NOBUYUKI HIROHASHI

Last Updated :2024/02/01

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Professor
Web Site
E-mail
hirohasihiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku, Hiroshima, Japan
TEL : (+81)1 82 257 58 FAX : (+81)
Self-introduction
Radiation Emergency Medicine Radiation Disaster Medicine Emergency and Critical Care Medicine, Acute medicine Aeromedical services Blood Purification in Critical Care

Basic Information

Major Professional Backgrounds

  • 1993/04/01, 1995/05/31, The University of Kansas
  • 1995/06/01, 1997/04/30, Kurume University, Research Associate
  • 1997/04/01, 1999/03/31, Professor
  • 1999/04/01, 2005/03/31, Kurume University, Lecturer
  • 2005/04/01, 2005/07/31, St. Marianna University School of Medicine, Researcher
  • 2005/08/01, 2006/10/31, Kurume University, Lecturer
  • 2006/11/01, 2007/03/31, Kurume University, Associate Professor
  • 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 2012/04/01, 2017/01/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2017/02/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Professor

Educational Backgrounds

  • Kurume University, Japan, 1989/04, 1993/03
  • Kurume University, Japan, 1983/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Kurume University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Emergency medicine

Research Keywords

  • EMERGENCY MEDICINE RADIATION DISASTER MEDICINE CRITICAL CARE MEDICINE ACUTE MEDICINE AEROMEDICAL SERVICES BLOOD PURIFICATION IN CRUTICAL CARE

Affiliated Academic Societies

  • Japanese Association for Acute Medicine, 1989/06
  • Japanese Society for Emergency Medicine, 1998/06
  • Japan Society for Blood Purification in Criticsl Care, 1997/06
  • Japanese Society of Intensive Care Medicine, 1999/04
  • Japanese Asoociation for the Surgery of Trauma, 1997/06
  • Japanese Society for Aeromedical Services, 2003/10
  • Japanese Society of Clinical Toxicology, 1997/06
  • Japanese Society for Burn Injuries, 1997/06
  • Japanese Society for Abdominal Emergency Medicine, 1997/06
  • Japan Endotoxin Society, 1995/11
  • Japan Shock Society, 2007/09
  • Society of Critical Care Medicine, 2007/09
  • International Endotoxin & Innate Immunity Society, 1994/08
  • Japanese Association for Radiation Accident Disaster Medicine, 2013
  • The Japanese Radiation Research Society

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 2Term, War and Peace from the Viewpoint of Medicine
  2. 2023, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  3. 2023, Undergraduate Education, Year, Systemic Disease Control
  4. 2023, Undergraduate Education, Intensive, Practice for medical research
  5. 2023, Undergraduate Education, Intensive, Practice of Medicine I
  6. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  7. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  8. 2023, Graduate Education (Master's Program) , First Semester, Research
  9. 2023, Graduate Education (Master's Program) , Second Semester, Research
  10. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  11. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  12. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  13. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  14. 2023, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  15. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Radiation Medicine
  16. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Radiation Medicine
  17. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Radiation Medicine
  18. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Radiation Medicine
  19. 2023, Graduate Education (Doctoral Program) , Second Semester, Radiological Disaster Medicine
  20. 2023, Graduate Education (Doctoral Program) , First Semester, Radiation Disaster Recovery Studies
  21. 2023, Graduate Education (Doctoral Program) , First Semester, Long-term Fieldwork/Long-term Internship
  22. 2023, Graduate Education (Doctoral Program) , Second Semester, Long-term Fieldwork/Long-term Internship

