MAI YOSHINO

Last Updated :2026/07/03

Affiliations, Positions
Center for Oral Clinical Examination, Assistant Professor (Special Appointment)
E-mail
myoshinohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2024/04/01, Hiroshima University hospital Center for Oral Clinical Examination, Clinical fellow
  • 2025/04/01, Hiroshima University hospital Center for Oral Clinical Examination, Project Assistant Professor

Educational Backgrounds

  • Hiroshima University Dentistry, 2013/04/01, 2019/03/31
  • Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Periodontal Medicine, 2020/04/01, 2024/03/31

Academic Degrees

  • Hiroshima University

Research Keywords

  • Regenerative medicine
  • Regenerative medicine, Tissue Engineering, Oral examination, Cell Therapy, Translational Research

Affiliated Academic Societies

  • International Association for Dental Research
  • The Japanese Society for Regenerative Medicine
  • The Japanese Society for Bone and Mineral Research
  • The Japanese Society of Periodontology

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, First Semester, Dental Research Practices I
  2. 2026, Undergraduate Education, Second Semester, Dental Research Practices II
  3. 2026, Undergraduate Education, Year, Clinical Practice (Oral Clinical Examination)

Research Activities

Academic Papers

  1. Two cases of long-term zinc acetate hydrate administration in patients with a zinc deficiency taste disorder with copper deficiency after upper gastrointestinal resection, CLINICAL NUTRITION ESPEN, 70, 309-313, 202512
    Link to Paper Search Results by DOI
  2. Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults., International dental journal, 75(3), 1759-1770, 202506
  3. Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells., Stem cell reviews and reports, 20(1), 347-361, 202401
  4. Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems, Applied Sciences (Switzerland), 13(23), 202312
  5. A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification., Stem cell reviews and reports, 19(6), 1812-1827, 202308
  6. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model., Journal of tissue engineering and regenerative medicine, 16(10), 945-955, 202210
  7. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration., Regenerative therapy, 20, 117-125, 202206
  8. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification., Biomedicines, 9(10), 20211007

