YOSHIYUKI KOBAYASHI

Last Updated :2026/06/28

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
yosikobahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2003/05/16, 2004/03/31, Hiroshima University, Hospital, Clinical Resident
  • 2004/04/01, 2005/03/31, Hiroshima University, Hospital, Clinical Resident
  • 2010/08/01, 2013/03/31, Hiroshima University, Hospital, Clinical Staff
  • 2013/04/01, 2019/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2019/04/01, Hiroshima University, Hospital, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2009/04, 2013/03
  • Hiroshima University, Faculty of Medicine, Japan, 1997/04, 2003/03

Academic Degrees

  • Hiroshima University

Affiliated Academic Societies

  • The Japanese Society of Child Neurology
  • The Japan Epilepsy Socaiety

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Systemic Disease Control

Research Activities

Academic Papers

  1. Age‐dependent electroclinical evolution from focal seizures to epileptic spasms in NUSAP1‐related malformations of cortical development, Epileptic Disorders, 202606
    Link to Paper Search Results by DOI
  2. Acute necrotizing encephalopathy associated with COVID-19 in a pediatric patient and a systematic review, Journal of Human Immunity (JHI), 202602
    Link to Paper Search Results by DOI
  3. Life-Threatening SARS-CoV-2-Associated Encephalopathy and Multiorgan Failure in Children, Asia and Oceania, 2022-2024, EMERGING INFECTIOUS DISEASES, 32(2), 169-179, 202602
    Link to Paper Search Results by DOI
  4. Effective relapse prevention with monthly intravenous immunoglobulin therapy in a pediatric patient with anti-neutral glycolipid antibody-positive Encephalomyeloradiculoneuropathy, Brain and Development Case Reports, 202506
    Link to Paper Search Results by DOI
  5. Epilepsy and Other Neurological Complications in Pediatric Patients With Hemophilia Complicated With Intracranial Hemorrhage: A Retrospective Case Series, Cureus, 202412
    Link to Paper Search Results by DOI
  6. A Pediatric Case of B Cell Precursor ALL With Blinatumomab-associated Encephalopathy, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 46(7), e550-e555, 202410
    Link to Paper Search Results by DOI
  7. A case of forced normalization due to perampanel, Brain and Development Case Reports, 202406
    Link to Paper Search Results by DOI
  8. Safety and Tolerability of COVID-19 Vaccination in Adolescents and Young Adults with Epilepsy: A Multicenter Questionnaire Study, JOURNAL OF PEDIATRIC EPILEPSY, 13(01), 1-5, 202403
    Link to Paper Search Results by DOI
  9. A Pediatric Case of B Cell Precursor ALL With Blinatumomab-associated Encephalopathy, Journal of Pediatric Hematology/Oncology, 202406
  10. A Successful Infliximab Treatment of a Pediatric Case of Severe Polyarteritis Nodosa With a Cerebral Infarction and a Decreased Adenosine Deaminase 2 Activity, CUREUS JOURNAL OF MEDICAL SCIENCE, 15(10), 20231030
    Link to Paper Search Results by DOI
  11. HFA analysis using scalp electroencephalograms in two cases of Rasmussen's syndrome, EPILEPSY RESEARCH, 196, 202310
    Link to Paper Search Results by DOI
  12. Evaluation of cerebrospinal fluid biomarkers in pediatric patients with spinal muscular atrophy, BRAIN & DEVELOPMENT, 45(1), 2-7, 202301
    Link to Paper Search Results by DOI
