Kouichi Koizumi

Last Updated :2025/05/09

Affiliations, Positions
Hiroshima University Hospital(Dental), Associate Professor or Lecturer
E-mail
kkoizumihiroshima-u.ac.jp
Self-introduction
After graduating from the Faculty of Dentistry at Kyushu University in 1996, I received training at the Second Oral Surgery of the same university for two years, and entered the Department of Oral and Maxillofacial Surgery at Hiroshima University in 1998. After working at Onomichi General Hospital and Mazda Hospital, I has been working at the current Department of Oral and Maxillofacial Surgery, Hiroshima University since 2001. My specialty is oral cancer and jaw deformity, I am also engaged in the medical treatment of outpatients referred by practitioners as an outpatient chief. Meanwhile, I am exploring CTC, a biomarker for oral cancer, and researching VEGF, associated with cancer infiltration or metastasis.

Basic Information

Major Professional Backgrounds

  • 2001/04/01, 2003/09/30, Dental Hospital, Hiroshima University, Assistant Professor
  • 2003/10/01, 2004/03/31, Medicine Dental Hospital, Hiroshima University, Assistant Professor
  • 2004/04/01, 2007/12/31, Hiroshima University Hospital, Assistant Professor
  • 2008/01/01, 2012/03/31, Institute of Biomedical & Health Sciences, Hiroshima University, Assistant Professor
  • 2012/04/01, 2017/03/31, Institute of Biomedical & Health Sciences, Hiroshima University, Assistant Professor
  • 2017/04/01, 2019/03/31, Graduate School of Biomedical & Health Sciences,Hiroshima University, Assistant Professor
  • 2019/04/01, 2022/02/28, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2022/03/01, 2024/01/31, Institute of Biomedical & Health Sciences, Hiroshima University, oral oncology, Assistant Professor
  • 2024/02/01, Hiroshima Hospital, Department of Oral and Maxillofacial Surgery, Lecturer

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 2000/04, 2005/03
  • Kyushu University, Faculty of Dentistry, Japan, 1990/04, 1996/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • Circulating Tumor Cell
  • molecular target therapy
  • oral cancer
  • VEGF
  • VEGF
  • β-catenin
  • NSAIDs
  • oral cancer
  • WNT

Affiliated Academic Societies

  • Japanese Society of Oral & Maxillofacial Surgeons, 1996/10
  • Japanese Stomatological Society, 2010/10
  • Japanese Society for Jaw Deformities, 2014/04
  • Japan society of head and neck cancer, 2022/04
  • Japanese Society of Oral Oncology, 2022/09
  • Japan Oral Oncology Group, 2023/06
  • Asian Association of Oral and Maxillofacial Surgeons, 2023/06

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 1Term, Oral and Maxillofacial Surgery I
  2. 2025, Undergraduate Education, 2Term, Oral and Maxillofacial Surgery II
  3. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  4. 2025, Undergraduate Education, 3Term, Basic Practice of Oral and Maxillofacial Medicine III
  5. 2025, Undergraduate Education, 4Term, Basic Practice of Oral and Maxillofacial Medicine IV
  6. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  7. 2025, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  8. 2025, Undergraduate Education, 2Term, Advanced Course in Oral and Maxillofacial Medicine
  9. 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  10. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  11. 2025, Undergraduate Education, Year, Clinical Practice (Oral Surgery I)