Research Activities

Academic Papers

  1. Radiation Emergency Medical Preparedness in Japan: A Survey of Nuclear Emergency Core Hospitals, DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS, 17, 20220207
  2. Results of the 2018 Japan Society for Blood Purification in Critical Care survey: current status and outcomes, RENAL REPLACEMENT THERAPY, 8(1), 20221112
  3. p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions, FRONTIERS IN PHARMACOLOGY, 13, 20220919
  4. Oncogenic Role of ADAM32 in Hepatoblastoma: A Potential Molecular Target for Therapy, CANCERS, 14(19), 202210
  5. Radiation Emergency Medical Preparedness in Japan: A Survey of Nuclear Emergency Core Hospitals, Disaster Medicine and Public Health Preparedness, 2022 Feb 7;1-7. doi: 10.1017/dmp.2021.348.(2022 Feb 7;1-7. doi: 10.1017/dmp.2021.348.), 1-7, 20220207
  6. ★, Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs, CELLS, 11(3), 202202
  7. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, SCIENTIFIC REPORTS, 11(1), 20210817
  8. GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A, CARCINOGENESIS, 41(9), 1184-1194, 20200924
  9. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells, PLOS ONE, 14(7), 20190719
  10. ★, Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway, TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 245(3), 193-204, 201807
  11. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13(2), 20180221
  12. ★, Health effects of radiation and other health problems in the aftermath of nuclear accidents, with an emphasis on Fukushima, LANCET, 386(9992), 479-488, 20150801
  13. Loss of life following evacuation: lessons learned from the Fukushima Daiichi Nuclear Power Plant accident, LANCET, 379, 889-891, 2012
  14. Estimating the proportion of DMAT members able to act during a radiation disaster through a questionnaire survey in Chu- goku-Shikoku District and Fukushima Prefecture, Japanese Journal of Disaster Medicine, 27(1), 65-74, 20220126
  15. Comparison of Airway Simulators for the AirwayScope Video-Laryngoscope, Emergency Medicine Investigations, 2, DOI: 10.29011/2475-5605. 000074, 20180309
  16. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report, BMC PULMONARY MEDICINE, 16, 20160812
  17. Iwasaki Y, Namera A, Giga H, Kida Y, Ota K, Une K, Otani T, Ohshimo S, Hirohashi N, Tanigawa K: A case of severe puffer fish poisoning: serum tetrodotoxin concentration measurements for 4 days after ingestion J CLIN TOXICOL 5: 226. doi:10.4172/2161-0495.1000226, 2015, J CLIN TOXICOL, 5(226), doi:10.4172/2161-0495.-doi:10.4172/2161-0495., 2015
  18. Influence of clinical experience of the Macintosh laryngoscope on performance with the Pentax-AWS Airway Scope®, a rigid video-laryngoscope, by paramedics in Japan., J ANESTH, 29(5), 672-677-677, 2015
  19. A PILOT STUDY: A COMBINED THERAPY USING POLYMYXIN-B HEMOPERFUSION AND EXTRACORPOREAL MEMBRANE OXYGENATION FOR ACUTE EXACERBATION OF INTERSTITIAL PNEUMONIA, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 31(4), 343-349, 2014
  20. Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 108(7), 1031-1039, 201407
  21. KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome, ORPHANET JOURNAL OF RARE DISEASES, 7, 20121217
  22. KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome, RESPIRATORY RESEARCH, 12, 20110322
  23. Tracheal Intubation of a Difficult Airway Using Airway Scope, Airtraq, and Macintosh Laryngoscope: A Comparative Manikin Study of Inexperienced Personnel, ANESTHESIA AND ANALGESIA, 110(4), 1049-1055, 201004
  24. 廣橋 伸之(広島大学 大学院医歯薬保健学研究院応用生命科学部門救急医学) Source:救急医学(0385-8162)39巻5号 Page586-591(2015.05), 39(5), 586-591, 20150501
  25. Differential Lung Ventilation with Two Endotracheal Tubes for Blunt Tracheal Injury: A Case Report, 44(8), 534-537, 20200810

Publications such as books

  1. 2017/08/14, Critical care neurology, Acute central nervous system infectious disease ( encepharitis, meningitis), encepharitis, meningitis, 2017, 8, Scholarly Book, Joint work, 日本語, 9784260017541, 4260017543, 664
  2. 2018/01/10, Today's therapy, Acute radiation syndrome, Acute radiation syndrome, 2018, 1, Dictionary/Encyclopedia, Single work, 日本語, Nobuyuki Hirohashi, 9784260032346, 4260032348, 2066