  13. Effect of Lacosamide therapy on blood cells and IgA levels in children and adolescents with epilepsy in a clinical setting, EPILEPSY RESEARCH, 187, 202211
    Link to Paper Search Results by DOI
  14. Paediatric anti-NMDA-receptor encephalitis with ovarian teratoma, JOURNAL OF PEDIATRIC SURGERY CASE REPORTS, 83, 202208
    Link to Paper Search Results by DOI
  15. Clinical impact of the dose and blood concentration of lacosamide in Japanese pediatric patients with epilepsy: A cohort study, EPILEPSY & BEHAVIOR, 129, 202204
    Link to Paper Search Results by DOI
  16. IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation, JOURNAL OF CLINICAL IMMUNOLOGY, 41(1), 125-135, 202101
    Link to Paper Search Results by DOI
  17. Contribution of gene mutations to Silver-Russell syndrome phenotype: multigene sequencing analysis in 92 etiology-unknown patients, CLINICAL EPIGENETICS, 12(1), 20200616
    Link to Paper Search Results by DOI
  18. Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy, EPILEPSY RESEARCH, 167, 202011
    Link to Paper Search Results by DOI
  19. Successful treatment of intractable life-threatening seizures with perampanel in the first case of early myoclonic encephalopathy with a novel de novo SCN1A mutation, SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 71, 20-23, 201910
    Link to Paper Search Results by DOI
  20. Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy, EPILEPSY & BEHAVIOR, 94, 82-86, 201905
    Link to Paper Search Results by DOI
  21. High Incidence of Renal Stones in Severely Disabled Children with Epilepsy Treated with Topiramate, NEUROPEDIATRICS, 50(3), 160-163, 201906
    Link to Paper Search Results by DOI
  22. Recurrence of Epileptic Spasms as Reflex Seizures induced by Eating: A Case Report and Literature Review., NEUROPEDIATRICS, 48(2), 119-122, 201704
  23. Anti-MOG antibody encephalitis mimicking neurological deterioration in a case of Rett syndrome with MECP2 mutation., BRAIN & DEVELOPMENT, 408(10), 943-946, 201811
  24. Late-onset epileptic spasms in a patient with 22q13.3 deletion syndrome., BRAIN & DEVELOPMENT, 38(1), 109-112, 201601
  25. Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent refractory generalized motor seizures., SEIZURE, 25, 136-140, 201502
  26. A case of trisomy 18 with exacerbation of seizures triggered by administration of valproic acid., AM J MED GENET PART A, 164A(1), 285-286, 201401
  27. Microarray and FISH-based Genotype-Phenotype Analysis of 22 Japanese Patients with Wolf-Hirschhorn Syndrome., AM J MED GENET PART A, 164A(3), 597-609, 201403
  28. Compound heterozygosity in GPR56 with bilateral frontoparietal polymicrogyria., BRAIN & DEVELOPMENT, 36(6), 528-531, 201406
  29. Management of advanced-stage neuroblastoma in a patient with 21-hydroxalase deficiency., PEDIATR INT, 55(4), 96-99, 201308
  30. Paroxysmal periodic dystonic postures in an infant with 18q23 deletion syndrome., NEUROPEDIATRICS, 44(3), 163-166, 201306
  31. Acute severe encephalopathy related to human herpesvirus-6 infection in a patient with carnitine palmytoyltransferase 2 deficiency carrying thermolabile variants., BRAIN & DEVELOPMENT, 35(5), 449-453, 201305
  32. Successful treatment with liposteroid followed by reduced intensity stem cell transplantation in an infant with perforin deficiency presenting with hemophagocytic lymphohistiocytosis., J PEDIATR HEMATOL ONCOL, 29(3), 178-182, 200703