Invited Lecture, Oral Presentation, Poster Presentation

  1. Development of novel bone regenerative cell therapy using direct conversion Osteoblasts and 3D cell clumps culture system, Yoshino Mai, Seki Makoto., Yoshimoto Tetsuya., Morimoto Shin., Shintani Tomoaki., Kajiya Mikihito, The American Society for Bone and Mineral Research (ASBMR) Annual Meeting 2025, 2025/09/08, Without Invitation, English, The American Society for Bone and Mineral Research, Seattle
  2. Establishment of novel bone regenerative cell therapy using direct conversion and 3D cell clumps culture system, Yoshino Mai, The 43th Annual Meeting of the Japanese Society for Bone and Mineral Research (Kumamoto), 2025/07/26, Without Invitation, English, the Japanese Society for Bone and Mineral Research, Kumamoto city
  3. Establishment of novel bone regenerative cell therapy using direct conversion and 3D cell clumps culture system, Yoshino Mai, Yoshimoto Tetsuya, Ando Toshinori, Shintani Tomoaki, Morimoto Shin, Suzuki Masayuki. Yasuda Gakuto, Seki Makoto. Kajiya Mikihito, The 68th Japanese association of Periodontology annual meeting in Spring (Naha), 2025/05/23, Without Invitation, English, Japanese Society of Periodontology, Naha city
  4. Bio-3D printed grafts of clumps of MSCs/ECM complexes induce periodontal tissue regeneration in a beagle dog one-wall defect model, Yasuda Gakuto, Takeda Katsuhiro, Yoshimoto Tetsuya, Morimoto Shin, Yoshino Mai, Takai Harumi, Torii Yoko, Maekawa Toshihiko, Shintani Tomoaki, Kajiya Mikihito, The 163th Meeting of the Japanese Society of Conservative Dentistry (Nagasaki), 2025/11/07, Without Invitation, English, the Japanese Society of Conservative Dentistry, Nagasaki city
  5. Improved Patient Satisfaction through Objective Evaluation of Whitening Effect: A Case Report, Yoshino Mai, Yano Kanako, Yoshimoto Tstsuya, Shintani Tomoaki, Kajiya Mikihito, The 18th Annual Meeting of Japanese Society for Evidence and the Dental (Okinawa), 2025/11/01, Without Invitation, Japanese, Japanese Society for Evidence and the Dental, Uruma city
  6. Development of novel periodontal tissue regenerative cell graft using with human clumps of MSCs/ECM complexes and Bio-3D printing., Kajiya M., Yoshii H, Yoshino M, Mizuno N, Suzuki M, Yoshimoto T, Takai H, Torii Y, Maekawa T, The Japanese Society for Regenerative Medicine, 2024, Without Invitation, Japanese, The Japanese Society for Regenerative Medicine, Niigata
  7. Development of Bio-3D Printed Grafting Tissue for Periodontal Regeneration, Kajiya M., Yoshii H.,Yoshino M.,Yoshimoto T., IADR/AADOCR/CADR, 2024, Without Invitation, English, New Orleans
  8. 3D-engineered osteogenic cellular constructs for bone regenerative therapy by Direct Conversion, Yoshino M., Yoshimoto T., Kajiya M., Second Round Selection for the Hatton Award 2025 and The 72nd Annual Meeting and Scientific Session of the Japanese Division of the International Association for Dental Research (JADR), 2024, Without Invitation, English, The Japanese Division of the International Association for Dental Research
  9. Development of cartilage tissue with bone shell that shows more effective bone regeneration for large-scale bone defects, Morimoto S., Kajiya M., Horikoshi S., Yoshii H., Yoshino M, Motoike S., Iwata T., Ouhara K., Ando T., Tetsuya Yoshimoto T., Shintani T., Mizuno N., The 67th Autumn Meeting of the Japanese Society of Periodontology, 2024, With Invitation, The Japanese Society of Periodontology, Sapporo
  10. Investigation of Human Osteoblast Direct Conversion Method Using an HDAC Inhibitor, Gennai K., Yoshimoto T.,Yoshii H.,Morimoto S.,Yoshino M.,Hayashi Y.,Suzuki M.,Seki M.,Kajiya M., The 42nd Annual Meeting of the Japanese Society for Bone and Mineral Research, 2024, Without Invitation, The Japanese Society for Bone and Mineral Research, Okinawa
  11. Mechanism of mechanical response-dependent innate immunity in osteocytes, Yoshimoto T., Yoshino M.,Yoshii H.,Morimoto S.,Yoshino M.,Gennai K.,Kajiya M., The 42nd Annual Meeting of the Japanese Society for Bone and Mineral Research, 2024, Without Invitation, The Japanese Society for Bone and Mineral Research, Okinawa
  12. Bacterially-inflamed osteocytes contribute to the pathogenesis of periodontitis by promoting the migration of inflammatory cells, Yoshimoto T., Yoshii H.,Morimoto S.,Yoshino M.,Hayashi Y., Suzuki M.,Yasuda G.,Kataoka N.,Kajiya M, The 67th Autumn Meeting of the Japanese Society of Periodontology, 2024, Without Invitation, The Japanese Society of Periodontology, Sapporo
  13. The Development of a Human Bone Marrow Adipose Tissue-Like Cellular Construct., Yoshino M., Kajiya M.,Yoshimoto T.,Iwata T.,Mizuno T., 102nd General Session & Exhibition of the International Association for Dental Research (IADR)., 2024, Without Invitation, English, IADR/AADOCR/CADR, New Orleans, USA.
  14. A cartilaginous construct with bone collar exerts bone-regenerative property via rapid endochondral ossification, Shin Morimoto, Mikihito Kajiya, Susumu Horikoshi, Hiroki Yoshii, Mai Yoshino, Kazuhisa Ouhara, Shinji Matsuda, Tomoyuki Iwata, Shinya Sasaki, Yuta Hamamoto, Misako Tari, Yuri Taniguchi, Tetsuya Yoshimoto, Noriyoshi Mizuno, The 66th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023, Without Invitation, The Japanese Society of Periodontology, Nagasaki
