KENTA UCHIBE

Last Updated :2024/07/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Associate Professor
E-mail
uchibekhiroshima-u.ac.jp
Self-introduction
My research is focusing on skeletal development and related diseases.

Basic Information

Major Professional Backgrounds

  • 2009/04, 2010/03, Okayama University Hospital, Clinical Resident
  • 2010/04, 2012/01, Okayama University Hospital, Clinical Fellow
  • 2012/02/01, 2015/04/30, The Children's Hospital of Philadelphia, Orthopaedic Surgery, Post-Doctoral Fellow
  • 2015/05/01, 2019/10/31, Okayama University, Assistant Professor
  • 2019/11/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Associate Professor

Educational Backgrounds

  • Okayama University, Japan, 2005/04, 2009/03
  • Okayama University, Japan, 1999/04, 2005/03

Academic Degrees

  • Okayama University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Morphological basic dentistry

Research Keywords

  • Bone, Cartilage, Tooth, Retinoic acid

Affiliated Academic Societies

  • Japanese Society of Oral Implantology
  • The Japanese Society of Cartilage Metabolism
  • The Japanese Association of Anatomists
  • Japanese Association for Oral Biology

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2024, Undergraduate Education, 2Term, Gross Anatomy
  3. 2024, Undergraduate Education, 3Term, Basic Practice of Anatomy I
  4. 2024, Undergraduate Education, 4Term, Basic Practice of Anatomy II
  5. 2024, Undergraduate Education, 2Term, Embryology
  6. 2024, Undergraduate Education, 1Term, Histology and Oral Histology
  7. 2024, Undergraduate Education, 1Term, Basic Practice of Histology I
  8. 2024, Undergraduate Education, 2Term, Basic Practice of Histology II
  9. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  10. 2024, Undergraduate Education, 3Term, Clinical Anatomy for Dentistry I
  11. 2024, Undergraduate Education, 4Term, Clinical Anatomy for Dentistry II
  12. 2024, Undergraduate Education, 3Term, Practice of Clinical Anatomy for Dentistry I
  13. 2024, Undergraduate Education, 4Term, Practice of Clinical Anatomy for Dentistry II
  14. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  15. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  16. 2024, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
  17. 2024, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
  18. 2024, Graduate Education (Master's Program) , First Semester, Human Anatomy

Research Activities

Academic Papers

  1. Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity, bioRxiv, 20231115
  2. Effects of Peripheral Nerve Injury on the Induction of c-Fos and Phosphorylated ERK in the Brainstem Trigeminal Sensory Nuclear Complex, ANNALS OF NEUROSCIENCES, 30(3), 177-187, 202307
  3. Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain, INTERNATIONAL JOURNAL OF NEUROSCIENCE, 132(12), 1210-1216, 20221202
  4. Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain, International Journal of Neuroscience, 20210118
  5. N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium, Cell Signal, 75
  6. Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866(6)
  7. Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation, 95(2)
  8. Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment, PLoS One, 13(2)
  9. Reduction of protein phosphatase 2A C alpha promotes in vivo bone formation and adipocyte differentiation, Molecular and Cellular Endocrinology, 470
  10. ★, Genetic and pharmacological inhibition of retinoic acid receptor gamma function promotes endochondral bone formation, Journal of Orthopaedic Research, 35(5)
  11. ★, Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation, Journal of Bone and Mineral Research, 31(9)
  12. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent, Bone, 90
  13. Selective Retinoic Acid Receptor gamma Agonists Promote Repair of Injured Skeletal Muscle in Mouse, The American Journal of Pathology, 185(9)
  14. Tendon progenitor cells in injured tendons have strong chondrogenic potential: the CD105-negative subpopulation induces chondrogenic degeneration, Stem Cells, 32(12)
  15. The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo, PLoS One, 8(10)
  16. Identification of novel transcription-regulating genes expressed during murine molar development, Developmental Dynamics, 241(7)
  17. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58, Developmental Cell, 17(6)
  18. Large-scale whole mount in situ hybridization of mouse embryos, Methods in Molecular Biology, 577
  19. Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken, Gene Expression Patterns, 8(3)

