MAKOTO YANOSHITA

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
m-yanoshitahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2021/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant professor

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Orthodontics / Pediatric dentistry

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, First Semester, Dental Research Practices
  2. 2022, Undergraduate Education, 3Term, Basic Practice of Orthodontics I
  3. 2022, Undergraduate Education, 4Term, Basic Practice of Orthodontics II
  4. 2022, Undergraduate Education, Second Semester, Dental Research Practices
  5. 2022, Undergraduate Education, First Semester, Dental Research Practices
  6. 2022, Undergraduate Education, Academic Year, Clinical Practice (Orthodontics)
  7. 2022, Undergraduate Education, 1Term, Orthodontics
  8. 2022, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  9. 2022, Undergraduate Education, Intensive, Clinical practice on oral health
  10. 2022, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  11. 2022, Undergraduate Education, 1Term, Orthodontics
  12. 2022, Undergraduate Education, 3Term, Practice of Orthodontics I
  13. 2022, Undergraduate Education, 4Term, Practice of Orthodontics II
  14. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  15. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  16. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  17. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  18. 2022, Graduate Education (Doctoral Program) , First Semester, Training Course for Orthodontic Specialist
  19. 2022, Graduate Education (Doctoral Program) , Second Semester, Training Course for Orthodontic Specialist

Research Activities

Academic Papers

  1. High-frequency near-infrared diode laser irradiation suppresses IL-1 beta-induced inflammatory cytokine expression and NF-kappa B signaling pathways in human primary chondrocytes, LASERS IN MEDICAL SCIENCE, 37(2), 1193-1201, 202203
  2. High-frequency Near-infrared Diode Laser Irradiation Suppresses IL-1beta-induced Inflammatory Cytokine Expression and NF-kappa B Signaling Pathways in Human Primary Chondrocytes, Lasers in Medical Science, 20210807
  3. ANGPTL2 induces synovial inflammation via LILRB2, Inflammation, 44(3), 1108-1118, 20210204
  4. Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, MEDIATORS OF INFLAMMATION, 2018, 2018
  5. Effects of high-frequency near-infrared diode laser irradiation on the proliferation and migration of mouse calvarial osteoblasts, LASERS IN MEDICAL SCIENCE, 33(5), 959-966, 2018
  6. Effect of high-frequency near-infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats, LASERS IN SURGERY AND MEDICINE, 50(7), 772-780, 2018
  7. ★, Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes, INFLAMMATION, 41(5), 1621-1630, 2018
  8. ANGPTL2 Promotes Inflammation via Integrin alpha 5 beta 1 in Chondrocytes, CARTILAGE, 20210201
  9. Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress, CELL BIOLOGY INTERNATIONAL, 44(4), 966-974, 2020
  10. High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1 beta-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes, JOURNAL OF CLINICAL MEDICINE, 9(3), 2020
  11. ★, FAK inhibition protects condylar cartilage under excessive mechanical stress, ORAL DISEASES, 26(8), 1736-1746, 2020