  15. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Tetsuya Yoshimoto, Shin Morimoto, Tomoyuki Iwata, Noriyoshi Mizuno, The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research, 2023, Without Invitation, The Japanese Society for Bone and Mineral Research, Tokyo
  16. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Shin Morimoto, Hiroki Yoshii, Noriyoshi Mizuno, 56th Annual Meeting of Hiroshima University Dental Society, 2023, Without Invitation, Hiroshima University Dental Society, Hiroshima
  17. YAP/TAZ mechanosignaling regulates cytoprotective factors production in mesenchymal stem cells, Hiroki Yoshii, Mikihito Kajiya, Shin Morimoto, Mai Yoshino, Noriyoshi Mizuno, 56th Annual Meeting of Hiroshima University Dental Society, 2023, Without Invitation, Japanese, Hiroshima University Dental Society, Hiroshima
  18. Transplantation of clumps of MSCs / ECM complexes treated with chondrogenic / osteogenic induction promotes bone regeneration via endochondral ossification manner, Shin Morimoto, Mikihito Kajiya, Susumu Horikoshi, Hiroki Yoshii, Mai Yoshino, Noriyoshi Mizuno, 56th Annual Meeting of Hiroshima University Dental Society, 2023, Without Invitation, Hiroshima University Dental Society, Hiroshima
  19. YAP/TAZ mechanosignaling regulates cytoprotective factors production in mesenchymal stem cells, Yoshii H., Yoshino M, Kajiya M., The 22nd Annual Meeting of the Japanese Society for Regenerative Medicine, 2023, Without Invitation, The Japanese Society for Regenerative Medicine, Kyoto
  20. YAP/TAZ mechanosignaling regulates cytoprotective factors production in mesenchymal stem cells, Hiroki Yoshii, Mikihito Kajiya, Shin Morimoto, Mai Yoshino, Susumu Horikoshi, Misako Tari, Yuri Taniguchi, Shinya Sasaki, Yuta Hamamoto, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Tetsuya Yoshimoto, Noriyoshi Mizuno, The 66th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023, Without Invitation, The Japanese Society of Periodontology, Nagasaki
  21. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Shin Morimoto, Hiroki Yoshii, Tetsuya Yoshimoto, Sususmu Horikoshi, Misako Tari, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Shinya Sasaki, Yuta Hamamoto, Yuri Taniguchi, Noriyoshi Mizuno, The 66th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023, Without Invitation, The Japanese Society of Periodontology, Nagasaki
  22. Clumps of MSCs/ECM complexes can induce periodontal tissue regeneration via direct differetiation, Hisakatsu Sone, Mikihito Kajiya, Shinya Sasaki, Susumu Horikoshi, Tomoya Ogawa, Hiroki Yoshii, Shin Morimoto, Mai Yoshino, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, Spring annual Meeting of The Japanese Society Of Periodontology, 2022, Without Invitation, The Japanese Society Of Periodontology, Tokyo
  23. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Shin Morimoto, Hiroki Yoshii, Susumu Horikoshi, Hisakatsu Sone, Tomoyuki Iwata,Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, The 43rd annual meeting of the Japanese Society of Inflammation and Regeneration, 2022, Without Invitation, The Japanese Society of Inflammation and Regeneration, Awaji city & on the WEB
  24. Transplantation of mesenchymal stem cell clumps of MSCs / ECM complexes inducted by combined cartilage /bone differentiation promote bone regeneration through a mode of endochondral ossification., Shin Morimoto, Mikihito Kajiya, Hiroki Yoshii, Mai Yoshino, Tomoyuki Iwata, Noriyoshi Mizuno, The 40th annual meeting of the Japanese Society for Bone and Mineral Research, 2022, Without Invitation, The Japanese Society for Bone and Mineral Research, Gihu
  25. YAP/TAZ mechanosignaling regulates cytoprotective factors production in mesenchymal stem cells, Hiroki Yoshii, Mai Yoshino, Mikihito Kajiya, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022, Without Invitation, Japanese Association for Oral Biology, Tokushima
  26. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Hiroki Yoshii, Mikihito Kajiya, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022, Without Invitation, Japanese Association for Oral Biology, Tokushima
  27. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Yoshino M., Yoshii H, Kajiya M., The 22nd Annual Meeting of the Japanese Society for Regenerative Medicine, 2023, Without Invitation, The Japanese Society for Regenerative Medicine, Kyoto

Awards

  1. 2025/06, ASBMR 2025 Travel Award, The Japanese society for Bone and Mineral Research, Establishment of novel bone regenerative cell therapy using direct conversion and 3D cell clumps culture system
  2. 2025/05, JSP Outstanding Presentation Award in Periodontal Regenerative Medicine, Japanese Society of Periodontology, Establishment of novel bone regenerative cell therapy using direct conversion and 3D cell clumps culture system
  3. 2024/10, JSP Best Paper Award for Periodontal Regenerative Medicine, Japanese Society of Periodontology, A Cartilaginous Construct with Bone Collar Exerts Bone‑Regenerative Property Via Rapid Endochondral Ossification

External Funds

Acceptance Results of Competitive Funds

  1. 2025/04/01, 2027/03/31
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  2. 2024/07/31, 2026/03/31
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