Publications such as books

  1. Latest Osteoporosis Science (2nd ed.), Chondrocytes, Nipponrinshosha Co., Ltd., 2023, 1, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. Local administration of CD1530, selective RAR gamma agonist, facilitates tendon healing by modulating the healing environment including reduced heterotopic ossification in a mouse Achilles rupture model, Yimiti D, Uchibe K, Toriyama M, Hayashi Y, Ikuta Y, Nakasa T, Takimoto A, Shukunami C, Adachi N, Miyaki S, ORS 2024 Annual Meeting, 2024/02/02, Without Invitation, English
  2. Targeted bone growth by local retinoid administration, Uchibe K, Terayama R, The 65th Annual Meeting of Japanese Association for Oral Biology, 2023/09/16, Without Invitation, English
  3. Differential changes in the induction of c-Fos and phosphorylated ERK in the trigeminal spinal tract nucleus after peripheral nerve injury, Terayama R, Uchibe K, The 65th Annual Meeting of Japanese Association for Oral Biology, 2023/09/16, Without Invitation, English
  4. Retinoic acid receptor agonist inhibits ectopic ossification and promotes Achilles tendon repair, Dilimulati Yimiti, Kenta Uchibe, Chisa Shukunami, Shigeru Miyaki, The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research, 2023/07/27, Without Invitation, English
  5. Effects of peripheral nerve injury on the induction of c-Fos and phosphorylated ERK in the trigeminal sensory nuclear complex., Terayama R, Uchibe K, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/17, Without Invitation, English
  6. Retinoid-loaded nanoparticles enable targeted bone growth by modulating function of the growth plate., Uchibe K, Terayama R, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/17, Without Invitation, English
  7. RAR gamma agonist loaded nanoparticle is a novel therapeutic modality to block heterotopic ossification., Iwamoto M, Uchibe K, Tian H, Matsuoka M, Liu T, Kane MA, Alferiev I, Chorny M, Pan H, Mishina Y, 5th International Conference on Retinoids, 2021/06/09, Without Invitation, English
  8. Local control of heterotopic ossification by synthetic retinoid loaded nanoparticle., Matsuoka M, Uchibe K, Pan H, Tian H, Chorny M, Alferiev I, Mishina Y, Iwamoto M, ASBMR 2021 Annual Meeting, 2021/10/01, Without Invitation, English, San Diego, USA
  9. Roles of retinoic acid signaling in chondrocytes, Kenta Uchibe, Ryuji Terayama, The 62nd Annual Meeting of Japanese Association for Oral Biology, 2020/09/11, Without Invitation, Japanese, Japanese Association for Oral Biology, Kagoshima
  10. Effect of N-acyl Homoserine Lactone (AHL) on the Metabolism of Osteoblastic MC3T3 cells, Guo Jiajie, Weng Yao, Yuan Haoze, Kaya Yoshida, Kenta Uchibe, Mika Ikegame, Hirohiko Okamura, 2019/07/19, Without Invitation, English
  11. The effects of OGA and OGT inhibition on osteoblast and osteoclast differentiation, Weng Yao, Guo Jiajie, Yuan Haoze, Kaya Yoshida, Kenta Uchibe, Mika Ikegame, Hirohiko Okamura, 2019/07/19, Without Invitation, English
  12. Controlling Targeted Bone Growth by Synthetic Retinoid Nanoparticles, Masatake Matsuoka, Kenta Uchibe, Ivan Alferiev, Joshua M Abzug, Liu Min, Norimasa Iwasaki, Motomi Iwamoto, Chorny Michael, Masahiro Iwamoto, The 32nd Annual Meeting of the Japanese Society of Cartilage Metabolism, 2019/03/01, Without Invitation, Japanese, Osaka

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. 2019, 2021
  3. 2019, 2021
  4. 2016, 2019
  5. 2016, 2017
  6. 2014, 2017
  7. 2011, 2012
  8. 2010, 2011