Invited Lecture, Oral Presentation, Poster Presentation

  1. The mechanism of condylar resorption by excessive mechanical stress, Yanoshita M, 35th Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2022/07/02, With Invitation, Japanese, Sapporo, experimental
  2. Morphological and histological changes in mandibular condyle of anterior disc displacement model rats, Kita D., Yanoshita M., Hirose N., Nishiyama S., Tsuboi E., Kubo N., Onishi A., Asakawa Y., Tanimoto K, The 35th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2022/07/02, Without Invitation, Japanese, experimental
  3. Effects of estrogen on mandible and cartilage during growth period, Kubo N., Hirose N., Awada T., Yanoshita M., Nishiyama S., Tsuboi E., Kita D., Onishi A., Asakawa Y., Tanimoto K, The 35th Annual Meeting of the Japanese Society for the Temporomandibuar Joint, 2022/07/02, Without Invitation, Japanese, experimental
  4. Effect of age difference on Semaphorin3A expression in rat temporomandibular joint and serum, Tsuboi E., Hirose N., Asakawa Y., Yanoshita M., Onishi A., Takano M., Nishiyama S., Kubo N., Kita D., Tanimoto K, The 35th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2022/07/02, Without Invitation, Japanese, experimental
  5. Role of Semaphorin 3A in endochondral ossification of mandibular condyle, Tsuboi E., Hirose N., Asakawa Y., Yanoshita M., Onishi A., Takano M., Nishiyama S., Kubo N., Kita D., Tanimoto K., The 34th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2021/10/24, Without Invitation, Japanese, experimental
  6. Effects of high-frequency near-infrared diode laser irradiation on IL-1beta-induced expression of inflammatory cytokines and matrix metalloproteinases in human primary chondrocytes, Sakata S., Kunimatsu R., Tsuka Y., nakatani A., Putranti NAR., Yanoshita M., Hirose N., Tanimoto K., 34th Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2021/10/24, Without Invitation, Japanese, experimental
  7. Resolvin D1 reduces inflammation in Human Fibroblast-Like Synoviocytes via p-38, NF-kappa b and AKT signaling pathway, Yanoshita M., Hirose N., Nishiyama S., Onishi A., Yamauchi Y., Tsuboi E., Kubo N., Kita D., Asakawa Y., Tanimoto K., 34th Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2021/10/24, Without Invitation, Japanese, experimental
  8. Effects of high frequency near infrared diode laser irradiation on expression of inflammatory cytokines in human chondrocytes, Sakata S., Kunimatsu R., Tsuka Y., Nakatani A., Putranti NAR., Yanoshita M., Hirose N., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  9. Assessment of masticatory function in adult cleft lip and palate patients after orthodontic treatment, Miura S., Hirose N., Iwai K., Cynthia CM., Ishida E., Onishi A., Yanoshita M., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  10. A case report of maxillary protrusion with Moebius syndrome, Onishi A., Hirose N., Yanoshita M., Yamauchi Y., Kubo N., Nishiyama S., Kagawa H., Kita D., Matsunaga M., Miura S., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  11. A case of orthodontic treatment for a maxillary protrusion with patient with systemic lupus erythematosus, Nishiyama S., Hirose N., Yanoshita M., Onishi A., Yamauchi Y., Kagawa H., Kubo N., Kita D., Matsunaga M., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  12. An orthodontic treatment for a patient with maxillary protrusion and fibrous dysplasia, Hirose N., Yanoshita M., Onishi A., Nishiyama S., Kagawa H., Kubo N., Kita D., Matsunaga M., Tanimoto K., The 80st Annual Meeting of the Japanese Orthodontic Society and The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  13. Orthodontic treatment with temporary anchorage devices for the patient with crowding occurred after serial extraction in childhood, Yanoshita M., Hirose N., Onishi A., Yamauchi Y., Nishiyama S., Kagawa H., Kubo N., Kita D., Matsunaga M., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  14. Effects of estrogen addition on mandibular growth and changes in cartilage, Kubo N., Awada T., Hirose N., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Kita D., Onishi A., Yamauchi Y., Matsunaga M., Tanimoto K., The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress, 2021/11/04, Without Invitation, Japanese, published
  15. LILRB2 controls inflammation induced by ANGPTL2 in synovial cells, Nishiyama S., Hirose N., Yanoshita M., Takano M., Tsuboi E., Kubo N., Onishi A., Yamauchi Y., Tanimoto K, 33rd Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2020/07/03, Without Invitation, Japanese
  16. Semaphorin3A inhibits the inflammation induced by excessive mechanical stress in chondrocytes, Hirose N., Yanoshita M., Takano M., Nishiyama S., Onishi A., Kubo N., Asakawa Y., Tanimoto K, 33rd Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2020/07/03, Without Invitation, Japanese, Kyoto
  17. Cyclic tensile strain upregulates pro-inflammatory cytokine expression via FAK-MAPK signaling inchondrocytes, Yanoshita M., Hirose N., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Kubo N., Asakawa Y., Tanimoto K.:, 33rd Annual Meeting of The Japanese Society for the Temporomandibular Joint, 2020/07/03, Without Invitation, Japanese
  18. Statistical study of temporomandibular disorders in Hiroshima University orthodontic clinic over the past 5 years, Onishi A., Hirose N., Awada T., Yanoshita M., Takano M., Yamauchi Y., Nishiyama S., Tsuboi E., Tanimoto K, The 78th Annual Meeting of the Japanese Orthodontic Society, 2019/11/22, Without Invitation, Japanese
