TAIICHIRO CHIKAMA

Last Updated :2024/04/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
chikamahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1991/06/01, 1993/05/22, Yamaguchi University, Clinical Resident
  • 1993/05/23, 1993/11/15, Yamaguchi University, Clinical Fellow
  • 1993/11/16, 1994/12/31, Yamaguchi University, Research Associate
  • 1995/01/01, 1996/03/31
  • 1999/04/01, 2001/03/31, Yamaguchi University, Faculty of Medicine, Research Associate
  • 2001/04/01, 2007/02/28, Yamaguchi University, Lecturer
  • 2007/03/01, 2007/03/31, Yamaguchi University, Faculty of Medicine
  • 2007/04/01, 2009/06/30, Yamaguchi University, Faculty of Medicine
  • 2009/07/01, 2010/12/31, Yamaguchi University, Associate Professor
  • 2011/01/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2017/04/01, Hiroshima University Hospital, Department of Ophthalmology, Clinical Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Educational Backgrounds

  • Yamaguchi University, Graduate School, Division of Medical Sciences, Japan, 1996/04, 1999/03
  • Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Yamaguchi University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Ophthalmology

Research Keywords

  • Photodynamic antimicrobial chemotherapy
  • infectious keratitis
  • Keratoplasty
  • ocular surface
  • genetic diseases in Ophthalmology

Affiliated Academic Societies

  • Japan Cornea Sciety
  • Keratoplasty Society in Japan
  • Japanese Association for Ocular Infection
  • The Japanese Sciety for Matrix Biology and Medicine.
  • The Japan Photodynamic Association
  • The Japan Sciety of Human Genetics
  • Japanese Ophtahlmological society
  • Japanese Society of Ophthalmic Surgery
  • Japan Contact Lens Society
  • Japanese Ocular Inflammation Society
  • Japanese Sciety of Cataract and Refratctive Surgery
  • The European Society of Cataract and Refrective Surgeons
  • The Association for Reserch in Vision and Ophthalmology

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Human genetics
  2. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment II
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, 1Term, Ophthalmology