Research Activities

Academic Papers

  1. Oral surgery under general anesthesia in a patient with catecholaminergic polymorphic ventricular tachycardia: A case report, ORAL SCIENCE INTERNATIONAL, 21(2), 275-279, 202405
    Link to Paper Search Results by DOI
  2. Perioperative management of maxillary cyst and genetic analysis in a patient with glycogen storage disease type 1a: A rare case report, ORAL SCIENCE INTERNATIONAL, 21(2), 285-290, 202405
    Link to Paper Search Results by DOI
  3. Anesthetic management of a patient with Sturge-Weber syndrome in sagittal split ramus osteotomy surgery, CLINICAL CASE REPORTS, 12(4), 202404
    Link to Paper Search Results by DOI
  4. A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer, JOURNAL OF CLINICAL MEDICINE, 13(4), 202402
    Link to Paper Search Results by DOI
  5. ★, Primary intraosseous carcinoma complicated by cervical hodgkin lymphoma: A rare case report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(1), 38-43, 202401
    Link to Paper Search Results by DOI
  6. Molecular and histopathological findings in malignant transformation of proliferative verrucous leukoplakia that was successfully controlled for 15 years, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(1), 153-158, 202401
    Link to Paper Search Results by DOI
  7. A case of dentigerous cyst originating from an impacted supernumerary tooth with a dens in dente deformity, 69(7), 337-340, 202307
  8. Trend Survey and Case Study of Oral Cancer Patients Visiting the Department of Oral and Maxillofacial Surgery at Hiroshima University Hospital, 55(1), 9-16, 20230601
  9. ★, Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report, DENTISTRY JOURNAL, 11(11), 202311
    Link to Paper Search Results by DOI
  10. Successful orthognathic surgery in a patient with severe congenital neutropenia, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(5), 464-467, 202309
    Link to Paper Search Results by DOI
  11. ★, A case of multiple myeloma diagnosed by extramedullary disease in the submandibular region, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(3), 247-250, 202305
    Link to Paper Search Results by DOI
  12. Tumor-Infiltrating CD45RO(+) Memory Cells Are Associated with Favorable Prognosis in Oral Squamous Cell Carcinoma Patients, CANCERS, 15(8), 202304
    Link to Paper Search Results by DOI
  13. ★, VEGF-A promotes the motility of human melanoma cells through the VEGFR1-PI3K/Akt signaling pathway, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 58(8), 758-770, 202209
    Link to Paper Search Results by DOI
  14. Identification of a familial cleidocranial dysplasia with a novel RUNX2 mutation and establishment of patient-derived induced pluripotent stem cells, ODONTOLOGY, 110(3), 444-451, 202207
    Link to Paper Search Results by DOI
  15. A case of cystadenoma of the palate, 54(1), 34-38, 20220601
  16. ★, Impact of Maximum Tongue Pressure in Patients with Jaw Deformities Who Underwent Orthognathic Surgery, DIAGNOSTICS, 12(2), 202202
    Link to Paper Search Results by DOI
  17. ★, Clinical investigation of oral cancer in adolescent and young adult generation, ORAL SCIENCE INTERNATIONAL, 18(2), 126-134, 20210501
    Link to Paper Search Results by DOI
  18. Induction of Noonan syndrome-specific human-induced pluripotent stem cells under serum-, feeder-, and integration-free conditions, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(10), 888-895, 20201201
    Link to Paper Search Results by DOI
  19. Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report, PATHOLOGY INTERNATIONAL, 68(1), 31-35, 201801
    Link to Paper Search Results by DOI
  20. Suture granulomas developing after the treatment of oral squamous cell carcinoma, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 50, 68-71, 2018
    Link to Paper Search Results by DOI
  21. A case of primordial odontogenic tumor: A new entity in the latest WHO classification (2017), PATHOLOGY INTERNATIONAL, 67(7), 365-369, 201707
    Link to Paper Search Results by DOI
  22. A Case of Mandibular Retrusion with Temporomandibular Disorders Treated by Two-jaw Surgery, The Journal of Hiroshima University Dental Society, 49(1), 23-30, 201706
