Noriyuki Yanaka

Last Updated :2023/11/24

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
Other Contact Details
1-4-4,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-7979 FAX : (+81)82-424-7916
Studies on the relationship between food factors and diseases.

Basic Information

Major Professional Backgrounds

  • 1991/04/07, 2001/11/30, Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory, Researcher
  • 2001/12/01, 2007/03/31, Hiroshima University, Faculty of Applied Biological Science, Associate professor
  • 2020/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • Kyoto University, Graduate School, Division of Agriculture, Japan, 1989/04, 1991/03
  • Kyoto University, Faculty of Agriculture, Japan, 1985/04, 1989/03

Academic Degrees

  • Ph.D. Agriculture, Kyoto University
  • Master of Agriculture, Kyoto University

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • obesity
  • lifestyle diseases
  • gene
  • choline
  • functional food
  • nutrition
  • adipose tissue
  • glycerophosphodiester phosphodiesterase

Affiliated Academic Societies

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2001/10
  • The Molecular Biology Society of Japan, 2001/10
  • Japanese Society of Nutrition and Food Science, 2001/11
  • The Vitamin Society of Japan, 2017/11
  • The Japanese Society for Genome Editing, 2016/04

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 3Term, Food safety and health science
  2. 2023, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
  3. 2023, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  4. 2023, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  5. 2023, Undergraduate Education, Second Semester, Graduation Thesis I
  6. 2023, Undergraduate Education, Second Semester, Graduation Thesis I
  7. 2023, Undergraduate Education, First Semester, Graduation Thesis II
  8. 2023, Undergraduate Education, First Semester, Graduation Thesis II
  9. 2023, Undergraduate Education, Second Semester, Graduation Thesis III
  10. 2023, Undergraduate Education, Second Semester, Graduation Thesis III
  11. 2023, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  12. 2023, Undergraduate Education, 2Term, Nutrition
  13. 2023, Undergraduate Education, Intensive, Laboratory work in nutritional biochemistry
  14. 2023, Undergraduate Education, Intensive, Problem Based Learning for Molecular Agro-Life ScienceII
  15. 2023, Undergraduate Education, 3Term, Food and health sciences
  16. 2023, Undergraduate Education, First Semester, Graduate Thesis III
  17. 2023, Undergraduate Education, Second Semester, Graduate Thesis IV
  18. 2023, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  19. 2023, Undergraduate Education, 3Term, Modern Food Science
  20. 2023, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  21. 2023, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  22. 2023, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  23. 2023, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  24. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  25. 2023, Graduate Education (Master's Program) , 4Term, Nutrition and Food Functions II
  26. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  27. 2023, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  28. 2023, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics

Research Activities

Academic Papers

  1. Satellite cell content and muscle regeneration in a mouse model of NAFLD, NUTRITION, 96, 202204
  2. Serum Amyloid A3 Promoter-Driven Luciferase Activity Enables Visualization of Diabetic Kidney Disease, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2), 202201
  3. Comparative study on molecular mechanism of diabetic myopathy in two different types of streptozotocin-induced diabetic models, LIFE SCIENCES, 288, 20220101
  4. Dietary GABA and its combination with vigabatrin mimic calorie restriction and induce antiobesity-like effects in lean mice, JOURNAL OF FUNCTIONAL FOODS, 78, 202103
  5. Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85(2), 447-451, 20210218
  6. Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16), JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, 19(1), 20211109
  7. Satellite cells exhibit decreased numbers and impaired functions on single myofibers isolated from vitamin B6-deficient mice, NUTRIENTS, 13(12), 202112
  8. Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid, JOURNAL OF BIOCHEMISTRY, 170(6), 713-727, 202112
  9. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles, AMINO ACIDS, 52(5), 743-753, 202005
  10. Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/I kappa B alpha/NF-kappa B, JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 57(7), 2659-2668, 202007
  11. Increased glucose metabolism inArid5b(-/-)skeletal muscle is associated with the down-regulation of TBC1 domain family member 1 (TBC1D1), BIOLOGICAL RESEARCH, 53(1), 20201006
  12. Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications, FRONTIERS IN NUTRITION, 7, 20201029
  13. ★, The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, Scientific Reports, 9, 20191001
  14. GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage, Am. J. Physiol. Cell Physiol., 316(2), C162-C174, 201902
  15. Novel metabolic disturbances in marginal vitamin B6-deficient rat heart., J. Nutr. Biochem., 65, 26-34, 201903
  16. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, Genes Cells, 23(3), 136-145, 201803
  17. Beneficial effects of dietary tempeh prepared with Rhizopus stolonifer on liver function in rats fed with a high-fat diet, J. Nutr. Sci. Vitaminol. (Tokyo)., 64(5), 379-383, 2018
  18. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, Journal of Functional Foods, 49, 162-167, 201810
  19. Gender difference and dietary supplemental vitamin B-6: Impact on colon luminal environment, J. Nutr. Sci. Vitaminol (Tokyo)., 64(2), 116-128, 2018
  20. Production of isoflavone aglycone-enriched tempeh with Rhizopus stolonifer, Food Sci. Technol. Res., 24(3), 493-499, 201803
  21. Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, Life Sciences, 184, 103-111, 20170901
  22. Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats, Exp. Ther. Med., 14(4), 3239-3246, 201710
  23. Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet, Journal of Functional Foods, 39, 250-256, 201712
  24. Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells, Biosci. Biotechnol. Biochem., 81(3), 534-540, 2017
  25. Molecular characterization of aspartylglucosaminidase, a lysosomal hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita, Biosci. Biotechnol. Biochem., 81(5), 938-950, 2017
  26. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, Biosci. Biotechnol. Biochem., 81(11), 2164-2167, 2017
  27. ★, Serum amyloid A3 gene expression in adipocytes is an indicator of the interaction with macrophages, Scientific Reports, 6, 20161208
  28. Time course analysis of skeletal muscle pathology of GDE5 transgenic mouse, PLoS One, 11(9), 20160922
  29. CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation, Int. Immunol., 28(6), 267-282, 20160101
  30. Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice, Biol. Open, 5(8), 1142-1148, 20160815
  31. De novo-synthesized retinoic acid in ovarian antral follicles enhances FSH-mediated ovarian follicular cell differentiation and female fertility, Endocrinology, 157(5), 2160-2172, 20160501
  32. Carnosine content in skeletal muscle Is dependent on vitamin B6 status in rats, Front. Nutr., 2, 20160119