Invited Lecture, Oral Presentation, Poster Presentation

  1. A case forced normalization due to perampanel, 2023/05/25, Without Invitation, Japanese
  2. Drug-induced pleural effusion due to dantrolene sodium hydrate in a severely disabled person, 2023/05/26, Without Invitation, Japanese
  3. Can seizure types be identified with raw expressions of patients and caregivers?, 2023/05/26, Without Invitation, Japanese
  4. Safety and Tolerability of the COVID-19 Vaccination in Children and Adolescents with Epilepsy : A multicentre Questionnaire Study, Yoshiyuki Kobayashi, Nobutsune Ishikawa, Yuichi Tateishi, Hiroki Izumo, Yuta Eguchi, Yuji Fujii, Hiroaki Ono, and Satoshi Okada1), American Epilepsy Society 76th Annual Meeting,, 2022/12/04, Without Invitation, English
  5. A study of epilepsy complicated in patients with hemophilia, Yuta Eguchi, Nobutsune Ishikawa, Hiroki Izumo, Yuichi Tateishi, Yoshiyuki Kobayashi, Yoko Mizoguchi, The 63rd annual Meeting of the Japanese Society of Child Neurology, 2022/06/02, Without Invitation, Japanese
  6. A 13-year-old girl case of polyarteritis nodosa who was diagnosed with multiple cerebral infarction, Hiroki Izumo, Nobutsune Ishikawa, Yoshiyuki Kobayashi, Yuichi Tateishi, Yuta Eguchi, Takehiko Doi, Satoshi Okada, The 63rd annual Meeting of the Japanese Society of Child Neurology, 2022/06/02, Without Invitation, Japanese
  7. A study of biomarkers of cerebrospinal fluid in spinal muscular atrophy, Yoshiyuki Kobayashi, Nobutsune Ishikawa, Yuichi Tateishi, Hiroki Izumo, Satoshi Okada, The 64th annual Meeting of the Japanese Society of Child Neurology, 2022/06/02, Without Invitation, Japanese
  8. Treatment with oral baclofen for dysphagia associated with acute flaccid myelitis, Yuishi Tateishi, Nobutsune Ishikawa, Yoshiyuki Kobayashi, Hiroki Izumo, Satoshi Okada, 2022/04/15, Without Invitation, Japanese
  9. Heterogeneous initial symptoms in pediatric NMDA receptor encephalitis, Yuta Eguchi, Nobutsune Ishikawa, Hiroki Izumo, Yuichi Tateishi, Yoshiyuki Kobayashi, The 125th Annual Meeting of the Japanese Pediatric Society, 2022/04/15, Without Invitation, Japanese
  10. A case of West syndrome of which diagnosis led to identification of a COL4A1 mutation., Yuichi Tateishi, Nobutsune Ishikawa, Yoshiyuki Kobayashi, Hiroo Tani, Satoshi Okada, 2021/09/23, Without Invitation, Japanese
  11. Efficacy of lacosamide for pediatric epilepsy - A studyfocused on dose and blood concentration, Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, Yoshiyuki Kobayashi, Satoshi Okada, The 54th Annual Congress of the Japan Epilepsy Society, 2021/09/23, Without Invitation, Japanese
  12. The efficacy of perampanel in pediatric patients with epileptic spams, Yoshiyuki Kobayashi, Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, The 54th Annual Congress of the Japanese Epilepsy Society, 2021/09/23, Without Invitation, Japanese
  13. A case of myasthenia gravis with Grave's disease requiring mechanical ventilation, Yuichi tateishi, Nobutsune Ishikawa, Yoshiyuki Kobayashi, Hiroo Tani, The 63rd annual Meeting of the Japanese Society of Child Neurology, 2021/05/29, Without Invitation, Japanese
  14. Assessment of clinical course in children with anti-MOG antibody-associated disease., The 63rd Annual Meeting of the Japanese Society of Child Neurology, 2021/05/29, Without Invitation, Japanese
  15. Assessment of treatment outcome in children with anti-NMDA receptor encephalitis, The 62nd Annual Meeting of the Japanese Society of Child Neurology, 2020/08/20, Without Invitation, Japanese
  16. A case of early onset epileptic encephalopathy caused by KCNQ2 gain-of-function mutation, Yoshiyuki Kobayashi, Nobutsune Ishikawa, Hiroo Tani, Yuuichi Tateishi, Mitsuhiro Katou, Hirotomo Saitsu, Mitsuko Nakashima, The 53rd Annual Congress of the Japan Epilepsy Society, 2019/10/31, Without Invitation, Japanese, Japan Epilepsy Society, Kobe

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020
  2. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2014, 2015