  23. A Case of Myoepithelioma of the Upper Lip, The Journal of Hiroshima University Dental Society, 49(1), 48-52, 201706
  24. Photodynamic therapy using Photofrin and excimer dye laser treatment for superficial oral squamous cell carcinomas with long-term follow up, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 14, 104-110, 201606
    Link to Paper Search Results by DOI
  25. The Second Report: A Case of Temporomandibular Joint Osteoarthritis with Mandibular Recession and Open Bite: Onset after the Orthodontic Treatment in Adolescence, The Journal of Hiroshima University Dental Society, 48(1), 56-62, 201606
  26. Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7), 840-844, 201507
    Link to Paper Search Results by DOI
  27. Weekly paclitaxel plus cetuximab reduces the lung metastasis of adenoid cystic carcinoma arising from the salivary gland, ORAL SCIENCE INTERNATIONAL, 12(2), 67-71, 201503
    Link to Paper Search Results by DOI
  28. Prediction of the Cervical Lymph Node Metastases in the Early Oral Tongue Cancer Patients using Primary Site SUVmax (maximum standardized uptake values) on FDG-PET (18-fluorodeoxyglucose positron emission tomography), The Journal of Hiroshima Dental Association, 46(1), 36-41, 201406
  29. A case of desmoplastic fibroma in the mandible, Journal of Japanese Stomatological Society, 62(1), 11-16
  30. Successful Multidisciplinary Collaboration for Primary Care and Defect Reconstruction in a Patient with Oral and Maxillofacial Severe Traumatic Injury, J.Jpn.Soc. O.M.F. Trauma, 12(1), 37-43
  31. A case of Skeletal maxillary prognathism treated by the upper and lower jaw bone osteotomy, The Journal of Hiroshima Dental Association , 41(1), 13-18
  32. Clinoco-Statistical Study of the Tongue Carcinoma in Clinic of Oral and Maxillofacial Surgery, Hiroshima University Hospital during the Past 14 years, The Journal of Hiroshima Dental Association, 44(1), 1-9
  33. A Survey of New Program in Dental Clinical Training at Hiroshima University Hospital, The Journal of Hiroshima Dental Association, 44(2), 107-111
  34. Clinoco-Statistical Study of Orthognathic Surgery in Clinic of Oral and Maxillofacial Surgery, Hiroshima University Hospital during the Past 14 years, The Journal of Hiroshima Dental Association, 43(2), 91-97
  35. A case of glandular odontogenic cyst arising in the molar region of mandible-comparison and review of domestic and international report-, Japanese Journal of Oral & Maxillofacial Surgery, 55(4), 359-363, 20090901
  36. A case of intramuscular lipoma extending to the infratemporal fossa that was associated with mental nerve neuropathy as an initial symptom, Japanese Journal of Oral & Maxillofacial Surgery, 55(11), 580-584, 20091101
  37. Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion., Oncol Rep., 17(2), 417-423, 20070201
  38. Photofrin-mediated photodynamic therapy for treatment of superficial gingival squamous cell carcinomas., Japanese Journal of Oral & Maxillofacial Surgery, 53(5), 262-270, 20070501
  39. A case of renal cell carcinoma metastatizing to the mandible, Japanese Journal of Oral & Maxillofacial Surgery, 53(7), 444-448, 20070701
  40. Application of a novel interconnective porous hydroxyapatite ceramic for defects in jaw bone, Journal of Japanese Stomatological Society, 56(4), 400-404, 20070901
  41. Primary intraosseous carcinoma of mandible associated with elevation of serum carcinoembryonic antigen level, Oral Oncology Extra, 41(10), 267-271, 20051101
  42. Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin, INTERNATIONAL JOURNAL OF ONCOLOGY, 27(3), 693-698, 200509
    Link to Paper Search Results by DOI
  43. Dedifferentiation in adenoid cystic carcinoma of submaxillary gland: A case of report, Oral Oncology, 41, 84-88
  44. ★, Role of vascular endothelial growth factor receptor system in the motility of human melanoma cell lines , J.J.Tissue Cult. Dent. Res, 14(1), 39-40, 20050701
  45. Participation of integrin αv in invasive growth of oral squamous cell carcinoma cells, J.J.Tissue Cult. Dent. Res, 14(1), 43-44, 20050701
  46. Primary leiomyosarcoma of the mandible, Asian J Oral Maxillofac Surg, 17(2), 131-134
