secretory granule formation, MOLECULAR METABOLISM, 79, 202401
- Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma, CELL DEATH DISCOVERY, 9(1), 20230708
- p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS, CELL REPORTS, 42(5), 20230530
- Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System, NEURAL PLASTICITY, 2023, 2023
- miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20230104
- Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System, NEUROCHEMICAL RESEARCH, 47(9), 2478-2487, 202209
- Advances in understanding the mechanisms of repairing damaged nuclear envelope (vol 171, pg 609, 2022), JOURNAL OF BIOCHEMISTRY, 172(6), 397-397, 2022
- Advances in understanding the mechanisms of repairing damaged nuclear envelop, JOURNAL OF BIOCHEMISTRY, 171(6), 609-617, 20220527
- Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis, COMMUNICATIONS BIOLOGY, 5(1), 20220722
- Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 12227, 202111
- OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 152, 20210629
- Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis, FASEB JOURNAL, 35(2), e21158, 202102
- The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 3921, 202006
- Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
- Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
- Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
- Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, SCIENTIFIC REPORTS, 9(1), 20301, 20191230
- Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
- Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
- NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 20190104
- Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9, 20180724
- Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
- Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
- ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 20170901
- The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 37310, 20161117
- Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
- Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 30955, 20160803
- Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
- IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 16580, 20151116
- OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 16455, 20151112
- Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, HUMAN MOLECULAR GENETICS, 24(2), 299-313, 20150115
- F-box and WD Repeat Domain-containing-7 (Fbxw7) Protein Targets Endoplasmic Reticulum-anchored Osteogenic and Chondrogenic Transcriptional Factors for Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(40), 28488-28502, 20131004
- The roles of endoplasmic reticulum stress in diseases, 37(3), 9-16, 20130920
- Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLOS ONE, 8(1), e55155, 20130130
- Involvement of endoplasmic reticulum stress in tauopathy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(2), 500-504, 20130111
- Activation of OASIS family, ER stress transducers, is dependent on its stabilization, CELL DEATH AND DIFFERENTIATION, 19(12), 1939-1949, 20121219
- Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, SCIENTIFIC REPORTS, 2, 799, 20121112
- The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43), 36190-36200, 20121019
- ★, Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 967, 20120724
- The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(11), 8144-8153, 20120309
- Regulation of osteogenesis and chondrogenesis by unfolded protein response, 84(1), 18-29, 20120125
- ★, Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., NATURE CELL BIOLOGY, 11(10), 1197-1204, 20091201
- Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice, JOURNAL OF NEUROCHEMISTRY, 110(3), 956-965, 20091001
- The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injury., JOURNAL OF PHARMACOLOGICAL SCIENCES, 109(2), 311-314, 20090701
- Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 334-344, 20090401
- Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil, BRAIN RESEARCH, 1208, 217-224, 20080801
- Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil, NEUROSCIENCE, 151(1), 111-119, 20080801
- A protective role of unfolded protein response in mouse ischemic acute kidney injury, EUROPEAN JOURNAL OF PHARMACOLOGY, 592(1-3), 138-145, 20080601
- Nerve fiber analysis on the so-called accessory subscapularis muscle and its morphological significance, ANATOMICAL SCIENCE INTERNATIONAL, 83(1), 55-59, 20080501
- A molecular chaperone inducer protects neurons from ER stress, CELL DEATH AND DIFFERENTIATION, 15(2), 364-375, 20080301
- The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes, JOURNAL OF IMMUNOLOGY, 179(2), 1210-1224, 20071201
- Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice, NEUROSCIENCE, 147(4), 957-967, 20071201
- Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle, ACTA NEUROPATHOLOGICA, 114(5), 527-535, 20071001
- Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1, HUMAN MOLECULAR GENETICS, 16(23), 2834-2843, 20071001
- Endoplasmic reticulum stress response in dendrites of cultured primary neurons, NEUROSCIENCE, 146(1), 1-8, 20070901
- HMGA1a:Sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of Presenilin-2 pre-mRNA, GENES TO CELLS, 12(10), 1179-1191, 20070801
- A novel ER stress transducer, OASIS, expressed in astrocytes, ANTIOXIDANTS & REDOX SIGNALING, 9(5), 563-571, 20070801
- Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation, ACTA HISTOCHEMICA ET CYTOCHEMICA, 40(1), 19-26, 20070301
- BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer, MOLECULAR AND CELLULAR BIOLOGY, 27(5), 1716-1729, 20070201
- Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 96(4), 1090-1100, 20060901