  19. Statistical study of temporomandibular disorders in Hiroshima University orthodontic clinic over the past 5 years, Onishi A., Hirose N., Awada T., Yanoshita M., Takano M., Yamauchi Y., Nishiyama S., Tsuboi E., Tanimoto K, The 58th Hiroshima Prefecture Dental Association, The 103rd Hiroshima University Dental Society, 2019/11/17, Without Invitation, Japanese, Hiroshima
  20. Cephalometric differences between the past and the present in Japanese adults with normal occlusion, Yamauchi Y., Hirose N., Sumi C., Yanoshita M., Onishi A., Nishiyama S., Yoshimi Y., Tanimoto K, The 62nd Annual Meeting of the ChuShikoku Orthodontic Society, 2019/07/07, Without Invitation, Japanese, Kure
  21. ANGPTL2 promotes inflammation via integrin alpha5beta1 in chondrocytes, Takano M., Hirose N., Yanoshita M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/28, Without Invitation, Japanese
  22. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, Yanoshita M., Hirose N., Takano M., Nishiyama S., Onishi A., Yamauchi Y., Tsuboi E., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/28, Without Invitation, English
  23. Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress, Yanoshita M., Hirose N., Takano M., Sumi C., Nishiyama S., Tsuboi E., Asakawa Y., Onishi A., Yamauchi Y., Tanimoto K.:, The 97th General Session of International Association for Dental Research, 2019/06/20, Without Invitation, English
  24. Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Hirose N., Sumi C., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 97th General Session of International Association for Dental Research, 2019/06/20, Without Invitation, English, Vancouver
  25. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress., Yanoshita M., Hirose N., Sumi C., Takano M., Nishiyama S., Tanimoto K, The 57th Hiroshima Prefecture Dental Association, The 102th Hiroshima University Dental Society, 2018/11/11, Without Invitation, Japanese, Hiroshima
  26. The role of Semaphorin3A in chondrocyte, Sumi C., Hirose N., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Asakawa Y., Tanimoto K, The 77th Annual Meeting of the Japanese Orthodontic Society, 2018/11/01, Without Invitation, Japanese, Yokohama
  27. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress, Yanoshita M., Hirose N., Sumi C., Takano M., Nishiyama S., Tanimoto K., The 77th Annual Meeting of the Japanese Orthodontic Society, 2018/11/01, Without Invitation, Japanese, Yokohama
  28. Elucidation of the inflammation promoted by ANGPTL2 in excessive mechanical loading on chondrocytes, Takano M., Hirose N., Okamoto Y.,Awada T., Sumi C., Yanoshita M., Asakawa Y., Tanimoto K, The 30th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2017/07/30, Without Invitation, Japanese, Yokohama
  29. A case of temporomandibular disorder with occlusal disharmony caused by an inappropriate use of splint, Hirose N., Yanoshita M., Takano M., Sumi C., Okamoto Y., Awada T., Asakawa Y., Tanimoto K, :The 29th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2016/07/18, Without Invitation, Japanese, Hakone
  30. Effect of Semaphorin3A in mandibular condylar cartilage, Sumi C., Hirose N., Okamoto Y., Awada T., Yanoshita M., Takano M., Asakawa Y., Tanimoto K, :The 29th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2016/07/18, Without Invitation, Japanese
  31. Effect of Defactinib on chondrocyte under the excessive mechanical stress, Yanoshita M., Hirose N.,Okamoto Y., Awada T., Sumi C., Takano M., Asakawa Y., Tanimoto K, The 29th Annual Meeting of the Japanese Society for the Temporomandibular Joint, 2016/07/18, Without Invitation, Japanese, Hakone
  32. Effect of hyaluronan on the expression of superficial zone protein through CD44 in synovial membrane cells, Mitsuyoshi T, Asakawa Y, Hirose N, Awada T, Okamoto Y, Yanoshita M, Tanimoto K, The 28th Annual Meeting of the Society for the Temporomandibular Joint, 2015/07/05, Without Invitation, Japanese, Nagoya
  33. Effect of Cilengitide on the metabolism of chondrocytes under excessive mechanical stimuli, Okamoto Y, Hirose N, Asakawa Y, Kunimatsu R, Mitsuyoshi T, Sumi C, Yanoshita M, Tanne K, Tanimoto K, The 28th Annual Meeting of the Society for the Temporomandibular Joint, 2015/07/05, Without Invitation, Japanese, Nagoya
  34. Effects of Low molecular weight hyaluronan on the expression of PRG4 through CD44 in synovial membrane cells, Mitsuyoshi T, Asakawa Y , Hirose N, Okamoto Y, Yanoshita M, Tanne k, Tanimoto K, 8th international orthodontic congress, 2015/09/27, Without Invitation, English
  35. Statistical analysis of patients with congenital disorder attending the orthodontic clinic at Hiroshima University Hospital, Yanoshita M, Koh M, Hirose N, Matsumura Y, Concepcion C, Sumi C, Ueda H, Tanimoto K, 2015/07/12, Without Invitation, Japanese, The 57th Annual Meeting of Chu-Shikoku Orthodontic Society, Takamatsu, published

Awards

  1. 2019/07/28, The 32nd Annual Meeting of the Japanese Society for the Temporomandibular Joint Excellence (Ishibashi) Award, The 32nd Annual Meeting of the Japanese Society, Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-aid for Scientific Research, New establishment of temporomandibular joint osteoarthritis model by anterior disc displacement and elucidation of OA mechanism, 2022
  2. Grant-in-Aid for Early-Career Scientists, Elucidation of osteocytes dynamics mediated by Semaphorin 3A under mechanical stress, 2020
  3. Support for Starting Research Activities, Establishment of effective treatment for temporomandibular joint disorders with Docosahexaenoic acid (DHA) and Resolvin, 2018