  47. ★, A case of carcinoma of the sigmoid colon metastatizing to the maxillary gingiva, Japanese Journal of Oral & Maxillofacial Surgery, 50(6), 396-399, 20040401
  48. Regulation of cell-cell adhesion of oral squamous cell carcinoma cells through plasminogen/prasmin system, J.J.Tissue Cult. Dent. Res, 13(1), 23-24, 20040601
  49. Role of stromal thrombospondin-1 in motility and proteolytic activity of oral squamous cell carcinoma cells, Intern. J. Molecular Medicine, 12, 447-452, 20030401
  50. Participation of integrin αv in invasive growth of oral squamous cell carcinoma cells, J.J.Tissue Cult. Dent. Res, 11(1), 11-18, 20020301
  51. A case of Warthin tumor showing cyst-like appearance, The Journal of Hiroshima Dental Association, 31(2), 215-219, 19991201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Secular Changes of Circulating Tumor Cells and Cell-free DNA in Blood with Oral Squamous Cell Carcinoma, Natsuki Eboshida, Atsuko Hamada, Yasuyuki Asada, Yume Ueda, Teru Uehara, Airi Odawara, Erika Yamasaki, Tamamo Matsuyama, Kento Okamoto, Taeko Fukutani, Tadayoshi Nobumoto, Fumitaka Obayashi, Nanako Ito, Ishida Yasutaka,Mirai Higaki, Sachiko Yamasaki, Tomoaki Hamana, Koichi Koizumi, Yukio Yoshioka, Ryoji Tani, Souichi Yanamoto, 9th World Congress of the International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, Incheon Korea
  2. A Retrospective Study of High-risk Factors for Metastasis in Patients with Resected T1-2N0 Tongue Cancer, Obayashi F, Koizumi K, Higaki M, Ito N, Nobumoto T, Fukutani T, Hamada A, Yamasaki S, Ishida Y, Ando T, Hamana T, Yoshioka Y, Shintani T, Tani R, Yanamoto S., 9th World Congress of the International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, Incheon Korea
  3. Clinical analysis of the elderly patients with oral squamous cell carcinoma, Atsuko Hamada, Koichi Koizumi, Taeko Fukutani, Erika Yamasaki, Teru Uehara, Natsuki Eboshida, Tadayoshi Nobumoto, Mirai Higaki, Fumitaka Obayashi, Sachiko Yamasaki, Nanako Ito, Yasutaka Ishida, Tomoaki Hamana, Yukio Yoshioka, Ryoji Tani, Souichi Yanamoto., 9th World Congress of the International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, Incheon Korea
  4. Clinical significance of extranodal extension of cervical lymph node metastasis in oral squamous cell carcinoma, Mirai Higaki, Koichi Koizumi, Toshinori Ando, Takafumi Obayashi, Nanako Ito, Tomoaki Shintani, Tomoaki Hamana, Yukio Yoshioka, Ryouji Tani, Souichi Yanamoto., 9th World Congress of the International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, Incheon Korea
  5. Investigation of Local Recurrence of Oral Cancer: Relationship with Anatomical Landmarks in Cases of Backward Progression, Nanako Ito, Koichi Koizumi, Tomoaki Shintani, Yasuyuki Asada, Taeko Fukutani, Atsuko Hamada, Sachiko Yamasaki, Tomoaki Hamana, Yukio Yoshioka, Souichi Yanamoto., 9th World Congress of the International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, Incheon Korea
  6. Reconstruction of the mandible by full custom-made titanium plate CosmofixⓇ, Yamasaki S, Yoshioka Y, Fukutani T, Shintaku Y, Koizumi K, Aikawa T, Yanamoto S, 2023/06/03, Without Invitation, Japanese
  7. Research about the circulating tumor cells and circulating cell-free DNA in blood of oral squamous cell carcinoma, Eboshida N, Hamada A, Matsuyama T, Okamoto K, Takahashi H, Mishima T, Fukutani T, Obayashi F, Taguchi Y, Kimura N, Ito N, Higaki M, Yamasaki S, Hamana T, Koizumi K, Yoshioka Y, Tani R, Hayashido Y, Yanamoto S, The 35th Annual Congress of Taiwanese Association of Oral and Maxillofacial Surgeons, 2023/03/11, Without Invitation, English, Taipei
  8. Clinical analysis of mandibular reconstruction with titanium plate in patients with oral cancer, Naohiro Kimura, Yukio Yoshioka, Mirai Higaki, Atsuko Hamada, Tomoaki Hamana, Koichi Koizumi, Ryouji Tani, Shigeaki Toratani, Souichi Yanamoto, 2022/06/11, Without Invitation, Japanese, Hiroshima
  9. A case of superficial mucous cyst on the lower lip, Obayashi F., Kanda T., Ito N., Takahashi H., Sakamoto S., Koizumi K., Tortoni S., The 66th Congress of the Japanese Oral and Maxillofacial Surgeons, 2021/11/12, Without Invitation, Japanese, Japanese Oral and Maxillofacial Surgeon