Research Activities

Academic Papers

  1. Corneal Copper Deposition Secondary to Monoclonal Gammopathy in a Patient With Chronic Lymphocytic Leukemia: A Case Report, Cureus, 15(12), e50801-e50801, 20231219
  2. Inflammatory Cells and Lipid Deposits Detected by in Vivo Confocal Microscopy in Brimonidine Tartrate Ophthalmic Solution-Related Corneal Disorders: A Case Series., Ocul Immunol Inflamm, 31(9), 1842-1847, 202311
  3. Refractory Fungal Keratitis Caused by Acrophialophora fusispora: A Case Report and Literature Review., Cureus, 15(8), e43181-e43181, 20230809
  4. Efficacy of azithromycin hydrate ophthalmic solution for treatment of internal hordeolum and meibomitis with or without phlyctenular keratitis., Japanese journal of ophthalmology, 20230716
  5. Usefulness of smear microscopy for therapeutic decision-making in patients with infectious keratitis., Japanese journal of ophthalmology, 20230713
  6. Case Report: Corneal Inlay Removal Following Myofibroblast Detection under in Vivo Confocal Microscopy., Optom Vis Sci, 20230419
  7. Inflammatory Cells and Lipid Deposits Detected by in Vivo Confocal Microscopy in Brimonidine Tartrate Ophthalmic Solution-Related Corneal Disorders: A Case Series., Ocular Immunology and Inflammation, 1-6, 20221028
  8. Technical Report: Automatic Measurement of Corneal Nerve Fiber Area Using Versatile Software., Optometry and Vision Science, 20220801
  9. Synergistic effect of TONS504-mediated photodynamic antimicrobial chemotherapy and additives widely contained in ophthalmic solutions: benzalkonium chloride and ethylenediaminetetraacetic acid., Photochem Photobiol Sci (2022), 20220720
  10. Vernal keratoconjunctivitis with a limbal mass lesion developing independently of severe papillae formation at the tarsal conjunctiva: a case report., BMC Ophthalmology, 20220326
  11. Long-Term Observation of Deep Anterior Lamellar Keratoplasty in Patients with Post-LASIK Granular Corneal Dystrophy Type 2: Two Case Reports., Ophthalmology and Therapy, 20211002
  12. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue., J Photochem Photobiol B, 221, 20210608
  13. Efficacy of Photodynamic Anti-Microbial Chemotherapy for Acanthamoeba Keratitis In Vivo., Lasers in Surgery and Medicine, 28, 166-171, 20201208
  14. Amantadine can induce intra-epithelial deposition in the cornea., American Journal of Ophthalmology Case Reports, 202009
  15. Deep Neural Network-Based Method for Detecting Obstructive Meibomian Gland Dysfunction With in Vivo Laser Confocal Microscopy, CORNEA, 39(6), 720-725, 202006
  16. Absence of the foveal avascular zone in a nanophthalmic child revealed by optical coherence tomography angiography., Am J Ophthalmol Case Rep, 201811
  17. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 201809
  18. Potential New Modes of Treatment of Neurotrophic Keratopathy, CORNEA, 34, S121-S127, 201511
  19. A Case of Paracentral Corneal Perforation Treated with One-Bite Mini-Keratoplasty., Turkish journal of ophthalmology, 51(1), 2021
  20. TONS504 mediated photodynamic antimicrobial chemotherapy inactivation for Acanthamoeba keratitis in rabbits in vivo, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9), 2019
  21. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(11), 2019
  22. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 2019
  23. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 2019
  24. In Vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9), 2018
  25. Comparison of semi-automated center-dot and fully automated endothelial cell analyses from specular microscopy images., International ophthalmology, 38(6), 2018
  26. Clinical and Histopathologic Evaluation of the Efficacy of Photodynamic Antimicrobial Chemotherapy for Experimental Keratitis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9), 2018
  27. Antimicrobial efficacy of photodynamic therapy with TONS504 against pathogenic filamentous fungi, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(8), 2017
  28. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12), 2016
  29. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy, Molecular Vision, 21, 532-537, 2015
  30. Antimicrobial performance of preservative agents in antiglaucoma ophthalmic solutions, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7), 2015
  31. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro, LASERS IN MEDICAL SCIENCE, 30(1), 383-387, 2015
  32. Neuropeptides Released From Trigeminal Neurons Promote the Stratification of Human Corneal Epithelial Cells, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(1), 125-133, 2014
  33. Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells., Japanese journal of ophthalmology, 58(6), 2014
  34. Efficacy of photodynamic antimicrobial chemotherapy against herpes simplex virus-type 1, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(13), 2014
  35. Effects of brimonidine on the intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation in glaucoma subjects, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(13), 2014
  36. [Influence on ocular surface and intraocular pressure of switching from preservative-containing to preservative-free carteolol hydrochloride ophthalmic solution]., Nippon Ganka Gakkai zasshi, 117(5), 2013
  37. Neuropeptide from trigeminal nerve promotes the stratification of human corneal epithelial cells, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 2013
  38. Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats, CELL BIOCHEMISTRY AND FUNCTION, 31(6), 482-488, 2013
  39. Efficacy of photodynamic antimicrobial chemotherapy on gram negative bacteria, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 2013
  40. Up-regulation of matrix metalloproteinase-1 and interleukin-6 expression in cocultures of corneal fibroblasts and neural cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 419(3), 537-542, 2012
  41. The Relation Between Visual Performance and Clinical Ocular Manifestations in Stevens-Johnson Syndrome, AMERICAN JOURNAL OF OPHTHALMOLOGY, 154(3), 499-511, 2012
  42. Differential expression of semaphorin 3A and its receptors during mouse retinal development, CELL BIOCHEMISTRY AND FUNCTION, 30(7), 563-568, 2012
  43. Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice, AMERICAN JOURNAL OF PATHOLOGY, 172(3), 638-649, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Impact of actin polymerization inhibitor YM-58483 on corneal stromal fibrosis in vitro, Fukuto A, Chikama T, Kiuchi Y, Cell Bio 2023, 2023/12/03, Without Invitation, English, The American Society for Cell Biology, Boston, MA