  33. ★, New members of the mammalian glycerophosphodiester phosphodiesterase family : GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity., J. Biol. Chem., 290(7), 4260-4271, 20150213
  34. Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats, Springerplus, 4, 280, 20150501
  35. Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle, J. Muscle Res. Cell Motil., 36(3), 275-286, 20150601
  36. I kappa B kinase epsilon expression in adipocytes is upregulated by interaction with macrophages, Biosci. Biotechnol. Biochem., 78(8), 1357-1362, 20140801
  37. Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis, J. Agrc. Food Chem., 62(24), 5589-5594, 20140618
  38. Vitamin B-6 activates p53 and elevates p21 gene expression in cancer cells and the mouse colon, Oncol. Rep., 31(5), 2371-2376, 20140501
  39. Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions, J. Muscle Res. Cell Motil., 35(2), 179-189, 20140401
  40. The emerging physiological roles of the glycerophosphodiesterase family, FEBS J., 281(4), 998-1016, 20140201
  41. High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway, Mol. Med. Rep., 8(4), 973-978, 20131001
  42. ★, RASSF6 expression in adipocytes is down-regulated by interaction with macrophages, PLoS One, 8(4), e61931, 20130423
  43. Comparative study on the responses of concentrations of B-6-vitamers in several tissues of mice to the dietary level of pyridoxine, J. Nutr. Sci. Vitaminol (Tokyo)., 58(6), 446-451, 20121201
  44. Consumption of vitamin B-6 reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet, J. Nutr. Sci. Vitaminol (Tokyo)., 58(5), 366-370, 20121001
  45. ★, Regulation of colon gene expression by vitamin B6 supplementation, Mol. Nutr. Food Res., 56(4), 641-652, 20120401
  46. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-alpha-stimulated HT-29 cells, Mol. Nutr. Food Res., 55(4), 635-643, 20110401
  47. Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1,2-dimethylhydrazine, Oncol. Lett., 2(6), 1243-1246, 20111101
  48. Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain, Biosci. Biotechnol. Biochem., 75(7), 1383-1385, 20110701
  49. Vitamin B6 regulates mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, Exp. Ther. Med., 2(3), 419-424, 20110501
  50. ★, A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism, J. Biol. Chem., 285(36), 27652-27663, 20100903
  51. The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle, Eur. J. Appl. Physiol., 110(5), 943-952, 20101101
  52. Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents, Biosci. Biotechnol. Biochem., 74(1), 185-187, 20100101
  53. Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer, Bioorg. Med. Chem., 17(1), 25-28, 20090101
  54. Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha., Biosci. Biotechnol. Biochem., 73(12), 2809-2811, 20091201
  55. ★, The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth., J. Biol. Chem., 284(37), 24848-24856, 20090901
  56. Mammalian glycerophosphodiester phosphodiesterases, Biosci. Biotechnol. Biochem., 71(8), 1811-1818, 20070401
  57. ★, Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells., FEBS Lett., 581(4), 712-718, 20070220
  58. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase, Biochimie, 89, 581-590, 20070501
  59. Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet., Biosci. Biotechnol. Biochem., 581(4), 712-718, 20060701
  60. Expression of zinc finger protein ZPR1 mRNA in brain is up-regulated in mice fed a high-fat diet., Int. J. Mol. Med., 17(3), 491-496, 20060301
  61. High protein buckwheat flour suppresses hypercholesterolemia in rats and gallstone formation in mice by hypercholesterolemic diet and body fat in rats because of its low protein digestibility., Nutrition, 22, 166-173, 20060101
  62. Vitamin B6 suppresses NF-kappaB activation in LPS-stimulated mouse macrophages., Int. J. Mol. Med., 16(6), 1071-1075, 20051201
  63. A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice, Oncology Reports, 14, 265-269, 20050501
  64. Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice, Biosci. Biotechnol. Biochem., 69, 209-211, 20050201
  65. Short-term feeding of fish oil down-regulates the expression of pyruvate dehydrogenase E1 alpha subunit mRNA in mouse brain., Biosci. Biotechnol. Biochem., 69(2), 301-306, 20050201