  10. A case of cleidocranial dysplasia with surgical orthodontic treatment, A 12-year course of treatment, Hamada A., Kanda T., Iwai K., Mishima T., Koizumi K., Tanimoto K., Tortoni S., 2021/02/06, Without Invitation, Japanese
  11. Establishment and Characterization of Disease-specific Human iPSCs in Serum-, Integration- and Feeder-free Cultures, Hamada A, Nakase Y, Obayashi F, Fukutani T, Nakatao H, Sakaue E, Yamasaki S, Kanda T, Koizumi K, Yoshioka Y, Tani R, Toratani S, JD. Sato, Okamoto T, Annual Meeting of Society for In Vitro Biology Meeting, 2019/06/09, With Invitation, English
  12. A case of dentigerous cyst associated with a wisdom tooth in the maxillary sinus, 2018/06/16, Without Invitation, Japanese
  13. A clinical study of elderly patients over 90 years old with oral malignancies, Taishi Sakaue,Yukio Yoshioka, Fumitaka Obayashi, Kouji Tsushima, Kensaku Matui, Atsuko Hamada, Sachiko, Yamasaki, Tomoaki Hamana, Kensaku Sumi, Taku Kanda, Koichi Koizumi, Ryoji Tani, Yasutaka Hayashidou, Hisako Sasahara, Shigeaki Toratani, Tetsuji Okamoto, The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, English, Annual Meeting of Hiroshima University Dental Society
  14. A clinical study on Adolescent and Young Adult (AYA) patients with oral cancer, Y. YOSHIOKA, T. SAKAUE, K. MATSUI, K. TSUSHIMA, F. OBAYASHI, A. HAMADA, S. YAMASAKI, T. HAMANA, K. SUMI, T. KANDA, K. KOIZUMI, R. TANI, Y. HAYASHIDO, H. SASAHARA, S. TORATANI, T. OKAMOTO, The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, Japanese, Annual Meeting of Hiroshima University Dental Society
  15. A Case Report : A Case of Multiple Suture Granulomas Mimicking Tumor Recurrence of Gingival Cancer, H. Nakatao, Y. Yoshioka, T. Hamana, A. Hamada, T. Kanda, K. Koizumi, S. Toratani, T. Okamoto, The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, Japanese, Annual Meeting of Hiroshima University Dental Society
  16. An overview of the dysphagia rehabilitation team at Mazda Hospital and its recent activities., Yuichi Arita, Akihiko Sakamoto, Ryouji Tani, Yukio Yoshioka, Koichi Koizumi, Tomoaki Shintani, Yasutaka Hayashido, Shigeaki Toratani, Tetsuji Okamoto, The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, Japanese, Annual Meeting of Hiroshima University Dental Society
  17. Clinical Study of Recent 10 year Orthognathic Surgery in Dent-Oral-Maxillofacial Surgery at JA Onomichi General Hospital, Fuyuyoshi Takatu, Yoku Ito, Jun-ichi Hara, Tomoaki Hamana, Taku Kanda, Koichi Koizumi, Masashi Kobayashi, Shigeaki Toratani, Tetuji Okamoto., The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, Japanese, Annual Meeting of Hiroshima University Dental Society
  18. Photofrin-mediated photodynamic therapy for treatment of oral squamous cell carcinomas 6th Asian Congress on Oral and Maxillofacial Surgery　, S. Toratani, R. Tani、D. Hayashi、Y. Fukuhara、T. Mashima、Y. Fukui、K. Koizumi、Y. Yoshioka、Y. Tanaka、T. Okamoto, 2004/10/20, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), Establishment study of liquid biopsy by isolation of circulating oral cancer cells in blood and analysis of their cell characteristics, 2018, 2020
  3. KAKENHI, 2012, 2014
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  4. KAKENHI, Development research into molecular diagnosis and treatment method of carcinoma of the oral cavity targeting WNT signal system transfer factor group, 2008, 2010
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  5. KAKENHI, Experimental study on the inhibition of invasion and metastasis of oral cancer by the suppression of processing of E-cadherin, 2005, 2006
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  6. KAKENHI, Development of molecular target therapy to VEGF and VEGFR against oral cancer with RNAi methods, 2005, 2006
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  7. KAKENHI, Suppression of angiogenesis in oral cancer by cyclooxygenase inhibitors, 2002, 2003
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Social Activities

Organizing Academic Conferences, etc.

  1. 2019/10, 2019/10
  2. 2016/05
  3. 2012/05