- The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients, NEUROSCIENCE LETTERS, 393(2-3), 102-107, 20060501
- Altered localization of amyloid precursor protein under endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 344(2), 525-530, 20060401
- Autophagy is activated for cell survival after endoplasmic reticulum stress, MOLECULAR AND CELLULAR BIOLOGY, 26(24), 9220-9231, 20060101
- Candidates for tumor-specific alternative splicing, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334(1), 23-29, 20050801
- XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(4), 1146-1153, 20050501
- ★, OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes, NATURE CELL BIOLOGY, 7(2), 186-194, 20050201
- Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex, BRAIN RESEARCH MOLECULAR BRAIN RESEARCH, 127, 128-135, 20041201
- Tra2b, SF2/ASF, and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA, GENES TO CELLS, 9, 121-130, 20041201
- Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death, JOURNAL OF NEUROSCIENCE, 24(15), 3721-3725, 20041101
- Identification of regulatory cis-acting elements for alternative splicing of presenilin-2 exon 5 under hypoxic stress conditions, JOURNAL OF NEUROCHEMISTRY, 91(5), 1191-1198, 20040901
- Induction of neuronal death by ER stress in Alzheimer's disease, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 67-78, 20040801
- Role of ARF4L in recycling between endosomes and the plasma membrane, CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 137-147, 20040701
- Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Ab-induced cell death, JOURNAL OF CELL BIOLOGY, 165(3), 347-356, 20040601
- Endoplasmic reticulum stress and neuronal death, JOURNAL OF CHEMICAL NEUROANATOMY, 28, 49-50, 20040301
- JAB1 participates in unfolded protein responses by association and dissociation with IRE1, NEUROCHEMISTRY INTERNATIONAL, 45, 765-772, 20040201
- Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12, NEUROSCIENCE LETTERS, 357, 127-130, 20040101
- The unfolded protein response is involved in the pathology of Alzheimer's disease, Annals of the New York Academy of Sciences , 977, 349-355, 20040101
- MDG1/ERdj4, an ER-resident DnaJ family member, suppresses cell death induced by ER stress, GENES TO CELLS, 8, 189-202, 20031001
- An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 15825-15831, 20030801
- Endoplasmic reticulum stress and Alzheimer's disease, Mapping the Progress of Alzheimer's and Parkinson's Disease. Mizuno, Y., Fisher, A., Hanin, I. (eds), 95-100, 20030101
- FAD-linked presenilin-1 mutants impede translation regulation under ER stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296, 313-318, 20021101
- Identification of a Cis-acting elements for the regulation of SMN exon 7 splicing, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 23271-23277, 20021001
- The cytosolic inclusion bodies that consist of splice variants that lack exon of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients, NEUROSCIENCE LETTERS, 328, 198-200, 20020601
- Inter-changeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling, ONCOGENE, 20, 4317-4323, 20010901
- Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor-2 (TRAF2) dependent mechanisms in response to ER stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 13935-13940, 20010801
- Upregulation of the pro-apoptotic BH3-only peptide Harakiri (HRK) in spinal neurons of amyotrophiclateral sclerosis patients, NEUROSCIENCE LETTERS, 313, 153-157, 20010501
- Impairment of response to ER stress in presenilin 1 mutant, Neuroscientific Basis of Dementia. Tanaka, C., McGeer, P., Ihara, Y. (eds), 193-199, 20010101
- Are cerebrovascular factors involved in Alzheimer's disease?, NEUROBIOLOGY OF AGING, 21, 215-224, 20000701
- Molecular cloning of a novel membrane glycoprotein, Pal, specifically expressed inphotoreceptor cells of the retina and containing leucine-rich repeat, JOURNAL OF NEUROSCIENCE, 20, 3206-3213, 20000601
- Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, MALT lymphoma-associated protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 11114-11120, 20000201
- ★, Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response, NATURE CELL BIOLOGY, 1, 479-485, 19991201
- A novel presenilin-2 (PS-2) splice variant in human Alzheimer's disease brain tissue, JOURNAL OF NEUROCHEMISTRY, 72, 2498-2505, 19990501
- IPP isomerase, an enzyme of mevalonate pathway, is preferentially expressed in postnatal cortical neurons and induced after nerve transection, MOLECULAR BRAIN RESEARCH, 67, 231-238, 19990401
- Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the girbil, MOLECULAR BRAIN RESEARCH, 56, 66-75, 19980901
- Expression of pattern of a novel death-promoting gene, DP5, in the developing murine nervous system, MOLECULAR BRAIN RESEARCH, 54, 316-320, 19980501
- Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 18842-18848, 19971001
- Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the girbil, JOURNAL OF NEUROSCIENCE, 17, 6678-6684, 19970801
- Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models, ENDOCRINOLOGY, 160(11), 2673-2691, 201911
- The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis, Neurochemistry International, 119, 26-34, 201810
- Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 3215, 201810
- Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
- 60th Anniversary of the Japanese Society for Neurochemistry, Journal of Neurochemistry, 141, 788-789, 201706
- The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy, Medical Research Archives, 4(4), 201611
- The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
- Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics, FEBS JOURNAL, 283(8), 1475-1487, 201604