  66. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6., Gene, 337, 173-179, 20040804
  67. ★, Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation., J. Biol. Chem., 278(44), 43595-43602, 20031031
  68. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles., Biosci. Biotechnol. Biochem., 67(5), 973-979, 20030501
  69. Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hair less mouse., J. Photochem. Photobiol. B: Biology, 71, 11-17, 20030401
  70. Antitumor effect of vitamin B6 and its mechanism, Biochim. Biophys. Acta, 1647, 127-130, 20030401
  71. Developmental expression of Na+/Ca2+ exchanger (NCX1) gene in the mouse embryo, Comp. Biochem. Physiol., 130(2), 191-198, 20010901
  72. Human Ca(2+)/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization, Biochim. Biophys. Acta, 1517(2), 278-287, 20010101
  73. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat, J. Biol. Chem., 275(47), 36991-36998, 20001101
  74. ★, Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis, J. Biol. Chem., 275(20), 14791-14794, 20000501
  75. ★, Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha, J. Biol. Chem., 275(7), 4897-4905, 20000201
  76. The specific domain of cGMP -dependent protein kinase Ibeta but not Ialpha functions as a transcriptional activator in yeast, IUBMB Life, 49(1), 17-22, 20000101
  77. Identification of a conserved residue responsible for the autoinhibition of cGMP-dependent protein kinase Ialpha and beta, FEBS Lett., 466(1), 175-178, 20000101
  78. Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice, DNA Seq., 11(42737), 75-81, 20000101
  79. ★, A novel interaction of cGMP-dependent protein kinase I with troponin T, J. Biol. Chem., 274(52), 37429-37434, 19991201
  80. Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5, Biochim. Biophys. Acta, 1452(3), 219-227, 19991201
  81. Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases, Eur. J. Biochem., 262(3), 866-873, 19990101
  82. 1,25-Dihydroxyvitamin D3 upregulates natriuretic peptide receptor-C expression in mouse osteoblasts, Am. J. Physiol., 275(42887), E965-973, 19981201
  83. Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase, J. Biol. Chem., 273(41), 26982-26990, 19981001
  84. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene, Eur. J. Biochem., 255(2), 391-399, 19980701
  85. Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation, Am. J. Physiol., 274(42795), L425-431, 19980501
  86. Isolation and characterization of the 5’-flanking regulatory region of the human natriuretic peptide receptor C gene, Endocrinology, 139(3), 1389-1400, 19980301
  87. TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345., J. Antibiot. (Tokyo), 51, 111-111, 1998
  88. Protein kinase C activation down-regulates natriuretic peptide receptor C expression via transcriptional and post-translational pathways., FEBS Lett., 418(3), 333-336, 19971201
  89. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development., Eur. J. Biochem., 249(2), 434-442, 19971015
  90. Structure of the 5'-flanking regulatory region of the mouse gene encoding the clearance receptor for atrial natriuretic peptide., Eur. J. Biochem., 237(1), 25-34, 19960401
  91. Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue., Biochemistry, 31, 9000-9007, 1992
  92. Nitrilase from Rhodococcus rhodochrous J1. Sequencing and overexpression of the gene and identification of an essential cysteine residue., J. Biol. Chem., 267, 20746-20751, 1992
  93. Hyperinduction of an aliphatic nitrilase by Rhodococcus rhodochrous K22., FEMS Microbiol. Lett., 77, 121-123, 1991
  94. Monohydrolysis of an aliphatic dinitrile compound by nitrilase from Rhodococcus rhodochrous K22., Tetrahedron, 46, 5587-5590, 1990
  95. Nitrilase-catalyzed production of pyrazinoic acid, an antimycobacterial agent, from cyanopyrazine by resting cells of Rhodococcus rhodochrous J1., J. Antibiot. (Tokyo), 43, 1316-1320, 1990
  96. Purification and characterization of a novel nitrilase of Rhodococcus rhodochrous K22 that acts on aliphatic nitriles., J. Bacteriol., 172, 4807-4815, 1990
  97. Nitrilase-catalyzed production of para-aminobenzoic acid from para-aminobenzonitorile with Rhodococcus rhodochrous J1., Biotechnol. lett., 11, 27-30, 1989

