TAIICHIRO CHIKAMA

Last Updated :2022/08/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
chikamahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1991/06/01, 1993/05/22, Yamaguchi University, Clinical Resident
  • 1993/05/23, 1993/11/15, Yamaguchi University, Clinical Fellow
  • 1993/11/16, 1994/12/31, Yamaguchi University, Research Associate
  • 1995/01/01, 1996/03/31
  • 1999/04/01, 2001/03/31, Yamaguchi University, Faculty of Medicine, Research Associate
  • 2001/04/01, 2007/02/28, Yamaguchi University, Lecturer
  • 2007/03/01, 2007/03/31, Yamaguchi University, Faculty of Medicine
  • 2007/04/01, 2009/06/30, Yamaguchi University, Faculty of Medicine
  • 2009/07/01, 2010/12/31, Yamaguchi University, Associate Professor
  • 2011/01/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2017/04/01, Hiroshima University Hospital, Department of Ophthalmology, Clinical Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Educational Backgrounds

  • Yamaguchi University, Graduate School, Division of Medical Sciences, Japan, 1996/04, 1999/03
  • Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Yamaguchi University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Ophthalmology

Research Keywords

  • Photodynamic antimicrobial chemotherapy
  • infectious keratitis
  • Keratoplasty
  • ocular surface
  • genetic diseases in Ophthalmology

Affiliated Academic Societies

  • Japan Cornea Sciety
  • Keratoplasty Society in Japan
  • Japanese Association for Ocular Infection
  • The Japanese Sciety for Matrix Biology and Medicine.
  • The Japan Photodynamic Association
  • The Japan Sciety of Human Genetics
  • Japanese Ophtahlmological society
  • Japanese Society of Ophthalmic Surgery
  • Japan Contact Lens Society
  • Japanese Ocular Inflammation Society
  • Japanese Sciety of Cataract and Refratctive Surgery
  • The European Society of Cataract and Refrective Surgeons
  • The Association for Reserch in Vision and Ophthalmology

Educational Activity

Course in Charge

  1. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Ophthalmology and Visual Science
  2. 2022, Undergraduate Education, First Semester, Human genetics
  3. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment II
  4. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2022, Undergraduate Education, 1Term, Ophthalmology
  6. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Ophthalmology and Visual Science
  7. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Ophthalmology and Visual Science
  8. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Ophthalmology and Visual Science