  2. Autologous corneal epithelial cell sheet transplantation for limbal stem cell deficiency, Chikama T, TCVGH International Medical Conference 2023, 2023/10/29, With Invitation, English, The International Society of Eye Research, Taichung, Taiwan
  3. The antifibrotic effect of silver nanoparticles on human corneal fibroblasts in vitro, Fukoto A, Chikama T, Kiuchi Y, ARVO2023, 2023/04/26, Without Invitation, English, The Association for Research in Vision and Ophthalmology, New Orleans, America
  4. Benzalkonium Chloride and Ethylenediaminetetraacetic Acid Enhance the Photodynamic Antimicrobial Effect, Shinji K, Chikama T, Sueoka K, Kiuchi Y, ISER2023, 2023/02/19, Without Invitation, English, International Society for Eye Research, Gold Coast, Queensland, Australia
  5. Clinical and Histopathological Features of Corneal Keloid, Chikama T, Shinji K, Kiuchi Y, ISER2023, 2023/02/19, Without Invitation, English, International Society for Eye Research, Gold Coast, Queensland, Australia
  6. Comparison of the clinical characteristics between Ocular rosacea and Meibomitis-related Keratoconjunctivitis, Minamoto A, Chikama T, Toda R, Mitoma K, Kiuchi Y, The 14th Joint Meeting of Japan-China-Korea Ophthalmologists, 2021/11/27, Without Invitation, English, Yuichi Hori, Koh-Hei Sonoda, virtual
  7. Evaluation of the effectiveness of azithromycin hydrate eye drops., Shimizu Y, Chikama T, Mitoma K, Kiuchi Y, ACS2020, 2021/04/28, Without Invitation, English, Asia Cornea Sciety, Osaka, Japan (Web)
  8. Efficacy and safety of photodynamic antimicrobial chemotherapy for Acanthamoeba keratitis., Chikama T, Pertiwia YD, Sueoka K, Shinji K, Ko JA, Kiuchi Y, Sakaguchi T, ACS2020, 2021/04/28, Without Invitation, English, Asia Cornea Sciety, Osaka, Japan (Web)
  9. Early postoperative graft detachment after Descemet's stripping automated endothelial keratoplasty (DSAEK) in eyes with a filtration bleb, Shinji K, Inokawa S, Chikama T, Toda R, Ideguchi K, Kiuchi Y, 32nd APACRS KYOTO2019 Annual Meeing of the Asia-Pacific Association of Cataract & Refractive Surgeons(APACRS), 2019/10/03, With Invitation, English, Asia-Pacific Association of Cataract & Refractive Surgeons(APACRS), kyoto,Japan
  10. TONS504 mediated photodynamic antimicrobial chemotherapy inactivation for Acanthamoeba keratitis in rabbits in vivo., Yunialthy D.P, Chikama T, Sueoka K, Ko JA, Kiuchi Y, ARVO 2019 Annual Meeting, 2019/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, VANCOUVER
  11. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis., Chikama T, Shinji K, kadohiro Y, kiuchi Y, 2019 Imaging in the Eye Conference, 2019/04/27, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Vancouver
  12. Automatic analysis to measure the area of corneal nerve fibers using in vivo confocal microscopy, Shinji K, Chikama T, Homtake T, kiuchi Y, 2019 Imaging in the Eye Conference, 2019/04/27, Without Invitation, English, The Association for Research in Vision and Ophthalmology, VANCOUVER
  13. In vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba, Chikama T, Pertiwi Y.D, Sueoka K., Ko JA, Kiuchi Y, Onodera M, Sakaguchi T, ISER 2018(Biennial Meeting of the International Society for Eye Research), 2018/09/11, Without Invitation, English, ISER, Berfast, Northern Ireland, UK
  14. Clinical and Histopathologic Evaluation of the Efficacy of Photodynamic Antimicrobial Chemotherapy for Experimental Keratitis., Chikama T, Sueoka K, Ko JA, Sakaguchi T, Kiuchi Y, ARVO-2018, 2018/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Honolulu,Hawaii
  15. In Vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba., Yunialthy D P, Chikama T, Sueoka,K, Ko JA, Kiuchi Y, ARVO-2018, 2018/05/01, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Honolulu,Hawaii
  16. Effcacy of Photodynamic Antimicrobial Therapy with TONS504PDT-Acanthamoeba, Pertiwi Yunialthy D, Chikama T, Japan Cornea Conference 2018 (42nd Japan Cornea Society / 34th Annual Meeting of Keratoplasty Society of Japan), 2018/02/17, Without Invitation, English
  17. Monitoring the effect of topical steroid administration for multiple subepithelial corneal infiltrates following epidemic keratoconjunctivitis, Chikama T, Kaneoka C, Inokawa S, Toda R, Kadohiro Y, Kiuchi Y, EuCornea 2017, 2017/10/06, Without Invitation, English, lisbon/Portugal
  18. Antimicrobial efficacy ofphotodynamic therapy with TONS504 againstpathogenic filamentous fungi., Chikama T, Sueoka K, Ko JA, Kiuchi Y, Sakaguchi T, Obana A, ARVO2017 Annual Meeting, 2017/05/10, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Baltimore
  19. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, Sueoka K, Chikama T, Latief M.A, Ko JA,Kiuchi Y, Sakaguchi T, Obana A, ARVO2016 Annual Meeting, 2016/05/01, Without Invitation, English, Seattle, USA
  20. A new adaptor development for a high-power objective lens in in vivo confocal microscopy, Chikama T, Kadohiro Y, Sone T, Toda R, Inokawa S, Kiuchi Y, 2016 ARVO Imaging in the Eye Conference, 2016/04/30, Without Invitation, English
  21. Medication-related dry eye, Chikama T, 2015 AsiaARVO, 2015/02/16, With Invitation, English
  22. Non-contact direct observation on pathogenic microorganisms by an in vivo laser confocal microscope attached with high-power objective lens, Chikama T, Abe E, Kadohiro Y, Sone T, Ideguchi K, Onodera M, Kiuchi Y, 5th EuCornea Congress, 2014/09/12, Without Invitation, English
  23. Effects of brimonidine on the intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation in glaucoma subjects, Kiuchi Y, Ideguchi K, Sugimoto Y, Chikama T, ARVO2014, 2014/05/05, Without Invitation, English
  24. Efficacy of photodynamic antimicrobial chemotherapy against herpes simplex virus–type 1, Chikama T, Latief M.A, Ko JA, Kiuchi Y, Sakaguchi T, Obana A, ARVO2014, 2014/05/05, Without Invitation, English
  25. Noncontact direct observation of the human cornea by in vivo confocal microscopy with a high-power objective lens, Ideguchi K, Abe E, Chikama T, Kadohiro Y, Sone T, Toda R, Inokawa S, Kiuchi Y, ARVO/ISIE, 2014/05/03, Without Invitation, English
  26. The Efficacy of Photodynamic Antimicrobial Chemotherapy against Herpes Simplex Virus Type 1, Latief M.A, Chikama T, Kiuchi Y, Sakaguchi T, Obana A, World Ophthalmology Congress 2014 Tokyo, 2014/04/04, Without Invitation, English