Invited Lecture, Oral Presentation, Poster Presentation

  1. Lesson Learned From Radiation Disaster In Japan, Nonuyuki Hirohashi, The Annual Scientific Meeting of The Disaster Working Group Faculty of Medicine, Public Health and Nursing, Gadjah Mada University (FK-KMK UGM), 2023/03/30, With Invitation, English
  2. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, ACE2, via aryl-hydrocarbon receptor signal, 2022/06/04, Without Invitation, Japanese
  3. Significance of up-regulation of the hypoxia-inducible EFEMP2 in cancer cells, Kengo Mekata, Keiji Tanimoto, Daichi Aoki, Takahiro Fukazawa, Nobuyuki Hirohashi, 2021/11/27, Without Invitation, Japanese
  4. Current Status and Issues of Nuclear Disaster Medical Training in Covid-19 pandemic, Nobuyuki HIROHASHI, Satoshi Yamaga, Masaki Murao Maryami Yuliana Kosim, Kenji Kamiya, Technical Meeting on Radiation in Medicine Communications and Methodologies – International Perspectives and the Role of Science, Technology and Society in Low-Dose Radiation Settings, 2021/11/10, With Invitation, English, IAEA, Hiroshima, web
  5. Human resource development after Fukushima accident including graduate education, Nobuyuki Hirohashi, Public Health consequences of Fukushima nuclear disaster: 10 years towards recovery WHO REMPAN Webinar Series, 2021/03/23, With Invitation, English, WHO RENPAM, WEB
  6. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima –, Nobuyuki HIROHASHI, 2019/12/17, Without Invitation, English
  7. The role of Hiroshima University as the new radiation/nuclear emergency medical support center for the next disaster, A new horizon of radiation health risk science education from the experience of nuclear disaster, Nobuyuki HIROHASHI, 2019/11/14, With Invitation, Japanese
  8. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima –, Nobuyuki HIROHASHI, 2019/10/28, With Invitation, English
  9. Code Blue,Black & Yellow - Lessons learned from Fukushima and Hiroshima and More -, Nobuyuki HIROHASHI, Joint meeting(Department of Nursing, U Indonesia and Research Institute for Radiation Biology and Medicine,U Hiroshima), 2019/10/10, With Invitation, English, Department of Nursing, U Indonesia, Depok, Indonesia
  10. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, 2019/09/02, With Invitation, English
  11. The role of Hiroshima University as the new radiation/nuclear emergency medical support center for the next disaster., Nobuyuki HIROHASHI, Crisis in Context: Minding the gaps in medical preparedness for a Rad/Nuke Incident The Radiation Injury Treatment Network Workshop, 2019/07/31, With Invitation, English, The Radiation Injury Treatment Network, Arlington, VA,USA, The Radiation Injury Treatment Network seeks to increase the understanding of and pre-paredness for the tremendous medical, environmental, and psychological consequences of a mass casualty radiological/nuclear incident for healthcare professionals. The 2019 RITN workshop will highlight recent developments in resource-constrained environments: (1) optimizing ARS initial assessment and triage, (2) ensuring the availability and appropriate use of medical and psycho-social supportive care, (3) disseminating the latest research in radiation-specific medical countermeasures, (4) applying technology as a force multiplier for care and education, and (5) enhancing collaboration among burn surgeons and RITN professionals. Additionally, the workshop will encourage open sharing of lessons learned from past efforts.
  12. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, 2019/07/23, Without Invitation, English
  13. New Radiation Emergency Medical System in Japan. , Nobuyuki HIROHASHI, Discussion were made involving authorities from the government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia and Radiation Safety Committee of NCC, about how to train doctors and medical professionals for radiation accident medical response, how to organize medical care pathway., 2019/06/14, With Invitation, English, Radiation Safety Committee of National Cancer Center (NCC) Deputy Prime Minister of Mongolia, Ulaanbaatar, Mongolia, discussion were made involving authorities from the government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia and Radiation Safety Committee of NCC, about how to train doctors and medical professionals for radiation accident medical response, how to organize medical care pathway. In this discussion total 20 guests attended: Dr. Hirohashi- Proffessor of Radiation Disaster Medicine Department, Hiroshima University, Toby Lowe- Radiation therapist from St.George Hospital, Australia and representatives from The government of Mongolia Nuclear Energy Commission, General Agency for Specialized Inspection Regulatory Agency of the Government of Mongolia, National Public Health Center and Second General Hospital as well as Radiation Safety Committee of NCC.