- Physiological Unfolded Protein Response Regulated by OASIS Family Members, Transmembrane bZIP Transcription Factors, IUBMB LIFE, 63(4), 233-239, 201104
- Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), e0125982, 2015
- OASIS is a Novel Cofactor of HIF1 alpha to Promote the Transcription Dependence on Hypoxia Response Element under the Hypoxic Condition, FASEB JOURNAL, 29, 2015
- An ER stress sensor PERK is involved in Post-operative Subcojunctival Scarring in a Mouse Model of Glaucoma Filtration Surgery, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7), 2015
- ★, Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, MOLECULAR CELL, 53(1), 127-139, 2014
- Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLOS ONE, 9(2), e88048, 2014
- Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 13810-13820, 2014
- OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex, JOURNAL OF NEUROCHEMISTRY, 130(5), 612-625, 2014
- Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor, CELL DEATH & DISEASE, 5, e1332, 2014
- The biological regulation by the endoplasmic reticulum stress response, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S79-S79, 2013
- [Endoplasmic reticulum stress response in osteogenesis]., Clinical calcium, 23(11), 2013
- [Endoplasmic reticulum stress response involved in osteogenesis and chondrogenesis]., Clinical calcium, 23(12), 2013
- The roles of unfolded protein response in osteogenesis and chondrogenesis, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 53P-53P, 2012
- [Regulation of osteogenesis and chondrogenesis by unfolded protein respone]., Seikagaku. The Journal of Japanese Biochemical Society, 84(1), 2012
- Roles of endoplasmic reticulum stress transducer OASIS in fracture healing, BONE, 49(4), 724-732, 2011
- ★, Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation., NATURE CELL BIOLOGY, 11(10), 1205-1211, 2009
- Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2 alpha-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4809-4818, 2011
- Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice, BONE, 48(3), 514-523, 2011
- The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology, JOURNAL OF BIOCHEMISTRY, 149(5), 507-518, 2011
- ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type, MAMMALIAN GENOME, 22(5-6), 318-328, 2011
- Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice, JOURNAL OF BONE AND MINERAL METABOLISM, 28(4), 384-394, 2010
- Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis, JOURNAL OF BONE AND MINERAL METABOLISM, 28(2), 131-138, 2010
- Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice, NEUROSCIENCE LETTERS, 484(1), 43-46, 2010
Invited Lecture, Oral Presentation, Poster Presentation
- Cell-specific regulation of cell cycle arrest by endoplasmic reticulum-resident transcription factor OASIS via p21 induction., Atsushi Saito, Yasunao Kamikawa, Issei Omura, Kazunori Imaizumi, American Society for Cell Biology 2023, 2023/12/04, Without Invitation, English, Boston, USA
- OASIS in podocytes promoted tubular injury by suppressing PRKCI expression, Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Takeo Harada, Takafumi Nakae, Shunsuke Noda, Sayuri Mitsuoka, Koki Tanaka, Shota Tanaka, Makiko Maeda, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio, American Society of Nephrology Kidney Week 2020, 2020/10/22, Without Invitation, English, Denver, USA(web)
- Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, Wu Y, Okamoto T, Imaizumi K, Kaneko M, ASCB|EMBO2019 meeting, 2019/12/08, Without Invitation, English, Washington, USA
- Suppression of transcription factor OASIS ameliorated kidney fibrosis, Masanori Obana, Ayaha Yamamoto, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Sayuri Mitsuoka, Shunsuke Noda, Makiko Maeda, Kazunori Imaizumi, Kotaro Matsumoto, Yasushi Fujio, The American Society of Nephrology, 2019/11/07, Without Invitation, English, Washington, USA
- Recovery of lysosomal functions by the shutdown of ER-associated degradation and therapy of mucopolysaccharidosis, Saito A, Osaki Y, Imaizumi K, NEURO2019, 2019/07/28, With Invitation, English
- The roles of ER-resident transmembrane transcription factor OASIS in cellular senescence of astrocytes, Matsuhisa K, Saito A, Asada R, Kaneko M, Imaizumi K, NEURO2019, 2019/07/26, Without Invitation, English
- The roles of an ER-resident transmembrane transcription factor OASIS in the response to impairment of nuclear envelope integrity., Imaizumi K, Joint Annual Meeting of 71st JSCB & 19th PSSJ, 2019/06/24, Without Invitation, English, Kobe, Japan
- ER-resident transmembrane transcription factor OASIS accumulates in the nuclear bleb in response to the disruption of the nuclear lamina, Matsuhisa K, Asada R, Kaneko M, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/11, Without Invitation, English, San Diego, USA
- Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, Osaki Y, Saito A, Masaaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/09, Without Invitation, English, San Diego, USA
- Neuronal activity-dependent formation of ER-PM contact sites in spines regulates spine formation and dendritic extension via local manipulation of unfolded protein response, Saito A, Imaizumi K, Society for Neuroscience 2018, 2018/11/04, Without Invitation, English, San Diego, USA
- Lysosomal ubiquitin ligase RNF182 regulates mTORC1 signaling and neuronal differentiation, Kaneko M, Kanemoto S, Guo X, Imaizumi K, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/05, Without Invitation, English, Kyoto, Japan
- Suppression of expression of ubiquitin ligase RNF183 ameliorates dextran sodium sulfate-induced colitis, Wu Y, Imaizumi K, Kaneko M, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/03, Without Invitation, English, Kyoto, Japan