Research Activities

Academic Papers

  1. Technical Report: Automatic Measurement of Corneal Nerve Fiber Area Using Versatile Software., Optometry and Vision Science, 20220801
  2. Synergistic effect of TONS504-mediated photodynamic antimicrobial chemotherapy and additives widely contained in ophthalmic solutions: benzalkonium chloride and ethylenediaminetetraacetic acid., Photochem Photobiol Sci (2022), 20220720
  3. Vernal keratoconjunctivitis with a limbal mass lesion developing independently of severe papillae formation at the tarsal conjunctiva: a case report., BMC Ophthalmology, 20220326
  4. Long-Term Observation of Deep Anterior Lamellar Keratoplasty in Patients with Post-LASIK Granular Corneal Dystrophy Type 2: Two Case Reports., Ophthalmology and Therapy, 20211002
  5. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue., J Photochem Photobiol B, 221, 20210608
  6. Efficacy of Photodynamic Anti-Microbial Chemotherapy for Acanthamoeba Keratitis In Vivo., Lasers in Surgery and Medicine, 28, 166-171, 20201208
  7. A Case of Paracentral Corneal Perforation Treated with One-Bite Mini-Keratoplasty, TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY, 51(1), 55-57, 202101
  8. Amantadine can induce intra-epithelial deposition in the cornea., American Journal of Ophthalmology Case Reports, 202009
  9. Deep Neural Network-Based Method for Detecting Obstructive Meibomian Gland Dysfunction With in Vivo Laser Confocal Microscopy, CORNEA, 39(6), 720-725, 202006
  10. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 201912
  11. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 201906
  12. Comparison of semi-automated center-dot and fully automated endothelial cell analyses from specular microscopy images, INTERNATIONAL OPHTHALMOLOGY, 38(6), 2495-2507, 201812
  13. Absence of the foveal avascular zone in a nanophthalmic child revealed by optical coherence tomography angiography., Am J Ophthalmol Case Rep, 201811
  14. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 201809
  15. Potential New Modes of Treatment of Neurotrophic Keratopathy, CORNEA, 34, S121-S127, 201511
  16. Vernal keratoconjunctivitis with a limbal mass lesion developing independently of severe papillae formation at the tarsal conjunctiva: a case report, BMC OPHTHALMOLOGY, 22(1), 2022
  17. Technical Report: Automatic Measurement of Corneal Nerve Fiber Area Using Versatile Software., Optometry and vision science : official publication of the American Academy of Optometry, 2022
  18. Synergistic effect of TONS504-mediated photodynamic antimicrobial chemotherapy and additives widely contained in ophthalmic solutions: benzalkonium chloride and ethylenediaminetetraacetic acid, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2022
  19. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 221, 2021
  20. Long-Term Observation of Deep Anterior Lamellar Keratoplasty in Patients with Post-LASIK Granular Corneal Dystrophy Type 2: Two Case Reports, OPHTHALMOLOGY AND THERAPY, 10(4), 1163-1169, 2021
  21. Efficacy of Photodynamic Anti-Microbial Chemotherapy for Acanthamoeba Keratitis In Vivo, LASERS IN SURGERY AND MEDICINE, 53(5), 695-702, 2021
  22. A Case of Paracentral Corneal Perforation Treated with One-Bite Mini-Keratoplasty., Turkish journal of ophthalmology, 51(1), 2021
  23. Deep Neural Network-Based Method for Detecting Obstructive Meibomian Gland Dysfunction With in Vivo Laser Confocal Microscopy, CORNEA, 39(6), 720-725, 2020
  24. Amantadine can induce intra-epithelial deposition in the cornea., American journal of ophthalmology case reports, 19, 2020
  25. TONS504 mediated photodynamic antimicrobial chemotherapy inactivation for Acanthamoeba keratitis in rabbits in vivo, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9), 2019
  26. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(11), 2019
  27. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 2019
  28. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 2019
  29. Absence of the foveal avascular zone in a nanophthalmic child revealed by optical coherence tomography angiography., American journal of ophthalmology case reports, 13, 2019
  30. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 2018
  31. In Vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9), 2018
  32. Comparison of semi-automated center-dot and fully automated endothelial cell analyses from specular microscopy images, INTERNATIONAL OPHTHALMOLOGY, 38(6), 2495-2507, 2018
  33. Clinical and Histopathologic Evaluation of the Efficacy of Photodynamic Antimicrobial Chemotherapy for Experimental Keratitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9), 2018
  34. Antimicrobial efficacy of photodynamic therapy with TONS504 against pathogenic filamentous fungi, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(8), 2017
  35. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12), 2016
  36. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy, Molecular Vision, 21, 532-537, 2015
  37. Antimicrobial performance of preservative agents in antiglaucoma ophthalmic solutions, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7), 2015
  38. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro, LASERS IN MEDICAL SCIENCE, 30(1), 383-387, 2015
  39. Neuropeptides Released From Trigeminal Neurons Promote the Stratification of Human Corneal Epithelial Cells, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(1), 125-133, 2014
  40. Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58(6), 522-527, 2014
  41. Efficacy of photodynamic antimicrobial chemotherapy against herpes simplex virus-type 1, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(13), 2014
  42. Effects of brimonidine on the intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation in glaucoma subjects, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(13), 2014
  43. [Influence on ocular surface and intraocular pressure of switching from preservative-containing to preservative-free carteolol hydrochloride ophthalmic solution]., Nippon Ganka Gakkai zasshi, 117(5), 2013
  44. Neuropeptide from trigeminal nerve promotes the stratification of human corneal epithelial cells, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 2013