  14. ER(Emergency room) management of Radiation/Nuclear disaster patients, Nobuyuki HIROHASHI, The onsite training, "how to organize emergency response for radiation accident" took place at NCC Conference hall, 2019/06/14, With Invitation, English, Radiation Safety Committee of National Cancer Center (NCC) supported by Deputy Prime Minister of Mongolia, Ulaanbaatar, Mongolia, The onsite training, about how to organize emergency response for radiation accident, took place at NCC Conference hall in the extension building during 09:00 – 12:00, on 14th June 2019 and led by Prof. Hirohashi Nobuyuki. Two radiation accident cases were prepared in advance, in order to show on site medical assistance, including how doctors and nurses should wear the protection suits and undress properly. Total 97 participants from either rural or urban hospitals attended this demonstration training.
  15. New Radiation Emergency Medical System in Japan - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, Radiation Accident Prevention and Medical Response, 2019/06/13, With Invitation, English, the Deputy Prime Minister of Mongolia, Radiation Safety Committee of National Cancer Center (NCC), Ulaanbaatar,Mongolia
  16. NHK Documentary Battling a Radiation Emergency: The Doctors at Fukushima, Nobuyuki HIROHASHI et al., NHK Documentary :Battling a Radiation Emergency: The Doctors at Fukushima, 2019/05/11, With Invitation, Japanese, NHK
  17. New Radiation Emergency Medical System in Japan. - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, HICARE SEMINAR, 2018/10/23, With Invitation, English, John A.Burns School of Medicine, University of Hawaii HICARE, Hawaii, USA
  18. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, HICARE special seminar, 2018/10/22, With Invitation, English, Kuwakini Medical Center,HICARE, Hawaii, USA.
  19. The role of Hiroshima University as the new radiation/nuclear emergency medical support center on communicating radiation/nuclear emergencies to the public, Nobuyuki HIROHASHI, Kenji Kamiya, International Symposium on Communicating Nuclear and Radiological Emergencies to the Public, 2018/10/04, Without Invitation, English, IAEA, IAEA Headquarters Vienna, Austria
  20. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, REAC/TS Advanced Radiation Medicine course, 2018/08/15, With Invitation, English, REAC/TS, Oak Ridge, TN, USA
  21. Radiation/Nuclear Emergency Medical System, NOBUYUKI HIROHASHI, Kick-off Seminar between Soochow University and Hiroshima University, 2018/04/24, Without Invitation, English, Hiroshima University, Soochow University, Hiroshima
  22. ER(Emergency room) management of Radiation/Nuclear disaster patients, NOBUYUKI HIROHASHI, HICARE INTERNATIONAL TRAINING COURSE on Medical Responses to Radiation Accidents and Disasters, 2018/02/20, Without Invitation, English, HICARE, HIROSHIMA, published
  23. Emergency medical response to radiation and nuclear accidents:Drill, NOBUYUKI HIROHASHI, Emergency Radiation Medicine Promoting Center, Hiroshima University, HICARE INTERNATIONAL TRAINIG COURSE on Medical Responses to Radiation Accidents and Disasters, 2018/02/20, Without Invitation, English, HICARE, HIROSHIMA, published
  24. Consultancy meeting on STS education support on return in the context of low-dose radiation, Nobuyuki HIROHASHI, Consultancy meeting on STS education support on return in the context of low-dose radiation, 2018/01/15, With Invitation, English, IAEA, FUKUSHIMA MEDICAL UNIVERSITY, FUKUSHIMA,JAPAN
  25. Immediate post-accident response, NOBUYUKI HIROHASHI, Consulting meeting on review and future of science and technology studies(STS) Curriculum in Japan, 2017/08/29, With Invitation, English, Consulting meeting on review and future of science and technology studies(STS) Curriculum in Japan, FUKUSHIMA,JAPAN, published
  26. Detection of suppressive activity on innate immune DAMPs response in sepsis, 2016/02/13, Without Invitation, English
  27. Loss of life after evacuation: lessons learned from the Fukushima accident Roles of DMAT and Hiroshima University Hospital in the management of nuclear catastrophe, Hirohashi N, INU(The International Network of Universities)nursing summer workshop, 2015/08/08, With Invitation, English
  28. Technical Meeting on Communication on Low-Dose Radiation – the Role of Science, Technology and Society, Nobuyuki HIROHASHI(Chair Person), Technical Meeting on Communication on Low-Dose Radiation – the Role of Science, Technology and Society, With Invitation, English, IAEA/FMU, FUKUSHIMA
  29. New Radiation Emergency Medical System in Japan.   - Lessons learned from Fukushima and Hiroshima -, Nobuyuki HIROHASHI, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Prevention of multiple organ dysfunction syndrome by modulation of the expression of endotoxin receptors (TLR4,RP105) on PBMC, 2003, 2004
  2. KAKENHI, 2001, 2002
  3. KAKENHI, 1998, 1999
  4. KAKENHI, 1995, 1995

Social Activities

History as Committee Members

  1. SHAMISEN STAKEHOLDER MEETING MEMBER, 2017/03/23, 2017/03/24

Organizing Academic Conferences, etc.

  1. The 7th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2023/02, 2023/02
  2. 2022/11, 2022/11
  3. 2020/09, 2020/09

History as Peer Reviews of Academic Papers

  1. 2022, Journal of Radiation Research, Others, reviewer, 1
  2. 2021, Acute Medicine & Surgery, Others, 1
  3. 2021, Journal of Radiation Research, Others, Reviewer, 2
  4. 2020, Journal of Radiation Research, Others, 4
  5. 2015, Associate Editor, Acute Medicine & Surgery, Others, 1
  6. 2016, Associate Editor, Acute Medicine & Surgery, Others
  7. 2018, Acute Medicine & Surgery, Others, associate editor