Awards

  1. 2014/01/30, Uchida Prize, Japan Cornea Society, Non-contact direct observation on pathogenic microorganisms by in vivo confocal microscopy attached with a high-power objective lens

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020
  3. KAKENHI, 2015, 2018
  4. KAKENHI, 2015, 2017
  5. KAKENHI, 2012, 2014
  6. KAKENHI, Analysis of nueroparalytic keratitics using coculture system of neural and corneal epithelial cells, 2011, 2013
  7. KAKENHI, 2009, 2011
  8. KAKENHI, Reciprocal interaction between epithelial cells and keratocytes in neurotrophic keratopathy, 2000, 2001
  9. KAKENHI, 2000, 2001

Social Activities

History as Committee Members

  1. trustee, 2012, Japan Cornea Society
  2. trustee, 2012, Japanese Association for Ocular Infection
  3. trustee, 2008, The Japanese Society for Matrix Biology and Medicine

History as Peer Reviews of Academic Papers

  1. 2022, Journal of Japanese Ophthalmoloical Society, Others, 2
  2. 2022, Japanese Journal of Ophthalmmology, Others, reviewer, 1
  3. 2021, Molecules, Others, reviewer, 1
  4. 2021, Journal of Japanese Ophthalmoloical Society, Others, 4
  5. 2020, Current Eye Reserch, Others, reviewer, 1
  6. 2020, Journal of Japanese Ophthalmoloical Society, Others, 2
  7. 2020, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  8. 2020, BMC Ophthalmology, Others, Reviewer, 1
  9. 2020, Journal of Ophthalmic Inflammation and Infection, Others, reviewer, 1
  10. 2019, Lasers in Medical Science, Others, reviewer, 1
  11. 2019, Scientific Report, Others, reviewer, 1
  12. 2019, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  13. 2019, Journal of Japanese Ophthalmoloical Society, Others, 1
  14. 2019, BMC Ophthalmology, Others, Reviewer, 1
  15. 2018, Japanese Journal of Ophthalmmology, Others, reviewer, 2
  16. 2018, Journal of Japanese Ophthalmological Society, Others, Reviewer, 2
  17. 2017, Journal of Japanese Ophthalmological Society, Others, 1
  18. 2017, Japanese Journal of Ophthalmology, Others, 1
  19. 2016, Journal of Ophthalmology, Others, 2
  20. 2016, BMC Ophthalmology, Others, 1
  21. 2016, Japanese Journal of Ophthalmology, Others, 1
  22. 2015, Japanese Journal of Ophthalmology, Others, 3
  23. 2015, Journal of Japanese Ophthalmoloical Society, Others, 1
  24. 2014, NOPE, Others, 1
  25. 2013, Current Eye Research, Others, 2
  26. 2013, Investigative Ophthalmology & Visual Science, Others, 1
  27. 2012, Japanese Journal of Ophthalmology, Others, 3
  28. 2011, Investigative Ophthalmology & Visual Science, Others, 1