  45. Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats, CELL BIOCHEMISTRY AND FUNCTION, 31(6), 482-488, 2013
  46. Efficacy of photodynamic antimicrobial chemotherapy on gram negative bacteria, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 2013
  47. Up-regulation of matrix metalloproteinase-1 and interleukin-6 expression in cocultures of corneal fibroblasts and neural cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 419(3), 537-542, 2012
  48. The Relation Between Visual Performance and Clinical Ocular Manifestations in Stevens-Johnson Syndrome, AMERICAN JOURNAL OF OPHTHALMOLOGY, 154(3), 499-511, 2012
  49. Differential expression of semaphorin 3A and its receptors during mouse retinal development, CELL BIOCHEMISTRY AND FUNCTION, 30(7), 563-568, 2012
  50. Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice, AMERICAN JOURNAL OF PATHOLOGY, 172(3), 638-649, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Comparison of the clinical characteristics between Ocular rosacea and Meibomitis-related Keratoconjunctivitis, Minamoto A, Chikama T, Toda R, Mitoma K, Kiuchi Y, The 14th Joint Meeting of Japan-China-Korea Ophthalmologists, 2021/11/27, Without Invitation, English, Yuichi Hori, Koh-Hei Sonoda, virtual
  2. Evaluation of the effectiveness of azithromycin hydrate eye drops., Shimizu Y, Chikama T, Mitoma K, Kiuchi Y, ACS2020, 2021/04/28, Without Invitation, English, Asia Cornea Sciety, Osaka, Japan (Web)
  3. Efficacy and safety of photodynamic antimicrobial chemotherapy for Acanthamoeba keratitis., Chikama T, Pertiwia YD, Sueoka K, Shinji K, Ko JA, Kiuchi Y, Sakaguchi T, ACS2020, 2021/04/28, Without Invitation, English, Asia Cornea Sciety, Osaka, Japan (Web)
  4. Early postoperative graft detachment after Descemet's stripping automated endothelial keratoplasty (DSAEK) in eyes with a filtration bleb, Shinji K, Inokawa S, Chikama T, Toda R, Ideguchi K, Kiuchi Y, 32nd APACRS KYOTO2019 Annual Meeing of the Asia-Pacific Association of Cataract & Refractive Surgeons(APACRS), 2019/10/03, With Invitation, English, Asia-Pacific Association of Cataract & Refractive Surgeons(APACRS), kyoto,Japan
  5. TONS504 mediated photodynamic antimicrobial chemotherapy inactivation for Acanthamoeba keratitis in rabbits in vivo., Yunialthy D.P, Chikama T, Sueoka K, Ko JA, Kiuchi Y, ARVO 2019 Annual Meeting, 2019/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, VANCOUVER
  6. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis., Chikama T, Shinji K, kadohiro Y, kiuchi Y, 2019 Imaging in the Eye Conference, 2019/04/27, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Vancouver
  7. Automatic analysis to measure the area of corneal nerve fibers using in vivo confocal microscopy, Shinji K, Chikama T, Homtake T, kiuchi Y, 2019 Imaging in the Eye Conference, 2019/04/27, Without Invitation, English, The Association for Research in Vision and Ophthalmology, VANCOUVER
  8. In vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba, Chikama T, Pertiwi Y.D, Sueoka K., Ko JA, Kiuchi Y, Onodera M, Sakaguchi T, ISER 2018(Biennial Meeting of the International Society for Eye Research), 2018/09/11, Without Invitation, English, ISER, Berfast, Northern Ireland, UK
  9. Clinical and Histopathologic Evaluation of the Efficacy of Photodynamic Antimicrobial Chemotherapy for Experimental Keratitis., Chikama T, Sueoka K, Ko JA, Sakaguchi T, Kiuchi Y, ARVO-2018, 2018/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Honolulu,Hawaii
  10. In Vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba., Yunialthy D P, Chikama T, Sueoka,K, Ko JA, Kiuchi Y, ARVO-2018, 2018/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Honolulu,Hawaii
  11. Effcacy of Photodynamic Antimicrobial Therapy with TONS504PDT-Acanthamoeba, Pertiwi Yunialthy D, Chikama T, Japan Cornea Conference 2018 (42nd Japan Cornea Society / 34th Annual Meeting of Keratoplasty Society of Japan), 2018/02/17, Without Invitation, Japanese
  12. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis, Chikama T, Kaneoka C, Inokawa S, Toda R, Kadohiro Y, Kiuchi Y, EuCornea 2017, 2017/10/06, Without Invitation, English, lisbon/Portugal
  13. Antimicrobial efficacy ofphotodynamic therapy with TONS504 againstpathogenic filamentous fungi., Chikama T, Sueoka K, Ko JA, Kiuchi Y, Sakaguchi T, Obana A, ARVO2017 Annual Meeting, 2017/05/10, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Baltimore
  14. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, Sueoka K, Chikama T, Latief M.A, Ko JA,Kiuchi Y, Sakaguchi T, Obana A, ARVO2016 Annual Meeting, 2016/05/01, Without Invitation, English, Seattle, USA
  15. A new adaptor development for a high-power objective lens in in vivo confocal microscopy, Chikama T, Kadohiro Y, Sone T, Toda R, Inokawa S, Kiuchi Y, 2016 ARVO Imaging in the Eye Conference, 2016/04/30, Without Invitation, English
  16. Medication-related dry eye, Chikama T, 2015 AsiaARVO, 2015/02/16, With Invitation, English
  17. Non-contact direct observation on pathogenic microorganisms by an in vivo laser confocal microscope attached with high-power objective lens, Chikama T, Abe E, Kadohiro Y, Sone T, Ideguchi K, Onodera M, Kiuchi Y, 5th EuCornea Congress, 2014/09/12, Without Invitation, English
  18. Effects of brimonidine on the intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation in glaucoma subjects, Kiuchi Y, Ideguchi K, Sugimoto Y, Chikama T, ARVO2014, 2014/05/05, Without Invitation, English
  19. Efficacy of photodynamic antimicrobial chemotherapy against herpes simplex virus–type 1, Chikama T, Latief M.A, Ko JA, Kiuchi Y, Sakaguchi T, Obana A, ARVO2014, 2014/05/05, Without Invitation, English
  20. Noncontact direct observation of the human cornea by in vivo confocal microscopy with a high-power objective lens, Ideguchi K, Abe E, Chikama T, Kadohiro Y, Sone T, Toda R, Inokawa S, Kiuchi Y, ARVO/ISIE, 2014/05/03, Without Invitation, English
  21. The Efficacy of Photodynamic Antimicrobial Chemotherapy against Herpes Simplex Virus Type 1, Latief M.A, Chikama T, Kiuchi Y, Sakaguchi T, Obana A, World Ophthalmology Congress 2014 Tokyo, 2014/04/04, Without Invitation, English

