広島大学

Basic Information

Major Professional Backgrounds

• 2018/04/01, 2019/03/31, Hiroshima University, Global Career Design Center, Special Postdoctral Researcher
• 2019/04/01, 2024/03/31, Hiroshima university, Graduate School of Integrated Sciences for Life, Assistant professor
• 2015/04/01, 2018/03/31, Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, DC1
• 2019/09/02, 2020/09/11, Robinson Research Institute; The University of Adelaide, Robinson Research Institute, Visiting research fellow

Educational Backgrounds

• Hiroshima University, 2009/04/01, 2013/03/23
• Hiroshima University, 2013/04/01, 2015/03/23
• Hiroshima University, 2015/04/01, 2018/03/23

Academic Degrees

• Hiroshima University
• Hiroshima University

Educational Activity

• [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Applied Animal and Plant Science Program
• [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Bioresource Science
• [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Bioresource Science

In Charge of Primary Major Programs

• Applied Animal and Plant Science Program

Research Fields

• Agricultural sciences;Animal life science;Animal production science

Research Keywords

• Animal reproduction, Reproductive biology, Reproductive technology

Affiliated Academic Societies

• Japan Society of Reproductive Endocrinology
• Japan Society for Ova Research
• Japan Society of Fertilization and Implantation
• Japan Society for Reproductive Medicine

Educational Activity

Course in Charge

1. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
2. 2024, Undergraduate Education, Intensive, Laboratory Work in General Biology II
3. 2024, Undergraduate Education, 3Term, Research Front of Bioresource Science
4. 2024, Undergraduate Education, 1Term, Reproductive Biology
5. 2024, Undergraduate Education, Intensive, Laboratory and Field Works in Animal Production I
6. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
7. 2024, Undergraduate Education, First Semester, Graduation Thesis II
8. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
9. 2024, Undergraduate Education, Intensive, (AIMS) Animal Science and Technology
10. 2024, Undergraduate Education, 3Term, Animal Science and Technology
11. 2024, Graduate Education (Master's Program) , 2Term, Assisted Reproductive Technology for Animal Production
12. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Bioresource Science A
13. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Bioresource Science A
14. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Bioresource ScienceB
15. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Bioresource ScienceB
16. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Bioresource Science

Research Activities

Academic Papers

1. Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle, FRONTIERS IN IMMUNOLOGY, 14, 20231219
   Link to Paper Search Results by DOI
2. Treatment with cholesterol just after thawing maintains the fertility of bull sperm, MOLECULAR HUMAN REPRODUCTION, 29(9), 20230830
   Link to Paper Search Results by DOI
3. ★, Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary, SCIENCE ADVANCES, 8(24), 20220617
   Link to Paper Search Results by DOI
4. The expression and roles of Semaphorin Type 3C in granulosa cells during the luteinization process., Journal of Mammalian Ova Research, 31, 31-39, 2014
5. ★, Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation., Molecular Endocrinology, 706-720, 2014
6. ★, Neuregulin 1 regulates proliferation of Leydig cells to support spermatogenesis and sexual behavior in adult mice., Endocrinology, 157, 4899-4913, 2016
7. ★, The acceleration of reproductive aging in Nrg1flox/flox; Cyp19-Cre female mice., Aging cell, 1288-1299, 2017
8. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice., PloS one, e0192458, 2018
9. ★, Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm., Human Reproduction, 1117-1129, 2018
10. The stromal fibrosis in aging ovary., Aging, 8-10, 2018
11. Roles of epidermal growth factor (EGF)-like factor in the ovulation process., Reproductive Medicine and Biology, 201-216, 2016
12. Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm, FRONTIERS IN PHYSIOLOGY, 10, 20190312
    Link to Paper Search Results by DOI
13. ★, Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm, PLOS BIOLOGY, 17(8), 201908
    Link to Paper Search Results by DOI
14. Negative effects of ROS generated during linear sperm motility on gene expression and ATP generation in boar sperm mitochondria, FREE RADICAL BIOLOGY AND MEDICINE, 141, 159-171, 201909
    Link to Paper Search Results by DOI
15. ★, A simple sperm-sexing method that activates TLR7/8 on X sperm for the efficient production of sexed mouse or cattle embryos, NATURE PROTOCOLS, 15(8), 2645-2667, 202008
    Link to Paper Search Results by DOI
16. Itaconate regulates the glycolysis/pentose phosphate pathway transition to maintain boar sperm linear motility by regulating redox homeostasis, FREE RADICAL BIOLOGY AND MEDICINE, 159, 44-53, 20201101
    Link to Paper Search Results by DOI
17. Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice, REPRODUCTIVE MEDICINE AND BIOLOGY, 19(4), 415-424, 202010
    Link to Paper Search Results by DOI
18. Methyl-beta cyclodextrin and creatine work synergistically under hypoxic conditions to improve the fertilization ability of boar ejaculated sperm, ANIMAL SCIENCE JOURNAL, 91(1), 2020
    Link to Paper Search Results by DOI
19. Adverse effect of superoxide-induced mitochondrial damage in granulosa cells on follicular development in mouse ovaries, FREE RADICAL BIOLOGY AND MEDICINE, 163, 344-355, 20210201
    Link to Paper Search Results by DOI
20. Saturated fatty acids accelerate linear motility through mitochondrial ATP production in bull sperm, REPRODUCTIVE MEDICINE AND BIOLOGY, 20(3), 289-298, 202107
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

1. The expressed genes from X chromosome in sperm alter sperm motility and provides a novel simple technology for sexing sperm., Takashi Umehara, The 5th World Congress of Reproductive Biology, With Invitation, English
2. Targeted disruption of neuregulin 1 in granulosa cells reveals an important role in oocyte maturation in vivo, Masayuki Shimada, Ikko Kawashima, Takashi Umehara, JoAnne S.Richards, SSR 46th Annual Meeting, 2013/07, Without Invitation, English, Montreal, Canada
3. The abnormal estrus cycle in aged granulosa-cell-specific Nrg1 KO mice, Takashi Umehara, JoAnne S. Richards, Masayuki Shimada, SSR 47th Annual Meeting, 2014/07, Without Invitation, English, Grand rapids, U.S.A
4. LH-induced NRG1 is essential for adult Leydig cell proliferation in the infant testis that determines androgen production and spermatogenesis in adult male mice., Takashi Umehara, Wenxian Zeng, JoAnne S. Richards, Masayuki Shimada, SSR 49th Annual Meeting, 2016/07, Without Invitation, English, San diego, U.S.A
5. Creatine enhances sperm capacitation and is associated with successful in vivo and in vitro fertilization in mice., Takashi Umehara, Satoshi Okuda, Tomoko Kawai, JoAnne S. Richards, Masayuki Shimada, SSR 50th Annual Meeting, 2017/07, Without Invitation, English, Washington D.C, U.S.A

Awards

1. 2018, THE 2018 AWARDS OF THE DIMITRIS N. CHORAFAS FOUNDATION, THE DIMITRIS N. CHORAFAS FOUNDATION, A study on the role of Neuregulin 1 in mammalian fertility

External Funds

Acceptance Results of Competitive Funds

1. 2023, 2025
2. 2021, 2021
3. 2021, 2022
4. 2015/.4, 2018/.3
5. Oversea research fellowship, A study on the treatment of reproductive disorder focusing on ovarian fibrosis, 2019/09/01, 2020/09/13