Publications such as books

  1. 2017/11, Science within Food: Up-to-date Advances on Research and Educational Ideas., Vitamin B6: a heart-protective molecule through a novel mechanism of increasing histidine-related compounds., Formatex Research Center., 2017, 11, Scholarly Book, Joint work, Kumrungsee T, Nirmagustina DE, Kato N, Yanaka N, and Lai HC:, 292-299

Invited Lecture, Oral Presentation, Poster Presentation

  1. Homocarnosine as a novel food factor increases brain GABA and homocarnosine levels, Jason Dumaguing Braga, Thanutchaporn Kumrungsee, Mikako Sato, Yukihiro Sugawara, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  2. Protective effects of D-beta-hydroxybutyrate on diabetic nephropathy and myopathy in mice, Kenshu Miyata, Mayu Horii, Tolulope Peter Saliu, Ayane Kudo, Jun Tsubota, Thanutchaporn Kumrungsee, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  3. Absorption and metabolism of glycerophosphocholine and lecithin, Shiho Inui, Ryoko Nakashima, Tatsuya Kawaguchi, Noriyasu Ohshima, Takuya Suzuki, Yoshiko Nakagawa, Tetsushi Sakuma, Takashi Yamamoto, Thanutchaporn Kumrungsee, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  4. NAFLD milieu alters satellite cell content and muscle regeneration in mice, Siyi Chen, Tolulope Peter Saliu, Thanutchaporn Kumrungsee, Koji Mitsumoto, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  5. Appetite-suppressing effects of dietary GABA and GABA degradation inhibition in lean and obese mice: a potential strategy for obesity treatment, Thanutchaporn Kumrungsee, Tomoka Nagao, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  6. Functional relationship between phosphatidylcholine profiles and skeletal muscle function—Metabolic analyses of skeletal muscle-specific GDE5 deficient mouse, Rahmawati Aisyah, Noriyasu Ohshima, Daiki Watanabe, Tetsushi Sakuma, Yoshiko Nakagawa, Thanutchaporn Kumrungsee, Shinji Miura, Takashi Yamamoto, Masanobu Wada, Noriyuki Yanaka, 22nd International Congress of Nutrition (ICN), 2022/12/06, Without Invitation, English, Organizing Committee of 22nd IUNS-ICN, Tokyo
  7. Dietary supplemental vitamin B6 increases concentrations of carnosine and anserine in the skeletal muscles and heart of rats., Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato., Jan Stautemas, Wim Derave, The 6th International Conference on Food Factors, 2015/11/22, Without Invitation, English, ICoFF, Seoul
  8. Carnosine and anserine in skeletal muscles and heart are dependent on vitamin B6 status., Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato, Wim Derave, 12th European Nutrition Conference (FENS 2015), 2015/10/23, Without Invitation, English, FENS, Berlin
  9. In vivo imaging model mice for assessing obese adipose inflammation and DSS-induced colon inflammation, Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato and Noriyuki Yanaka, 17th International Conference of FFC, 2015/09/15, Without Invitation, English, Functional food center, Massachusetts
  10. GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity., Isaji C, Kudo T, Ohshima N, Yamashita Y, Araki M, Honda A, Nagano T, Kato N, Konishi A, Kishimoto K, Tatei K, Yanaka N, Izumi T, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015), 2015/02/12, Without Invitation, English, Tokyo
  11. Transcriptomic analysis identities novel genes expression in response to choline deficiency in rat liver and in rat primary hepatocytes., Rina Watanabe, Kouji Mitsumoto, Hisaki Yonenaka, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, English, Federation of Asian Nutrition Societies, Yokohama
  12. In vivo imaging of adipose tissue inflammation by using Saa3 promoter activity., Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, English, Federation of Asian Nutrition Societies, Yokohama
  13. Maternal choline deficiency affects offspring health., Yoshiko Tsukuda, Yukino Miyachi, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, English, Federation of Asian Nutrition Societies, Yokohama
  14. Effect of vitamin B6 on the expression of IGFBPs, anti-disease factors, in HepG2 cells, Sofya Suidasari, Peipei Zhang, Tomomi Hasegawa, Noriyuki Yanaka, Norihisa Kato, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, English, Federation of Asian Nutrition Societies, Yokohama
  15. Dietary supplemental vitamin B6 to a low vitamin B6 diet modulates gene expression of myokines in skeletal muscle of rats., Shinji Uragami, Sofya Suidasari, Noriyuki Yanaka, Norihisa Kato, The 12th Asian Congress of Nutrition (ACN2015), 2015/05/15, Without Invitation, English, Federation of Asian Nutrition Societies, Yokohama


  1. 2005, The Japan Bioscience, Biotechnology, and Agrochemistry Society Award for the Encouragement of Young Scientists in 2005., 日本農芸化学会, 動物の新規酵素の探索とホスホジエステラーゼ類に関する基盤的研究

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2021, 2024
  2. -, 2021/04/01, 2022/03/31
  3. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  4. KAKENHI, 2014, 2016
  5. KAKENHI, Cellular functions of a cytosolic glycerophosphocholine phosphodiesterase GDE5, 2011, 2013
  6. KAKENHI, Study on the antitumor effect of vitamin B6, 2009, 2011
  7. KAKENHI, Physiological functions of novel mammalian glycerophosphodiester phosphodiesterases, 2008, 2010
  8. KAKENHI, Isolation and characterization of mammalian glycerophosphodiester phosphodiesterases, 2006, 2007
  9. KAKENHI, 2015, 2018
  10. KAKENHI, 2012, 2014
  11. KAKENHI, 2006, 2008
  12. KAKENHI, Study on vitamin B6 as an anti-ageing factor, 2005, 2007
  13. KAKENHI, 2003, 2004

Social Activities

Organizing Academic Conferences, etc.

  1. 2007/11
  2. 2004/03
  3. 2004/03