Awards

  1. 2014/01/30, Uchida Prize, Japan Cornea Society, Non-contact direct observation on pathogenic microorganisms by in vivo confocal microscopy attached with a high-power objective lens

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020
  3. KAKENHI, 2015, 2018
  4. KAKENHI, 2015, 2017
  5. KAKENHI, 2012, 2014
  6. KAKENHI, Analysis of nueroparalytic keratitics using coculture system of neural and corneal epithelial cells, 2011, 2013
  7. KAKENHI, 2009, 2011
  8. KAKENHI, Reciprocal interaction between epithelial cells and keratocytes in neurotrophic keratopathy, 2000, 2001
  9. KAKENHI, 2000, 2001

Social Activities

History as Committee Members

  1. trustee, 2012, Japan Cornea Society
  2. trustee, 2012, Japanese Association for Ocular Infection
  3. trustee, 2008, The Japanese Society for Matrix Biology and Medicine

History as Peer Reviews of Academic Papers

  1. 2022, Journal of Japanese Ophthalmoloical Society, Others, 2
  2. 2022, Japanese Journal of Ophthalmmology, Others, reviewer, 1
  3. 2021, Molecules, Others, reviewer, 1
  4. 2021, Journal of Japanese Ophthalmoloical Society, Others, 4
  5. 2020, Current Eye Reserch, Others, reviewer, 1
  6. 2020, Journal of Japanese Ophthalmoloical Society, Others, 2
  7. 2020, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  8. 2020, BMC Ophthalmology, Others, Reviewer, 1
  9. 2020, Journal of Ophthalmic Inflammation and Infection, Others, reviewer, 1
  10. 2019, Lasers in Medical Science, Others, reviewer, 1
  11. 2019, Scientific Report, Others, reviewer, 1
  12. 2019, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  13. 2019, Journal of Japanese Ophthalmoloical Society, Others, 1
  14. 2019, BMC Ophthalmology, Others, Reviewer, 1
  15. 2018, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  16. 2018, Journal of Japanese Ophthalmological Society, Others, Reviewer, 2
  17. 2017, Journal of Japanese Ophthalmological Society, Others, 1
  18. 2017, Japanese Journal of Ophthalmology, Others, 1
  19. 2016, Journal of Ophthalmology, Others, 2
  20. 2016, BMC Ophthalmology, Others, 1
  21. 2016, Japanese Journal of Ophthalmology, Others, 1
  22. 2015, Japanese Journal of Ophthalmology, Others, 3
  23. 2015, Journal of Japanese Ophthalmoloical Society, Others, 1
  24. 2014, NOPE, Others, 1
  25. 2013, Current Eye Research, Others, 2
  26. 2013, Investigative Ophthalmology & Visual Science, Others, 1
  27. 2012, Japanese Journal of Ophthalmology, Others, 3
  28. 2011, Investigative Ophthalmology & Visual Science, Others, 1